Table S3. Mortality, renal function, and hematological parameters in Cfh-/-.FHΔ16-20 and Cfh+/-.FHΔ16-20 mice

 

Mortality
at 8 wk

Hematuria
grade 0 to
+++

Urea mmol/l

Red cell fragments
peripheral blood
smear

Platelet count
× 109 per liter

Cfh-/-.FHΔ16-20

9/15
(60%)a

8/8 grade +++
(100%)

31.8
(26.3–42.8;
n = 8) b

8/8 (100%)

64
(28–291;
n = 7) c

Cfh+/-.FHΔ16-20

0/11

All negative

10
(4.8–16.5;
n = 11)

All negative

517
(445–584;
n = 4)

aFunctional assessment was possible in 8 out of the 9 mice that died.

bP = 0.0003 versus Cfh+/-.FHΔ16-20 using the Mann-Whitney test.

cP = 0.0061 versus Cfh+/-.FHΔ16-20 using the Mann-Whitney test.