Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells -- Data Supplement - JEM--Marti et al. -- The Journal of Experimental Medicine

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Figure S1. Comparison of recombinant TSAd- versus CD3/CD28-mediated LCK activation. Experiments were conducted as in Fig. 4 A using LCK immunoprecipitated from LN T cells from mice of the indicated genotypes. CD3/CD28 stimulation was performed for 3 min. Smt-TSAd was used at the optimal concentration of 1 mM. LCK is activated to a lesser degree by TSAd in vitro than by CD3/CD28 engagement in vivo.