>NvEfn1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MDLYLYRIVTLLVLMAAN- ----LSLVESMFYKSIVWS-PQNPIFSG--------TAIKCVIPK-----SKMTIVCPTQ ALVVQ--DSPLIPPKEQLYENIWLVNRGSYDSCNISTADSEKRLLLRCDTP--------- ---------------LVLKWYTLIFQEQSATAQGLEFVPEREYYFIATSTGDKSSLDSTA GGRCS---SSRMRLQIHICRDVDDIHCKSEAQCQALLNKEESTVAPATTTQYHPTDDNFT EGYSRNNLTS-------------------------------------------TPAPCIG KPDSHGRRDFFTEMKYQFAVGFLTAVCLVFIVSTAYLGYRLYRKTKESPRMCSENGRFSM RASTRTTSDGADSIDGAEHELLRDSSHC-------------------------------- ------------------------------------------------------------ ------------- >NvEfn2 MASFKEVRDLLLLEHSNGLISDDELLFFMGEYQSKNPEFTYDIYERFNLDDVEEPECKAY FRFEKNNIPVLAETLGLPDFFKCTQRTVAGKIEGLCLVLRRMAYPCRLGDLIPVFGRPVQ ELSMIANCVLEEIYDLHAHQYQSKNPEFTYDIYERFNLDDMEEPECKAYFRFEKNDIPVL AETLGLPDFFKCTQRTVAANERGCIELNDVRGYSNLRASQANERGCIDLNDVRGYSNLRA SQEHGYRGLCEIYPPLIWS-PLNPAFRPVPFGTENDTVYSMNVLP----MSKLYIICPNQ VLN--PTKVQLNTPKELLYENLWIVDKNSFDSCQVNTLLRRNKQLMECTTP--------- ---------------LALKYYPLVFQDFSATADVLEFERGKDYFFIATSNGQQSSLQSTR NGRCQ---THNMKLQVHVCHSATDPVCNPTEPPTTLPTTTQATTTPQPTTQSTPTTLTTT TAATTTTTPSTS----------------------------------TPTTQPTTLPKVVQ AAPPETPSPRQPEPRTKEDVDVRDSITGPRAGASKGTRCPRDPEDTTWLILVAVMGAIIA VSISCNIYILCCKKQSSSHQPRSDDKRSSAAHALLRENSRIDKV---------------- ------------------------------------------------------------ ------------- >CeEfn-1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MHPPIKIQTILLFILT--- ----TVHCSAKRLPQIYWN-STNPLVER-----------YAAIG------DTLDIVCPFF D---------ENSDELTEQSIIYRVTEEEYENCER---RSKAKELGRCTQP--------- ---------------YQEEKLKVAFRLMSPNPSGLDYRPGVTYYFISTSTGSRKGLYNEQ GGLCA---SHNLKMVIHITDRNGDIGPHHHRHHHKKTTTTTTTSTSTSTPKTIPPVVEMD SSAEKLWEQFY-------------------------------EKVMPIDNTWPEITRGER VTLYQGNKKDEYEQVPAEVVDFEIHEIGDVESLYSSSGRLRYVLLLPALLLLRIF----- ------------------------------------------------------------ ------------------------------------------------------------ ------------- >CeEfn-2 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MQIATFILLSLFPFIG--- --------WARKIPDINWI-SSNPIFDVSN----TDHVISVHIG------DRVSIRCPKS D-----------ETGKYEYSYIYMVSDEEYDHCFL----SKPRLVGACDNQ--------- ---------------TINASINIVFRSFTPTPGGFEFQPGKNYFLISTSDGTLEGIDRKK DGLCT---AKQMKIKFEVGQDRRGIENPKFAARTLKKDRDAEHSTPVMYVVHDE------ --------------------------------------------------------SDID DDDDGSNACSYFVSIVVLLASRYLL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------- >CeEfn-3 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MSSSWALFLLLFVAPLVS--- ---------CRNTHDVMWNSKQFPVAFK-------TTPIKVDLG------DQLTIICPKA YG------------MTYEYAKLYWVGETEWSQCWL----HEPVWLGVCATEN-------- ----------------YTTEVKLIFRQTNPIPDGMDFQVGKTYYIISTSTGDIEGINQAV GGLCK---YHHMKLAISVVGYEKQSHSKSEITEKNFAHGIGYEIHEVG------------ ------------------------------------------------------------ -QLVSSGHQNFTLLTTTSLLFCTMFLSGVLF----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------- >CeEfn-4 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MKQFFEFLITTFLLLG--- -------LAAADEHIVYWN-STNSLFRN------RQPTIEVRMG------DVVRFVCPDN EE----------GRNDGEYLIVYEVTEFAMDDCAL---ESHSREVIRCAPEGTAEKVLRT QQLSGGRREDWKKQKVPPKNVAQLIRQLNPIPNGKEYQPGQTYYYMTTSTGKANGTNHRM YGLCE---SQNMRLSMKVSASQPHPTRRAPTRRQEDFVTTASAELMGGQEDEDSDNDNAH LLPRDLEGSTN-----------------------------------------PKFRRPSQ LETAGVENQQFMKVVQMAQAGKTGTFENEKEAIAQKSSEKDGWHPVNVQYVADLMNNAYQ NADERISYQRDFEIHEENDLAVKSLEYSSSSTSLSTNFAILLAVIYVLY----------- ------------------------------------------------------------ ------------- >DmEfn ------------------------------------MQERSKQLRLTVSWTQSKSQIHDS CQRRSMLACKRRLTTSKVLEDSHPPVAFPNCKSHRHQQQKEKHKVQLYSGKPLSIKLYVP GSIESIPKIRHKALTTTNKQQPAMHRKSKSKSKFQGFNNLKPLYSPSKRQPPEKHSSVLV EAGIESKASRHFVGKKRIKNRNCLLSSPQPSPMRCKMMIPFPKFGATSFVTLLTLICMET -VLLSTMSSCAKTFYMHWN-TSNSIFRIDN----TDHIIDVNKGNLAFEFDQVHIICPVY EP--------GTFENETEKYIIYNVSKVEYETCRIT--NADPRVIAICDKP--------- ---------------QKLMFFTITFRPFTPQPGGLEFLPGNDYYFISTSSKDDLYR--RI GGRCS---TNNMKVVFKVCCAPEDNNKTTALSNSKSVTDTGGAINVNIANNDESHVNSHG NNIAIGTNIGINGGQIIGGPQSAGIPINPLSGNNNINGIPTTINSNIDQFNRIPIQPNII GNHVGTNAVGTGIVGGGGIILTPGHAHGNINMLQPGRGGINGAYPGHHHIQTGIRINNVP TQHNYPSHKGNANSNINGNDDHHHYNKHPNEVVKNEELTYNSGAATSDGNIFALWIWILS IFPLLSIQSCHLSSYWISASFLVSTIAILGIHYLIQITLQTTVQRYSPGMVEITATSMNG MFDQNAGTIEYDR >SpEfn ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MALPKAKSGIIFFVNAVLL--- ---LWSVTLAKTLQPIAWD-KNNSNFTS------TGLNISVEIN------DLIDIQCPQT EN-------TTEGRLKAQYLKFMQVSYQGYEQCSL---SARNRHLLSCNRP--------- ---------------YVQNRLTLLFQEHTPYPRGPTFRHGEEYYFITTSNGSANGIDNSR GGLCE---SHYMKLRVYVKPKPTASPTTGGPPTTPSNSSTPPDISRAATSMTSRTTTRAT TTLRTTSLPP-------------------------TTTRRTTRYTTGGKIKSTEEGNNIP DNMTRGAANRRHVSTTLLLASLLVAVVRWLHP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------- >CiEfnA-a ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MLIHQCVFLLTCLS--- ---LVKLVISRTRHVVFWDRSINSSLTT-------ELRLQVQIN------EWMDILCPKP AR-------NDEKRGEELYIDVFNVTAAQYHRCNT----QKIQRVLRCSDP--------- ---------------KREIKLTTKFQERSPSPLGFVFRPGQSYYYISKPSKGGTR---GC STDTL---RLVVEVESQHGRVEANKHTRFDPWLDQSEFGMKHNKRHHHLKNAENELEKRE PQEP------------------------------------------------VVLSQKNS AAPPDGGNSAVGIHSRRHDTRLLALITSSLLMVLFTKWV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------- >CiEfnA-b ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPLSKVNRMILSLFMCYLLFDG- -VRSKRFNSGTITHEVMWDPRENGGFAFG-----NEFSIEVHMR------DYMNIHCPQY D----------QDDKAKLSFIIYNVSEQSYNSCSL---TDMKTAIFKCDNP--------- ---------------VKGRKLTTKFQRRSPNPLGFVYQPNKDYFFMAFKKDEPQNCKSAM KMKVH---VLPKRLHEHDRKPVTAGTTRSSTPRTLSSTTTTTTIATTTTTTPRTSQKPHI PRQS--------------------------------------STRNTPPTKTLKPGYVRG DGEGDGPGGGVGRITCATTWMLVALVLTVLLQN--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------- >CiEfnA-c ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MIRSLAICFSLLLFQ--- ----GEGNAKRRHHVIYWNTVMNPGLLS-----TSEHTYHVKIG------EFLDILCPQN S-----LMGITDGLEEPETFNLYNVTQTDFEQCSHG--DNKNFI-FACDRP--------- ---------------ERENKLTIKFQTISPSPLGFRFQYCSEYYFVAASRDPNK-RTNGC NKNSM---RLRIFVECRETRHHKHDKKTTTASTTTTTTLPTTTITKVRTTTSRKPRIVLP NVEHSNTTKS----------------------IPDKK-----PSED------PETLRQIK NRRGNNSSSCLSFSINTWTLTFFVYVITTWVMS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------- >CiEfnA-d ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MATQFTYYLFTLCLIC--- ----VNSQATVDRHVLYWNSVMTPGLK------KNDYVMQVKMG------QFMDILCPQR S-----LMGIT-GPKEPTTFDLYNVTEDNYQQCNTG--GHKNFI-FACDRP--------- ---------------ERENKLTIKFQTISPSPLGFRFQYCSEYYFVAVPRNGRRGKQSGC HKQST---RLRISVGCHETTTTSTTTTTTTTTTTTTTTTTPKPTTSTANPDYEFIKKLLA STKDTQSSRDETF-------------------VPKLKSLLIKSSEKNSPVVLASSLDQTS DNKGNAAPSHTSVFSTTLLVMLTSWVLRSLLLV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------- >CiEfnB ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MTTVKMDKLTIFVAALSIVIWG- --PESVTVEGKTREPIYWN-SANPLWDS------ETRLINVAIN------DRLDIICPRR G---------RDEGEELFYYKLYLVSKEDFKRCNAS--NNDRRRLITCNVP--------- ---------------DREKKYTFYFQEISPSPWGIEFQPDETYYVISTSDGTKSGIESLQ GGVCT---RMNMKLELRVHPEDTPIVDNRVMVDTTEHNLPKPHLPPKVTDRKPIIDPNPP THYNPVVVPPG------------------------TPKNTPPQSINPVDPPVDPVAPTQS ENSTSVGSNGLVIGVVLGACAVLFIVLLGFLGYKVYRRRRHMKKYQSPPMTPTRGATPLH QVTLLPISTPHGHHARIQSEHERHRTGTMSSHSERPPPSYNESFLDNGGPVVAV------ ------------------------------------------------------------ ------------- >BfEfn1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MALNKWTWFSRLKSYPAAHVFTFLFLTM LDRTEGYFFGRVLPDINWN-QNDDIFQR-----EGGYVLEVDIG------DKLDIICPRL FN---------------QYNVMYEVSREGYETCNS----TGGRLLLRCNLP--------- ---------------ETDLVLTVLFQEVSPSPFGLEFKKGKDYYYIATSGGTLDTLDNRV GGNCE---SPTYMKLTIRVRGDPTERSESTDGNYAGRGDGVTTLPSVAKSADRR------ --------------------------------------------------------VNSA SQLRRGALDFVTLLLTALLATVFGTLRL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------- >BfEfn2 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------MALQ TLLPELAVQSLTSCTFLGTRLENHRKSLWPGKVFLRRLGQDRLKTVSAKTSQPQCKERFG VSRPDFLLCVLRPPHLMWSQDAQQGFSG------GGYHLSPNVN------DMVTVFCPHY EVG---------STDLVEYNVLYEVDEDGYNRCDA----ERGRPLLRCDRPYR------- ---------------SYPLSLTIYFQEFSPSPYGLEFDRGRDYYYISTSTGEYGGLNATV GGNCVNGMKMKLSICCKSNTSDTSVANTLHLGVSWFCGLSVAALFFNMASLSPPSLSATE TPNVVEEQTQR------------------------------------------RSPPHIP SNRIPVAGFLAFRAAFKGLSRFPCHRGKGSCDEGICHPELLQVLVIEPYPVKDRFRSSSY REDGTDGSEHCPYGGEKTLSLTGPDLSSVMSALSYLAIQYHAAGPPHCLQHMQSTGSG-- ------------------------------------------------------------ ------------- >HsEfnA1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MEFLWAPLLG--- ---LCCSLAAADRHTVFWN-SSNPKFRN------EDYTIHVQLN------DYVDIICPHY -------EDHSVADAAMEQYILYLVEHEEYQLCQP---QSKDQVRWQCNRPS-------- -------------AKHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYIS-KPIHQH------ EDRCL---RLKVTVSGKITHSPQAHDNPQ--------------EKRLAADDPEV------ --------------------------------------------------------RVLH SIGHSAAPRLFPLAWTV--LLLPLLLLQTP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------- >HsEfnA2 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MAPAQRPLLPLLLLLLPLPPPPF ARAEDAARANSDRYAVYWN-RSNPRFHAGAGDDGGGYTVEVSIN------DYLDIYCPHY -------GAPLPPAERMEHYVLYMVNGEGHASCDH---RQRGFKRWECNRPA-------- -------------APGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAV------ DRPCL---RLKVYVRPTN---------------------------ETLYEAPE------- --------------------------------------------------------PIFT SNNSCSSPGGCRLFLST--IPVLWTLLGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------- >HsEfnA3 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MAAAPLLLLLLLVPVPLLP--- LLAQGPGGALGNRHAVYWN-SSNQHLRR------EGYTVQVNVN------DYLDIYCPHY NSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCN----ASQGFKRWECNRPH-------- -------------APHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYIS-TPTHNL------ HWKCL---RMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQV------ --------------------------------------------------------PKLE KSISGTSPKREHLPLAVGIAFFLMTFLAS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------- >HsEfnA4 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MRLLPLLRTVLWAAFLG--- ---SPLRGGSSLRHVVYWN-SSNPRLLR------GDAVVELGLN------DYLDIVCPHY --------EGPGPPEGPETFALYMVDWPGYESCQAE--GPRAYKRWVCSLP--------- ---------------FGHVQFSEKIQRFTPFSLGFEFLPGETYYYIS-VPTPES------ SGQCL---RLQVSVCCKERKS------------------------ESAHPVGSP------ --------------------------------------------------------GESG TSGWRGGDTPSPLCLLLLLLLLILRLLRIL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------- >HsEfnA5 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MLHVEMLTLVFLVLWMCVFS--- --QDPGSKAVADRYAVYWN-SSNPRFQR------GDYHIDVCIN------DYLDVFCPHY -------EDSVP-EDKTERYVLYMVNFDGYSACDH---TSKGFKRWECNRPH-------- -------------SPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNG------ RRSCL---KLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAE------- --------------------------------------------------------PSRG ENAAQTPRIPSRLLAIL--LFLLAMLLTL------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------- >HsEfnB1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MARPGQRWLGKWLVAMVVW-- ALCRLATPLAKNLEPVSWS-SLNPKFLS-----GKGLVIYPKIG------DKLDIICPRA E------AGRP-----YEYYKLYLVRPEQAAACST---VLDPNVLVTCNRP--------- ---------------EQEIRFTIKFQEFSPNYMGLEFKKHHDYYITSTSNGSLEGLENRE GGVCR---TRTMKIIMKVGQDPN--AVTPEQLTTSRPSKEADNTVKMATQAPGSRGSLGD SDGKHETVNQ-------------------------EEKSGPGASGGSSGDPDGFFNSKVA LFAAVGAGCVIFLLIIIFLTVLLLKLRKRHRKHTQQRAAALSLSTLASP-KGGSGTAG-- -TEPSDIIIPLR---TTENNYCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV------ ------------------------------------------------------------ ------------- >HsEfnB2 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MAVRRDSVWKYCWGVLMV---- -LCRTAISKSIVLEPIYWN-SSNSKFLP-----GQGLVLYPQIG------DKLDIICPKV D------SKTVG---QYEYYKVYMVDKDQADRCTI---KKENTPLLNCAKP--------- ---------------DQDIKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQE GGVCQ---TRAMKILMKVGQDASSAGSTRNKDPTRRPELEAGTNGRSSTTSPFVKPNPGS STD--------------------------------------GNSAGHSGN--NILGSEVA LFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATP-KRSGNNNG-- -SEPSDIIIPLR---TADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV------ ------------------------------------------------------------ ------------- >HsEfnB3 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MGPPHSGPGGVRVGALLL--- -LGVLGLVSGLSLEPVYWN-SANKRFQA-----EGGYVLYPQIG------DRLDLLCPRA R------PPGPHSSPNYEFYKLYLVGGAQGRRCEA---PPAPNLLLTCDRP--------- ---------------DLDLRFTIKFQEYSPNLWGHEFRSHHDYYIIATSDGTREGLESLQ GGVCL---TRGMKVLLRVGQSPR-GGAVPRKPVSEMP-MERDR-GAAHSLEPGKENLPGD PTSN-------------------------------------ATSRGAEGP---LPPPSMP AVAGAAGGLALLLLGVAGAGGAMCWRRRRAKPSESRHPGPGSFGRGGSLGLGGGGGMGPR EAEPGELGIALRGGGAADPPFCPHYEKVSGDYGHPVYIVQDGPPQSPPNIYYKV------ ------------------------------------------------------------ -------------