Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis -- Data Supplement - JEM--Onoyama et al. -- The Journal of Experimental Medicine

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Figure S6. Lck-Cre/Fbxw7^F/F/p53^–/– mice develop thymic lymphomas derived from DP thymocytes. (A) Gross appearance of the thymus from p53^–/– (control) and Lck-Cre/Fbxw7^F/F/p53^–/– littermates at 8 wk of age. The two Lck-Cre/Fbxw7^F/F/p53^–/– mice had developed thymic lymphoma. Bar, 5 mm. (B) Surface expression of CD4 and CD8 on thymocytes from an Lck-Cre/Fbxw7^F/F/p53^–/– mouse that had not developed lymphoma (left) and on thymic lymphoma cells from Lck-Cre/Fbxw7^F/F/p53^–/– mice (middle and right) at 8 wk of age. The percentages in each quadrant are shown. (C) Surface expression of TCRβ and B220 on spleen cells from the two Lck-Cre/Fbxw7^F/F/p53^–/– mice that had developed the thymic lymphomas in B. The percentages in each quadrant are shown.