Loss of p53 promotes RhoA-ROCK-dependent cell migration and invasion in 3D matrices -- Data Supplement - JCB--Gadea et al. -- The Journal of Cell Biology

[HELP with Viewing Videos] [To Figure]

Video 10
p53 deficiency-driven rounded morphology is prevented by RhoE in 3D matrix. Corresponds to Fig. 5 D. DIC analysis of p53^-/- MEFs transfected with GFP-RhoE recorded at the frequency of one image every 5 s. The first 10 images show the overlaying of GFP fluorescence and DIC to enable the identification of transfected cells. p53^-/- MEFs transfected with RhoE are converted from a rounded blebbing to an elongated morphology.