Consequences of localized frustration for the folding mechanism of the IM7 protein -- Sutto et al. 104 (50): 19825 Data Supplement - HTML Page - index.htslp -- Proceedings of the National Academy of Sciences

Sutto et al. 10.1073/pnas.0709922104.

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SI Figure 4
SI Figure 5
SI Table 2
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SI Figure 4

Fig. 4. Free-energy profiles of IM7 with various degrees of explicit cooperativity.

Fig. 5. IM7 local frustration upon complexation. Local frustration is depicted on the structure of the IM7 monomer alone (A) and in complex with Colicin E7 (B) (PDB ID 7CEI). The surface of the Colicin E7 monomer appears above IM7 in B. The surface of the top three mutations from our design procedure (residues 49, 55, and 56) are shown in yellow in B.