Table S1. BubR1, Cenp-E, and Mad2 fluorescence intensity values at prometaphase kinetochores after exposure to the various drug combinations for 1 h.

 

Control

ZM

Noc

NZ

Taxol

TZ

BubR1

10.98 6 1.10
(26/3)

0.95 6 0.17
(35/3)

   10.76 6 1.00
(46/4)

1.33 6 0.22
(46/4)

 8.07 6 0.62
(54/4)

1.37 6 0.28
(42/4)

Cenp-E

 8.89 6 1.01
(37/3)

2.53 6 0.79
(49/4)

 7.55 6 0.89
(41/3)

4.48 6 0.87
(57/4)

10.96 6 1.62
(43/3)

2.57 6 0.89
(50/4)

Mad2

1.28 6 0.19
(30/3)

0.06 6 0.02
(44/4)

 1.40 6 0.09
(49/4)

0.43 6 0.08
 (46/4)

  0.90 6 0.14
 (53/4)

0.39 6 0.11
(37/3)

Values represent the mean ± SEM. All fluorescence intensity values are normalized to ACA staining. The numbers in parentheses represent the number of kinetochore pairs quantitated and the number of cells analyzed.