SUPPLEMENTARY MATERIAL
Conserved and divergent domains of nonhistone Scm3 provide insights into centromere evolution
L. Aravind1, Lakshminarayan M., Iyer1 and Carl Wu2
1 National Center for Biotechnology Information, National Library of Medicine, 2 Laboratory of Biochemistry and Molecular Biology,
National Cancer Institute, National Institutes of Health, Bethesda, MD 20894, USA
E-mail: aravind@ncbi.nlm.nih.gov; carlwu@helix.nih.gov
Multiple alignment of the Scm3 domain
Secondary Str. ---HHHHHHHHHHHHHHHHHHHHHHHHH----------EEEEE---E------EEEEE------- (H: Helix, E: Strand)
68468371 KQFKNKFKQLENQSLQRFKSQWDAIIDKYSKIDDSTQSDEIDIVTGE------LITNNGHLDKLN Candida albicans SC5314
50421237 EDFQAEINRLKKQSTNRFKSKWEEILEKYAQIDDEKESDEIDLASGE------IITDNGHLRSLR Debaryomyces hansenii CBS767
126132916 TEFQEELHRLKTKSSQKFRTKWEEILAKYSSIDDEKESDEIDLATGK------IVVDNGHLRSLH Pichia stipitis CBS 6054
71021089 PDGTETVEYLHQQSTQRLKRKWDSIFERFKD-AHLQEQDEIYLGNRANGEPIVVVKDRGSLRSLR Ustilago maydis 521
19114428 PTACDDVFCKRIESEKKYNDFLESLFKKYGR-DTSDIADEVDLATGE------IIVNNGHLEALK Schizosaccharomyces pombe 972h-
unifnished6 EDVCKNLACQRVASRQRYEAKLSALFEKYGQ-DTSEYADEIDLATGA------IVVDHGHLRGLH Schizosaccharomyces japonicus
50257917 QWKKEELARRRQESRDKLKSSWDLLFEKY-R-DVED-DDEIDLATGT------IVKDRGKLRALQ Cryptococcus neoformans var. neoformans B-3501A
58267448 QWKKEELARRRQESRDKLKSSWDLLFEKY-R-DVED-DDEIDLATGT------IVKDRGKLRALQ Cryptococcus neoformans var. neoformans JEC21
116503001 SPEDIDFQQKRQASALRLLDVWSKLAERYTR-RLDE-DDIVDIVSGR------IVKDNGVLRKSK Coprinopsis cinerea okayama7#130
46107590 RDPDIQLALKRVNANQKLHATMAHIIEKYSR-DFEGIGDEIDMATGE------IVVNNGHLRNMR Gibberella zeae PH-1
145615924 LALDRQFQRSTYRSAFSFKSTLENIFEKYGR-DFGDEGDEIDLNTGE------ITVDRGHFRGIF Magnaporthe
119188451 SSRGVNIHEARRANNLRLKSRLELIYQKYGR-DFGNIGDEINLRTGQ------IVVDNGHLNQME Coccidioides immitis RS
115491221 DPNEMDLQEARAQNDLRLKSIFESIFEKYGK-DFTEVGDEIDLNTGD------IIVNNGHIFTME Aspergillus terreus NIH2624
67522114 ETSDIDLQEARTQNDLRLKSIFEGIFEKYGR-DFTDVGDEIDLQTGK------ITVNNGHIDALE Aspergillus nidulans FGSC A4
121719856 EPDDIDLQEARAHNDLRLKSIFEGIFEKYGK-DFTEVGDEIDLQTGA------IVVNNGHLRGMS Aspergillus clavatus NRRL 1
70983590 DPDDIDLQEARAQNDLRLKSIFERIFEKYGK-DFTDIGDEIDLQTGK------IVVNNGHLQRMS Aspergillus fumigatus Af293
119484568 DSDDIDLQEARAQNDLRLKSIFERIFEKYGK-DFTDIGDEIDLQTGK------IVVNNGHLQRMS Neosartorya fischeri NRRL 181
85116033 RDPGYQLEQARSFAAFKLKSAFENIFEKYGK-DFDGIGDEIDLRTGA------IVVDNGHIKSLK Neurospora crassa OR74A
50289969 KLTDEEVMEKHKLADQRMKTVWSNIIDKYS--NVVDEGDVIDLQSGE------IITDNGHIRNLN Candida glabrata CBS 138
50310585 KLSDEEVMERHKKADENMKRVWSQIIQKYE--SIDNQGDVIDLQTGE------VIEDNGHLRNLS Kluyveromyces lactis NRRL Y-1140
45187961 RLSDAEVMERHRRADENMKQAWTRIIEKYE--ALDDQGDVVDLRTGE------IVEDNGHIRGLA Ashbya gossypii ATCC 10895
50556794 EEISKEIPSFS-ASLAMFEKEWNSIIDKYS--NVEDQGDVVDLASGS------IVKNNGHLELLE Yarrowia lipolytica CLIB122
1419222 KLTDDEVMERHKLADENMRKVWSNIISKYE--SIEEQGDLVDLKTGE------IVEDNGHIKTLT Saccharomyces cerevisiae
unfinished1 DLSIEDVAKLRTESLERLKSTWEIICSKYGR-SFEGESDEIDLTTGR------IVIDRGFLKRSH Batrachochytrium dendrobatidis
unfinished2 RDPDIQLALKRANADHKLQATMAHIIEKYSR-DFEGIGDEIDMNTGE------IVVNNGHLRNMR Fusarium oxysporum
unfinished3 RDPDYKLSVERAYADQRFQATMAHIFEKYGR-DFEGIGDEIDLVTGE------IVVNNGHVRNMR Trichoderma reesei
unfinished4 DEENEEYINAKRKQQQKFKGRLESIFDKYGS-MHESMSDEIDMKLNR------VVVDRGHLRRLK Pyrenophora tritici
unfinished5 LALDRQFQRSTYRSAFSFKSTLENIFEKYGR-DFGDEGDEIDLNTGE------ITVDRGHFRGIF Magnaporthe
consensus/100% .....ph......s...h...h..lh.+a.........D.l.h.s........l..spG.l....
consensus/95% .....ph...c..s..phpp.hp.lhp+Y...s....sD.lsl.oG.......ll.spGplp.hp
consensus/90% .....ph.b.+..s..phcp.hp.lhpKY...s..p.sD.lDl.oG.......ll.spG+lp.hp
consensus/85% p..p.pl.b.+..s..ph+p.ap.lhpKY...s.pp.sD.lDL.oGp......Il.sNG+lp.hp
consensus/80% p..p.cl.b.+..spb+h+p.ap.IhcKY...s.pp.uDblDL.oGp......Il.sNGHlc.hp
consensus/75% p..p.cl.b.+.bssb+h+s.ap.Ih-KY.p.shpp.uDbIDL.TGp......Il.sNGHlc.hp
consensus/70% p..p.-lbb.+pbusb+hKs.appIh-KYsp.chpcbuDEIDL.TGp......Il.sNGHLcshp
Domain architectures of Scm3
45187961 184 Scm3+ Ashbya gossypii ATCC 10895
50310585 200 Scm3+ Kluyveromyces lactis NRRL Y-1140
50289969 202 Scm3+ Candida glabrata CBS 138
37362629 223 Scm3+ Saccharomyces cerevisiae
50556794 227 Scm3+ Yarrowia lipolytica CLIB122
19114428 336 Scm3+charged C-cluster Schizosaccharomyces pombe 972h-
71021089 726 Scm3+charged C-cluster Ustilago maydis 521
46107590 992 Scm3+2*AT Hooks+C-cluster Gibberella zeae PH-1
85116033 1378 Scm3+AT hook like +AT-hook+C-cluster Neurospora crassa OR74A
unfinished Scm3+MYB+C-cluster Botryotinia fuckeliana
unfinished Scm3+MYB+C-cluster Sclerotinia sclerotiorum
115491221 434 Scm3+MYB Aspergillus terreus NIH2624
119188451 514 Scm3+MYB Coccidioides immitis RS
119484568 537 Scm3+Myb Neosartorya fischeri NRRL 181
70983590 541 Scm3+Myb Aspergillus fumigatus Af293
121719856 555 Scm3+Myb Aspergillus clavatus NRRL 1
67522114 579 Scm3+Myb Aspergillus nidulans FGSC A4
68468371 623 Scm3+specialized-3*C2H2 Candida albicans SC5314
126132916 691 Scm3+specialized-3*C2H2 Pichia stipitis CBS 6054
50421237 695 Scm3+specialized-3*C2H2 Debaryomyces hansenii CBS767
111066889 717 Scm3+C2H2 Phaeosphaeria nodorum SN15
58267448 986 Scm3+charged C-cluster+C2H2 Cryptococcus neoformans var. neoformans JEC21
50257917 986 Scm3+charged C-cluster+C2H2 Cryptococcus neoformans var. neoformans B-3501A
145615924 828 Scm3+low complexity Magnaporthe grisea 70-15
116503001 1371 Scm3+low complexity Coprinopsis cinerea okayama7#130
Additional domains in Scm3
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Multiple alignment of the MYB domains in Scm3
Sec. Str ...HHHHHHHHHHHHHHH.............HHHHHHHH..............HHHHHHHHHHH.... \Myb \ Tf-like MYB
18655633.a KTRWTREEDEKLKKLVEQNGTDD--------WKVIANY------LP--NRTDVQCQHRWQK-VLNPELI Mus musculus | |
18655633.b KGPWTKEEDQRVIKLVQKYGPKR--------WSVIAKH------LK--GRIGKQCRERWHN-HLNPEVK Mus musculus / |
18655633.c KTSWTEEEDRIIYQAHKRLGNR---------WAEIAKL------LP--GRTDNAIKNHWNS-TMRRKV- Mus musculus \Trf1/Trf2 |
1w0uA KQKWTVEESEWVKAGVQKYGEGN--------WAAISKn------yPFVNRTAVMIKDRWRT-MKRLgmn Homo sapiens / |
1ityA RQAWLWEEDKNLRSGVRKYGEGN--------WSKILLh------yKFNNRTSVMLKDRWRT-MKklKLI Homo sapiens \ Scm3 |
119188451.a VGPLTAEEINYLLDLRMVKRRS---------WPEVLSA------MP--WRS-ARLLKHWYS-KHCIEVK Coccidioides immitis RS | |
67522114.a RTVLGPQEARLIIQMRHIQGMK---------WKEISDH------FP--QKK-PANIQAWHH-VHWKQRK Aspergillus nidulans FGSC A4 | |
121719856.a RTIMTPDEAKLIVRMRQIDGKK---------WKEILHY------FP--QKK-EINLIQWNH-THWNERQ Aspergillus clavatus NRRL 1 | |
70983590.a RTLMTPDEAKLIIRMRQIEGKK---------WKEVHEH------FP--QRK-LISLIQWNQ-THWTERH Aspergillus fumigatus Af293 | |
119484568.a RTLMTPDEAKLIIRMRQIEGKK---------WKEVQEH------FP--QRK-LISLIQWNQ-THWTERH Neosartorya fischeri NRRL 181 | |
67522114.b SGPWSKAELEKLEILKDQPELT---------WPGIRAE------FP--GRL--LAEIEFKLLQLWAGDN Aspergillus nidulans FGSC A4 | |
121719856.b SRPWSKPELNKLRALKDQQGLG---------WSEIRAA------FP--GRS--LQEVEFQLLCLWAESG Aspergillus clavatus NRRL 1 | |
70983590.b SKPWSKEEVDKLQAFKDQQGLT---------WSHIRAA------LP--GRS--HAEIEFALLRLWAELG Aspergillus fumigatus Af293 | |
119484568.b SKPWSKEEVDKLQAFKDQQGLT---------WPHIRAA------LP--GRS--HAEIEFALLRLWAELD Neosartorya fischeri NRRL 181 | |
119188451.b IRDWVSQEKERPPSVQQVSPFS---------LESVQPY------DV--SVD--RVQGKCNQGSGERQSG Coccidioides immitis RS / /
Botfuc HNLFTEEEDKILIAKVAEAHDQGLAFATDSIWEGLAIN------INRHSKVS-W-KQRYRK-KYLHLWS Botryotinia fuckeliana \Scm3 \Rap1-like
Sclscl RNAFTEEEDEILIAKVAEARDQGLALGAESTWEELASN------LDRHTIAS-W-KNRYRQ-RYLHLWS Sclerotinia sclerotiorum / |
1ignA KASFTDEEDEFILDVVRKNPTRR---TTHTLYDEISHY------VPNHTGNS-I-RHRFRV-YLSKRLE Saccharomyces cerevisiae \Rap1 |
1fexA RIAFTDADDVAILTYVKENARspsSVTGNALWKAMEKSS-----ltQHSWQS-L-KDRYLK-HLRGSSl Homo sapiens / /
111066889 KYVFTEEDDVYLYKRKVLHNRT---------YTEIRDSKEKWKNWP---LWT-F-QNRWHKHLKERNLH Phaeosphaeria nodorum SN15 \Scm3 |
Pyren KYHFTHEDDVYISKRRLIDGMT---------WPHIKASKKKWEQWP---LKA-L-HNRWSR-IKNDNLH Pyrenophora tritici / /
................
Multiple alignment of the C-cluster associated with Scm3
Umay HGTRRKSLANPTCGGPGR-CSKTFCFDCA Ustilago maydis
Fusa NTVKTPGGTLRTCGIDGYQCGRDFCFTCI Fusarium oxysporum
Gibb GTIKTPGGTIKICGVDGHHCGRDYCFTCI Gibberella zeae
Tric SLVKTPGGTLRACGVDGYRCGRDFCFTCL Trichoderma reesei
Bfuc GMVKTPGGTLRKCGQDGFACQRAFCFRCG Botryotinia fuckeliana
Scle GMVKTPGGTFRKCGQDGFACKRTFCFRCG Sclerotinia sclerotiorum
Nspo EVIQTPGGTLRRCGEAGFRCDRDFCFGCL Neurospora crassa
Spom QTSFSGSSTQNPHSSS--TCKKAFCFQCI Schizosaccharomyces pombe
Sjap PLVSTPTSSSPTHISS--TCRKPFCFRCL Schizosaccharomyces japonicus
* * * *
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Alignment of the Phaeosphaeria nodorum SN15 C2H2 with other classical C2H2 fingers
111066889 NILSVCDFCHTTFNTFRGLRVHLRVHLRVHQA Phaeosphaeria nodorum SN15 >Scm3
91089229 LEIYICEVCNTNFPTFKSLRLHRRMHEPIKAR Tribolium castaneum \ Other classical C2H2 finger proteins
39587904 NQKLMCQFCKKTYLTYFGLRRHLQFHKEGKLQ Caenorhabditis briggsae |
108877564 GERVTCDICLKTFASSSGLIVHRRIHLGIHPY Aedes aegypti |
33354273 NKHNRCEFCKRTFSTQVALRRHERIHTGKKPY Homo sapiens |
125849369 DKTHECDQCGKTFSTLSVLRIHLRVHTKEKPY Danio rerio /
* * * *
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Multiple alignment of the AT-hook-like domain
85116033 Neurospora crassa OR74A VIKARRGRKPKTPI SCM3
6322520 Saccharomyces cerevisiae MQPGRRGRKPTTLA CBF1
45198932 Ashbya gossypii ATCC 10895 KPTGRRGRKPAPSA CBF1
50304387 Kluyveromyces lactis NRRL Y-1140 GAAPRRGRKPGTET CBF1
85110262 Neurospora crassa OR74A PAAVKRGRKPAAPV Mif2
85110262 Neurospora crassa OR74A AAKKKPGRKPKAKE Mif2
67537890 Aspergillus nidulans FGSC A4 RKGPRKGRKPLTAA Mif2
70984188 Aspergillus fumigatus Af293 RGGTRGGKRPAHAP Cse4
6320433 Saccharomyces cerevisiae GENKKIGKRPPEIM Sir4
6323523 Saccharomyces cerevisiae GKTLREGRKPGSGR Dat1
6323575 Saccharomyces cerevisiae PPPKKRGRKPKDPS Orc1
6324545 Saccharomyces cerevisiae PQRLKPGRKPKSKR Yap7
6324948 Saccharomyces cerevisiae GRIKKNGKKPSKFQ Ndd1
6325457 Saccharomyces cerevisiae PRGRKGGRKPSLTP Arr1p
6319300 Saccharomyces cerevisiae STTSRNGRKPIVKF Fun30
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Multiple alignment of the triple C2H2 found in C.albicans Scm3 and orthologs from related fungi
<..........C2H2-1.............> <.........C2H2-2.............> <-------------C2H2-3------------->
68468371 FDDEYSIIEEPYYFLDVKSLPLPTIFNCAFIKCHYCTGNKKLYELHLLQSHSSTLAEMGYPINLNSQNAAYENSNTDSDKENHKIEFTRDITDVDLDKLYQVFPKTYKLPP-----QKEALTCGKELANGQTCQKFYLVQEQLDQHQEAG-DECSDKRQVLFCPILGCGYLTDGGYKEWREHMITANHSQEE
126132916 FDDEYLIISEPYFLKQRGE--QGTIYECAFFGCSYCTGNKLLYQSHLLLKHSLELYLLGYPV-----------------ESREENNSGLTISTDERDKVLKHFPITYAIPPLPSSSNGQVFDCSR-LDCGRKCQRFFLTEEDLSEHENAETSQCSWRTQVLLCPLLGCGYITEGGYLEWRAHFIKQGHHIEP
50421237 FDDEFLIVTDPCIYPPTES--STNIYSCAIEHCHYCTGNKSLYQSHLLDKHSTVLHSLGYPIR----------------EDTSAIILNPNISQSTVKKLTKYFPLIFEVPRLPLSKNSQPFICGLNLGNSRTCQKFFVTKHDLILHHQNAPNECSYKKQVLICPMLGCGYMTDMGYLEWRSHFIEKKHHLDP
Pichg PFLERKEKTSKYTLCDLSTPTTDAVYHCAFHYCKFCTGNRFLYKEHLLKLHPKELKQIGYPVQ----------------------TETETGVDTISSDTIENISKVFPLTFDKLLQSDSLLHCNMKLSPTERCRRVFFTLNDLKEHQNTS-SGCDSRLFTFSCPILGCPFQTRLFEALQN-HFRTY-NINSS
Clavi SHGSPNGSHLFLIRSDLVETPQIALYPCAF-GCSYTSDSKTAYRAHLLSTHAHLLLRIGYPVK---------------------ISDSNHISHNEHISELTILRLTLHFP-LRIQMPLKPYSCGREFKYG-KCQRIFLDEKSAQAHQEAYPHECSARRQVLLCPILGCDFMTDEGYKEWKDHVL--GHEREQ
* * * * * * * * * * * *
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Alignments of key centromere proteins discussed in text
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Multiple alignment of Scm3
111066889 Phaeosphaeria nodorum SN15 ---------------------------------------------------------------------------------------------------MEPPAKRLRILQSVDVDE----------TNPDFYWREAKAA---TKSMSDEIDLHQGK------MVVDRGHLRRLA-----------RQAHREET----------------------------------------------------------------------------------------------------------------------M--------LLNSLALGTGSRSPRKNPRKREK---------------------------------------------------------------------------------------------------------RKTPRMNWRPH-----------------------SPVVSRSAQKDNKRRRSTALDEAHSLSSNTVEPQAHTKTSASTPIAQTGVQPAPQTPNPITNLLQFVQ----------------------------------------FPQTPAGQQARSSFYTTLTQTI-----------------------------------------------------------------NYAVQQTVAPLFSGALPSTPNVQLPFLNALPLQTTPIPSADHVAPARDPKW---------------------FFPPLSNELPMADLVQSSPIPAPATSATALEESTQEEPCIPESDPQLEPSTD----------------------------DDMRMETISTAAMVQAEETADMGSK-------KAARRTSPRVEIQRRPGRLPNKYVFTE---------EDDVYLYKRKVLHNRTYTEIRDSKEKWKNWPLWTF----------------------------------------------------------------------------QNRWHKHLKERNLHAKGHSAFEIKQDDKTKYDNETIAVTLHHLPTPSSSGLEDD--------------------------------------NTPVLNRAEDSIADAVSSSVPFDDDERELLSLAGADLSEEQLLLE-------------------------------------TEEEPFFPDADETVLPSVEQEEFVDEDLLQQGLLEDSASEEIKVTM-PSKIKSEVQQSPPTSTR------RRTRAAIVHHTVPDTEADSSFQNGNNSVSQENILSVCDFCHTTFNTFRGLRVHLRVHLRVHQANSPSTHEKARPKSPSIDLVGDDELQAD---------------------------------VPSTPKIKREFSTPPPTSFLFSTPAAQSQSRPDATSSDVKSASGLSRRAYLKQVKQSWTKKSSPAPKTLSKRKSFHTLPRKKGLG----------------------------------------------------------------------------
68468371 Candida albicans SC5314 ----------MNTGIENDFKYLHSRNLQQLPNNNTKNPSQNIPYNYPSSDEDIEDEYYSDDE------------------------------SQNQLDYEINQLINQQNEKQFKNKFKQLENQSLQRFKSQWDAIIDKYSKIDDSTQSDEIDIVTGE------LITNNGHLDKLN-----------QNHNQKGD----------------------------------------------------------------------------------------------------------------------IT-------KMDIWRQDYG--------QQLEN---------------------------------------------------------------------------------------------------------WRQRDFRMKKQ-----------------------AKQRKNEQRQILKKLDLFNKPIYGYPKFEKLEENDFLKQSPTKNKVPSGIESDESPTKKRRV----------------------------------------------FTDKKVVSKNSNYLEFSDDDDE-------------------------------------------------------------------EVENKSLYTKTVIAHGKLYKRESDNVLYGSSADTFSPYIDRQSFRPESN---------------------------------------------ELQSEDSQDYESNLSSDISDDEYDDETY-----------------------------QSIIINDKKYSPKFKEHFDESETE-------SISETPQPQTSSEETPGLSSQTEEISP---------SP-----HPESSFDDEYSIIEE----------PYY---------------------------------------------------------------------------------------------------FLDVKSLPLPTIFNCAFIKCHYCTGNKKLYE-------------------------------------LHLLQSHSSTLAEMGYPINLNSQNAAYENSNTDSDKENHKIEFTRDITDVDL-------------------------------DKLYQVFPKTYK-----LPPQKEALTCGKELANGQTCQKFYLVQEQ-LD------QHQEAGDEC------SDKRQVLFCPILGCGYLTDGGYKEWREHMITANHSQEETAEKETKKENLEKLISRP---------------------------------------------------------------------------------------IATRKVSVKVPKFTETDFKVSFIDQGYESIDELFN----------------------------------------------------------------------------------------------------------
50421237 Debaryomyces hansenii CBS767 ------MQMGKIPENLISIDSSDDYDDDVDNNDNNTERSQSNLSVYPSLHMNGNVYR---------------------------------------------------TEEDFQAEINRLKKQSTNRFKSKWEEILEKYAQIDDEKESDEIDLASGE------IITDNGHLRSLR-----------TGIRANTD----------------------------------------------------------------------------------------------------------------------VKF------DGDIWSVTYDLERDIHNRYVKEARHKQQ----------------------------------------------------------------------------------------------------KMELKRQLKDQ-----------------------KLFHNVSLQSSPLKADDFTRGSSFALSSEDNLLSLNPSPTKKFKVSPVKGIRGSSPVRDDDISLL-------------------------------------------TPTKRKSRKLSNIYNAKSLPTK------------------------------------------------------------------------LHFDDIPRLHMDDYNIAKSGDESYDDMTNSPFFVYNSSLRDNSR-------------------------------------------SYETNSPQDYDDDTPNTATASDGKGYAETS-----------------------------ETSDVESDDNKATKLSSSDQYLVG----------SNTNQYVSESEDDNDDYSLD--------------------FDDEFLIVTDPCIYP----------PTE----------------------------------------------------------------------------------------------------------SSTNIYSCAIEHCHYCTGNKSLYQ-------------------------------------SHLLDKHSTVLHSLGYPIREDTSAIILNPNISQSTV-----------------------------------------------KKLTKYFPLIFEVPRLPLSKNSQPFICGLNLGNSRTCQKFFVTKHD-LIL-----HHQNAPNEC------SYKKQVLICPMLGCGYMTDMGYLEWRSHFIEKKHHLDPKHKRNRQNEEGLKHEETRENEESNLSQLSYIPNLYEEEEEYEKLSHLDK------------------------------------INMPSLNISNLDQPTKVSTILDVVNEINDIFSDSGSDASINEYLNDDGDIEFSKMSVDVKRDPQRPYHNEMPNLKIQLNLHEDLPYPLDEDLQTGHESIEELFDD--------------------------------------------------------
126132916 Pichia stipitis CBS 6054 ----------------------------------MADASDSTSDLSPASSFSLSEIFPETRYEPQKIEPLIALESESES---------GLSDQERLLGSLHSDGRVYRDETEFQEELHRLKTKSSQKFRTKWEEILAKYSSIDDEKESDEIDLATGK------IVVDNGHLRSLH-----------DGNGRMGN----------------------------------------------------------------------------------------------------------------------VNI------DGNIWAMSYD--------IDKDF---------------------------------------------------------------------------------------------------------SRMRKREVTKK-----------------------ERKRELKLRLKQQNLFHIHSNSDYNYDNGSNRLKRAPLEDNLLQLNPSPTKKSKSKPVIGS-----------------------------------------------RLSSPVRSEYDSPTKKRIPSHS--------------------------------------------------------------------------------------IHLDSSSPKPEAIKRGSYFELSPTRQDARK---------------------------------------------LVSSSRTASVETELSFVQSDDDLESETS-----------------------------QTSQVESLENDLLMNEFDTDPNQH-------KLSYNCKTRSDSQQDKEES------------------------SDSDSFDDEYLIISE----------PYF-----------------------------------------------------------------------------------------------------LKQRGEQGTIYECAFFGCSYCTGNKLLYQ-------------------------------------SHLLLKHSLELYLLGYPVESREENNSGLTISTDER------------------------------------------------DKVLKHFPITYAIPPLPSSSNGQVFDCSRLDCG-RKCQRFFLTEED-LSE-----HENAETSQC------SWRTQVLLCPLLGCGYITEGGYLEWRAHFIKQGHHIEPETGFKFTEHRNDAEAKASNHIKREHYDTNSLDKGLIFSDDINVLFSDNDDFDSPADDEN--------------------------TDVEEDGIEETGDEETGDEETGDEEASDEEASDKEVGNDETGNEETDDDKIKELNHVHNETLYSLPVKQTRQVTITQTPKFDHSLEVSDLAPEVSFEGYESIEELFSN-----------------------------------------------------
71021089 Ustilago maydis 521 ------------------------MHSAYAPTGSVAGAGPSRPRLEPPNSETRSDLP-------------------------PKQRKRRRLQFSSQLHSNTVQ----RYNPDGTETVEYLHQQSTQRLKRKWDSIFERFKD-AHLQEQDEIYLGNRANGEPIVVVKDRGSLRSLR-----------QSMEFGVF----------------------------------------------------------------------------------------------------------------------IKDE-----ELQGWKERPEARETQEQDNGYED---------------------------------------------------------------------------------------------------------DFDPSHAPLLR-----------------------LQLAGASSSESEEEEDDPAANDPDLREFLQAEARRKAMLGESGDDEEDEVV---------------------------------------------------------DFAHPLSSAQVTARIAPQPLVE-------------------------------------------------------------SAPAPVGASDRTAAQPPSISGAPDLIISSSEDEDDTDVVTVHSDSDEELFDSIRT--------------------------------------------------KRQNIEELVQCTTPFETLPYNDI-----------------------------FALADLLKISDNTSRLYVDLVSDDEDQDVSKQIPEDDVLELTASLPNPLLQALPSKTA----------------SADGTVVEVNHPVRD----------TNP---------------------------------------------------------------------------------------------------------VAIDNLSPISSLFADAPSSPLSELP---------------PSRASSAALNASASTQASASTEASSHNANGVAIIADATSSPSSPLSPSQASSIASNASALTQAASPFQ-------------------------------------ARSPKCNAPTSMRAISPFETPRSMPNDVGTATDASSSPLTQLTPSR-ASSIAANAPGLTPAVRC------LETRALPYSVGVVDRTPERVAAKPLDFALSSPSRPVAAPAVSLPTLQSDPIEPATLERTEHALYHDTHFPRATPTRHLESERDMGTSTS----------------------------------TARSPFKISASCSAPLFRSHLERSRSRSSSASDKHSAPRSSPLRKNHARPSKHAHGTRRKSLANPTCGGPGRCSKTFCFDCASSPHA--------------------------------------------------------------------------
19114428 Schizosaccharomyces pombe 972h- ----------------------------------MCNRQPKAVDLPPNYSCPHLLSF-----------------------------------QSV----------EFNTNPTACDDVFCKRIESEKKYNDFLESLFKKYGR-DTSDIADEVDLATGE------IIVNNGHLEALK-----------T--------------------------------------------------------------------------------------------------------------------------------------KDDIW-------------DPTFN-------------------------------------------------------------------------------------------------------------------N-----------------------LEISASNGYEKKLDSSIGNPGEKAV-----------------------------------------------------------------------------------SPVHIEDFQSPQIYKFKNLSLR------------------------------------------------------------------------------------------------------DEMVSDCVFA------------------------------------------------------DEVPLASLFVENVCNETIPSQSC-----------------------------VRLKIN---DKTRKVDASALEKKS-------CLLPNSSGTLTDQRGLD--------------------------TIKHKSIEQNEILHV----------ISD---------------------------------------------------------------------------------------------------------------------TLSSPRRRNPLLS---------------------------------------------------SPKTPLRRSFSKSKVRNSNSTKRRNFISLI---------------------------------------SMISPRPNLSTHHFNLGFQPLSQQTSFSGSSTQNP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSSSTCKKAFCFQCISESKKC-------------------------------------------------------------------------
50257917 Cryptococcus neoformans var. neoformans B-3501A --------------------------------MFSPATPIAGPSNPSHLRPSFSSPAFRRGGSIFPYEYGASNQPFSPHYSAPFTTTGVRIRSGS----------VFSREQWKKEELARRRQESRDKLKSSWDLLFEKY-R-DVED-DDEIDLATGT------IVKDRGKLRALQQPMWFGQKEGDDGESTGGG----------------------------------------------------------------------------------------------------------------------GHDFESDEDELGDWDEKAGLDPQLPEWEEVEGFHQAWTEEDDADFREFMRA--------------------------------------------------------------------------------------EQRRKSTFGSD-----------------------NEDEDSLSEHDSKKPAGFEEYLDVSPRSRGTQILPLPTLDDLFASDNKASSEDELEAISDSDAEEKGVR---------------------------------------DNLSALSSLHGTPIVSRRPKRR-------------------------------------------------------------TIIEVVIPPRPRSKSTGGMEEKSSEHHLLDCVPKSISTPTLADLFTPPPAQMRRSLSGSSATSGSSALSKSKGKKRMPGERPMEDTSSGNHSIIQLREPSNSTETIKRCDEKLFRCDSCRVAGGTRKCQAPFCPGRTDGCIVEDSSGSFEQFARKSATRSRPS---GKSFAADTRLVEGAGPTKQRTCRLCREAGGE--RAKTAGVCLGRHSYRR---------CN-----WRKRAIHSSTANTHT----------VTPVDVAKGESNPSQVNMSTDTPQLRTKHSPLLNMKVPSLRSSSAIRKHRRRVIESVSDDDDPRFTTDTALPLREPSSNFIRKPQETAPLPSPPPTSSVAPSSPPIASLHKPSRSPLLSLPPSSPPRPDIFSP----------------VPSQAARPTPSPSVSLTHPISSNYVTDAYKQTGVMYHPTPPPSTDDTLGLQSSSSSIKRTRFSLIRS-------------------------------------PMRHPSSDEEGSEDELDLLSNLDSSSIIACSSSPKHSSSPIRTEWS-VRAADVGIKLGPEHTGR------LPSDMVKTLVPSMGLFRPTLGSSSQASSKYTLPTPPSSYRPSQPRPVSDPQNPSSGSGGNPQARLMLPPPLPAKRSTHPNSLSTPK-------------------------------------ELKNSTSTFSTSSPAPSHIRLTSLPAVVVRARARSRSLSMAPPCALRTPKAQRSIMSPGSKVPKTAPTRKGKVLMDLQRVAKEIGDEAGLEWGLDEETDDGGRMWREGSVAAYK-----------------------------------------------
58267448 Cryptococcus neoformans var. neoformans JEC21 --------------------------------MFSPATPIAGPSNPSHLRPSFSSPAFRRGGSIFPYEYGASNQPFSPHYSAPFTTTGVRIRSGS----------VFSREQWKKEELARRRQESRDKLKSSWDLLFEKY-R-DVED-DDEIDLATGT------IVKDRGKLRALQQPMWFGQKEGDDGESTGGG----------------------------------------------------------------------------------------------------------------------GHDFESDEDELGDWDEKAGLDPQLPEWEEVEGFHQAWTEEDDADFREFMRA--------------------------------------------------------------------------------------EQRRKSTFGSD-----------------------NEDEDSLSEHDSKKPAGFEEYLDVSPRSRGTQILPLPTLDDLFASDNKASSEDELEAISDSDAEEKGVR---------------------------------------DNLSALSSLHGTPIVSRRPKRR-------------------------------------------------------------TIIEVVIPPRPRSKSTGGMEEKPSEHHLLDCVPKSISTPTLADLFTPPPARIRRSLSGSSATSGSSALSKSKGKKRMPGERPMEDTSSGNHSIIQLRKPSNSTETIKRYDEKLFRCDSCRAAGGTRKDQAPFCPGRTDSCIFEDSSGSFEQFARKSATHSRPS---GKSFAADTRLVEGAGPTKQRTCRLCREAGGE--RAKTAGVCLGRHSYRR---------CN-----WRKRAIHSSTANTHT----------VTPVDVAKGESNPSQVNVSTDTPQLRTKHSPLLNMKVPSLRSSSAIRKHRRRVIESVSDDDDPRFTTDTALPPREPSSNFIRKPQETAPLPSPPPTSSVAPSSPPIASLHKPSRSPLLSLPPSSPPRPDIFSP----------------VPTQAARPTPSPSVSLTHPISSNYVTDAYKQTGVMYHPTPPPSTDDTLGLQSSSSSIKRTRFSLIRS-------------------------------------PMRHPSSDEEGSEDELDLLSNIDSSSIIACSSSPKHSSSPIRTEWS-VRAADVGIKLGPEHTGR------LPSDMVKTLVPSMGLFRPTLGSSSQASSKYTLPTPPSSYRPSQPRPVSDPQNPSSGSGGNPQARLMLPPPLPAKRSTHPNSLSTPK-------------------------------------ELKNSTSTFSTSSPAPSHIRLTSLPAVVVRARARSRSLSMAPPGALRTPKAQRSIMSPGSKIPKTAPTRKGKVLMDLQRVAKEIGDEAGLEWGLDEETDDGGRMWREGSVAAYK-----------------------------------------------
116503001 Coprinopsis cinerea okayama7#130 TRFKSLAHSQQVPMSGLMEPPPLKIHQKPPLVTPSASPPPSRPYLPKQPSSAPSATSSSHRSASVSSAQQRSRVSATPKPHQTPAPSTGQTP------------------SPEDIDFQQKRQASALRLLDVWSKLAERYTR-RLDE-DDIVDIVSGR------IVKDNGVLRKSK-----------TVWFGNGE----------------------------------------------------------------------------------------------------------------------KTHGEESGEDEDEEEEEDGEERAGDDGHQDDDDELDAFADVDDGGDEEEDREGDQEEEEEEVLEIKG----------------------------------------------------------------------KVDPVPPVTPQ-----------------------NPLDAADLKEFLETERLRRDVLGSEPEDDPVDPNALDNDGTDAYGTGGSDIYDVDYADVEVDVETPKQKTEKST---------------------------VRRSRGVPPVGESDSEDELNFNLAEEAIP-------------------------------------------------EDIQEPEYLASSTDSDDEIEIVKIVQRPPPKPKASPAFKAPIVKADHQTQLQTPPLSRTSMQPTFSSLADELFSTPPPQEEPSIDAPPETPEIPIASTSFKPAKSTPRTPKAQKSQPKDIPSTSKAQKPICATSSPFPKP-----------------------------KVPGKL---VPEVVIERQTPFEGA-------SHHSMNSVERRPGTSPTKGELRRERLR---------EE-----KREGAPEDSTPTTSA----------STP------------------------------------KASRGPTASSVNTKFPTVDIPSIDKRPDSMNEDHPVAEPSSRRKRKRSIPPSASPGETLAGPSRFPQHSVASSSKVQLTSYRDPDPNVSEGGSPTRAKDARKSIQQRSPRKRRSKSRPRPSPSEDADDSGSESETLQHPNHFYPYYSQHPPNPTYPYAQPLYPPPPPPGPS---QYT-------------------------------------RGFTPMPPPNVPQHGRGYTPMPDPHSDYFVSQVASRVVAALWNPGA-MPPHFGPPPGQPPFTPSSSHHRMSHHYNYATPPHQHYPYPPYHHPDF---SRATAPPDTPSERESSSCRSEGGRKKSIVHRSRSKGRAVSFKPSTDRKRRDASPTDDDDDDDDSVLAHSSPLKGKDAASTSASGMRRSNSTSAIPFHASTSKGKGKARQEDWEDEDVADRARSRSDPSSEEESVEEGPLSSGLRGRSRARERTPQPPSSSRSKTASNSKGVSVAKERKGNVSGGNKKSTKNKSAAMSIS----------------------------------------------------------
46107590 Gibberella zeae PH-1 -----------------------------------MEPPTKKRRHGPSPPKAAQDED-----------------------------------DDDELASHPQE---IKIRRDPDIQLALKRVNANQKLHATMAHIIEKYSR-DFEGIGDEIDMATGE------IVVNNGHLRNMR-----------DEGDVEGL----------------------------------------------------------------------------------------------------------------------WVEGESNIDEDEGILLEDLTDEYSDNEEQANEIHHSQTDNENSQASSTKESDTETHRQDQNVIIDEASNNVSNIASSQNDAPHDETTVLPHGLPQDDSQLSPPSFGPGPPPGFGIPHPTFGPWGMMPGFPMQAWGRDDIPPYFNMPPSMPGPWFTGGRYDTASNNGQASIWGRKWTRKTKRAGSMKGSFKKVSDKRPSDAAVGVSSETPDNDRGSESKSAGGSPNRQEAPLSDQTTNASEEDEDFLCSGTSDATPIVQQKPSLVPSGDNALSKNYSSYDPPHETLEETNGNIGKVSQQPDENDDSGQRRSGRARKQTEYLGKISWGDAREFKRSGKTFTIQIHGADPSLREEYQSVDLANDETEGEVFLPSEQTRKGSRLLEEVGTKVTSEKLVVPDSQDTATSFNSSAPQAAQSKN----------VEEPSPLIQTMIPTMELSDDEAPLALSRIRVPKRQIAAPVAVSPVSSLLTEQDERSTEPANAT----------------------------SAPLKSNNEPSPEAEITVDVVDGTM-------QLLKRKRGRPKGSTSAAKATPSKTPVP----------------VRTKEIEPTSPTFIV----------VSL---------------------------------------------------------------------------------------------ADHLPESTKRKRGRPRKSVGATSTVQDEENNPTKELA------------------------------NVDDVVSESDHQGPVNEISSNEVSGKPPPLSNELKWLLKTKPKDFTTDRACDTFLYKFVH------------------------------PRKPKEILQQAKDDEPGSQVTQETKEVPKDIEDDLKEQTILYKPQAPMQEADTSMEDVTETREDSESGQHDQTSPSSSSPPYHGDGTPGDDESPEVDEPIEHGTPIPHIISDDEAIESEGSLPPLPQDALIQEAPTLRKPKQMRSSFIEP-------------------------------------------PSSSQKPRTPRHKSIRTNQAPSSRRSLLSFVSDSESDNEGSRDELIRRVKSHSKSASVRPSSRKIRRPATLTREIYRTPRPLAADWACRRGN---------------------------------------------------------------------
119188451 Coccidioides immitis RS -----------------------------------MSPPTTCPTVGQSKAISP---------------------------------------------------------SSRGVNIHEARRANNLRLKSRLELIYQKYGR-DFGNIGDEINLRTGQ------IVVDNGHLNQME-----------NEQDIGGC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FSNNLHPH-----------------------GKTHREKDITEPVTRFTETITSLQPTKSRQPMKMHLPELGRRCRHSQPALAN--------------------------------------------------------ADQGPDQLLDGSILKVSADSNP--------------------------------------------------------------------------------GEYEGYCILTGSRSPTALAPAVVGEPFSAGFPKLEQ-------------------------------------------------PRSEQIESVWAAP----------------------------------------KRLPRG-------------RQRTG---------WADRNARALLAPQPGPDSDSDDPLQ---------EN-----SSKARTVSRRPCISK----------YTH-------------------------------------------------------------------------------------------------------------------MRLSTNRGYGGAQLP-------------------------------------------------------QKKGSEFHYNVLLCGNQQISAK---QHR-------------------------------------SNARTTFDPISKVITM-------DSEFNQESEESKR-------PLL-QER-----PKVGPLTAE------EINYLLDLRMVKRRSWPEVLSAMPWRSARLLKHWYSKHCIEVKNIRPLDIRDWVSQEKERPPSVQQVSPFSLESVQ--PYDVSVDRV------------------------------------QGKCNQGSGERQSGTIKFRDPSVEQAITKEVRMDEDDNLRSPVHLLRYTQVKSSARAATDMIKSESPDPLVDTS---------------------------------------------------------------------------------------
115491221 Aspergillus terreus NIH2624 -----------------------------------MESPTKRPRLDRSPEPEV---------------------------------------------------------DPNEMDLQEARAQNDLRLKSIFESIFEKYGK-DFTEVGDEIDLNTGD------IIVNNGHIFTME-----------GEDDTG---------------------------------------------------------------------------------------------------------------------------------ERVDWMSDDADSPASISHGQDS----------------------------------------------------------------------------------------------------------EEDPDQQITAR-----------------------GIADYMESRFGSYGPRRDDIQPEDLPIKTEPETKQSPTETRGPQDEPPL-----------------------------------------------------------ADSEADDDMDSVVFVQMNVQSA------------------------------------------------------------------------------------PKHSQPETKTTETGTEKAKFAPGTSTQSLNRL---------------------------------------------------PEPVESIWRVPEIDADFSTPVP-----------------------------RRSRPT---SSFSAVRSASPPGRR-------SLWAL-PWTKQRRSTDATKKRSAKK------------------PRRTKKHQSSPAVYD----------WSF----------------------------------------------------------------------------------------------------------------------AETADASDSDDP---------------------------------------------LQDNHQPSPTPKQALTIRGKWEGSGTPSRTT----DRC-------------------------------------DFCKKTFSRDGYIAHLRAVVESGSPDDQHDAAKASK-------RLG-AIS-----KDVPETPKT-----------------------------------VTKHAPSNTAQMTDMQSLDDAATHLTPTKPVGPA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67522114 Aspergillus nidulans FGSC A4 -----------------------------------MGSPLKRKRLYLWSGADDEY-------------------------------------------------------ETSDIDLQEARTQNDLRLKSIFEGIFEKYGR-DFTDVGDEIDLQTGK------ITVNNGHIDALE-----------VEGN-----------------------------------------------------------------------------------------------------------------------------------GYGDWLSDARPQAPRHVLAERTD---------------------------------------------------------------------------------------------------------YEGKPARLALD-----------------------ADAWGAEDTALEGDHDLQHPGRRTVHLLSHMRPGSRRGLGETTETDSDQGAAGDGEDRATSEAE--------------------------------------------DDRSSVDSLLGTALSIPAQKVG-----------------------------------------------------------------------------------------KTTKGETGTEKAIPPHDGSHQYQAAHT------------------------------------------------ERLDETVDPIWRVPEISAKFTTPTL----------------------------PSRPRPNPKPVINNAVRSQSPPGAS-------SVWAL-SGTRKRDTDVVKKIKQKGSP-----------------KRRVKHHSSPDAVWD----------WSF----------------------------------------------------------------------------------------------------------------------ADAPDGSESDDP---------------------------------------------LQEDYVPSPTPKDSVYIREKRKGPFSAGAAQ----KTC-------------------------------------SFCKRIFSRKAYDMHL-KDVLANPADNEHDSVELKR-------QLA-TVTGDGTTESAPGATNR------SPAPAGLIVRITNTPREPDSEAGQ---RTNHESTPTGSKRARTVLGPQEARLIIQMRHIQGMKWKEISDHFPQKKP--ANIQAWHHV------------------------------------HWKQRKANPPRLSGPWSKAELEKLEILKDQPELTWPGIRAEFPGRLLAEIEFKLLQLWAGDNVSQPLRSASPAD---------------------------------------------------------------------------------------
121719856 Aspergillus clavatus NRRL 1 -----------------------------------MERPQKRPRLAFASDGDT---------------------------------------------------------EPDDIDLQEARAHNDLRLKSIFEGIFEKYGK-DFTEVGDEIDLQTGA------IVVNNGHLRGMS-----------SEDDTG---------------------------------------------------------------------------------------------------------------------------------DQHGWLFEEENEEDGNLLASA-----------------------------------------------------------------------------------------------------------MNYRISDITME-----------------------GSTHDSGTAFGGDNPQDGAQAVMI--------PSPAFGFDRSCEELQPHGADGADSDRDDD-----------------------------------------------DDKSSVDSLLDTALCVQTESDA----------------------------------------------------------------------------------------VPGNWVPANKIEAIPGKPKATAETSIQS-------------------------------------------QLQHGSTRAEPVESIWRVPEIRGMFSTPSI-----------------------------NKLRQK---IPLTAVRSASPLGAG-------SLWAL-PGTS-RRNTDGKKGRSAKKLG---------TD-----QRKHEAHHSSPVLQD----------WSF----------------------------------------------------------------------------------------------------------------------AETPDGNESDDP---------------------------------------------LQEDYQPSPTPRSTINIRGKSKAQATTPSRTK---DKS-------------------------------------NHPEPPPSQQNPSRQL-------PPDPPHEVTEAKR-------PEN-RVS-----QAQPEIV------------IITADQDDPSIETRANAETEPKASPVTVQTPSQTRSKRTIMTPDEAKLIVRMRQIDGKKWKEILHYFPQKKE--INLIQWNHT------------------------------------HWNERQANPPPLSRPWSKPELNKLRALKDQQGLGWSEIRAAFPGRSLQEVEFQLLCLWAESGKDIKAESNGP-----------------------------------------------------------------------------------------
70983590 Aspergillus fumigatus Af293 -----------------------------------MERPRKRPRLSLGVHGE----------------------------------------------------------DPDDIDLQEARAQNDLRLKSIFERIFEKYGK-DFTDIGDEIDLQTGK------IVVNNGHLQRMS-----------SEGDTGEK-------------------------------------------------------------------------------------------------------------------------------DEAGWFFK----------EDLPT---------------------------------------------------------------------------------------------------------STVQISKATLP-----------------------GSVHDLEVA-TETGHDDTTDGVQLQRTLTSPQPLPALRLDRAYDEKRPPETGEADLD---------------------------------------------------DDSRSVDSLLDCALIVPNDSDK-----------------------------------------------------------------------------------------PDSQALPLESEAFPTKAITTAKPPVQS-------------------------------------------QQTRGVQANEPVESIWRVPEIKGGFSTPVF-----------------------------YRSRPK---LPLTAVRSVSPPKAG-------SLWAL-PGQS-RCNTDGRKGKRRKKPG---------VD-----QRKYK-LQSSPVLHD----------WSF----------------------------------------------------------------------------------------------------------------------AKTPDGNESDDP---------------------------------------------LQEDYQPSPTPKTPIHIRAKSHLENTPS-------RTK-------------------------------------DERRRLPPQLNPGSQP-------TINALHGATEPRI-------ANS-AAS-----QLEPETIEK------RADQCLSVDTHISAAKQHA--------DPAIAQASTPTRAKRTLMTPDEAKLIIRMRQIEGKKWKEVHEHFPQRKL--ISLIQWNQT------------------------------------HWTERHDKPPRISKPWSKEEVDKLQAFKDQQGLTWSHIRAALPGRSHAEIEFALLRLWAELGQSTDVQGS-------------------------------------------------------------------------------------------
119484568 Neosartorya fischeri NRRL 181 -----------------------------------MERPQKRPRLSLGVNGE----------------------------------------------------------DSDDIDLQEARAQNDLRLKSIFERIFEKYGK-DFTDIGDEIDLQTGK------IVVNNGHLQRMS-----------GEDDTGAK-------------------------------------------------------------------------------------------------------------------------------DEAGWLFK----------EQLPT---------------------------------------------------------------------------------------------------------STVQISKATLA-----------------------GSVHDSEVE-TETDRDDTKDGVQLQRALTSPQPLPALRLDRAYDEKQPPETGEADSD---------------------------------------------------DDSKSVDSLLDCALIVPNDSDK-----------------------------------------------------------------------------------------RDGQALPLESEAFPAKANTTANTPIQS-------------------------------------------QQTRGDKADKPVESIWRVPEIKGEFSTPIF-----------------------------YRSRPK---LPLTAVRSGSPPKAG-------SLWAL-PGQS-RRNTDGRKEKSRKKLG---------VS-----QRKYK-HQSSPVLHD----------WSF----------------------------------------------------------------------------------------------------------------------AATPDGSESDDP---------------------------------------------LQEDYQPSPTPKNPIHIRAKIHVENTPS-------RTK-------------------------------------DERRPLLPQLNPGSQP-------TINALHGATEPKI-------ANG-AAS-----QLEPETIEK------RADQCLSVDTHISAAEQHA--------DPVIAQASTPTRAKRTLMTPDEAKLIIRMRQIEGKKWKEVQEHFPQRKL--ISLIQWNQT------------------------------------HWTERHDKPPRISKPWSKEEVDKLQAFKDQQGLTWPHIRAALPGRSHAEIEFALLRLWAELDDCSK-----------------------------------------------------------------------------------------------
50556794 Yarrowia lipolytica CLIB122 ----------------------------------------------------------------------------------------------------------MSQNENGDKETPSETTEYHVNSTNLFDKGNTPFRR----------SLGTNS------ITGTNSSPTRQN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKNPNNSTKLL-----------------------KITKVTKIDAESKGEDGTTSLSVN------------------------------------------------------------------------------------VGAHEADQTAGSSLNVEEISKE-----------------------------------------------------------------------------------------------------IPSFSASLAM-----------------------------------------------------------FEKEWNSI-------IDKY-----------------------------SNVEDQ---GDVV------DLASG-------SIVKN-NGHLELL------------------------------------EDEEETIWD----------CMF----------------------------------------------------------------------------------------------------------------------PIHKEGEGKGDE----------------------------------------------------------------------------------------------------------------------------------AAVSGPPTPSLLQQMGEFQSDSEDEV-------------------EEKEENTTK---------------------------------KRRISLWDV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85116033 Neurospora crassa OR74A -----------------------------------MERPTKRSRTGPAPFDDEAI-------------------------------------VGDELNHQPEE---VNQLRDPGYQLEQARSFAAFKLKSAFENIFEKYGK-DFDGIGDEIDLRTGA------IVVDNGHIKSLKTATIGVESEDDDESESESGNEEEATSHGQKSKQNATALQTVPRPLPSMAPPSPFGASGPGYNSFPGGPPLLSNTMYPVQTQFQSLPMPFGAFSSANASIDPAWRAPDLPPPVPWGGFWTPGTQSRFKTVAKVQQLAARTNHDQEGEDEDDILLDISTTGATMATENTPVINKKLAPFRPPSNVSSPANHQLKTFAATSTPKSVDSFDVAKADGEKKKITKRKTPAKKTPAKTKAIEERIASLVDEFGI-------------QIAGSPVVDSPSADTQPVTDTQPA-----------------------VKQTPVAEKPVIEGRASAVKNTEAVKRRRTPNKKTPTSKKASLEESADLLRASLENSAPVPAAKEFFAELECETRPVVEHEPSIEKGSGQFSDEKSRVEAPVVEDPAVGTGQKTSKRQTPSRVSTREQHFGGPSSNHSASDSNRPALASTVEHPLVETELVVEIQSSSTVQNGPGQPYVQETIAGEPAVEKSSIDEVAVAEIEPPSAKGDGDQSASIPTTITKSVNHDLPEVPSSADSRTARRKRRLSMRGQSSPAGAKRSSRKQVASRYEQSLFNGATNANTTLKYYSPSCGALVTKPSNQQLWVEIPVDGTLDTKAF------------------QVVVEDDNLIPEVPAMEIGPGTTNTLAVDEMARNGVARPQVHGDHEPQAEAVEKRSPPSNDLSHEVFTRNVVDSAYAFSDEDEPAIPKARIRRTEPIQPN----------PKP------KTTEKSNAKEFGIPTPASSFDRNSQSTEFQATPEAEIPMEELPIISATVTTQTARQTPSAGSALLDKTNTNSEGPSLPQPVQVIKARRGRKPKTPIDLSVTASAVATSTPAVTEQPSEPVPIITALASTRPRRQSLRLSRGRRDSDITIAESNTPQHATATISQYEDESLVIQESPQGTPEPESVDEHKAGSPASPTLIVTIPASPKLTETLAPDQQLLENSLLEEAIARQRFWSPKPESIILGHEPSPPEPQAETLLEVLIPSERMPPRSASPPPQEQEPNIEVIQPQK-EPEQPTTPVKTRSRRGRPSSAASLPTATVTTTTKVKTKTGSASGSQPGRRKVQTPSTVTCTTTRTTNTTTAPMTSSRTRTTLTGTLQKQSQVQTPGTTKSTKSLLGSNNNNTTILSLISSDTDDEDELTLDFGGGTPSGISKKGVKPASSTTTTKTTTKRTAAASTYPLASLLLRTPSRKPPPPPAAGGGGIRRTTSLAKNASSIGSVGRRSRSTSSPPTAARAVTPTTGVGSEAGAEGEEEEEFVGSEVIQTPGGTLRRCGEAGF------RVIEVVAEIVGGVLFRRCYGWRRGSVIDTAFRSRN
38567281 Neurospora crassa -----------------------------------MERPTKRSRTGPAPFDDEAI-------------------------------------VGDELNHQPEE---VNQLRDPGYQLEQARSFAAFKLKSAFENIFEKYGK-DFDGIGDEIDLRTGA------IVVDNGHIKSLKTATIGVESEDDDESESESGNEEEATSHGQKSKQNATALQTVPRPLPSMAPPSPFGASGPGYNSFPGGPPLLSNTMYPVQTQFQSLPMPFGAFSSANASIDPAWRAPDLPPPVPWGGFWTPGTQSRFKTVAKVQQLAARTNHDQEGEDEDDILLDISTTGATMATENTPVINKKLAPFRPPSNVSSPANHQLKTFAATSTPKSVDSFDVAKADGEKKKITKRKTPAKKTPAKTKAIEERIASLVDEFGI-------------QIAGSPVVDSPSADTQPVTDTQPA-----------------------VKQTPVAEKPVIEGRASAVKNTEAVKRRRTPNKKTPTSKKASLEESADLLRASLENSAPVPAAKEFFAELECETRPVVEHEPSIEKGSGQFSDEKSRVEAPVVEDPAVGTGQKTSKRQTPSRVSTREQHFGGPSSNHSASDSNRPALASTVEHPLVETELVVEIQSSSTVQNGPGQPYVQETIAGEPAVEKSSIDEVAVAEIEPPSAKGDGDQSASIPTTITKSVNHDLPEVPSSADSRTARRKRRLSMRGQSSPAGAKRSSRKQVASRYEQSLFNGATNANTTLKYYSPSCGALVTKPSNQQLWVEIPVDGTLDTKAF------------------QVVVEDDNLIPEVPAMEIGPGTTNTLAVDEMARNGVARPQVHGDHEPQAEAVEKRSPPSNDLSHEVFTRNVVDSAYAFSDEDEPAIPKARIRRTEPIQPN----------PKP------KTTEKSNAKEFGIPTPASSFDRNSQSTEFQATPEAEIPMEELPIISATVTTQTARQTPSAGSALLDKTNTNSEGPSLPQPVQVIKARRGRKPKTPIDLSVTASAVATSTPAVTEQPSEPVPIITALASTRPRRQSLRLSRGRRDSDITIAESNTPQHATATISQYEDESLVIQESPQGTPEPESVDEHKAGSPASPTLIVTIPASPKLTETLAPDQQLLENSLLEEAIARQRFWSPKPESIILGHEPSPPEPQAETLLEVLIPSERMPPRSASPPPQEQEPNIEVIQPQK-EPEQPTTPQQSPQPPRS------------------RPKQAPPRGSQPGRRKVQTPSTVTCTTTRTTNTTTAPMTSSRTRTTLTGTLQKQSQVQTPGTTKSTKSLLGSNNNNTTILSLISSDTDDEDELTLDFGGGTPSGISKKGVKPASSTTTTKTTTKRTAAASTYPLASLLLRTPSRKPPPPPAAGGGGIRRTTSLAKNASSIGSVGRRSRSTSSPPTAARAVTPTTGVGSEAGAEGEEEEEFVGSEVIQTPGGTLRRCGEAGFSVVSRRRVIEVVAEIVGGVLFRRCYGWRRGSVIDTAFRSRN
50289969 Candida glabrata CBS 138 --------------------MSNSKIKIKKNKKNGKSLKQLHKALSGLLQK-------DNKPQKKDVSIDKKHSKRENSCERGSKDDPYKEVKKKNGRAYIYSKENQLIPKLTDEEVMEKHKLADQRMKTVWSNIIDKYS--NVVDEGDVIDLQSGE------IITDNGHIRNLNTGFT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSRGKETRYTSVVKD----------ILL------------------------------------------------------------------------------------------------------------------------DENVPAHDSY-----------------------------------------------------------------------------------------------------------------------------------------------DEYSIWEDNNAEE-------EEA---------------------------------------------------VFTDPEEPLTSESE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37362629 Saccharomyces cerevisiae -------------------------MKTNKKISKRRSLKNLHGALKGLLKESGKKSESKIRKHSDCNPVHRVYPPNIEKRKTKKDDGISRPIAERNGHVYIMSKENHIIPKLTDDEVMERHKLADENMRKVWSNIISKYE--SIEEQGDLVDLKTGE------IVEDNGHIKTLTANN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STKDKRTKYTSVLRD----------IID---------------------------------------------------------------------------------------------------------------------ISDEEDGDKNDEY-------------------------------------------------------------------------------------------------------------------------------------------------TLWANDSEASD-------------------------------------------------------------SEVDADNDTEEEKDEKLIDADFKKYEAKLSKRILRD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50310585 Kluyveromyces lactis NRRL Y-1140 ------------------------MIKRPSNSKKKANLRRLTGALRDLL------------------------------GEEEPKKEENLKQITRDGVVYIMSKENRLIPKLSDEEVMERHKKADENMKRVWSQIIQKYE--SIDNQGDVIDLQTGE------VIEDNGHLRNLSNEKSVLHSS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPDGGSVSYKSVLND----------IMD----------------------------------------------------------------------------------------------------------------------IKDSSYNSSVWQ-----------------------------------------------------------------------------------------------------------------------------------------------DHETNDSETGSES-------ESG-LEA-----DGLDEGSGS------------------------------------EADNSNEVYMKKLRPNPESN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45187961 Ashbya gossypii ATCC 10895 ----------------------------MIKKRRTGRLRRLTGALRELL---------------------------------DERPAPPAADTRPAGVVYVMSRENEPIPRLSDAEVMERHRRADENMKQAWTRIIEKYE--ALDDQGDVVDLRTGE------IVEDNGHIRGLADGVR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEVRYESALRD----------LVD------------------------------------------------------------------------------------------------------------------------VDEARGGVWS-----------------------------------------------------------------------------------------------------------------------------------------------AEDTDGADSGAES-------EGA-AES-----EGAASGAEH--------------------------------DDSATPEPPAPGPAARAPAPVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.........
Multiple alignment of Cse4 histone 3 <-----------------------------------histone-fold------------------------------------------------------------->
71022349 Ustilago maydis 521 --------------------------------------------------------------------------------------------------MVFSGSPWLACAHWLISAAFTNTGNV------------------------GQKKRFKPGTVALREIRKYQKSTDLLLRKLPFARLVREIANDFVTSYEHGEYGSG-LRWQSSAILALQEATEAFLVHLFEDANLCAIHGKRVTLMKKDFQLARRLRGR-WDGLGGY
19113265 Schizosaccharomyces pombe 972h- ---------------------------------------------------------------------------------------------------------------MAKKSLMAEPGDPIP---------------------RPRKKRYRPGTTALREIRKYQRSTDLLIQRLPFSRIVREISSEFVAN---FSTDVG-LRWQSTALQCLQEAAEAFLVHLFEDTNLCAIHAKRVTIMQRDMQLARRIRGA--------
85081112 Neurospora crassa OR74A ----------------------------------------------------MPPKKGGVTKSKAVSKKAAA----------------------VPTPKATPPGRRKS------RASSVQPGDPVP---------------------QGKKRRYRPGTLALKEIRNYQRTTDLLVAKLPFARLVREIAMQFRPM------DEE-MRWQSQAILALQEAAEAFLVHLFEDTNLCAIHAKRVTIMQKDIQLARRIRGV-WGGAGWV
115386254 Aspergillus terreus NIH2624 ----------------------------------------------------MPPKTGRGHKITAAPRTEASSSRTTAAAAGPSTASPSAH-RVRKSTGPSRGGKRPAGAP---RDSDVQPGDPTP---------------------TGRRRRYRPGTVALKEIRKYQRSYDLLIQKLPFARLVREVALDILPA----ERGAE-LRWQSHAIQALQEAAEAFLVHLFEDTNLCALHAKRVTIMQKDIQLARRIRGV-WGGLG--
83771704 Aspergillus oryzae ----------------------------------------------------MPPKTGGGRKVIAASR--AKAD-GAGKESAAAKGSPSTRGR--KSAGGARAGKRPAGAS---RKSDVQPGDPTP---------------------QGRHRRYRPGTVALKEIRKYQRSYDLLIRKLPFARLVREVALDLLPA----DVGSE-LRWQSQAIMALQEAAEAFLVHLFEDTNLCALHAKRVTIMQKDIQLARRIRGA-WGGLG--
121703636 Aspergillus clavatus NRRL 1 ----------------------------------------------------MPPKTGRGRKAVSAGR--PRKD-ESGPSDAPATASPSTRGQ-RKSSGATRGGKRPAGAP---RKSDVQPGDPTP---------------------QGRPRRYRPGTVALKEIRKYQRSYDLLIQKLPFARLVREVALDLLPT----EVGAQ-LRWQSHAIQALQEAAEAFLVHLFEDTNLCAIHAKRVTIMQKDIQLARRIRGA-WGGLG--
70984188 Aspergillus fumigatus Af293 ----------------------------------------------------MPPKTGRGRKAIGAPRTQPRDDGGAGPSNAAATASPSTRGQPPKFRGGTRGGKRPAHAP---RPSDVQPGDPTP---------------------QGRRHRYKPGTVALKEIRRYQRSYDLLIQKLPFARLVREVALELLPA----EVGAE-LRWQSHAIQALQEAAEAFLVHLFEDTNLCALHAKRVTIMQKDIQLARRIRGI-WGGLG--
119467732 Neosartorya fischeri NRRL 181 ----------------------------------------------------MPPKTGRGRKAIGAPRTQPRDDGGAGPSNAAATASPSTRGRPPKSRGGTRGAKRPARAP---RPSDVQPGDPTP---------------------QGRRHRYKPGTVALKEIRKYQRSYDLLIQKLPFARLVREVALELLPA----EVGAE-LRWQSHAIQALQEAAEAFLVHLFEDTNLCALHAKRVTIMQKDIQLARRIRGV-WGGLG--
50546747 Yarrowia lipolytica CLIB122 ------------------------------------------MARISLASSSAGVAGKPRGGGGLHP---------------------------------------------LGQTRKTLPGERRDTTQ------------------KITKPRYKPGQKALKEIRRYQRGTELLIAKLPFARVVREVALNYLGS------EYGNLQWQSMALLALQEAAEAFLVHLFEDVNLCAIHAKRVTIMQKDMQLARRIRGA-WGGAG--
68491104 Candida albicans SC5314 ------------------------------------------MARLSGQSSGRQTGQGTSAEAIRQQREELRRQRELRLQQQQQAERQQQRQQYRTEQSPIVPAATSSSRYSQFGIYRNQPGDVVDTLASSLPRRTTTTRPEVNRTVPRVKKRYRPGTKALREIRQYQKSTDLLIRKLPFARLVREISLDFVGP------SYG-LRWQSNAILALQEASESFLIHLLEDTNLCAIHAKRVTIMQKDIQLARRIRGQSWIL----
126131874 Pichia stipitis CBS 6054 ------------------------------------------MARISTSSNRPLPSSNALRRQRERERQEQQRGRQPQRS-----------------AAPGSRPQSGASRQQQTGIYRNQPGDPTVQ--------------------ATVKRRYRPGTVALREIRQYQKNTDLLIRKLPFARLVKEVAEDYIGA------DYG-IRWQSNAVLALQEACEAYLVHLLEDTNLCAIHAKRVTIMQKDIQLARRIRG--YL-----
50407281 Debaryomyces hansenii CBS767 ------------------------------------------MARISTSSSNRNLPSSNALRRQREREEQIRRGRVGQSS-------------------ANHSRQSSVNRQRETGIYQNQPGDPPTAKATS----------------TKRKRRYKPGTNAIREIRQFQKSTDFLISKLPFSRLVREIAENYIGA------SYG-IRWQSNAVLALQEASEAYLVHLLEDTNLCAIHAKRVTIMQRDIQLARRIRG--HI-----
50295008 Candida glabrata CBS 138 MSTRQAVFERDVDEDRWPRSARGLAGVNTVFEGDSEINSKAMRLLEKTRHRRNLLNRREDRRRYLGGVKAKAIESDYYHRNQLPSSYDAGNDDFEPINNSHVESEEENKRLPEKYSLDKYVKRSRKQRDHRHIVAK-----------PKEKRNFAPSKLAMYEIEKYQRSTALLIQKIPFAKLVKEVTEEFAGE------SQD-LRWQSMAILALQEASEAYLVGLLEHTNLLALHAKRITIMKKDMQLARRIRGQ-FI-----
27808712 Saccharomyces cerevisiae MSSKQQWVSSAIQSDSSGRS---LSNVNRLAGDQQSINDRALSLLQRTRATKNLFPRREERRRYESSKSDLDIETDYEDQAGNLEIETENEEEAEMETEVPAPVRTHSYALDRYVRQKRREKQRKQSL-------------------KRVEKKYTPSELALYEIRKYQRSTDLLISKIPFARLVKEVTDEFTTK------DQD-LRWQSMAIMALQEASEAYLVGLLEHTNLLALHAKRITIMKKDMQLARRIRGQ-FI-----
50305593 Kluyveromyces lactis NRRL Y-1140 --------MEQSIRSIDGSRS--LSNVGASLIDRESINQRALQLLQRNRRRRLLLNRSEDKARYIQPER----------------------------------------------SASSQQIHPPEHHISAHERIT-----------KARGTRYKPTDLALAEIRKYQRSTDLLISRMPFARLVKEVTDQFTTE------SEP-LRWQSMAIMALQEASEAYLVGLLEHTNLLALHAKRITIMRKDMQLARRIRGQ-FI-----
45185312 Ashbya gossypii ATCC 10895 --------MEQSMSSEQAERVAGRVEQLGGFQNNESINQRALLLLQRNRQRRQLLQRQEDRTRYIPDDA----------------------------KRRVVERVAEPAAAESRADGAREEERPARPARPRETRRI-----------AKKPQRYRPSDVALQEIRRYQRSTELLISRMPFARLVKEVTDQFTTV------DQQ-MRWQSMAILALQEASEAYIVGLLEHTNLLALHAKRVTVMRKDMQLARRIRGQ-FI-----
.........
Multiple alignment of Cbf1
13182946 Candida glabrata MERSNRSRKSRRQEVSEDILERELKQYVNSSERMHESDAVERSPKRRKGSHREVDIETTVHTTVHYDEKEEVNGSDLNDDEQRRAIEGAASEDETHAVEGEHEDEDERENHVNDHDDNRDPNVDDELHRADADHQEHDEEDRDEDQHQ-HQHQEQEQEQEQGHEP--EHEQEQEAEHEQEPEQEQGQEPEEEHGHEHDHEENMESIREIANDSGDAAAAVSTIRIHYQDLSGNSRGDTTINVGLK-PELYASLSSRSDVKTENKKKRGKQTKGD--ESIQDWRKIRKESHK-----EVERRRRETINLAIDNLRKLLPKP--E---YSKAGILNSAAALIQKLKESESSQMNKWAIQRIVTEQTKTAHQKSNEKLA-------AALDDAYQELTRLKSILKENNIKYEDKFVIPEDTLREAKELESELNRAQEEIDQIDPRASAEPEEEEEERDEEAGEDESKE
50288897 Candida glabrata CBS 138 MERSNRSRKSRRQEVSEDILERELKQYVNSSERMHESDAVERSPKRRKGSHREVDIETTVHTTVHYDEKEEVNGSDLNDDEQRRAIEGAASEDETHAVEGEHEDEDERENHVNDHDDNRDPNVDDELHRADADHQEHDEEDRDEDQHQ-HQHQEQEQEQEQGHEP--EHEQEQEAEHEQEPEQEQGQEPEEEHGHEHDHEENMESIREIANDSGDAAAAVSTIRIHYQDLSGNSRGDTTINVGPENPELYASLSSRSDVKTENKKKRGKQTKGD--ESIQDWRKIRKESHK-----EVERRRRETINLAIDNLRKLLPKP--E---YSKAGILNSAAALIQKLKESESSQMNKWAIQRIVTEQTKTAHQKSNEKLA-------AALDDAYQELTRLKSILKENNIKYEDKFVIPEDTLREAKELESELNRAQEEIDQIDPRASAEPEEEEEERDEEAGEDESKE
116505115 Coprinopsis cinerea okayama7#130 -----------------------------------MASAAPEQQQPQQQQQPPAVPPPPPAPAQATAAAAAPPVPQPAPGTAPY--------EYQQQLFNGITGIEPNALLKILRSLPGVFPSVLDPANQKQDAAQALSNLSQYPQQGLQYPPPAGIPGINEPGPS-SHPRGPPTLNQLTAAVAMQVAPTPVQGQQPPADGAGKPPTQPAPVPTDPNAQASTSAQPAQPPPQPAPAATPAPTTTG---------------------GRRQRNPA--IGTDEWARQRKDNHK-----EVERRRRGNINEGINELGRIVPNGTGE---KAKGAILARAVQYIHHLKENEARNIEKWTLEKLLMDQAMGDLQAQLEEVKRLWDEERTARQRLEAELELLRGRQSAAPKD---------------EATAAGTKRRSEEEGGEAPAASAAPAENAEERDGKRQRTE---
71013476 Ustilago maydis 521 ---------------------------------MSATTDTAPTETASTDEHITDVSSVTNQPAQSSARSEAASASDSAPAAAPAAAVVAAAAALESTPSAGRDHIERDVSNILAELNQEQLASIVAAARASEARTADGTTSSESFAQGANLPPGLGQAASALTSIAAGFKRTPGNDRTSLGTPTKASADAPPSSEEDVKQLDVDSAVKSATDTATAAALASLGSLGASQPTSTTYNNDAGDESIE---------------YDSPPNGASPSRSLKRARGPELDRQRKDNHK-----EVERRRRSAINDGIVQLSHIVPGC--DAKNTNKGAIIHAAVRYIQDLKHNEASNIEKWTLEKLLMDQAMGDLTAQLDEAT-------AQIERLRHELDE-----RSAG-----------------------------------------PHPQDAAPNT---------
50551493 Yarrowia lipolytica CLIB122 -----------------------------------------MSAIRRTRSTTSEDEAITKRLKQEVMVSEEAIDDKDELNESDAAAAVAAVAAAVQEKKDHDDSVKAADVLRQTLEHVNEHVTDDAQGHVPQQQQHQQQEQQGHVQQQQEQQGHVQQQDQQSHVQ--QDTQNHVQQQQQDPQNHVQQQQQQQGLGQHVSQDQGQGLDSHVHHGMTAI---------NQHVPQQAHVTQPYELDLN-----------------PYNQAPNSAKPP--VGSEQWHQMRRDNHK-----EVERRRRETINDGINTLAELIATS--E---KNKGQILKNAIEFIKQLKEQDDARTQKAAMDKFSLMNQVTETSAQNNRLK-------IELQRAWREAETWKGKYQE------------------------------------------LEGKKE--------------
119182276 Coccidioides immitis RS ----------------------------------MSDNIGSISTADGKRKRESLDAGDSQRLARSPPMANTNANMHPNNGNIHG--------------AQFPPEYYYGYQEAAPPAKRFQLGYDTHGLNNPTELSHIDQQLLQHVGGQNGVSDDNAMTAKAALA---AHPQPKFSAPESAFDNNALG---------HNIAAFGEDVTQV--------------------AMPGVHGHNSTAAAVY---------------AAREAQSISHSKPP--VGSPEWHTQRKNNHK-----EVERRRRETINEGINELAKLVPGC--E---KAKGSILQRAVQYISKLQEDNKTMVDRWDTTQMTTTQAIAEISAQNAKLK-------AEVNRRGVLAMKWLQRCREAGLD--------------------------------------FPDYDDDKDLSQLEIDDVQI
83772257 Aspergillus oryzae -------------------------------------------------MSDPSLGATDGMNNKRKRESTDSTGPDAQRLNRSS-----NGSNGSIPAPDTQPNFGHASLG----------SYDTHGLPGAASELNIDQQILQHVGPQNGISDENALTAKAALAA--HQPQNKYPPPPDATFDSSLP----------HGLTFGDEMGQ---------------------AIGGAHGHNSTAAAVY----------------AAREAQSMNQKPS--VGSPEWHQIRKNNHK-----EVERRRREAINEGINQIARLVPNC--D---KNKGAILQRAIEYICQLHDEKKAMSERWEQNNMTTSHAINEISAQNSKLK-------VEVNRRGDIALKWLQRCRDAGLE--------------------------------------FDDYEEAKELEPLEVDQGQV
119479711 Neosartorya fischeri NRRL 181 ------------------------------MADADLANLQGDHTTSYIMSDQSLGAPDSNITNKRKREGDDSAGPDPQRLNRSS-----NGSSGSMPGADAQNNFAHSSLT----------SYDAHGLPTSTSELNIDQQILQHVGPQNGISDENALTAKAALAA--HNPQNKYPPPPEPSFDANNL---------AHGLTFGDDMGQ---------------------AMGPTHGHNSTAAAVY----------------AAREAQSMNQKPS--VGSPEWHQIRKNNHK-----EVERRRREAINEGINQLARLVPNC--D---KNKGAILQRTIEYICQLHDEKKTMSERWEQNNMTTSHAINEISAQNSKLK-------LEVNRRGDIAQKWLQRCRDAGLE--------------------------------------FDDYNDAEELEPLEVDQGQV
6322520 Saccharomyces cerevisiae -----------------------------MNSLANNNKLSTEDEEIHSARKRGYNEEQNYSEARKKQRDQGLLSQESNDGNIDS----ALLSEGATLKGTQSQYESGLTSNKDEKGSDDEDASVAEAAVAATVNYTDLIQGQEDSSDA-HTSNQTNANGEHKDS---LNGERAITPSNEGVKPNTSLEGMTSSPMESTQQSKNDMLIPLAEHDR------------GPEHQQDDEDNDDADIDLK--------------KDISMQPGRRGRKPTTLATTDEWKKQRKDSHK-----EVERRRRENINTAINVLSDLLPVR--E---SSKAAILACAAEYIQKLKETDEANIEKWTLQKLLSEQNASQLASANEKLQ-------EELGNAYKEIEYMKRVLRKEGIEYED---------------------------------MHTHKKQENERKSTRSDNPHEA
45198932 Ashbya gossypii ATCC 10895 ----------------------------MTKRLHGEHEINGANRGNVKRSHLDDTGNIDSELLRDVEVDNEVNKGNPGASSIGD-----------------------------------EAAAAAAAAAAAAARFTNLNDDEDEVGVG-GHGMGRGVGGHPGDA---DHVHDEDDDDEDDDEDDDMDDLKKDPNVDLDGDDDDDED-------------------------GKLRGDKPTG--------------------------RRGRKPAPSAGTPEWKQQRKDSHK-----EVERRRRENINTAINKVAELLPVK--E---SSKAAILSRAAEYIQELKETENTNIEKWTLQKLLSEQQVSQLTSTNEKLE-------EELNNAFKEIETLKNKLKSAGIE---------------------------------------P------------------
50304387 Kluyveromyces lactis NRRL Y-1140 -----------------MSGKRSYQDDQLDVEEANKRHQMVDTLLRGSEDKDGDNDNSVYDDLLQDPEEVEKENKENRDGDKVGDDEHDVVKGESEGQAAEQSSADQNDENINVDVDPSVTAVARAAQHASQRREAGDEDEDEDEEEEEDEDDHVDIDDVDKDPD--AVIDEDDDEEDEDQAQRRRGKKNIEGTGESNDSERATKIGESGSSNETAGADGSGDREDGSQPDGTEHDDEENGGAGA-----------------GGAAPRRGRKPGTETGSTAWKQQRKESHK-----EVERRRRQNINTAIEKLSDLLPVK--E---TSKAAILSRAAEYIQKMKETETANIEKWTLQKLLGEQQVSSLTSANDKLE-------QELSKAYKNLEELKKKLKEAGIE--------------------------------------DPTEEE--------------
19114856 Schizosaccharomyces pombe 972h- --------------------------------------------------------------MQRDMSINHLLPPLSGPGQVEQ-----------------------------------------------LTGFTNDIVYNDFYAHAVSYN---------------PYPSEKIDFPKKNTAHKNST---------------------------------------------TSTVASSGNTTME--------------------------KPC--VGSEEWYKAKRLSHK-----EVERRRREAISEGIKELANIVPGC--E---KNKGSILQRTAQYIRSLKEMEEMCREKSNLEKLVADHTIQELARENARLK-------SECERAWRSVELWKQAARS------------------------------------------FDSELDVEENSES-------
50412396 Debaryomyces hansenii CBS767 ------------------------------MSKRSSEDGSHQTDKKLKGDDKKDEIAIDSELLGQQSSYTNNGPDDSRVDSHGG----------------NNDNNVNAAAAAAVAAAAASEPANAAAAALSSQQQHHSQQLQQHLAYQNAFRQQQQVQQQQVQQQ--HHQHHQHGHHNQHQSHS---------------------------------------------PQNSLSHLQPTTLPQT----------------------SSTSKPQ--HGSDEWHKQRRENHK-----EVERRRRESINQGIKELAALIPTN--D---TNKAQILQRAVEYIKRLKENENNNIEKWTLEKLLTEQAVSELSASNDKLK-------QELERAYREIEQWKKLVKD-------------------------------------------EKNMK--------------
68480870 Candida albicans SC5314 ------------------------------------MEIDAELLTQQASDSAHTDTATAAVAAVNNEQGKELEQTESSTNQTSA-------------------------------------------------LDKDDKETKDNLNPREETQSSHQEIDIPKDQL--TNQQNLADQHQQYQYHQQLA--------------------------------------------QTNFKTEPTN----------------------------SAKPP--HGSEEWHRQRRENHK-----EVERKRRESINTGIRELARLIPTT--D---TNKAQILQRAVEYIKRLKENENNNIEKWTLEKLLTEQAVSELSASNEKLK-------HELESAYREIEQLKRGKK---------------------------------------------------------------
11596255 Pneumocystis carinii ----------------------------------------------------MSLYLILIILVDKVYRTEDALSKE----------------------------------------------------------FHGLSEITRYTGMNGEEEEEEESGGIYSVESGEEILKSGVIRRDEEIHD------------------------------------------------------------------------------------AGGHKPI--VGSEEWHRVRRSNHKVRVKREVERRRRETINESISELSRIVPGC--E---KNKGKILERTVSYIQQLKENEANNIEKWTLEKLLTDQAISELSATNQKLK-------AECDRLWREVSVWKQAA-TCGIN--------------------------------------NDKDEKKDDPISNVRAEKMD
111069739 Phaeosphaeria nodorum SN15 ----------------------------------------MADTAGYPTDAKLDSHNAHTNKRKRDTRDQGLNRPAPNTNSDLA---------------------------------------DQVTANFLAAHNAGADDMEQQFDVHQNGGNTASVGDTAAAAL--AYHQMTVPQATELQFQTQGSSGDSFSMGDHHQNQTGMQDFSLEALK-------------AATQTGRSGQSAPSESPPQ----------------------SASHKPT--VGSEEWHKVRRDNHK-----EVERRRRETINEGINELAKIVPGC--E---KNKGSILQRAVQFITQLKENEQQNIEKWTLEKLLTEQAITELSTSCDKFK-------AECQRAWDECQIYKRACENAGIL--------------------------------------PDEIKERQENGEQSGPNPIS
46122379 Gibberella zeae PH-1 --------------------------------------------MSEDLAEQSELMGLTTSPGHKRKR--ESGSPDLSRNKRPA--------PAAHMSTDAASFIDSAMES-----------HAVNANGVNVADFNALQQATQEHDHP-DAPDPTSATSTAQAALG-MYPTLHVPPSTEEQFAAQAATDP-----DHGHDTSFNPDVTPSVDGIMEPP---------QVGPPQHQHTPPNGVPHA---------------PPRYNPAAPNPKPT--VGSEEWHKMRKDNHK-----EVERRRRETINEGINELAKIVPGC--E---KNKGSILQRAVSFISQLKENEQQNIEKWTLEKLLTEQAITELSASNDKLK-------HECERLYRELEIWKRVAQNAGLE--------------------------------------PPQPKEENNAATASS-----
39952041 Magnaporthe grisea 70-15 ---------------------------------------MAEVAQPMEQPSLKAEAPIPSSPTQKRKRASESASPDSRRSKRGA---IATPNNVSVPVPVPVPVAEDTSGQLYMDSAMAASAPQPGSDNINADDFSALQQATV--DHG-DVSDPANASSTAAAALGSMYPTLHVPQTTEETFAAQVGADT-----EHNDNSFGVTPDGLP----------------MESPMEDMQQSQFNQLQQR----------------------NGPQKPA--VGSEEWHKLRKDNHK-----EVERRRRETINEGINELAKIVPGC--E---KNKGSILQRSVAFITQLKDNETQNIEKWTLEKLLTEQAIAELSQSNDKLK-------TECERLYGELESWKRVAQAAGLS---------------------------------------PEPKEETGAAS--------
85091694 Neurospora crassa OR74A -------------------------------------------MAAPVAMEHPDLTDLSNAPGQKRKRASESASPDSRRNKRGV-------PPATMAVPEPEAFLENAVSI-----------AQAAHDHVSADDFNALAQAASDHT---DTADANSATNTAAAALN-MYPTLHVPPPTEETFAPPPPGPE----MQHHHENAYHNPSPVQEPDG------------LPPMTPQTSLPPANGVQPE----------------PPKWGTHLPPKPA--VGSEEWHKMRKDNHK-----EVERRRRETINEGINELAKIVPGC--E---KNKGSILQRAVQFITQLKENETQNIEKWTLEKLLTEQAIQELSQSNDKLK-------QEVDRLYREKEMWKSIAESAGLQ--------------------------------------PPQPKEEPEGSS--------
116207842 Chaetomium globosum CBS 148.51 -------------------------------------------MAATVSVPHPDLPEASTSPSQKRKRVTESASPDSRRNKRGA-----PAAAMSVPDTDAQTFLSDTVSI-----AQAAQAAQAAHDHVNVDDFSALAQASA--SDHNDTTDASNASSTAAAALN-MYPSLHIPQSTEEAFANQATPET-----QHEDNTFSNHSVSQAPPDGLP----------LPPPPSTIQQPPSNGVQQE-----------------QRYSAPPNAKPA--VGSEDF--------------AVERRRRETINEGINELAKIVPGC--E---KNKGSILQRAVSFITQLKENETQNIEKWTLEKLLTEQAIAELSQSNDKLK-------LECDRLYRDMETWKQIAQSAGLQ--------------------------------------LPQQKEESGSSS--------
.........
Multiple alignment of Mif2
119196319 Coccidioides immitis RS -----------------------------------------------MAARRAPTKAREM-----DFGNVGVAGRRTGVTLEK-GKLDEHGMEEIDGMFSSPEKS----PMRANHNGIANDTVLN--------SEDMETAGSSSMPEP---ADMLSARRPGRNSYVLPPRS-----RSPIKTHLSGSPRRTPGIRSSPIPQSDQISS--------PSSRPVTMRALDLSRAQTRLGKSPLKQIRATSIPPELESPAARESEEDVDIEVSGETADFSDDG-----------NYLVEEAEEDSGFVEPYGDYHESG------QGGPTETVENEDTNNIENGTEQDDPEEE----------------------------------------------------------------------PSPSVVAKAARRGRKRKSTPVEPETSAK------------SVDKVPP-------PKRKRGRPPKAVREEANEANAEGQNPRSAKR--------TKTTA-ATGASTLKMSADQE-RDLNQV----------------------------------------------------------------------------------------------------IEN---------ITKRDGPHNKQRSLHILRREAPSDDN--------VRRTRSGRVSVRPLAYWRNEKCVYGTGEAE----------LG------------------ERFP-LSTIKEIVRIDEPEPIYTKAKRSSKKAKAKKKRDELS-------------------------DEEDEDVEPWE-TDEGVFYGPVKTWDPELQAGTL---------QEELMDVAYAPSAIQTHEVK----GS-TFRFAKILST--PFLGSGFVEMPP-GAVKKQKNSKRMHMVFFVYRGRIRVDVSGLVFSAGKGCVFQVPRGNNYSFANEYDK-PAAIFFTQGCIPLDADGNIDTGAPAPPLPDPTQQPQEEGQSPEQAEGQQPQEEQEHIQAVAKEKKEKKGKKRRGRPKQNP--------------------------------------
83770968 Aspergillus oryzae ------------------------------------------------MAPRGPAKARDY-----DYSNVGKLGRRTGITVKE-GKRDEHGMEDIDEMWSSPEKS----PVRENGFSNGNESLVGS--------DGMSMDEG----------------------------------NAPGPADFLSDWLDWVPSENSWF-----------------TIIPKPTTG------------SPLLYARSKANKKTQEVAASFSDSDANSQSNPDENANSHEHT--------------------RDDFADSFDAGNDTILGGGLEEPDEN-STATQSPSILAVGLQKKGQI------------------------------------------------------------------------KIGHQPKKKARNGSSRTQIPVESNE---------------PQEHGSSQ------KRKRPGRPAKNQRSTSYDTEEQ-----------------RLSKKSKASIKETREPNTSGHPDLNRV----------------------------------------------------------------------------------------------------VED---------HVNRTGPL-KGRSLYILKRETPTDSS--------TTHTRSGRVSVRPLAYWKNERCVYGDGEAA----------EG------------------ERYP-LSTIKEIIRTEELE---PERRKSKKGRPSKKSKSGKP--------RVDNDS-----------EDDEDYIDPWE--KEGILHGYIRKWDPDAQAGID---------EEEVLDIAYAPSGIETRDVK----GS-SFRFAKLLSS--PFLGSGIVELPS-GGVKKPKNSKKMHMVFYVCRGRVQVDISGVQFSAGKGCVFQVPRGNYYSFANTHGK-DARLFFTQGCVPVEGSNSAPGSASKN-DTMEEEPTPQVERPPGVGKGRP------------------KGKQKAG-GSKAS--------------------------------------
67537890 Aspergillus nidulans FGSC A4 ------------------------------------------------MAPRASVKARDF-----DYSNVGKAGRRTGITLAE-GKRDEHGMEEVDGIFSSPEKS----PLGDNGLDTSESIG-----------SDMSMDEGNG----PGPADFLSGTNGTRTPRFPPPVP-----RSPSKSGITGSPRRTPGLRSSQSPQ--------------RHLPSSSPSDGRSVRRDSRREVSPLTDRSVNATPSLEHSHAARTKGSRKAEKPARIDVSDSEAN-----------GDENGDSMDQDGFVGSYINGDDTTLGNDPEEVEDNSAEERPVQSPPSNK-------------------------------------------------------------------------------RKGPRKGRKPLTAAKSRQTLTAQDA---------------SEEQETTQ------KRKRAGRPPKSQNQPTDDIEER-----------------RPQKKAKTTVPERRVSGPSGDPELDKM----------------------------------------------------------------------------------------------------VEN---------YVNRTGPL-KGRSLYILKRENPADPS--------ATHTRSGRVSVRPLAYWKNERCVYGDEEAA----------EG------------------QRFP-LSKIKEIIRTEELE---PEKRK---RRKTKKSKSKKS--------K-DGSD-----------SEDDQYRDPYE-EKGGVLHGYIRKWDNETQTALD---------EEEVLDIAYAPSGIETRDVK----GA-SFRFAKLLSS--PFIGSGIVELPP-GGVKKPKNAKKMHMIFYVVNGRVLVDISGVQFSAGKGCVFQVPRGQY--------------------------------------------------------------------------------------------------------------------------------
121702281 Aspergillus clavatus NRRL 1 ------------------------------------------------MAPRGPAKTRDY-----DYSNVGKAGRRTGITLKE-GKRDEHGMEEIDGMFSSPENS----PGIENGFSNNSSIGS----------DGMSMDEGNG----PGPADFLNGANGGRASFLPPPHG-----RSPMKSGLTGSPRRTPGLRSSATPQRDI-----------PSSSPSDGKGLGSAKGDARRDISPLTNRSINA-PSLNQVNGTRNNKGINKTSEIAVEFSDDDSN-----SQLNGDENANSSEHLRDDYDSSFMAGNDTLAEEQLEEPEQVVVETDVSPSLVTGSRRSERS-------------------------------------------------------------------------RAAPKSKKKTTSGKGRIQDNIQPDE---------------PEIQETAQ------KRKRPGRPPKSQRQNVDDAGEQ-----------------PPPKKTKTAEQDKRDVKSSGDRELDKV----------------------------------------------------------------------------------------------------VEN---------YVNRTGPL-KGRSLYILKREMPTDGS--------ATHTRSGRVSVRPLAYWKNERCVYGDGEAA----------EG------------------QRYP-LSTIKEIIRTEELE---PEKRK-TKRRSSKKSKSRKS--------RDDDSD-----------GEEDNSFDPWE-KEGGVLHGYVRQWDPETQAGSV---------EEEVLDIAYAPSGIETRDVK----DS-TFRFAKLLSS--PFIGSGIVELPP-GGVKKPKNSKKMHMVFYVCHGRVQVDISGVQFSAGKGCVFQVPRGNYYSFANTHGK-DARLFFTQGCVPVENDLSSPQSASKP-IGTEDDSNTESGQAPGFGKGKP------------------RGKQKAGTASKA---------------------------------------
119496275 Neosartorya fischeri NRRL 181 ------------------------------------------------MAPRGPAKTRDY-----DYSNVGKAGRRTGVTLKE-GKRDEHGMEEIDGIFSSPEKS----P---EAYGNNTTIGS----------DGMSMDEGNG----LGPADFLSGTNGGRASFLPPPVA-----RSPMKSGLSGSPRRTPGLRSSASPQRDIL-----------SSSPSDGKGLGSAKGETRRDVSPLTNRSINA-PSLNHVNGLRNNKGINKTADTTVTVDFSDSD---ANSQMNGDENANAFEQMRNNYDDSIDAGDDTLAEDQQDESERVDRVDMDISSYIAAGSRKTERS------------------------------------------------------------------------RVVPKPKKPAQSKKTRAQEVTQQNE---------------TSEQGNVQ------KRKRPGRPPKSQRMNNDEDDAVE----------------RPSKKSKTASQTGRGLKSSGNPELDKV----------------------------------------------------------------------------------------------------VEN---------YVNRTGPL-KGRSLYILKREIPTDGS--------ATHTRSGRVSVRPLAYWKNERCVYGDGEAA----------EG------------------HRYP-LSTIKEIIRTEELE---PEKKKVSKRRSSKKSKSRKS--------RDDDSD-----------NEDDDYVDPWE-KEGGVLHGYVRKWDPDTQAGSI---------EEEVLDIAYAPSGIETRDVK----DS-TFRFAKLLSS--PFIGSGIVELPP-GGVKKPKNSKKMHMVFYVCHGRVQVDISGVQFSAGKGCVFQVPRGNYYSFANTHGK-DARLFFTQGCVPVENDQSSPGSASKPAVSTEDESTTQRGRPNGTGKGRP------------------KGKQKAGSGSKAS--------------------------------------
116200219 Chaetomium globosum CBS 148.51 ------------------------------------------------MAPRPSIARRTLAPQGEHIYELGVVGRKTGVTVPDSGVRDEHGMEPIENLFSSPGKS----DHEDQQDEGSDEYGSG--------EEAMDITTTSG----IGPAALLNG----HGSRLPVSLSRI---RSPAKPLLNSPAQRNRFLARNSSSPARGAVIRNDDS----RSSSQPTNDQTATKRKLDFGSVANGGPHSLSQPQAHGNRLQPLRHDSEEEEEAQSEGGHGAED--------------DEVNDFVEESMAMLNEGEDYELAEQEQDLEPAQSEEEEED-----------------------------------PPAPAAKKKPGRPPKQKVA-----------------------------------ASAKAVKPQKKPTRQVVEEEVEEEEEEEGPEEDGGHSEEEQEPTPKPQKPTPGKRGRPPKAGKAQAAAPPPPARGSKKRRSLDEEAAAEEPSPEPQPKRQRTSPAANAKKPGKKAPETAPAPAPKPRGRKR-------------------------------------------------------------------------------------KSSIDPGDVSQVAIARRPPLPKSRGLLINRREVPGDPGSS------MSRTRSGRTSFKPLAYWRNERVEFDKDEAE---DAFVGRSRR------------------SRFV-LPSVNAVHRVDEPE---PEVRAKSRRGGGGGGRKGAA---------KRGRRRRSGGFEDDDDGEDDGPAEVWE-LDPGTVTGEVVVWQPEYEFSPPAPNDLV---SVMDKQLAISGPAIKTTEVV----GG-EFRYAKVFSE--GFIGAGVVDLPP-GAIKRLKNSRKVFMIFFVHAGRVLVTVQETSFRISKGGIFIVPRYNEYTINNDYDQ-SARIFFAQGQEMAVNAPPEQDAAEEEEDADEEVEVSEGEEMDSEDE------------------------------------------------------------------------
46107904 Gibberella zeae PH-1 ------------------------------------------------MIAPRGGARRTEVEEPQDINILGVRGRKTGAELRDRGNRDEHGMQPLDDLSSSPEREI-SIPRFDDDEEDDDHDETGDNEDDDQGSEDMDIETSPLT---EAYCFGPGPQTVLRKSMIPLPRS-----RSPIKTGILSSPRRNPNLEHLSSPSRS------------PARSPVPKDRDNTVTRKIDFGSKPTGRGKRATNGANGTLHEDEDEDEEEMEDAPEGGDDEVEDD-----------------VELLNESLQLVEDMGGHSSAHGSEPESESEPEPAPAPVPKTAKATAKSSQAKA-------------------DASPKKPGRRGRPPKAKIV-----------------------------------EEEP------------------------------TEEEHSEEEPEEPQETTKPAKGRPGRKPKNTAQPKESKVPPSRKRPAQEE-----IEENE-EQENEESEQEQERAEPPRQVK---KQRTEAPKPSKSTKSAPSKAASTAEAKEPRGRPGRKPKVQAAA------------------------------------------------------DAADDVGETSFAALQRGPPLPKKRGLVSVRHDVDE-----------VHTTRSGRHSFKPLSWWAGDKVVQEEEEFK-------DVSGR------------------DRFV-LSTIKEVIRAPVED-------------------------VRAKPSKPRGRPGKAKSKATR--QVETVEPEDWE-LDPGTVNGEVILWDPEHEKNPPGDEEPV---EVMDDRIAISGPAIQTRDVQ----GV-SFRMAKTLTT--PFMGAGVVDLPA-GSEKRPKNSRKMHMAFFVHTGKVLVTVNEASFRLSAGGMWFVPRGNYYSITNDYDT-DSRIFFTQGCEIAAQSTEPDQSQMSMMA------------------------------------------------------------------------------------------
39978151 Magnaporthe grisea 70-15 ------------------------------------------------MAPQGRKSLAAPRSTQEKVFELGKQGRKTGVTLPESGVRDENGIESFKGIFDSPGKGS-VAADSDEDESSEEEDDEAEA------SMDMDIAETPG----PEPLSLLAK----HTQSLRRPTAKA---KSPALTSLQSPPVRAGQNSPLRRAP-----------------PVAPVNGHKSATMRLNFDARQHGLPKPGAFGGKALQNGGQSEEEEEEYEEEEDQDVAGGEE--------DREMSQEEVEEFIEESMQMLDAGDDEGDVDESEPEPEPEPEPRPAPV----------------------------------TKQANVPKKRGRPPKSADS-----------------------------------TMELPEHPQDEDNSRATADS---------------------------SPPIAKKRGRPAKGGKAKESPAPSSSSGNSAKKRGRGVRTSNSDSIPEEAEPEPENAPATKRQRVAAAPAAAKGKPGRKPLVARAAPQAESSTAAAKPAGKRGRPAKRSSGDGDRGA-----------------------------------------------------------ADESVVIMPRPPLPKRGGLVISRPEESDG----------VIRTRSGRNSYRPLQHWRNERVEFEQVSLD----ARLGTSKS------------------RDLL-MPSIKEIVRVEEEE-AQTTRRYGSRRGAKKGGRGRRR--------TADS-------------EDEDEEPSPWE-QDPGELIVPVQQWQPEHEFDPPGPDDEL---PEGEDVVAVSGPAIRTREIL----GS-SFRFTKTLSL--PFFGTGVVDLPP-GAEKKAKNSRKMHMTFIVHTGRVTVTVNNTAFSIGKGGMWFVPRGNYYSIANEGAK-SSRIFFAQACEYRRPDEDEQDEMTESS-------------------------------------------------------------------------------------------
85110262 Neurospora crassa OR74A ------------------------------------------------MAPRPSGARRSLFPEPEHVYELGVAGRKTGVTLKDSGIRDEHGMQPLEDLFSSPHKP----TEDRDEDEGEDDEDGGASEDGRADSEDMDITTTSG----IAPAALLNG----NASRLPLPVSRTN--RSPVKVVVNSPARNRLMARSSSPTRGSLGANKENYD---RGSSSQPAEDINTARRRLNFEALKAGGRSLSQPTTTNGLNGLNGYHDEAEEEEQENTAVPDETD------------------AFIEESMAMLEDNGEVE-EEQPADQEEEEPEDAPEAVPV---------------------------------------------------------------------PAAKKKPGRKPKAKEPSPAPAAVKRGRKPAAPVVEEEEREEEREAEGEPEEVAPQVAGKRGRGAKGKAAAVEEPAPAAKPGRKRRTVE------------------------EPATDAEESSSSRQ-PKRQRT-----------------------ETAPAPAKGRGRPRKSLTPAPREVEEPEPEPVEGGPSRSRAAKGKGRAPTPAAEPVNEKVTKATKATKPKGGRKRQPSPAPAADADTSIAIPRGPPLPKSRGLVINRREVPGDSNA-------IIRTRSGRHSFKPLAYWRNEHVDYEYEEDEFVADHAPKASKGSSAGEVARK---------RKFV-LPTIKEVVRVEEEVVDFPRSRGRGTKRGGNNAAAGGT--------SRRAQR-----------DEDPSPPEPWE-LNPGILGGDVVTWYPQHEFHPPALDDEV---EVQEKQLAISGRAIRTQKVK----DA-AFRYAKTVNE--GFFGAGVVDLPP-GAVKRPKNSRKMFMTFFVYTGRVLVTVNETVFRIGKGGMWFVPRGNYYSIENDYDQ-PARVFFSQGCEVQVRPSSEGDEGVSGAENSVLDTSAAASASA----------------------------------------------------------------------------
45185244 Ashbya gossypii ATCC 10895 ----------------------------------------------------------------MDYMNLGITSRKTGLRVKQSIRRDEHSMENVDDFFAEDDE------------------------------STVSSRRQS------------------RRTSL----------LSDLKPHLSGAGAAHLFLDEDGF-----------------RIPSSAPQPRKQAAWSQRRQTETELDEYPPLDPGLPPIEDAFEEEPVAAGKYTGNGTPPYGTK-----------------------YATRYDIPREED-------SDVEESTIRLTPTKPTDD--------DYRDVPGL---------------------------------------------------------------VDDNETTRDNTSFNTSEHALLEDEMED-------------DYEVDSADEEDGEYVDAVSRAEDSSASEHDDSDDSSASDA-------------DDAGLSRQNQRSKNGYMGDSDSEVLDS----------------------------------------------------------------------------------------------------DEE---------YIQQQAKQLLPSGLDGGRS---------------TGIRRSKRVRVPPLDYWRNEKVVYKRKSDK---------------------------------P-VLEIDKIITYDQEE----EEDEEEVRPKKKNPKTKARPYNYIPTGRPRGRPRKNAPQPATN-NNEPNRDLLLK-LENGEISNGEWLKHGILKGTVNISAD-----KKGNEIVAFAPGLSQSEQVQESE-DE-KFTLAVMFDKYREMFASGMLILPV-DGMKSVSDSYNAFITFYVVQGIVEVTLSENKFICTEGSSFQVPAFNTYAFQNAGHN-EAKLFFVQVTVPENFDGSNGAAVDLQETSSRRTTGHSLSSSDMSLTTP----------------------------------------------------------------------
50304377 Kluyveromyces lactis NRRL Y-1140 ----------------------------------------------------------------MDYMNLGVKSRKTGLTVNKTVQKDEYSMENLNDFFKDEQD------------------------------SFIDMRRRS------------------RRSSILLNTKIRS--NAAASLSQPGAAENVSSFDDDRF----------------KIVSNIPEPGTSQVQQDRTPDNADVYDKRDSGLPQGYETDDFPDIHADGGDIMDDNDPLPDSYR------------TPPKPTRRERRFMRQLPEADENE--------EDEDISVQLTPVRRELD--------DYRDVPD----------------------------------------------------------------LINDADTTRDESFNTSENALLEDELDD-------------DFQPGSEEEEDRDYVEGISGFRDASSDSSEDSSDYD-----------------SEEDDAVLSDVRKQKRDIESASDVYDS----------------------------------------------------------------------------------------------------DED---------YIQTQAKDLLKDESPSTE----------------GGIRRSNRVKVAPLEYWRNEKIVYKRKSEK---------------------------------P-VLEIEKIITYDHDQDEEEEQLLKSKRAKKQVMKTKTRPYNYIPSGKPRGRPRKIKPVDDQN-ITDPNAPIIQD-IQQGTYPNAEWLKQGILQSKVNVTADE----KKEQNILAFAPGLAQTEQVTSTN-QD-KFTLSILFDKHKERFASGMLKLPL-DGEKTPSDSHNAFINFFVVKGVVEISVGDNKFVCTTGSSFQVPAFNTYGFLNKGMT-EAQLFFVQTTVPEDFNGADDIFEDSEMSSNKSSSDMSLTST-----------------------------------------------------------------------------
50294752 Candida glabrata CBS 138 ----------------------------------------------------------------MDYMNLGLRSRKTGIDVKKNLAKDEYSMENIDDFFKDDDT------------------------------SFLSRRKS-------------------RKSSLLP--------EADIQNRILPSPLTKQHNV--------------------RDTDGFKVPQNINVSHRSTIERAPTEFQHSVISEDIPEVIPYEGQSATPDRNIEPIDEDELANM-------------------PKPRYRSQYNLGAGND----------DTDLINLTPEKDGRG--------TYNDVPDLI--------------------------------------------------------------DDEGDTSKDNTTFNTSDHAMLEDEV---------------EDGFVLESEEDRDYMESDEGSLADDTDDASDSGDDIGTQFAAEIN--------RPGNE-SPLSSDDEDYISENSTGHNRL----------------------------------------------------------------------------------------------------EDE---------IDNPSLPTRLSKPYDIV-----------------DGVRRSKRVKIPPLEYWRNEKIQYKRRRNE---------------------------------P-VLDIDKVITYNHSESEEESEEEQKKVKKQRKPVTRTRPYNYVPNGRPRGRPRKNI-------SDDPNGNLIRK-IENGEEPKGEWLKHGMLEATVKNLHG-----EAKTELVAMAPNVSQSEETKASG-ED-DYSIEILFDKYNEAFASGMLKVPV-DGRKSPADSNTAFITFHVLDGIVEVTLDGKNFICTKGSSFQIPAYNEYAFANIGSN-EVRMFFVQVSPPSDFYSEHY--------------------------------------------------------------------------------------------------
6322761 Saccharomyces cerevisiae ----------------------------------------------------------------MDYMKLGLKSRKTGIDVKQDIPKDEYSMENIDDFFKDDET------------------------------SLISMRRKSR-----------------RKSSLFLP------------STLNGDTKNVLPPFLQSYKSQD------------DEVVQSPSGKG---------DGSRRSSLLSHQSNFLSPANDFEPIEEEPEQEENDIRGNDFATP--------------ITQKLSKPTYKRKYSTRYSLD--------TSESPSVRLTPDRITNK-------NVYSDVPDLV--------------------------------------------------------------ADEDDDDRVNTSLNTSDNALLEDELE--------------DDGFIPESEEDGDYIESDSSLDSGSDSASDSDGDNTY----------------------QEVEEEAEVNTNDN-----------------------------------------------------------------------------------------------------------EDD---------YIRRQASDVVRTDSIIDR----------------NGLRKSTRVKVAPLQYWRNEKIVYKRKSNK---------------------------------P-VLDIDKIVTYDESE-DEEEILAAQRRKKQKKKPTPTRPYNYVPTGRPRGRPKKDPNAKENLIPEDPNEDIIER-IESGGIENGEWLKHGILEANVKISDTKE---ETKDEIIAFAPNLSQTEQVKDTK-DE-NFALEIMFDKHKEYFASGILKLPAISGQKKLSNSFRTYITFHVIQGIVEVTVCKNKFLSVKGSTFQIPAFNEYAIANRGND-EAKMFFVQVTVSEDANDDNDKELDSTFDTFG---------------------------------------------------------------------------------------
71003540 Ustilago maydis 521 ------------------------------------------------MASQASR----------RFHEAGVGS-RTGLRLSA-VARDQDGFEDLEAFYKASQAALDHQKQ-QHPDELEDDDEDYDS------FDEATFNRRRQAASS---SSMMDI----QNSSAPSPRSLLRSSRGSAAVASVSSPERAGQAHGNITLADDD-----------DQLDLPELSTGSRSFNLVTMASNDANDDEEPEQRLRAPSTPQRGLSERKAGTLPNAKRKGKEPVTARRNIQLSDSDDDDILASIQQRLESAYDDEQDQW-----PMSEDEIVPVKPSPAKMTTAAASSHTKPRKRSRMTKG--------------------------------------------------------------TADERPAVSAPSGASSKRPKKAKEPTNESSVVTAPPAASSKNKPERPPKS-RAVEKEPEPEPELAFGLDEDEPEPAHFAARSSSISTPPPAAKQLPKR-KRGEPAKKSSAEQPAAASRVPQKASTTSTGVGRPAA-------------------------------------------------------------------------------------SSE---------KHKATKPKKVADEVVERVRLQPREATVINE----NGVRRSTRQRFAPLEYWRGERIRYGRPSLPSGTTPDDLCGSQGRGEDE-FEEDPSMMLVRRRVP-VLDIKEVIRVPRAPGEGTFSGTTMRARTTTRRKVERKSEERAPRLTPQTRV-----------PEDEDEYARLDPTADTIYVEDGWDEETVETGMVIKDEAS----AEVEVSVVRTKATHRPIPVA----NQ-RFRFEKFFNSG-GVMATGILHLPP-GASKPTKSAKDNSFVFCVLQGALRASVHRKSFIIGPKGVFQVPAGNTYSLENICQR-EVHLFFAQCIKTKIANAGDLTMFTQMSDTSYGTPGFKAGLYSHDQRGGRDDQRLEDEMRKTTESAAGESMQLQQQRGNGKVLDHRPVLTARSDADDSDEDDFELSRRVKSAKRVFRKL
58270782 Cryptococcus neoformans var. neoformans JEC21 MVTPKVGAKINSAHPSAIAILASTTNEQTSISHLYFPTALLQNISSMSHITPSRRKEERYIPFNNDPRNIG---TRTGLPMPQNVPRDSNGFEIPALFFGSSPENG------ANRTISSIKSKVAQTPGGRSTYSRADSTPGTARRLTRRLSDLDMDDGLRGGDDLLMD-------EDDLAIATPGSLFANSEPPPSIILP---------------SRSRLPISSPANASFDSVPSPSVRPSPRKSHYSAASRVSSSLAKTVTKVHELSGDEEEPFLTPGDGLNQEGEPEESPVKSKKKTPRAASSDDDGSPAKDKEAAFPPEGRSASMSGNKPANDYD-------AGYEGNHTVD--------------------------------------------------------------FDDLPPMGPIDDYDVETVLRTERE-----------------EDDEDAQNVDNNVVEEERTMEEEEMQVSESEDGEERRPVVAKRKK-------SPKKQ-EKGKDRARSARSGS-----------------------------------------------------------------------------------------------------------TAA---------QRKRTRPSELGPGDDGYHGN--------------FVTRRSGRQHYKPLEFWRGEKVEYMRG------------------------------------PGCAVIKEIITIPEDPPVPLALRKSRKNGRARSGSVAVG--------KRKR-------------EDSVEDEEGWDHKTEPT---------GLVQDYPFG--------EECYRKIACPKALLDPKLVS----GG-NFKYQKVFGEG-HFMAAGIVYIPV-GQIKNTKPSKDNTYVFYVIQGAVQVTIYRTSFVMAPGSQFLVPRGNDYCIENISPDKEAQLFFAQARKIRANEIDADGVSESQAGEAGLPSRKSISASQTQGGKKSNRLPSVREESRDISQSEREDEEEDEEEEEITVKKRRKSKGKSRR-------------------------
50557112 Yarrowia lipolytica CLIB122 ------------------------------------------------MLKRERGKTP-------FSIGDGLTGRRTGVTVEDTGERDENGMEKIDNIYQESADEDSEEEKPLKGSHAMSDFKVQRDDSDDEQASHVSLPPQTLTRPPKTKIQAIGLNDVTQRATNQLPKQTTKQTTTPARGTTLKAPSSARRLKIVSAVPVSKVVSKPSTSSKASSFDSKPATQSSSTAPKITKVSAIKSIQPVPAQKLPAPQPKQRQPSPDDTVDSLDMSPAPYNNPYVAPPTKFVPKTFSSTKPFTATDSVFKTPARANSLYGDSPADSTPGVPTPAFKPAQFNPGTFQFGGAKDVFDIPEDEPINMGMDIDMGMDMSMDMDVHDESIGYSSPKNEIKGVRPADVFNSPNVPNSRDSRGSLFGSPDVPKPLPKPKAKSKEPKKKPAKERKPSFAEKYKPRDFSKANDDLFKPFKVPSKTVSSKTVTSKPASRVEDDSIEAMSDNDSNAMDFTSIVKHSGPGSF-VNGKSSKSKDTKTHKPNTSVDSLDFDLSGTDDIGGGDYDISMGGDDDVATNGGNGSLGEDDSISSTPRH-------------FDRSINYREISTVDDSRMDYEEDSDDDYYDQSYRMEDDGDDDDDDDDDDEYNSAVDETMNHGRGVLPSPPRS-------------LRRHRPKRNVGRPVRYWMGEGIQYKLEKSE----------AG------------------GFVP---VVKSVTRLPDNE--EAAERTKRKRRKAYDVDDAIA-------------------------EADADANENTN-DNNGVVTN--WQKKKSVEVEVFNYTAEEGDPETHMETVAYSHDGCDYTDPS----PE-GLSVAQLFGDKKDFTQSGMVRLIG-GGRKPERNSRHHLHHFYVLSGIVDVTIGEKVIRIKAGCPFIIPRGTMFALQNASETIEALLFYVRSHDTLLRYEERVAQAEMDGVNETGEGEGVQD-------------------------------------------------------------------------------
63054808 Schizosaccharomyces pombe 972h- --------------------------------------------MTMNETSAIPARQREN-----QFFEIGVVGRKTGFTVPRDVKKGDDGFEDMDAYFLSDGS-------IHLDEDNGDIEQDMPPVTRLQPTSPMAVNAAS--DEA---SHASSSDSSDKNPDIPSSPLLM--NSRALRASRGSSGPLIVPIDHSAFQA-ED-----------EGTADKTKVDGNKLSIQPRKANRIVDFSRIKASPDRKKFEPRRSTELPSKIPSSTPKDDNVQ----------ESPAFPDENITALQKNVANFTSIKDSGGRDNLYIQTISKPRRSYVQ---NNK-------SEQTIKPSKQ--------------------------------------------------------------NKQKEEKKTISQGNKPNSRDEDSELSIDVPLSMLNR----SLANNSQKNKKRTPNKPLQESSINSVKEGESNPVVKRKRGRPRKNKLEIGNSVQTSEA-TQVKGAKKPAIRNA-KKMSNE----------------------------------------------------------------------------------------------------KDD---------SLNSQSDSASGEFIKTIARNNLQEIKQVEREDTLVGVRRSKRTRIAPLAFWKNERVVYELHRDE------------------------------NRIPALPEVKQIIRVDDPS---PSIRQGRKKRHAKRSGVEIK----------------------SNLEAKSNDVEEYDAFYKDEINCEVLSWNEQNPK------------ASEERVVGYSLPSVNLQQIS----NQ-QLKFASLFKEE-PSFAAGVVEMPA-GAEKPVKPSKHNIMSFCILQGKIEVTVNATTFRMKKDGVFIVPRGNYYSIKNIGKE-AVRLYYTHATDTLENKRRGIGDFPNER-------------------------------------------------------------------------------------------
68473346 Candida albicans SC5314 ----------------------------------------------------------------MYLSNLGGQSRKTGIRPKTNLKTDKYGMEDVDDFFEDDDD------------------------------DRINKSKG-------------------QKSTIALPRGE----EVSNYKSTISQPFNNIARKINFNQED-------------DETFNLPSTSSSSATVTASSVSNKKSPVTTQQSPLRSPLP-----------------EQDYDYN--------------------------QFDVEEDYG--------DITEEDKQPSPPPPVPK-----------TKSKAK--------------------------------------------------------------TKAKASTTTNTNTKSTKAASSFTK----------------KMALGKTKRLPSSFDSVNTSSVTEYYDEDDEDNDRDY----------------GESQQ-DSIEDSMVDSTFNDYSQPSSN----------------------------------------------------------------------------------------------------NNKTRR------KIIKESPLPSPPPDNP------------------NGLRRSKRTRIKPLAFWRNERIIYSKDLDYDDEQDTTLARDI------------------HNIP-LQSIKEVVHIPDNESVDNSGSPNTRTGAAGSTKTRSN--------RKRTYK-----------QTTTTAPTDYDYESDPEISGSEWFKEDNLSLEVNDNG------ESKLRKIAYNHKGGNYVKPT----DD-NYLVASLFDEDKSFFAGGMLQLPS-DGFKPPVTVTGSTYMFNVMKGLIQVTLNENMFVVTKGCKVQIPEGNEYSLRNIGQG-DAYLFFVQIRKPEEIDTNW---------------------------------------------------------------------------------------------------
126138014 Pichia stipitis CBS 6054 ----------------------------------------------------------------MDLLNLGAQSRKTGIKPRQNLTKDKYDMEDIDEFFADDDE----------------------------------LSRIH------------------RRSNTSRSRK-----STSAQSSTPKDNFDNVARFLNFTDA-EA-----------ENFNLSPIS----------LSSKLVPNKDNKKSPLLSPLAVRRDNKEYDRNDISEVDDDLYD------------------------YEPDFYDDHNDNG--------QSFEEHLSLSPVPLSPV------------LPISG--------------------------------------------------------------NGKKTSSTPKSKSTSSKLSSALTK----------------RMALGKSSKSSVPKVLEQEESDEGVLEAKSN----------------------NESSE-LLSPPPTNKRSSKEKPAKSTS----------------------------------------------------------------------------------------------------------------TISKPSPLPSPPP---------------------DGLRRSKRTRVRPVAFWRNEKVRYRRANENSQDPNTTLGSDI------------------KNIP-LQEIQEVVHIPEPA-SNNTLAPSRKRSRLKSRTTPPK-------------------------FKKATKKEVYDYESDPEISGSEWFKNDTLQLEVFENE------KKVRTLVAYTPDGADLRDPPAPQEGDENFKVATLFEHDKDFSASGLLEFDF-GGYKQFRNSGEFVYSFHVVKGLIEVTLNNTKFVVTRGCSFQVPDGNSYGFKNIGQD-SARLFFVQCKI-----------------------------------------------------------------------------------------------------------
50423151 Debaryomyces hansenii CBS767 ----------------------------------------------------------------MDLLNLGSQSRKTGLKPRANLSKDRYNMEDVDEFFAEEEEDK-DSDNNERRLHESDKYIQA---------SGLAVSRGS---------------------------------EFSAESSTPRHDFNNVARKINFTDVEAG------------PFNLSPIS-----------IPSKRSKSRNKKSPLRSPLQENKGNKRREEATGDDEEYGYNDNN----------------------------DMDNDLY---------GDDIDMSLSPVDLSPI-------KLRTEFMSKD--------------------------------------------------------------TKKSDTGTPKSKSNRDKSASSLTK----------------KMALGTTKPRKKRSIIEDDSEEETTQDYSKD----------------------------DRGDLISPPPTTKKEPVRNKI----------------------------------------------------------------------------------------------------SEE---------TITKPSPLPSPPP---------------------DGLRRSKRTKIAPLAFWRNERIVYTRAIDE-EDADTTLASDI------------------KNIP-LQEIEAVVHIPETN-KQAATNVNKKRSVLKLRITPPK--------LKKSLP-----------KQVA-----YDYESDPEISGSEWFKDKSLKLRVFEGPSD----DRVERSVAWAPNEGDFENPPNTGEIE-NFKVAALFGNDRDFTAGGLIEFPY-GGFKSLRNSSDSVYIFHVVKGLIEVTINEDKFVVTRGCSFHVPRANSFAFKNLGQD-TSKLFFVQSKMVIADEDEEWE-------------------------------------------------------------------------------------------------
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Scm3 sequences from incomplete genomes
>Fusarium oxysporum
MEPPTKKRRRGSSAQKEVQDESDDDELASHPQEIRMRRDPDIQLALKRANADHKLQATM
AHIIEKYSRDFEGIGDEIDMNTGEIVVNNGHLRNMRDEGDVEGLWMEGDSNIDEDEGVLLEDLTDGYSDS
EEPVKGVQHSQSDNQNNQEPTFAEQGAPTSQRTHSEVAREALQTDMDTAMDPSQISNAMLHTSESHFGPP
SYGPGSSVGFGPTPGFGPWGRMHGFPMQAWGRDDIPPYFNMPPSMPGPWFSGGRYDFPTHNGQTSIWSRN
RAKRTKRAGSMKASSKQATSRHPSSSRTEEEAVADDHHKSMSEEQPRDNQEDLAPDRTINDTDDDDDLMF
SETTEVASTPEASLVLPTKETSPAKGQVHRHSQGALEETNGNAVKVPQKNDEEDDSGRRRSGRARKQTEY
MGKISWDDAKEWQKSGQRLSVELYKADPVIRKDFESVDHIGDECASSSEELHDNTLPTKVLERGTTSQRQ
VVPDSQDTATPFNSSAPEAPERKTGNDRHYASDVPTVPSMELSDDEAPLVLSRIRAPKRQVENRKPPPPL
MPTQDRIRSAEPIVYVASNSPKPNQRAAPIVEPTVGGMQGQTIEPLKRKRGRPKGSTRKAQNNNTVSSTK
VITRGPTVPQQHDAGAPKKSNPANPDIEVRAKDHSTYATRSHGCPDRDEETLQKSDHDDTETEERTVTHH
LTSEPKSPASYRSQARTSDETIKLRRSWEKLQKSNNSTDESTELNEDISDDQEEQPVPLTPSGLLQEPST
ILEGPMEAPETFIIIGDEQSSAASPSSPVHVEEPPNYSDPPDESRSRLNDNSSDYAPPQDEAVHDDESLP
ELPRDTMVHGASTPRKPKDTRTPLTEPPSSSHKPHTPRHASIRTTRAPSSRRSLLSFVSDSESDTGESRD
ELARRVKSTSKTASVRPSTKRIWRASALTREIQRTPSRKRFHEMSSPTNTVKTPGGTLRTCGIDGYQCGR
DFCFTCI
>Gibberella zeae
MEPPTKKRRHGPSPPKAAQDEDDDDELASHPQEIKIRRDPDIQLALKRV
NANQKLHATMAHIIEKYSRDFEGIGDEIDMATGEIVVNNGHLRNMRDEGDVEGLWVEGESNIDEDEGILL
EDLTDEYSDNEEQANEIHHSQTDNENSQASSTKESDTETHRQDQNVIIDEASNNVSNIASSQNDAPHDET
TVLPHGLPQDDSQLSPPSFGPGPPPGFGIPHPTFGPWGMMPGFPMQAWGRDDIPPYFNMPPSMPGPWFTG
GRYDTASNNGQASIWGRKWTRKTKRAGSMKGSFKKVSDKRPSDAAVGVSSETPDNDRGSESKSAGGSPNR
QEAPLSDQTTNASEEDEDFLCSGTSDATPIVQQKPSLVPSGDNALSKNYSSYDPPHETLEETNGNIGKVS
QQPDENDDSGQRRSGRARKQTEYLGKISWGDAREFKRSGKTFTIQIHGADPSLREEYQSVDLANDETEGE
VFLPSEQTRKGSRLLEEVGTKVTSEKLVVPDSQDTATSFNSSAPQAAQSKNVEEPSPLIQTMIPTMELSD
DEAPLALSRIRVPKRQIAAPVAVSPVSSLLTEQDERSTEPANATSAPLKSNNEPSPEAEITVDVVDGTMQ
LLKRKRGRPKGSTSAAKATPSKTPVPVRTKEIEPTSPTFIVVSLADHLPESTKRKRGRPRKSVGATSTVQ
DEENNPTKELANVDDVVSESDHQGPVNEISSNEVSGKPPPLSNELKWLLKTKPKDFTTDRACDTFLYKFV
HPRKPKEILQQAKDDEPGSQVTQETKEVPKDIEDDLKEQTILYKPQAPMQEADTSMEDVTETREDSESGQ
HDQTSPSSSSPPYHGDGTPGDDESPEVDEPIEHGTPIPHIISDDEAIESEGSLPPLPQDALIQEAPTLRK
PKQMRSSFIEPPSSSQKPRTPRHKSIRTNQAPSSRRSLLSFVSDSESDNEGSRDELIRRVKSHSKSASVR
PSSRKIRRPATLTREIYRTPSKNRVHEISSPIGTIKTPGGTIKICGVDGHHCGRDYCFTCI
>Neurospora crassa
MERPTKRSRTGPAPFDDEA
IVGDELNHQPEEVNQLRDPGYQLEQARSFAAFKLKSAFENIFEKYGKDFDGIGDEIDLRTGAIVVDNGHI
KSLKTATIGVESEDDDESESESGNEEEATSHGQKSKQNATALQTVPRPLPSMAPPSPFGASGPGYNSFPG
GPPLLSNTMYPVQTQFQSLPMPFGAFSSANASIDPAWRAPDLPPPVPWGGFWTPGTQSRFKTVAKVQQLA
ARTNHDQEGEDEDDILLDISTTGATMATENTPVINKKLAPFRPPSNVSSPANHQLKTFAATSTPKSVDSF
DVAKADGEKKKITKRKTPAKKTPAKTKAIEERIASLVDEFGIQIAGSPVVDSPSADTQPVTDTQPAVKQT
PVAEKPVIEGRASAVKNTEAVKRRRTPNKKTPTSKKASLEESADLLRASLENSAPVPAAKEFFAELECET
RPVVEHEPSIEKGSGQFSDEKSRVEAPVVEDPAVGTGQKTSKRQTPSRVSTREQHFGGPSSNHSASDSNR
PALASTVEHPLVETELVVEIQSSSTVQNGPGQPYVQETIAGEPAVEKSSIDEVAVAEIEPPSAKGDGDQS
ASIPTTITKSVNHDLPEVPSSADSRTARRKRRLSMRGQSSPAGAKRSSRKQVASRYEQSLFNGATNANTT
LKYYSPSCGALVTKPSNQQLWVEIPVDGTLDTKAFQVVVEDDNLIPEVPAMEIGPGTTNTLAVDEMARNG
VARPQVHGDHEPQAEAVEKRSPPSNDLSHEVFTRNVVDSAYAFSDEDEPAIPKARIRRTEPIQPNPKPKT
TEKSNAKEFGIPTPASSFDRNSQSTEFQATPEAEIPMEELPIISATVTTQTARQTPSAGSALLDKTNTNS
EGPSLPQPVQVIKARRGRKPKTPIDLSVTASAVATSTPAVTEQPSEPVPIITALASTRPRRQSLRLSRGR
RDSDITIAESNTPQHATATISQYEDESLVIQESPQGTPEPESVDEHKAGSPASPTLIVTIPASPKLTETL
APDQQLLENSLLEEAIARQRFWSPKPESIILGHEPSPPEPQAETLLEVLIPSERMPPRSASPPPQEQEPN
IEVIQPQKEPEQPTTPVKTRSRRGRPSSAASLPTATVTTTTKVKTKTGSASGSQPGRRKVQTPSTVTCTT
TRTTNTTTAPMTSSRTRTTLTGTLQKQSQVQTPGTTKSTKSLLGSNNNNTTILSLISSDTDDEDELTLDF
GGGTPSGISKKGVKPASSTTTTKTTTKRTAAASTYPLASLLLRTPSRKPPPPPAAGGGGIRRTTSLAKNA
SSIGSVGRRSRSTSSPPTAARAVTPTTGVGSEAGAEGEEEEEFVGSEVIQTPGGTLRRCGEAGFRCDRDF
CFGCL
>Trichoderma reesei
MEPPAKRRRRSQLLLDKDNADEDDDELAFRPFE
VEAKRDPDYKLSVERAYADQRFQATMAHIFEKYGRDFEGIGDEIDLVTGEIVVNNGHVRNMRDEGDVGDG
LRGDLTDGEDDEDEGILLEDLYDDEEEYKEEAGEKAKPADFAREGAHSGNDADDDDDEDRIIQGRQATRD
SHSTALVLGSSSRNSLLARASPFGMQTASPLHFEPPTELPFASSPFSFDRSPFASEPWGFPGQNSDPLWD
RPDLFAVQRPPSEQLPLKPSRYQFPARSGKSSIWAPGSRFRADDEEPLPSAFAATFGKHLLPRRRKILKH
PLLPPSAKLNEQVDDGRGDAEEDEEDEDEILMGKRSGENPIEASARTGDSRPSNNPAEKEAEEKGGEGTS
SDSGYKSAQSTRRSRKRKQRADEGPTRDENLVQPPGISRKPSSREPKEQSRINALKAKESAPTTTALELA
EEGNGCRRSGRMRKQVEYLNKIPWAQALAEQKAEKQATLLPASESQTSGDDAHVEEESSTGGDSENEGQA
ALTGSEHECIPDSAAEDDDEEEEEQGEEKEEEVEGEDEAEDVVEAEKNSDEGGEAEKEEKQRRVPTPLKD
LPTSHGPHIRDPDIAEHRHTQAPAGFPFKTTNSGCLLSDDEAPTSLSKPRKSTPKNRHEDVLPLREIRNV
RAQAHIELSSSDVSKEERPNHSSKKRRRKADAPTDVSPTASRSSMRHLDAPTEDSSGVAPLSSSPTRFLS
RITLNVSLDDTPQPPDAAPDEARHQLEAVPSSSPCARVNEDIPKPTASRRKRRQSKKPVSPVVEQLSAEI
AQSKQPAKATALPTVIEDSSYETCDDSSHIEPSSPVKASPHDEPAPSSSSKRTVSPPEAVARPSSQSPTK
RAPQSPFKSPTKSPLKRAFAAEPDEPLPSLSRPPQTPRRPKRRLKVPSSRHSILSLLSDDEEEEDEEIDE
LGRNLAAMPKLQSSVAQSTARKVWRSSSRTREVYHTPVKKRPSEPVSPGSLVKTPGGTLRACGVDGYRCG
RDFCFTCL
>Botryotinia fuckeliana +Myb+CClus
MESPTKGQKIPADSNLVDLEINDDYSEDYSDTEEDDFIVDDENNDIIYEPGYDPDQELQQKRA
RLDYKLKSTFESIFEKYGKDFDGVGDEIDLLTGEILVDNGHLKEMQDERDAGGKKAGGDLLRALTVEPES
VTETSGDEYSNVEERDDREGEDNARDKTFDKDGVAEISDEDMEEDDIILRGYDESNQDPFLDMASATETE
SVRNITPKNDLERRQNIQSEGHSISFPSYNEILRSFGPEVAPQIVSIISQKQSHDDTNIEPAWRVPEIPS
LEPRKRPALRDFIPEPETERSPSPDISESIWALPKGRGAKRVPRASHKPKAVSMPKSLGDTTLLSDGLST
SSYAASPRGHNLFTEEEDKILIAKVAEAHDQGLAFATDSIWEGLAIINNRHSKVSWKQRYRKKYLHLWSE
ERSTRPGSRGSYHKKDQESESSITSASRSSHPISFFQRSSRTRKPAQQAPTLVSWSDAVATIKSLDRRLH
KDLARDASVFDLTDVKPVDVDEDALNLRSSDLESSEESDDQPELPTHIGPRVRRITPVTVNPAYEFSDEE
TGFDLKEPLHSNGSTAKLKKTARKLSSSKLKDKTGRKSKSTQRKSKKKFVSEDVDELSLGLEGDDILLVC
SLPGKDKQKQSQITIKRKEKLVAVSEKNAVTFVPPKKGLSVLKDLDEFDELSAEWPQSSPITSSKKPTLE
MKSEPEPEPEIVDVDVAVALSNRVDETDIDVFDIDQLPETSPKTALDSRRKYKRNRKFSSSAVIPSTSQL
ESSPSVAVDERIQSRIQQRRNSVDNGPVPRTSSPHQSSPTPRPKRKFVDLDEKENTPLTPSRHINREIET
PTSNSEDLALQNMINGNRTSTVSPHKRRGGIITPTHSESRKPRTPLLDYTTPTRRDLMRKRGLRDSSHSP
GMVKTPGGTLRKCGQDGFACQRAFCFRCGSSAKRMGG
>Sclerotinia sclerotiorum +Myb+CClus
MESPTKRQGISNEPNDVDFEVDDDYFERYSEVEEDEDDFIVDDDNDDVVYEPGY
DPDQELQQRRARLDYKLKSTFESIFEKYGKDFDGVGDEIDLLTGEILVDNGHLKEMQDERDAGDNKAGGN
LLRALTVEPESIMETSDDEYSTEEGEVMNEGDKAQEKSDHRANVEEISCEDMEEDDMILRGYDEPNRDPF
LDVVPTIETESASDHPLGDLKYQRNSKPEGRSVSFPSYNEILHSFGPDVAPQIVNIISRKNVHDDTHIEP
AWRVPELPALEPRKRPALRPFVPEPESERSPSPDVSESIWALPRGRGPGRPRGPYKSKASFRLRNIGDTV
LLPDGLNTPSSAASKSPRVRNAFTEEEDEILIAKVAEARDQGLALGAESTWEELASLNDRHTIASWKNRY
RQRYLHLWSPEGTARPGSSGLRRPYRSKNREESKSSIKSASRSRHPVSFFQRPSRTRKPAQQGPNVVSWS
DAVAVIKALDPRLHKDLIKDASTFDLTDVGPVNVDDEALNLRTSDLEFSEVSDDEPELPAHIESGVQRIA
PVAVNPAYEFSDEETGSNFKALQQSSGSTPKPNEEKGSWLVTPQSKESKKRARKPTSIKSKDGTNGESRS
HQSIVRKRLMSEEVDELSLCVEEEDVLFVRSMPRKDKQKEPQTFIKREGQDSTISDAITPVPPKERIPIL
SDYDEFDELSAEWPPVLPTVYAKRPIVEIKSEPDQAIEVGLFDNTKETNVDLFDIDQLPETSPSALDARK
QSRINKRFSSSAIIPSTSQIESSPTVAVDRRIQSRIQQRTDSIGNGSVLPSSSDMVSSPTPRPKRKFFDL
DEKENVSLTPSQKANQETETPVSDVEDLPLENMISGKRTATSTPNKKTGGLTTPTHSESRKSRTPLLDYT
TPTRRDSTRKRTPRGTSRSPGMVKTPGGTFRKCGQDGFACKRTFCFRCGLSSKCMGIE
>Pyrenophora tritici
MESPAKRMRILQSVEVDEENEEYINAKRKQQQKFKGRLESIFDKYGSMHESM
SDEIDMKLNRVVVDRGHLRRLKRQVNRKETMLLDTLGLTVGHEPEEQCEEEEEKVEDSEDELALTQPVKS
KGGRPGQDKHGEAIQPAQDKAQHSDASHPASYQPYPSATSIPQLTSPQAPNTPNPTANLLQLVQFPQTPA
GQQAQTAFYTTLTQTINQAIHQAVVPLFAGLLPSNAPIPFATAAPPPTTPITTSDKVAPATDPKWFFPPL
SAKGNHNPVAQSSPLPTLPASTAVPAAQEAIIRQDGDGVLQQPREEQAVDNQPAKKQTSNERAWNLVGTR
IHQSSPTVPRRSSPRVEIQRRIARHIVKKYHFTHEDDVYISKRRLIDGMTWPHIKASKKKWEQWPLKALH
NRWSRIKNDNLHVQEAPVVLVGSPIQGNDHSSVTQAELPSVQTHHLPTPSSSEHEDNQQDKMESTQEEGN
YNILSSSTHFDDDERDLLSLAGDDLAEDQLLMPRDDTPDPVPEDVIIPSIETRDFIDEEQLQQDLLASLP
MRGATLTPTLPVPAKVKKESVTSSPISTRKPDKAPASWGVVPDSEAEDDEDGSAKTDPTTPTITTSAKSL
APHQQSPHATHNTAHGNSNSIDLVDDDNFPTPATPQIKRETSTPPANFLSTLQTPITQPNRLLMLDSSGS
KSASKANRKTYLKQIKQSWTRKNSPAPKSLVKRKSFPSLGARKRAWIDDGDDDVDELAM
>Chaetomium
MEPPTKRPRFGP
APFEYDPNHPNYEDPEADELNERPEAVNARRDPAARLERSRAFAAFKLKSAFERIFEKYERDFTGVGDEI
DLRTGEIVVDNGHVHSLKDAELGGADEDEEEEEKEEGDGASEAGSLNEEERMVRGRVEERLSRVGGGDAA
FSGSSGRGTPFCCGWVVFAHANVGRAATRVFGNDVPESDVVRDADAVWHADFDADHRSDLENPRVAVAVY
EECAHLRRRYRFGQAKDSTPIAERCSRTGCRGRR
>Crytpococcus
MFSPATPIAGPSNPSHLRPSFSSPAFRRGGSIFPYEYGASNQP
FSPHYSAPFTTTGVRIRSGSVFSREQWKKEELARRRQESRDKLKSSWDLLFEKYRDVEDDDEIDLATGTI
VKDRGKLRALQQPMWFGQKEGDDGESTGGGGHDFESDEDELGDWDEKAGLDPQLPEWEEVEGFHQAWTEE
DDADFREFMRAEQRRKSTFGSDNEDEDSLSEHDSKKPAGFEEYLDVSPRSRGTQILPLPTLDDLFASDNK
ASSEDELEAISDSDAEEKGVRDNLSALSSLHVRVFVKTPCFRKLTSYRAPLSYHGDRNDAPSSKW
>Magnaporthe
MEPPSKKPRLSHSLDQDGDELDLSIEDLALDRQFQRSTYR
SAFSFKSTLENIFEKYGRDFGDEGDEIDLNTGEITVDRGHFRGIFGANLPVATGDDGADAADQEDGEGDE
DGDDEDGIDLNQLYSEDEEEDDEEEGSIDLEADGDGEEESRHLFPLDAMPDPSDVPEPPQLPPSFSALES
SVNGCQSTSGTLLGTLNRLLSMAAASRGTSDPSFDPLSVTNELVEPAWRVPALPPALLQKKPTVPVNTKS
SAALKSIVRKPRPRLTHDTESEDEITTRESHIGPEWTSSNQQIPSPNGSLTRSAASPENSGCTQVAPNQE
SHTKSTSRAGKSKHHKPHSDVTARKSPPTEDERDVVESRCMELDGLQRQLKRKHETIVIHIIDERLQKLE
QDRLLLNAPVGTPQPVRQGLSVRGDSVVEFGSEVLVNPESSSRPREFTDEGLLETSTESAKQIPGAVSSI
EETTKLSPRLPSEAKTGPTNQSEAPAETFTKNYVDPSYGFSDEENGGWVPAPKAAGRGRRRGPLILRPRS
VSPELGSPPRPARSPPTMPEPVTVATDITLSKPPSSNGPDAEAEPQSEQPLVDDAEHQNTPPAASEDYES
SMLVGYQPPEAAAAQNPTVISVGVEEGEASQSSESSGLGQPVDESVLEENLVSANEQHVEQASELDGEVK
PQTSVDSSLSQPEISLRRRAVPQDQTSPQSSPQSFSTQLGNKRSSGKQGSAYLPRRTRRQWLPKGNVPHE
ALSMQDTQPATPSPPAAQTSRRRSVRSVASLLSFVNGGSDEDELSTYFTPRTRSVASSGGYAGPARLYRE
TLSSPIKKKTPRSLSRRLFMTKASSSAQAKRGTLVFFALVGRAVSYHSALPPRTYTR
>Batrachochytrium dendrobatidis
MDQPLVNKKHLLKP
RPAALIHKDSRPVAFLSVENSPQDPESSTDKSTEPADELESDILEDDSIALGETTGLPDLSIEDVAKLRT
ESLERLKSTWEIICSKYGRSFEGESDEIDLTTGRIVIDRGFLKRSHSKAIGHSIPSTLLARDMKLAIDSL
ENENTHDGLGPHVATEDPHLDPLTSHPIPTTSFGAGMASAITNITKSSTSSLPTESQADMIISELLYDDD
AFDRILLPRSEIYRSMTTLNLPFEDLDSSDEDGLLDMSDYTSETSGTYTIDLTDDINNNSIDPLVLQDSQ
LSPFNQAGNASLPRTDRIISAFDQNLSHSSSPLSRSIYMDNHYDLDPLTTPTKMIRRLSPIRQEYWSMDT
QAMAQRKNPRYSHRMRSYHSPTRRSHAMLPRNPSLGRRDWPNQHIEDASQHQWIDLKNTFEYLSDFDSHQ
FEEHVPIHQQLPGHAPHSRQHTEPRSRHYTSRLERVDHCWDTMSQHDVYQSELDTQVQFETPRQSRMQHN
IQFDHYVENEWE
>Coprinopsis cinerea
MEPPPLKIHQKPPLVTPSASPPPSRPYLPKQPSSAPSATS
SSHRSASVSSAQQRSRVSATPKPHQTPAPSTGQTPSPEDIDFQQKRQASALRLLDVWSKLAERYTRRLDE
DDIVDIVSGRIVKDNGVLRKSKTVWFGNGEKTHGEESGEDEDEEEEEDGEERAGDDGHQDDDDELDAFAD
VDDGGDEEEDREGDQEEEEEEVLEIKGKVDPVPPVTPQNPLDAADLKEFLETERLRRDVLGSEPEDDPVD
PNALDNDGTDAYGTGGSDIYDVDYADVEVDVETPKQKTEKSTVRRSRGVPPVGESDSEDELNFNLAEEAI
PEDIQEPEYLASSTDSDDEIEIVKIVQRPPPKPKASPAFKAPIVKADHQTQLQTPPLSRTSMQPTFSSLA
DELFSTPPPQEEPSIDAPPETPEIPIASTSFKPAKSTPRTPKAQKSQPKDIPSTSKAQKPICATSSPFPK
PKVPGKLVPEVVIERQTPFEGASHHSMNSVERRPGTSPTKGELRRERLREEKREGAPEDSTPTTSASTPK
ASRGPTASSVNTKFPTVDIPSIDKRPDSMNEDHPVAEPSSRRKRKRSIPPSASPGETLAGPSRFPQHSVA
SSSKVQLTSYRDPDPNVSEGGSPTRGELRSHRSCNCVSNVSLGEKPKMPGKAFSSDRRASVGLNLDLGHP
RLKMRTTLDLKAKRSNIPTIFILITVNIRPTRHTPMRNPYTHLPHLLVHLNTPGDSRLCHLRMYHSTVEV
IRRCRILTRTTSCRRSLRE
>Pichia guilliermondii
MASPGDPETHISTVTASRYLFSRSPPNLAGHTNKAFG
NSHRRYYKDSNSLKPKRDAEALFEKRVANLQARSRTRFQNQWEAILEKYSQIDDEKESDEIDLSTGEIIT
DNGHLRALARKDVSSSSLDDIWSANLVEEPHQSRQYMTSKSGQNTFISPARQKDVSEIRRSSSMKDNVLL
LSPSPTKKTRYSPSKTPSKTASPSRNTPPSKFTSPRLSSPRLSPSRLSSPQLSSPSANPNNSGFERITDS
KSLFQPTRLFPTAKETPKREHNPFLERKEKTSKYTLCDLSTPTTDAVYHCAFHYCKFCTGNRFLYKEHLL
KLHPKELKQIGYPVQTETETGVDTISSDTIENISKVFPLTFDKLLQSDSLLHCNMKLSPTERCRRVFFTL
NDLKEHQNTSSGCDSRLFTFSCPILGCPFQTRLFEALQNHFRTYNINSSHLTKESRSISKKPLINEHSTK
ANDLPTNPKIALTKTEVMNEIDELFDSD
>Clavispora lusitaniae
MEYGSTDPPCVHVTSSLCSRLIQRHICMAHEKLISLAEIGDFSSEEELDRALRQDSAELENRLRQLKQDSSA
RFLRRWDEIISKYSQIDDNTQSDEIDLRTGEIVRDNGHLRSLATDGSLHGVSIQSSIWAGDYDFERGLKA
EEKERRHQQRAKRRLKERLKTQQLFRTASAGPVLLSEPLQDNLLILSPSPTKKQRTAASSPLKERQSPEP
WTQYEREEKMRKDYKSERKNASLRENIKWDQKNRPDLIYRLLSELLASDMDSPVKLSLKFLEQLDLHSPQ
KLDLRQFELSKRDSFDERPGLEYPHSSELEITETHGNSSSPKCRNGVSDVQSPKRSTTEKYAIVCETSPF
YDHSSAPLDYKLEGPMYSHGSPNGSHLFLIRSDLVETPQIALYPCAFGCSYTSDSKTAYRAHLLSTHAHL
LLRIGYPVKISDSNHISHNEHISELTILRLTLHFPLRIQMPLKPYSCGREFKYGKCQRIFLDEKSAQAHQ
EAYPHECSARRQVLLCPILGCDFMTDEGYKEWKDHVLGHEREQTKKFSVVPIEDAEVSDIFSDSVSSLSF
SEDEEQKEGANLNGILQESNHSGIEQNSNGETSQHRSVSQKPIHDILKDNESYTLSKLDNLITSHHITSS
PVEEKKAPPQAFDICSNASEDDFSAVGGTIEYDSIDEFFQLD
>Candida albicans
MNTGIENDFKYLHSRNLQQLPNNNTKNPSQNIPYNYPSSDEDIEDEYYSDDESQNQLDYEINQLINQQNEKQFKNKFK
QLENQSLQRFKSQWDAIIDKYSKIDDSTQSDEIDIVTGELITNNGHLDKLNQNHNQKGDITKMDIWRQDY
GQQLENWRQRDFRMKKQAKQRKNEQRQILKKLDLFNKPIYGYPKFEKLEENDFLKQSPTKNKVPSGIESD
ESPTKKRRVFTDKKVVSKNSNYLEFLDDDDEEVENKSLYTKTVIAHGKLYKRESDNVLYGSSADTFSPYI
DRQSFRPESNELQSEDSQDYESNLSSDISDDEYDDETYQSIIINDKKYSPKFKEHFDESETESISETPQP
QTSSEETPGLSSQTEEISPSPHPESSFDDEYLIIEEPYYFLDVKSLPLPTIFNCAFIKCHYCTGNKKLYE
LHLLQSHSSTLAEMGYPINLNSQNAAYENSNTDSDKENHKIEFTRDITDVDLDKLYQVFPKTYKLPPQKE
ALTCGKELANGQTCQKFYLVQEQLDQHQEAGDECSDKRQVLFCPILGCGYLTDGGYKEWREHMITANHSQ
EETAEKETKKENLEKLISRPIATRKVSVKVPKFTETDFKVSFIDQGYESIDELFN*FHYGFL*SLFIDIC
AMYKRNKMKMMKL
>Lodderomyces
MAPSPIKPPSSWDHDESPTKR
AKTIHGLSQPRYTTIPSLRYQEREHIVGEDEDEDEDGEDGEDDEELSEHEGATQEEHELHHKIRQLIKLR
NDRQFHELIKKLEAESLAKAKDRWSKIIDKYSQINDDAVSDEIDIVSGRVVRDNGHLRRMKVKRSQRRSN
LRDRGAGSSSELVSELVSETESEFDSEYETEPEFESGFGEGSESELDEVDLSIADSSTSSENTSLSIIQG
QDETEKDAEDEYRAIRKDNETLSVNNNNNMTNNHNNSPTKRKVEKGLIPLPTKLTPLPILRHLGKDKEKI
QLTKRIVFPILRHPDNVEVDNTSDRSDLPEQDSIDELFNS
>Schizosaccharomyces japonicus
MDTSSVNDRPHNACRVCGGLLDAEEAVTDVGDFFESEDVCKNLACQRVASRQRYEAKLSALFEKYGQDTSEYADEIDL
ATGAIVVDHGHLRGLHPHTPTDELVESVEEPVEAAQSGSRCPTEEVEQVSMGGSLTYPTDPPQDDPIVDN
PTSSPPVSPAAGTPTRTSPISTTKTPSPLSPLSPVSDPPYPILESPAQPTQTASIFPSTPTPAAPPPHTP
SSRTRSSLRVRIRLLSLVTPTPPRSSPLTSPLVSTPTSSSPTHISSTCRKPFCFRCLREKKKSKQSSPTG
LNVPHYPPHSPLPRTSTTPRHGR