Table 1. Reactivity of normal human tissue sections with the anti-Neu5Gc antibody
Tissue | Staining pattern |
Lung | Luminal edges of bronchiolar epithelial cells and associated secretions. Endothelium of blood vessels. |
Skin | Luminal edges of epithelial cells of eccrine glands and associated ducts. Endothelium of blood vessels. |
Colon | Luminal edges of colonic epithelial cells and associated secretions. Endothelium of blood vessels. |
Prostate | Cytoplasmic staining of glandular epithelial cells. Endothelium of blood vessels. |
Uterus | Epithelial cells of endometrial glands (nonsecretory phase studied). |
Kidney | Edges of collecting duct epithelium and associated secretions. No glomerular staining. |
Spleen | Periarteriolar lymphoid sheath lymphocytes. Endothelium of blood vessels. |
Pancreas | Epithelial cells of acini. Endothelium of blood vessels. |
Testis | Basal cell layer (spermatogonia) of the seminiferous tubules. Endothelium of blood vessels. |
Liver | Luminal edges of some bile duct epithelial cells. Endothelium of blood vessels. |
Fetal stomach | Luminal edges of epithelial cells of the villi and associated secretions. Endothelium of blood vessels. |
Placenta | Endothelium. |
Breast carcinoma | Majority of carcinoma cells and some blood vessels. |
See Fig. 2 for some examples of the staining pattern.