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Figure S2. Heterozygous genetic deficiency for plasminogen and early neurovascular damage. PDAPP;plg^+/2 mice are consistent with changes observed in TgCRND8;plg^+/2 mice, as indicated by increased Evans blue extravasation at 12 mo of age relative to PDAPP littermates. Data are represented as mean ± SEM, where n = 4 for both PDAPP and PDAPP;plg^+/2 mice and compared to data from Fig. 5. *, P