Supplementary Table 5 Eukaryotic SR proteins [13] were blasted against all translated C. neoformans genes. Only reciprocal best hits were retained. C. neoformans genes identified as similar to SR genes were submitted to Pfam [59] searches under standard search parameters. Significant hits are given below. The number in parentheses denotes the number of occurences of the domain in the protein if >1 Species and protein C. neoformans gene Pfam domain Blast score Expectation Spom_SRP2 cn10074 RRM_1 (2) 127 6.00E-34 Species abbreviations Agam_SR40 cn10074 RRM_1 (2) 125 2.00E-32 Cint_SR40b cn10074 RRM_1 (2) 123 5.00E-32 Agam Anopheles gambiae Rnor_SR40 cn10074 RRM_1 (2) 120 6.00E-31 Atha Arabidopsis thaliana Mmus_SR75 cn10074 RRM_1 (2) 120 8.00E-31 Cele Caenorhabditis elegans Hsap_SR40 cn10074 RRM_1 (2) 120 6.00E-31 Cint Ciona intestinalis Dmel_SR55 cn10074 RRM_1 (2) 120 6.00E-31 Dmel Drosophila melanogaster Drer_SR40a cn10074 RRM_1 (2) 119 2.00E-30 Drer Danio rerio Drer_Tra2A cn01241 RRM_1 118 1.00E-27 Dvir Drosophila virilis Agam_SR40 cn10074 RRM_1 (2) 117 3.00E-27 Frub Fugu rubripes Drer_SR40a cn10074 RRM_1 (2) 116 5.00E-27 Ggal Gallus gallus Dmel_SR55 cn10074 RRM_1 (2) 116 8.00E-27 Hsap Homo sapiens Frub_SR40a cn10074 RRM_1 (2) 115 2.00E-29 Mmus Mus musculus Rnor_Tra2A cn01241 RRM_1 114 2.00E-26 Olat Oryzias latipes Mmus_Tra2A cn01241 RRM_1 114 2.00E-26 Pfal Plasmodium falciparum Hsap_Tra2A cn01241 RRM_1 114 2.00E-26 Rnor Rattus norvegicus Ggal_Tra2A cn01241 RRM_1 113 5.00E-26 Sjap Schistosoma japonicum Drer_Tra2A cn01241 RRM_1 112 3.00E-28 Spom Schizosaccharomyces pombe Olat_Tra2B cn01241 RRM_1 111 2.00E-25 Tbru Trypanosoma brucei Spom_SRP2 cn10074 RRM_1 (2) 110 4.00E-25 Tcru Trypanosoma cruzi Ggal_SR40b cn10074 RRM_1 (2) 110 5.00E-28 Tnig Tetraodon nigroviridis Tnig_SR40a cn10074 RRM_1 (2) 109 9.00E-28 Mmus_SR75 cn10074 RRM_1 (2) 109 1.00E-24 Rnor_Tra2A cn01241 RRM_1 108 4.00E-27 Mmus_Tra2A cn01241 RRM_1 108 4.00E-27 Hsap_Tra2A cn01241 RRM_1 108 5.00E-27 Ggal_Tra2A cn01241 RRM_1 106 6.00E-27 Agam_Tra2b cn01375 RRM_1 105 4.00E-24 Agam_Tra2b cn01375 RRM_1 105 1.00E-26 Olat_Tra2B cn01241 RRM_1 105 3.00E-27 Tnig_Tra2B cn01241 RRM_1 104 2.00E-23 Frub_Tra2B cn01241 RRM_1 104 2.00E-23 Cele_RSP2 cn10074 RRM_1 (2) 103 3.00E-23 Cele_RSP2 cn10074 RRM_1 (2) 103 3.00E-26 Cint_9G8b cn04474 no hits 103 4.00E-23 Cint_Tra2 cn01375 RRM_1 103 2.00E-23 Cint_Tra2 cn01375 RRM_1 103 4.00E-26 Rnor_SR40 cn10074 RRM_1 (2) 102 6.00E-23 Hsap_SR40 cn10074 RRM_1 (2) 102 6.00E-23 Frub_SR40a cn10074 RRM_1 (2) 101 2.00E-22 Ggal_SR40b cn10074 RRM_1 (2) 100 2.00E-22 Cele_Tra2 cn01375 RRM_1 100 3.00E-25 Tnig_Tra2B cn01241 RRM_1 99 1.00E-24 Frub_Tra2B cn01241 RRM_1 99 3.00E-24 Cele_Tra2 cn01375 RRM_1 98 2.00E-21 Cint_9G8b cn04474 no hits 97 4.00E-24 Tnig_SR40a cn10074 RRM_1 (2) 96 8.00E-21 Dvir_Tra2 cn01375 RRM_1 94 2.00E-24 Dmel_Tra2 cn01375 RRM_1 92 2.00E-22 Dmel_Tra2 cn01375 RRM_1 87 2.00E-18 Cint_SR40b cn10074 RRM_1 (2) 84 2.00E-17 Dvir_Tra2 cn01375 RRM_1 84 2.00E-17 Atha_SRp30 cn10074 RRM_1 (2) 80 8.00E-19 Cele_RY1 cn07088 DUF1777 73 7.00E-17 Atha_SRp30 cn10074 RRM_1 (2) 67 3.00E-12 Mmus_SC35 cn07183 RRM_1 67 7.00E-15 Ggal_SC35 cn07183 RRM_1 67 3.00E-15 Drer_SC35a cn07183 RRM_1 65 3.00E-14 Drer_T1Ba cn03025 zf-C3HC4 65 5.00E-11 Sjap_SC35 cn07183 RRM_1 64 1.00E-11 Sjap_SC35 cn07183 RRM_1 64 1.00E-15 Hsap_SC35 cn07183 RRM_1 64 6.00E-14 Frub_SC35b cn07183 RRM_1 64 4.00E-14 Agam_SC35 cn07183 RRM_1 64 1.00E-11 Agam_SC35 cn07183 RRM_1 64 3.00E-14 Dmel_SC35 cn07183 RRM_1 62 7.00E-11 Dmel_SC35 cn07183 RRM_1 62 1.00E-13 Hsap_T1B cn03025 zf-C3HC4 62 7.00E-10 Pfal_SR cn01448 RRM_1 (2) 62 2.00E-10 Atha_SR45 cn01448 RRM_1 (2) 62 4.00E-13 Agam_RY1 cn07088 DUF1777 61 1.00E-10 Dmel_T1B cn03025 zf-C3HC4 61 9.00E-10 Pfal_SF cn10074 RRM_1 (2) 60 1.00E-13 Atha_SC35 cn07183 RRM_1 60 4.00E-10 Atha_SC35 cn07183 RRM_1 60 3.00E-13 Rnor_T1B cn03025 zf-C3HC4 60 3.00E-09 Pfal_SR cn01448 RRM_1 (2) 60 1.00E-13 Agam_RY1 cn07088 DUF1777 59 1.00E-12 Atha_SC28 cn03112 RRM_1 (4) 59 8.00E-10 Atha_SC28 cn03112 RRM_1 (4) 59 4.00E-12 Mmus_T1B cn03025 zf-C3HC4 59 4.00E-09 Rnor_RY1 cn07088 DUF1777 58 6.00E-12 Mmus_RY1 cn07088 DUF1777 58 6.00E-12 Hsap_RY1 cn07088 DUF1777 58 7.00E-12 Dmel_RY1 cn07088 DUF1777 57 2.00E-09 Cint_RY1 cn07088 DUF1777 57 8.00E-12 Agam_T1B cn03025 zf-C3HC4 57 2.00E-08 Atha_SR45 cn01448 RRM_1 (2) 57 8.00E-09 Dmel_RY1 cn07088 DUF1777 56 1.00E-11 Cele_SC35 cn08310 RRM_1 55 1.00E-08 Cele_SC35 cn08310 RRM_1 55 2.00E-11 Mmus_SC35 cn07183 RRM_1 55 1.00E-08 Ggal_SC35 cn07183 RRM_1 55 1.00E-08 Tnig_RY1 cn07088 DUF1777 55 3.00E-11 Rnor_RY1 cn07088 DUF1777 55 5.00E-09 Mmus_RY1 cn07088 DUF1777 55 5.00E-09 Hsap_RY1 cn07088 DUF1777 55 5.00E-09 Frub_RY1 cn07088 DUF1777 55 6.00E-09 Frub_RY1 cn07088 DUF1777 55 4.00E-11 Frub_T1Bb cn03025 zf-C3HC4 54 2.00E-07 Pfal_SF cn10074 RRM_1 (2) 53 5.00E-08 Cele_RY1 cn07088 DUF1777 53 2.00E-08 Hsap_SC35 cn07183 RRM_1 52 1.00E-07 Frub_T1Bb cn03025 zf-C3HC4 52 1.00E-09 Frub_SR86 cn02197 RRM_1 (2) 52 2.00E-07 Frub_SR86 cn02197 RRM_1 (2) 52 1.00E-09 Frub_SC35b cn07183 RRM_1 51 1.00E-07 Tnig_T1Bb cn03025 zf-C3HC4 50 1.00E-06 Atha_RY1 cn07088 DUF1777 49 2.00E-09 Tnig_T1Bb cn03025 zf-C3HC4 49 7.00E-09 Drer_T1Ba cn03025 zf-C3HC4 48 1.00E-08 Mmus_SR86 cn02197 RRM_1 (2) 48 5.00E-06 Mmus_SR86 cn02197 RRM_1 (2) 48 3.00E-08 Tnig_RY1 cn07088 DUF1777 47 1.00E-06 Atha_RY1 cn07088 DUF1777 47 3.00E-06 Dmel_T1B cn03025 zf-C3HC4 47 2.00E-08 Drer_SR86 cn02197 RRM_1 (2) 47 5.00E-06 Drer_SR86 cn02197 RRM_1 (2) 47 4.00E-08 Hsap_SR86 cn02063 RRM_1 (2) 47 6.00E-06 Drer_SC35a cn07183 RRM_1 46 4.00E-06 Agam_T1B cn03025 zf-C3HC4 46 4.00E-08 Dmel_RSF1 cn02197 RRM_1 (2) 46 5.00E-06 Dmel_RSF1 cn02197 RRM_1 (2) 46 7.00E-08 Rnor_T1B cn03025 zf-C3HC4 45 1.00E-07 Mmus_T1B cn03025 zf-C3HC4 45 1.00E-07 Hsap_T1B cn03025 zf-C3HC4 45 1.00E-07 Cint_SR86a cn02121 RRM_1 45 3.00E-05 Cint_SR86a cn02121 RRM_1 45 2.00E-08 Hsap_SR86 cn02063 RRM_1 (2) 44 1.00E-07 Cint_SR300 cn01754 no hits 43 2.00E-04 Cele_RSPY cn09254 RRM_1 40 1.00E-04 Cele_RSPY cn09254 RRM_1 40 4.00E-07 Dmel_SR300 cn05158 DUF926 40 0.002 Atha_RS21 cn02085 RRM_1 (2) 40 3.00E-04 Atha_RS21 cn02085 RRM_1 (2) 40 3.00E-06 Cint_RY1 cn07088 DUF1777 37 0.001 Tbru_pTSR1 cn10074 RRM_1 (2) 35 2.00E-06 Tcru_SR1 cn09223 RRM_1 (2) 33 9.00E-06 Tcru_SR1 cn09223 RRM_1 (2) 32 0.11 Cele_SRRM2 cn06152 no hits 32 0.29 Frub_p45b cn05065 "Metallophos, Mre_11_DNA_bind" 32 0.18 Cele_SRRM2 cn06152 no hits 31 0.001 Tbru_pTSR1 cn10074 RRM_1 (2) 30 0.78 Dmel_SR300 cn05158 DUF926 28 0.007 Cint_SR300 cn01754 no hits 27 0.008 Frub_p45b cn05065 "Metallophos, Mre_11_DNA_bind" 24 0.21