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Figure S1. Representative demonstration of joint histology in mice infected with wild-type B. burgdorferi, bmpA/B^— mutant, and bmpAB complemented isolates. 3 wk after spirochete infection, tibiotarsal joints were analyzed for histopathology. (left) Indicated low-resolution (4×) joints isolated from mock complemented wild-type B. burgdorferi (WT), mock complemented bmpA/B^— mutant (bmpA/B^—), and bmpAB-complemented bmpA/B^— mutant (bmpAB com) isolates. (right) Higher-resolution (20×) images of selected areas from corresponding sections (boxed area). Histological changes in the joint, including infiltration of inflammatory cells, alteration in the thickness of tendons or ligament sheaths, and hypertrophy and hyperplexia of the synovium were more obvious in mice infected with the bmpAB-complemented isolates, compared with bmpA/B^— mutants. B, bone; S, synovium. Bars: (low resolution) 400 µm; (high resolution) 80 µm.