Table S1. FBW7 mutations are only present in human T-ALL cell lines with HD mutations or wild-type NOTCH1

Cell lines

Notch1 mutation or translocation

FBW7 mutation

Sensitivity to γ-secretase inhibitor

P12-ICHIKAWA

HD

Yes

No

CEM

HD

Yes

No

RPMI 8402

HD

Yes

No

Be13

WT

Not expressed

No

Jurkat E6

WT

Yes

No

KOPTK

HD-PEST

WT

Yes

HPB-ALL

HD-PEST

WT

Yes

ALL-SIL

HD-PEST

WT

Yes

DND41

HD-PEST

WT

Yes

PF382

HD-PEST

WT

No

CUTLL1

t(7;9)(q34;q34)

WT

Yes

SUPT1

t(7;9)(q34;q34.3)

WT

Yes

Loucy

WT

WT

No