Table S2. IC50 values of five compounds for inhibiting pAkt accumulation in dHL60 cells

IC50 and pIC50 values and corresponding SEMs were derived from the curves shown in Fig. S1 using Prism software (GraphPad). NR, the curve-fitting algorithm did not yield relevant values. The GraphPad software was able to calculate 95% confidence intervals (unpublished data) and from these to calculate the statistical significance of differences between pIC50 values. At the P < 0.05 level, no pIC50 value differed from any other except that (1) PI-103 inhibits the fMLP response significantly less potently than do PIK-90 and -93, and (2) PI-103 inhibits the fMLP response significantly less potently than it inhibits the insulin response.