Table S1. Frequencies of CFH polymorphisms in patients with aHUS, AMD, or MPGN2

  
Genotypes
Allele frequenciesa
 SNP (allele1>allele2)
1/1
1/2
2/2
Sum
1
2
p-valueb
OR
(95% CI)
Controls-332C/T (rs3753394)
72
66
13
151
0.7
0.3
 c.184G/A (V62I)
(rs800292)
70
61
7
138
0.73
0.27
 c.1204T/C (Y402H)
(rs1061170)
73
65
8
146
0.72
0.28
 c.2016A/G (Q672Q)
(rs3753396)
92
55
5
152
0.79
0.21
 c.2808G/T (E936D)
(rs1065489)
90
56
5
151
0.78
0.22
aHUS-332C/T (rs3753394)
27
43
18
88
0.55
0.45
0.0016
1.91
(1.30–2.79)
 c.184G/A (V62I)
(rs800292)
71
17
3
91
0.87
0.13
0.00032
0.38
(0.23–0.64)
 c.1204T/C (Y402H)
(rs1061170)
54
32
7
93
0.75
0.25
NS
–
 c.2016A/G (Q672Q)
(rs3753396)
43
36
14
93
0.66
0.34
0.0015
1.92
(1.28–2.9)
 c.2808G/T (E936D)
(rs1065489)
41
39
13
93
0.63
0.37
0.0017
1.92
(1.27–2.88)
AMD-332C/T (rs3753394)
31
33
8
72
0.66
0.34
NS
–
 c.184G/A (V62I)
(rs800292)
61
14
3
78
0.87
0.13
0.00065
0.39
(0.23–0.67)
 c.1204T/C (Y402H)
(rs1061170)
24
37
18
79
0.54
0.46
0.00012
2.23
(1.49-3.35)
 c.2016A/G (Q672Q)
(rs3753396)
40
29
7
76
0.72
0.28
NS
–
 c.2808G/T (E936D)
(rs1065489)
43
28
7
78
0.73
0.27
NS
–
MPGN2-332C/T (rs3753394)
10
3
2
15
0.77
0.23
NS
–
 c.184G/A (V62I)
(rs800292)
11
4
0
15
0.87
0.13
NS
–
 c.1204T/C (Y402H)
(rs1061170)
4
8
3
15
0.53
0.47
0.036
2.27
(1.06–4.88)
 c.2016A/G (Q672Q)
(rs3753396)
12
1
2
15
0.83
0.17
NS
–
 c.2808G/T (E936D)
(rs1065489)
12
1
2
15
0.83
0.17
NS
–
aBold type indicates allele frequencies in AMD, aHUS, and MPGN2 that are significantly different from those seen in healthy controls.

bp-values shown are the results of the two-sided FisherÕs exact test for the comparison of allele frequencies between the control and aHUS, AMD, or MPGN2.