Supplementary material for Chong et al. (1999) Proc. Natl. Acad. Sci. USA 96 (25), 14330-14335.

Table 8.

Energetic analysis of the 48G7 mature antibody-hapten complex formation

 

Antibody

Hapten

Complex

 

Complex formation

<Eelec>

-

12316.3

(2.6)

5.3

(0.1)

-

12660.1

(3.0)

<

DEelec>

-

349.1

(1.5)

<Evdw>

-

1962.8

(1.6)

6.4

(0.2)

-

1991.9

(1.6)

<

DEvdw>

-

35.5

(0.4)

<Eint>

3668.4

(2.7)

25.4

(0.4)

3693.8

(2.7)

<

DEint>

0.0

(0.0)

<EMM>

-

10610.6

(3.4)

37.0

(0.4)

-

10958.2

(3.7)

<

DEMM>

-

384.6

(1.4)

G

np

109.8

(0.1)

3.4

(0.1)

109

(0.0)

D

Gnp

-

4.2

(0.1)

G

PB

-

4559.9

(1.9)

-

207.7

(0.2)

-

4413.7

(2.3)

D

GPB

354.0

(1.2)

G

solv

-

4451.4

(1.8)

-

204.2

(0.2)

-4306.0

(2.3)

D

Gsolv

349.6

(1.2)

G

elec,tot

-

16876.2

(1.8)

-

202.4

(0.2)

-

17073.8

(1.9)

D

Gelec,tot

4.9

(0.5)

G

tot

-

15062.0

(2.9)

-

167.2

(0.4)

-

15264.1

(2.8)

D

Gtot

-

35.0

(0.5)

-

TS

-

1086.1

 

-

45.4

 

-

1112.2

 

-

TDS

19.3

 

G

bind

-

16148.1

 

-

212.6

 

-

16376.3

 

D

Gbind

-

15.7

 

See Table 7 legend.