Preferential protection of protein interaction network hubs in yeast: Evolved functionality of genetic redundancy -- Kafri et al. 105 (4): 1243 Data Supplement - HTML Page - index.htslp -- Proceedings of the National Academy of Sciences

Kafri et al. 10.1073/pnas.0711043105.

Supporting Information

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SI Appendix 1
SI Appendix 2
SI Appendix 3
SI Table 1
SI Table 2
SI Figure 7
SI Appendix 4

Fig. 7. Joint dependence of gene dispensability on connectivity within the protein interaction network, and on expression similarity among paralogs. (A) Proportion of dispensable genes from the total set of paralogs is shown (blue, low proportion of dispensable genes; red, high proportion of dispensable genes) as a function of their degree of connectivity in the protein interaction network, and the expression similarity between the paralogous pair members. Note that the values of high degree and expression similarity below -0.2 often contain no genes. These appear as dark purple in the plot. (B) P values (plotted in red), illustrating the association between degree connectivity and dispensability, were tested for paralogous pair populations and stratified according to expression similarity. These are compared with the P values (plotted in black), illustrating the enrichment of functionally redundant paralogs. The plot was generated by sliding a window of width 0.3 along the expression similarity axis. For statistical details on P value calculations, see Materials and Methods.