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Figure S1. Determination of the genotype of different subjects with respect to the single nucleotide polymorphism G534E. DNA was isolated from whole blood, and exon XIII was sequenced using primers as described previously^{(Hoppe, B., F. Tolou, H. Radtke, H. Kiesewetter, T. Dorner, and A. Salama. 2005. Blood. 105:1549-1551).}