Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release -- Data Supplement - JCB--Weisleder et al. -- The Journal of Cell Biology

Table S1. Parallel disruption of triad junctions in aged wt and young mg29(-/-) skeletal muscle

	TT swelling	SR fragmentation	Large SR aggregates
Young wt hindlimb	13/483 (n = 8)	1/315 (n = 6)	0/5,255 (n = 8)
Aged EDL	5/183 (n = 3)	65/150* (n = 3)	418/2,771* (n = 3)
Aged soleus	77/165* (n = 3)	68/200* (n = 3)	0/1,427 (n = 3)
Young mg29(-/-) hindlimb	55/73* (n = 2)	Nishi et al., 1999	0/2,264 (n = 2)
Muscle sections were examined by electron or light (for large SR aggregates) microscopy. Hindlimb indicates muscle biopsies containing a mixture of soleus and EDL. Data presented are the total number of positive cells/number of cells examined. , P < 0.005 versus young wt for percentage values. n, number of mice examined. Nishi, M., S. Komazaki, N. Kurebayashi, Y. Ogawa, T. Noda, M. Iino, and H. Takeshima. 1999.Abnormal features in skeletal muscle from mice lacking mitsugumin29. J. Cell Biol.* 147:1473–1480.