J. Biol. Chem., Vol. 283, Issue 44, 29897-29903, October 31, 2008

MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1
J. Biol. Chem. Miller et al. 283: 29897

Sarmila Majumder

bio pic

Current Position: Research Assistant Professor in the Department of Molecular and Cellular Biochemistry in the College of Medicine at The Ohio State University

Education: Ph.D. in Biochemistry (1990) from University of Calcutta in India

Non-scientific Interests: Photography and gardening

After a productive postdoctoral training at Michigan State University and Cleveland Clinic, I joined The Ohio State University Medical Center where I am currently an assistant professor in the Department of Molecular and Cellular Biochemistry and Comprehensive Cancer Center. My major research interest is in transcriptional and epigenetic regulation of tumor suppressor genes in liver and breast cancer; I am also interested in leukemia research.

While studying DNA methylation of a tumor suppressor gene encoding receptor type protein tyrosine phosphatase O (PTPRO) in breast cancer and its role in tamoxifen sensitivity, I became interested in studying the underlying mechanism of tamoxifen resistance in breast cancer patients. This study was designed to determine if a specific microRNA signature could define tamoxifen resistant breast cancer.

A very bright and highly motivated undergraduate student, Tyler E. Miller (pictured here), who is majoring in biomedical sciences became interested in the project in its early stages and worked with me to complete this project.

Read Dr. Majumder's article on page 29897.

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Copyright © 2008 by the American Society for Biochemistry and Molecular Biology.