Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo -- Data Supplement - -- Proceedings of the National Academy of Sciences

Supplementary material for Clish et al. (1999) Proc. Natl. Acad. Sci. USA 96(14), 8247-8252.

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Fig. 8. ATL analogs induce vasodilation in isolated rat aorta: relaxation relative to Iloprost. Rats were killed with pentobarbital overdoses. The aorta was isolated and a preload of 300-400 mg was given. The vessels were precontracted with U46619 (25 ng/ml). Relaxation was induced with addition of Iloprost, 5(R/S)-methyl-LXB₄, 15-epi-16-phenoxy-LXA₄, ATLa₁, or ATLa₂ to a final concentration of 1 mM. Aorta smooth muscle relaxation was measured with a force transducer, and the data were digitized and stored on a personal computer. 5(R/S)-methyl-LXB₄, 15-epi-16-phenoxy-LXA₄, ATLa₁, and ATLa₂ caused 42.8%, 37.0%, 38.1%, and 40.0% relaxation of smooth muscle, respectively. Values represent mean ± SEM (n = 4-6).