Movie 1.
PIB kinetics observed over time in 3D volumes of the brain in a live transgenic mouse. Each frame in the sequence is a maximum intensity projection measuring 615 ´615 µm by ≈150 µm deep. At t = 0 a bolus i.v. injection (2 mg/kg) of PIB was administered. This series was acquired from a Tg2576 mouse expressing a heavy amyloid burden. PIB enters the circulation labeling cerebral amyloid angiopathy almost instantaneously, crosses from small blood vessels into the parenchymal space, and proceeds to label dense core plaques. Amyloid remains labeled for > 24 h.