Blood, Vol. 111, Issue 3, 1552-1559, February 1, 2008

FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications
Blood Whitman et al. 111: 1552

Supplemental material for: Whitman et al

Files in this Data Supplement:

• Document 1. The following Cancer and Leukemia Group B institutions, principal investigators, and cytogeneticists participated in this study (PDF, 14.9 KB).
  
  
• Table S1. FLT3-TKD gene expression signature (probe sets ordered by fold-change, TKD/WT) (PDF, 187 KB).
  
  
• Table S2. Order of probe sets comprising the TKD signature as they appear in the heat map Figure 2 (PDF, 145 KB).
  
  
• Figure S1. Disease-free survival for molecular subsets of de novo CN-AML patients FLT3-ITD, grouped by FLT3-TKD status (PDF, 21.5 KB). -
  (A) FLT3-TKD groups in the NPM1-mutated and NPM1-WT subsets. (B) FLT3-TKD groups in the low and high BAALC expression subsets. (C) FLT3-TKD groups in the low and high ERG expression subsets.
  
  
• Figure S2. Graphs of over-represented gene ontology terms among the genes over-expressed in FLT3-TKD relative to FLT3-WT in the derived gene expression signature (PDF, 508 KB). -
  Specific terms are at the top, while general terms are at the bottom within a subfigure: A) cellular components (8 over-represented), B) biological processes (14 over-represented), and C) molecular functions (10 over-represented). Over-represented terms are represented by a solid oval (with p-value indicated). Terms represented by a dashed oval are not over-represented but are displayed in order to show the relationships among over-represented terms. An "is_a" relationship indicates that the more specific term is a particular subclass of the more general term. A "part_of" relationship indicates that when the more specific term is present it is always a part of the more general term, but the more specific term is not a necessary component of the more general term.
  
  
• Figure S3. Graphs of over-represented gene ontology terms among the genes under-expressed in FLT3-TKD relative to FLT3-WT in the derived gene expression signature (PDF, 379 KB). -
  A) cellular components (7 over-represented), B) biological processes (18 over-represented) and C) molecular functions (3 over-represented). Specific terms are at the top, while general terms are at the bottom. Over-represented terms are represented by a solid oval (with p-value indicated). Terms represented by a dashed oval are not over-represented but are displayed in order to show the relationships among over-represented terms. An "is_a" relationship indicates that the more specific term is a particular subclass of the more general term. A "part_of" relationship indicates that when the more specific term is present it is always a part of the more general term, but the more specific term is not a necessary component of the more general term.