Table 1. Reactivity of normal human tissue sections with the anti-Neu5Gc antibody

Tissue

Staining pattern

Lung

Luminal edges of bronchiolar epithelial cells and associated secretions. Endothelium of blood vessels.

Skin

Luminal edges of epithelial cells of eccrine glands and associated ducts. Endothelium of blood vessels.

Colon

Luminal edges of colonic epithelial cells and associated secretions. Endothelium of blood vessels.

Prostate

Cytoplasmic staining of glandular epithelial cells. Endothelium of blood vessels.

Uterus

Epithelial cells of endometrial glands (nonsecretory phase studied).

Kidney

Edges of collecting duct epithelium and associated secretions. No glomerular staining.

Spleen

Periarteriolar lymphoid sheath lymphocytes. Endothelium of blood vessels.

Pancreas

Epithelial cells of acini. Endothelium of blood vessels.

Testis

Basal cell layer (spermatogonia) of the seminiferous tubules. Endothelium of blood vessels.

Liver

Luminal edges of some bile duct epithelial cells. Endothelium of blood vessels.

Fetal stomach

Luminal edges of epithelial cells of the villi and associated secretions. Endothelium of blood vessels.

Placenta

Endothelium.

Breast carcinoma

Majority of carcinoma cells and some blood vessels.

See Fig. 2 for some examples of the staining pattern.