Video 5 (652 KB)
MCF-7 cells transfected with vector alone with uPA gradient applied. Cells display increased protrusion formation and translocate in random directions but with no sensing of the uPA gradient. Video shows cells on a Matrigel substratum with any chemoattractant source applied at the top of the video and are comprised of 10-min interval frames over a 5-h period of time.