Blood, Vol. 111, Issue 3, 1420-1427, February 1, 2008

On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis
Blood Hadinoto et al. 111: 1420

Supplemental materials for: Hadinoto et al

Files in this Data Supplement:

• Document 1. A detailed description of the calculation performed to estimate the half life of CTL_IE (PDF, 120 KB)
  
  
• Table S1. A complete listing of all the values for all the parameters tested for all of the patients analyzed in this study (PDF, 205 KB) -
  All the graphs presented in the paper were derived from data in this table.
  
  
• Figure S1. log(CTL_IE) plotted against the number of days post-presentation (JPG, 34.3 KB) -
  Red squares show data for Patient IM4. Fitted curve shows a clear transition from mB_Lat half-life to CTL_IE half-life at around day 20. A data point at day 360 has been omitted as this lies in the persistent phase.
  
  
  
  
  
  
• Figure S2. log(CTL_IE) plotted against the number of days post-presentation (JPG, 31.3 KB) -
  Red squares show data for Patient IM5. Fitted curve does not show a transition from mB_Lat half-life to CTL_IE half-life. The reported CTL half-life appears to be a result of over-fitting.
  
  
  
  
  
  
• Figure S3. log(CTL_IE) plotted against the number of days post-presentation (JPG, 31.5 KB) -
  Red squares show data for Patient IM7. Fitted curve does not show a transition from mB_Lat half-life to CTL_IE half-life. The curvature and reported CTL half-life appear to be a result of over-fitting.
  
  
  
  
  
  
• Figure S4. log(CTL_IE) plotted against the number of days post-presentation (JPG, 33.7 KB) -
  Red squares show data for Patient IM8. Fitted curve shows a clear transition from mB_Lat half-life to CTL_IE half-life at around day 15. A data point at day 360 has been omitted as this lies in the persistent phase.
  
  
  
  
  
  
• Figure S5. log(CTL_IE) plotted against the number of days post-presentation (JPG, 30.6 KB) -
  Red squares show data for Patient IM10. Fitted curve shows a clear transition from mB_Lat half-life to CTL_IE half-life at around day 12.
  
  
  
  
  
  
• Figure S6. log(CTL_IE) plotted against the number of days post-presentation (JPG, 31.1 KB) -
  Red squares show data for Patient IM11. Fitted curve does not show a transition from mB_Lat half-life to CTL_IE half-life. The reported CTL half-life appears to be a result of over-fitting.