This file contains a list of COGs in the following format:
CSN_COG#_one line description of COG members
Average identity between core members (genes that are members due to congruent BeTs)
List of genes in COG core in this format:
[Virus_#gene number] [the sequence's PID number] [Genbank annotation] [add. annotation (op.)]
Average identity to the core members of the additional members
List of genes that are Additional Members of the COG
(due to non-congruent BeTs to Core members) Same format as core.
The COG# assigned each COG is arbitrary and not related to the number assigned any similar COGs at other CSNs. The "gene number" after the "#" was assigned for internal reference purposes.
COG Stringency Number for cores is 6
COG Stringency Number for addition is 6
6_1_Large Subunit of Ribonucleotide reductase
Core Members : Average percent Identity : 20.6603257575758
EHV1_#21 gi|330813 ribonucleotide reductase RR1
EHV2_#62 gi|695234 ribonucleotide reductase, large subunit
EHV4_#21 gi|2605964 21 (Large subunit of Ribonucleotide reductase)
HCMV_#59 gi|1780823 Homology to large subunit of ribonucleotide reductase
HSV1_#42 gi|59539 ribonucleotide reductase large subunit
HSV2_#42 gi|1869862ribonucleotide reductase large subunit
VZV_#19 gi|60008 ORF19 (AA1-775)
EBV_#23 gi|1334856 BORF2 early reading frame, 2 NXT/S. Homology HSV 140K ribonucleotide
HHV6_#38 gi|854007 U28,RR1(Sim to lg subunit of ribonuc. reduct., but no encoded sm subunit)
HHV7_#33 gi|1139630 ribonucleotide reductase, large subunit
MHV68_#59 gi|2317993 ribonucleotide reductase large
HVS2_#62 gi|60382 ribonucleotide reductase,large subunit
Additional Members : Average Identity to Core : 0
6_2_Tegument Protein
Core Members : Average percent Identity : 15.1987843137255
EHV2_#65 gi|695237 tegument protein
HCMV_#62 gi|1780826 HCMVUL48
VZV_#22 gi|60011 ORF22 (AA1-2763)
EBV_#20 gi|1334853 BPLF1 reading frame, 1 NXT/S, analogous to VZV RF22
HHV6_#41 gi|854010 U31, large tegument protein
HHV7_#36 gi|1139633 large tegument protein
MHV68_#62 gi|2317959 tegument protein
HVS2_#65 gi|60385 ORF 64; EERF2; sim. to other HV
Additional Members : Average Identity to Core : 17.5654
EHV1_#24 gi|330816 tegument protein
6_3_Capsid protein ?
Core Members : Average percent Identity : 18.440380952381
EHV2_#67 gi|695239 ORF 66
HCMV_#63 gi|1780827 HCMVUL49
EBV_#18 gi|1632788 BFRF2 early reading frame, homologous to HFLF5 in CMV
HHV6_#43 gi|854012 U33 (capsid protein)
HHV7_#38 gi|1139635 capsid protein
MHV68_#64 gi|2317996 unknown
HVS2_#67 gi|60387 ORF 66; ECLF6; sim. to other HV
Additional Members : Average Identity to Core : 0
6_4_DNA Helicase/Primase component
Core Members : Average percent Identity : 20.5429848484849
EHV1_#7 gi|330799 encodes for a protein associated with a DNA helicase/primase complex;
EHV2_#57 gi|695229 DNA helicase-primase complex component
EHV4_#7 gi|2606017 7
HCMV_#84 gi|1780848Homology to HSV-1 protein required for DNA replication
HSV1_#56 gi|59552 UL52 . component of helicase/primase complex
HSV2_#56 gi|1869876UL52
VZV_#6 gi|59995 ORF6 (AA1-1083)
EBV_#29 gi|1334862 BSLF1 reading frame, homologous to RF 6 VZV
HHV6_#53 gi|854022 U43, helicase-primase complex
HHV7_#48 gi|1139645 primase
MHV68_#53 gi|2317955 DNA replication protein
HVS2_#57 gi|60376 ORF 56; EDRF4; sim. to other HV
Additional Members : Average Identity to Core : 0
6_5_dUTPase
Core Members : Average percent Identity : 19.7846222222222
EHV1_#9 gi|330801 dUTPase
EHV2_#55 gi|695227 ORF 54
EHV4_#9 gi|2606026 9
HSV1_#54 gi|59550 deoxyuridine triphosphatase
HSV2_#54 gi|1869874deoxyuridine triphosphatase
VZV_#8 gi|59997 ORF8 (AA1-396)
EBV_#31 gi|1334864 BLLF3 early reading frame (BLLF2 in Baer et al, 1984). Homologous to
IHV_#49 gi|331259 dUTPase
MHV68_#51 gi|2317954 dUTPase
HVS2_#55 gi|60375 dUTPase
Additional Members : Average Identity to Core : 0
6_6_Tegumant Protein ?
Core Members : Average percent Identity : 27.9329756097561
EHV2_#68 gi|695240 tegument protein
HCMV_#64 gi|1780828 HCMVUL50
EBV_#17 gi|1334850 BFRF1 early reading frame, 1 NXT/S, homologous to HFLF4 in CMV
HHV6_#44 gi|854013 U34
HHV7_#39 gi|1139636 putative virion protein
MHV68_#65 gi|2317997 tegument protein
HVS2_#68 gi|60388 ORF 67; ECLF5; sim. to other HV
Additional Members : Average Identity to Core : 0
6_7_Glycoprotein M
Core Members : Average percent Identity : 26.0679696969697
EHV1_#52 gi|330843 membrane protein
EHV2_#40 gi|695212 glycoprotein M
EHV4_#52 gi|2605998 52
HCMV_#115gi|1780879 Multiple hydrophobic domains
HSV1_#12 gi|59510 virion glycoprot M, in virions + plasma membrane of infected cells.
HSV2_#12 gi|1869832virion glycoprotein M
VZV_#49 gi|60040 ORF 50 (AA1-435)
EBV_#59 gi|1334889 BBRF3 late reading frame
HHV6_#82 gi|854051 U72, integral membrane protein, glycoprotein M, gM
HHV7_#76 gi|1139673 glycoprotein M
MHV68_#37 gi|2317979 glycoprotein M
HVS2_#40 gi|60360 integral membrane protein
Additional Members : Average Identity to Core : 0
6_8_Virion Protein Kinase
Core Members : Average percent Identity : 17.2192846153846
EHV1_#49 gi|330840 virion protein kinase
EHV2_#37 gi|695209 virion protein kinase
EHV4_#49 gi|2605994 49
HCMV_#112 gi|1780876 Phosphotransferase? (13)
HSV1_#15 gi|59514 protein kinase
HSV2_#15 gi|1869835protein kinase
VZV_#46 gi|60036 ORF 47 (AA1-510)
EBV_#62 gi|1334892 BGLF4 early reading frame, homologous to RF 47 VZV
HHV6_#79 gi|854048 U69, ganciclovir kinase, phosphotransferase
HHV7_#73 gi|1139670 phosphotransferase
MHV68_#34 gi|2317947 kinase
HVS2_#37 gi|60357 tyrosine-specific protein kinase
Additional Members : Average Identity to Core : 0
6_9_DNA packaging/Terminase?
Core Members : Average percent Identity : 22.8097876712329
EHV1_#45 gi|330792 DNA packaging protein
EHV2_#29 gi|695201 ORF 29b; possible terminase; ORF 29a and 29b probably expressed as a s
EHV4_#45 gi|2605992 47/44
HCMV_#104 gi|1813970Conserved herpesvirus spliced gene
HSV1_#17 gi|59501 UL15 req for DNA packaging
HSV2_#17 gi|1869837UL15
VZV_#44 gi|60034 ORF45 (spliced to ORF42) (352 AA)
EBV_#65 gi|1632798 probable DNA packaging protein
HHV6_#70 gi|854039 U60, late spliced gene(U60-66)
HHV7_#66 gi|1139663 late spliced gene
IHV_#62 gi|331210 terminase
MHV68_#26 gi|2317977 packaging protein
HVS2_#30 gi|60355 ORF 29; conserved spliced gene
Additional Members : Average Identity to Core : 19.4873255813954
EHV2_#34 gi|695206 ORF 29a; expression of ORF 29a and 29b is likely as a spliced mRNA OF Equine Herpesvirus
EBV_#64 gi|1334893 BGRF1 reading frame, homologous to RF 45 VZV and spliced HSV gene (Co
EBV_#69 TRANSLATE of: v01555 check: 1039 from: 129188 to: 130348
HHV6_#76 gi|854045 U66, late spliced gene (U60- 66)
MHV68_#31 gi|2317978 packaging protein
6_10_Glycoprotein H
Core Members : Average percent Identity : 18.8716608695652
EHV1_#40 gi|330832 membrane glycoprotein H
EHV2_#22 gi|695194 glycoprotein H
EHV4_#40 gi|2605984 39
HCMV_#89 gi|1780852 Glycoprotein H (10)
HSV1_#24 gi|59522 virion glycoprot H, binds gL, role in entry, egress, cell-cell spread.
HSV2_#24 gi|1869844virion glycoprotein H
VZV_#37 gi|60026 ORF37 (AA1-841)
EBV_#76 gi|1334905 BXLF2 late reading frame, encodes gp85; homologous to RF 37 VZV and g
HHV6_#58 gi|854027 U48, glycoprotein H, gH
HHV7_#53 gi|1139650 glycoprotein H
MHV68_#20 gi|2317937 glycoprotein H
HVS2_#23 gi|60343 glycoprotein H
Additional Members : Average Identity to Core : 0
6_11_Protease-scaffold+assembly
Core Members : Average percent Identity : 23.9678409090909
EHV1_#36 gi|330827 protease
EHV2_#17 gi|695188 proteinase/capsid scaffold protein
EHV4_#36 gi|2605979 35
HCMV_#94 gi|1780857 HCMVUL80
HSV1_#28 gi|59526 protease
HSV2_#28 gi|1869848protease
VZV_#33 gi|60022 ORF33 (AA1-605)
EBV_#80 gi|1334909 BVRF2 early reading frame, N-terminus homologous to RF 33 VZV
HHV6_#63 gi|854032 U53, protease-assembly protein
HHV7_#58 gi|1139655 protease
MHV68_#15 gi|2317972 capsid protein
HVS2_#18 gi|60339 ORF 17; similarity to other herpesviruses (HV)
Additional Members : Average Identity to Core : 13.9453333333333
EHV1_#35 gi|330828 capsid assembly protein
6_12_Tegument Protein
Core Members : Average percent Identity : 24.0343787878788
EHV1_#37 gi|330829 virion protein
EHV2_#19 gi|695191 tegument protein
EHV4_#37 gi|2605981 36
HCMV_#91 gi|1780854 HCMVUL77
HSV1_#27 gi|59525 capsid associated tegument protein
HSV2_#27 gi|1869847capsid associated tegument protein
VZV_#34 gi|60023 ORF34 (AA1-579)
EBV_#79 gi|1334908 BVRF1 early reading frame, homologous to RF 34 VZV
HHV6_#60 gi|854029 U50
HHV7_#55 gi|1139652 viron protein
MHV68_#17 gi|2317973 tegument protein
HVS2_#20 gi|60340 ORF 19; sim. to other HV
6_13_Unknown
Core Members : Average percent Identity : 28.6021732283465
EHV1_#38 gi|330830 ORF 37
EHV2_#20 gi|695192 ORF 20
EHV4_#38 gi|2605982 37 (counterpart to HSV1 UL24 & VZV 35)
HCMV_#90 gi|1780853 HCMVUL76
HSV1_#26 gi|59523 UL24 membrane associated?
HSV2_#26 gi|1869846UL24
VZV_#35 gi|60024 ORF35 (AA1-258)
EBV_#78 gi|1334906 BXRF1 late reading frame, homologous to RF 35 VZV. Basic (core?) prot
HHV6_#59 gi|854028 U49 Sim.to HCMV UL79, HSV 20, EBV BxRF1, EHV1 37, HSV1 UL24, put. fusion prot.
HHV7_#54 gi|1139651 U49 gene product
MHV68_#18 gi|2317974 unknown
HVS2_#21 gi|60342 ORF 20; sim. to other HV
Additional Members : Average Identity to Core : 0
6_14_Major Capsid Protein
Core Members : Average percent Identity : 33.7684090909091
EHV1_#43 gi|330835 major capsid protein
EHV2_#25 gi|695197 capsid protein
EHV4_#43 gi|2605988 42
HCMV_#101 gi|1780864 Major capsid protein (12)
HSV1_#21 gi|59519 major capsid protein
HSV2_#21 gi|1869841major capsid protein
VZV_#40 gi|60029 ORF40 (AA1-1396)
EBV_#73 gi|1334902 BcLF1 late reading frame, homologous to RF 40 VZV and major capsid pr
HHV6_#67 gi|854036 U57, major capsid protein
HHV7_#63 gi|1139660 major capsid protein
MHV68_#23 gi|2317938 major capsid protein
HVS2_#26 gi|60346 major capsid protein
Additional Members : Average Identity to Core : 15.2658666666667
HHV7_#106 gi|1139703 H3' gene product
HHV7_#7 gi|1139604 H3 gene product
MHV68_#52 gi|2317989 unknown
6_14_Unknown
Core Members : Average percent Identity : 29.9836
EHV2_#18 gi|695190 ORF 18
HCMV_#93 gi|1780856 HCMVUL79
HHV6_#62 gi|854031 U52 (sim. to HCMV UL79, HSV1 gene 18)
HHV7_#57 gi|1139654 U52 gene product
MHV68_#16 gi|2317935 unknown
HVS2_#19 gi|60338 ORF 18; similarity ((sim.) to other HV
Additional Members : Average Identity to Core : 0
6_16_Helicase/Primase
Core Members : Average percent Identity : 26.7292380952381
EHV1_#57 gi|330848 encodes for a protein associated with a DNA helicase/primase complex;
EHV2_#45 gi|695217 DNA helicase-primase complex component
EHV4_#57 gi|2606003 57
HCMV_#120 gi|1780883 Homology to helicases
HSV1_#7 gi|59507 complexes with UL8 & UL52 proteins. UL5
HSV2_#7 gi|1869827 UL5
VZV_#54 gi|60044 ORF 55 (AA1-881)
EBV_#54 gi|1334885 BBLF4 early reading frame, very good homology to RF55 VZV
HHV6_#87 gi|854056 old name HDRF2; helicase, part of helicase-primase complex, homologue
HHV7_#81 gi|1139678 helicase
IHV_#25 gi|331235 SFI helicase
MHV68_#41 gi|2317951 helicase-primase
HVS2_#45 gi|60364 helicase
Additional Members : Average Identity to Core : 0
6_17_Thymidine Kinase
Core Members : Average percent Identity : 18.0870609756097
EHV1_#39 gi|330831 thymidine kinase
EHV2_#21 gi|695193 thymidine kinase
EHV4_#39 gi|2605983 38
HSV1_#25 gi|59524 thymidine kinase
HSV2_#25 gi|1869845thymidine kinase
VZV_#36 gi|60025 ORF36 (AA1-341)
EBV_#77 gi|1334907 BXLF1 early reading frame, thymidine kinase (Littler et al, 1986). We
IHV_#5 gi|331215 thymidine kinase
MHV68_#19 gi|2317936 thymidine kinase
HVS2_#22 gi|60341 thymidine kinase
Additional Members : Average Identity to Core : 14.3448
IHV_#83 gi|331292 thymidine kinase
6_18_Uricil-DNA glycosylase
Core Members : Average percent Identity : 28.7044242424243
EHV1_#61 gi|330852 uracil-DNA glycosylase
EHV2_#47 gi|695219 uracil DNA glycosylase
EHV4_#61 gi|2606008 61
HCMV_#131 gi|1780896 Homology to uracil-DNA glycosylase
HSV1_#4 gi|59503 uracil-DNA glycosylase (aka UL2)
HSV2_#4 gi|1869824 uracil-DNA glycosylase
VZV_#58 gi|60048 ORF 59 (AA1-305)
EBV_#52 gi|1632795 BKRF3 reading frame, homologous to RF 59 VZV
HHV6_#90 gi|854059 U81, uracil-DNA glycosylase
HHV7_#86 gi|1139683 uracil-DNA glycosylase
MHV68_#43 gi|2317983 uracil DNA glycosylase
HVS2_#47 gi|60367 uracil DNA glucosidase
Additional Members : Average Identity to Core : 0
6_19_Alkaline Exonuclease
Core Members : Average percent Identity : 18.363303030303
EHV1_#50 gi|330841 deoxyribonuclease
EHV2_#38 gi|695210 deoxyribonuclease
EHV4_#50 gi|2605996 50
HCMV_#113 gi|1780877 DNase homologue
HSV1_#14 gi|59513 deoxyribonuclease
HSV2_#14 gi|1869834 deoxyribonuclease
VZV_#47 gi|60037 ORF 48 (AA1-551)
EBV_#61 gi|1334891 BGLF5 early reading frame, homologous to RF 48 VZV and alkaline exonu
HHV6_#80 gi|854049 U70, alkaline exonuclease
HHV7_#74 gi|1139671 alkaline exonuclease
MHV68_#35 gi|2317948 alkaline exonuclease
HVS2_#38 gi|60358 alkaline exonuclease
Additional Members : Average Identity to Core : 0
6_20_Immediate Early Transcription Regulator
Core Members : Average percent Identity : 19.7928666666667
EHV1_#64 gi|330855 transcriptional activator
EHV4_#64 gi|2606027 64 (transcription regulator)
HCMV_#75 gi|1813968 HCMVUL61
HSV1_#63 gi|59558 RS1 (immediate early transcription regulator)
HSV2_#63 gi|1869883 RS1 (immediate early transcription regulator)
VZV_#61 gi|60051 ORF 62 (AA1-1310)
Additional Members : Average Identity to Core : 20.1592571428571
EHV1_#80 gi|330871 transcriptional activator
EHV4_#79 gi|2606011 64 (Transcription regulator)
HSV1_#77 gi|59571 RS1 (immediate early transcription regulator)
HSV2_#77 gi|1869897RS1 (immediate early transcription regulator)
VZV_#70 gi|60060 ORF 71 (AA1-1310)
MHV68_#79 gi|2317968 unknown
MHV68_#80 gi|2318003 unknown
6_21_Origin Binding Protein
Core Members : Average percent Identity : 27.5678095238095
EHV1_#53 gi|330844 origin-binding protein
EHV4_#53 gi|2605999 53 (origin binding protein)
HSV1_#11 gi|59511 UL9 binds origin, helicase, ATPase
HSV2_#11 gi|1869831 UL9 (origin binding protein)
VZV_#50 gi|60039 ORF 51 (AA1-835)
HHV6_#83 gi|854052 U73, origin binding protein
HHV7_#77 gi|1139674 replication origin binding protein (OBP)
Additional Members : Average Identity to Core : 0
6_22_Membrane Protein
Core Members : Average percent Identity : 19.3947910447761
Fake_#17 gi|m0x17 multi T
EHV1_#71 gi|330862 membrane glycoprotein
EHV2_#77 gi|695249 ORF E9; ser/thr rich protein with hydrophobic N- and C-termin
EHV4_#71 gi|2606019 71 (envelope glyco protein[gp2] possitional counterpart to HSV1 US5)
HCMV_#133 gi|1780898HCMVUL116
EBV_#34 gi|1334869 BLLF1a, late reading frame, gp350 membrane antigen, 36 NXT /S (Hummel
HHV6_#57 gi|854026 U47,(variable secreted glycoprot, possition homologue:HSV1 UL74, HSV 51?)
IHV_#50 gi|331260 ORF 50
HVS2_#52 gi|60372 glycoprotein
Additional Members : Average Identity to Core : 16.2939833333333
EHV2_#28 gi|695200 ORF 28
EHV4_#16 gi|2605958 16 (envelope glycoprotein gC; role in cell entry)
HCMV_#12 gi|59603 RL11 FAMILY
HCMV_#13 gi|59604 HCMVTRL13 = IRL13
HCMV_#136gi|1780901 HCMVUL119
HCMV_#141gi|1780907 HCMVUL124
HCMV_#149gi|1780915 HCMVUL132
HCMV_#151gi|1780917 HCMVIRL13 = TRL13
HCMV_#152gi|1780918 RL11 FAMILY
HCMV_#20 gi|59611 RL11 FAMILY
HCMV_#25 gi|59616 RL11 FAMILY
HCMV_#46 gi|59637 pp150 (4)
HCMV_#88 gi|1780851 HCMVUL74
EBV_#35 gi|1334868 BLLF1b, late reading frame gp220 membrane antigen, spliced form of BL
EBV_#70 gi|1334899 BDLF3 late reading frame 9xNXT/S
HHV6_#33 gi|854002 U23, glycoprotein
HHV7_#27 gi|1139624 U23 gene product
HHV7_#52 gi|1139649 U47 gene product
IHV_#7 gi|331217 membrane protein
IHV_#85 gi|331294 membrane protein
6_23_DNA Polymerase
Core Members : Average percent Identity : 26.2881805555555
EHV1_#30 gi|330822 DNA polymerase
EHV2_#9 gi|695181 DNA polymerase replicative subunit
EHV4_#30 gi|2605974 30 (catalytic sub unit of replicative DNA polymerase)
HCMV_#68 gi|1780832 DNA polymerase (8)
HSV1_#33 gi|59530 DNA polymerase
HSV2_#33 gi|1869853 DNA polymerase
VZV_#28 gi|60017 ORF28 (AA1-1194)
EBV_#84 gi|1334913 BALF5 DNA polymerase (early), homologous to many DNA polymerases, CMV
HHV6_#48 gi|854017 U38, DNA polymerase
HHV7_#43 gi|1139640 DNA polymerase
IHV_#57 gi|331267 DNA polymerase
MHV68_#9 gi|2317930 DNA polymerase
HVS2_#10 gi|60330 DNA polymerase
Additional Members : Average Identity to Core : 12.6004
HHV7_#20 gi|1139617 HCMV US22 gene family; U16-U17 spliced exon
6_24_Unknown
Core Members : Average percent Identity : 23.6859834710744
EHV1_#47 gi|330838 ORF 46
EHV2_#33 gi|695205 ORF 33
EHV4_#47 gi|2605991 46 (tegument protein; counterparts: HSV1 UL16, VZV gene 44)
HCMV_#109 gi|1780872 HCMVUL94
HSV1_#18 gi|59516 UL16 loc in intron of UL15
HSV2_#18 gi|1869838 proposed start codon is CTG
VZV_#43 gi|60033 ORF44 (AA1-363)
EBV_#66 gi|1334895 BGLF2 late reading frame, poor homology to RF 44 VZV
HHV6_#75 gi|854044 U65 (AKA 11R; homologues: HCMV UL94, HVS 33, EBV BGLF2, EHV46 VZV 44, HSV1 UL16)
HHV7_#70 gi|1139667 U65 gene product
MHV68_#30 gi|2317944 unknown
HVS2_#34 gi|60353 ORF 33; sim. to other HV
Additional Members : Average Identity to Core : 0
6_25_Unknown
Core Members : Average percent Identity : 20.7121550387597
EHV1_#55 gi|330846 ORF 55
EHV2_#43 gi|695215 ORF 42
EHV4_#55 gi|2606001 55 (Counterparts: HSV1 UL7, VZV gene53)
HCMV_#118 gi|1780882 HCMVUL103
HSV1_#9 gi|59508 UL7 unknown
HSV2_#9 gi|1869829 UL7
VZV_#52 gi|60042 ORF 53 (AA1-331)
EBV_#56 gi|1632797 BBRF2 late reading frame, homologous to RF 53 VZV
HHV6_#85 gi|854054 U75 (AKA HDLF2;homologues: HCMV UL103, HVS 42, EBV BBRF2, EHV1 55, VZV33, HSV1 UL7)
HHV7_#79 gi|1139676 U75 gene product
MHV68_#39 gi|2317980 unknown
HVS2_#43 gi|60363 ORF 42; sim. to other HV
Additional Members : Average Identity to Core : 0
6_26_Post Translational regulator...or...treanscriptional activator
Core Members : Average percent Identity : 17.3338115942029
EHV1_#5 gi|330797 transcriptional activator
EHV2_#58 gi|695230 ORF 57 (Transcriptional control)
EHV4_#5 gi|2605995 5 (post translational regulator. Counterparts: HSV1 UL54, VZV 4)
HSV1_#58 gi|59554 UL54 Nucleotidylylated multifunction regulatory prot. Negitively regulates early genes, positively late genes. Inhibits splicing?
HSV2_#58 gi|1869878UL54 (immediate early post translational regulator of gene expression)
VZV_#4 gi|59993 ORF4 (AA1-452)
EBV_#27 gi|1632790 BMLF1 early reading frame. Diffuse early antigen (Cho
MHV68_#55 gi|2317957 immediate-early protein
HVS2_#58 gi|60378 ORF 57; EJRF1
Additional Members : Average Identity to Core : 0
6_27_Ribonucleotide Reductase, Small sub-unit
Core Members : Average percent Identity : 41.78275
EHV1_#20 gi|330812 ribonucleotide reductase RR2
EHV2_#61 gi|695233 ribonucleotide reductase, small subunit
EHV4_#20 gi|2605963 20 (small subunit of ribonucleotide reductase)
HSV1_#43 gi|59540 ribonucleotide reductase small subunit
HSV2_#43 gi|1869863 ribonucleotide reductase small subunit
VZV_#18 gi|60007 ORF18 (AA1-306)
EBV_#24 gi|1334857 BaRF1 early reading frame, homologous to HSV 38K ribonucleotide reduc
MHV68_#58 gi|2317992 ribonucleotide reductase small
HVS2_#61 gi|60381 ribonucleotide reductase,small subunit
Additional Members : Average Identity to Core : 0
6_28_Minor Capsid Protein
Core Members : Average percent Identity : 21.4712954545455
EHV1_#56 gi|330847 virion protein
EHV2_#44 gi|695216 minor capsid protein
EHV4_#56 gi|2606002 56 (Minor capsid protein; role in DNA packaging)
HCMV_#119 gi|1780884 HCMVUL104
HSV1_#8 gi|59506 minor capsid protein
HSV2_#8 gi|1869828 minor capsid protein
VZV_#53 gi|60043 ORF 54 (AA1-769)
EBV_#55 gi|1334884 BBRF1 late reading frame, homologous to RF 54 VZV
HHV6_#86 gi|854055 U76 (possible virion protein)
HHV7_#80 gi|1139677 putative viron protein
MHV68_#40 gi|2317981 capsid protein
HVS2_#44 gi|60365 ORF 43; sim. to other HV
Additional Members : Average Identity to Core : 0
6_29_Unknown
Core Members : Average percent Identity : 24.2803333333333
EHV2_#54 gi|695226 ORF 53
HCMV_#87 gi|1780850 HCMVUL73
EBV_#32 gi|1334865 BLRF1 late reading frame
HHV6_#56 gi|854025 U46, membrane-secreted protein
HHV7_#51 gi|1139648 U46 gene product
MHV68_#50 gi|2317988 unknown
HVS2_#54 gi|60374 ORF 53; EDLF2; sim. to other HV
Additional Members : Average Identity to Core : 0
6_30_Unknown
Core Members : Average percent Identity : 18.0368095238095
EHV2_#24 gi|695196 ORF 24
HCMV_#102 gi|1780865 HCMVUL87
EBV_#74 gi|1632799 BcRF1 reading frame
HHV6_#68 gi|854037 U58 (AKA 5R; homologue: HCMV UL87, HVS 24, EBV BcRF1)
HHV7_#64 gi|1139661 U58 gene product
MHV68_#22 gi|2317976 unknown
HVS2_#25 gi|60345 ORF 24; sim. to other HV
Additional Members : Average Identity to Core : 0
6_31_ssDNA Binding Protein
Core Members : Average percent Identity : 27.1420909090909
EHV1_#31 gi|330823 single stranded DNA binding protein
EHV2_#6 gi|695178 single-stranded DNA binding protein
EHV4_#31 gi|2605975 31 (ssDNA binding protein)
HCMV_#71 gi|1780835 Major DNA binding protein
HSV1_#32 gi|59529 UL29 ssDNA binding protein
HSV2_#32 gi|1869852 UL29 (ssDNA binding protein)
VZV_#29 gi|60018 ORF29 (AA1-1204)
EBV_#87 gi|1334916 BALF2 early reading frame, homologous to RF 29 VZV and major DNA bind
HHV6_#51 gi|854020 U41, major DNA binding protein
HHV7_#46 gi|1139643 major DNA binding protein
MHV68_#6 gi|2317927 ssDNA binding protein
HVS2_#7 gi|60327 major ssDNA-binding protein
Additional Members : Average Identity to Core : 0
6_32_DNA cleavage/Packaging Protein...virion or transport protein?
Core Members : Average percent Identity : 24.3074545454545
EHV1_#32 gi|330824 virion protein
EHV2_#7 gi|695179 ORF 07 (role in capsid maturation/DNA packaging)
EHV4_#32 gi|2605976 32 (role in DNA packaging; counterparts: HSV1 UL28, VZV 30)
HCMV_#70 gi|1780834 HCMVUL56
HSV1_#31 gi|59528 UL28 Req for DNA cleavage-packaging
HSV2_#31 gi|1869851 UL28 (role in DNA packaging)
VZV_#30 gi|60019 ORF30 (AA1-770)
EBV_#86 gi|1334915 BALF3 reading frame
HHV6_#50 gi|854019 U40 (AKA tp; transport capsid assembly protein?)
HHV7_#45 gi|1139642 U40 gene product (transport protein)
MHV68_#7 gi|2317928 transport protein
HVS2_#8 gi|60328 transport protein
Additional Members : Average Identity to Core : 0
6_33_Unknown
Core Members : Average percent Identity : 23.023380952381
EHV2_#31 gi|695203 ORF 31
HCMV_#107 gi|1780870 HCMVUL92
EBV_#68 gi|1334897 BDLF4 early reading frame
HHV6_#73 gi|854042 U63 (AKA 9R; homologues: HCMV UL92, HVS 31, EBV BDLF4)
HHV7_#68 gi|1139665 U63 gene product
MHV68_#28 gi|2317942 unknown
HVS2_#32 gi|60351 ORF 31; sim. to other HV
6_34_Glycoprotein B Role in Cell entry
Core Members : Average percent Identity : 19.3601818181818
EHV1_#33 gi|330825 membrane glycoprotein B
EHV2_#8 gi|695180 glycoprotein B
EHV4_#33 gi|2605977 33 (envelope glyco protein gB role in cell entry)
HCMV_#69 gi|1780833 Glycoprotein B (9)
HSV1_#30 gi|59527 virion glycoprot B, cell entry, dimer, induces neutralizing antibody.
HSV2_#30 gi|1869850glycoprotein B
VZV_#31 gi|60020 ORF31 (AA1-868)
EBV_#85 gi|1334914 BALF4 late reading frame 9xNXT/S homologous to HSV1 glycoprotein B (P
HHV6_#49 gi|854018 U39, glycoprotein B (infection)
HHV7_#44 gi|1139641 glycoprotein B
MHV68_#8 gi|2317929 glycoprotein B
HVS2_#9 gi|60329 glycoprotein B
Additional Members : Average Identity to Core : 13.122
HHV6_#71 gi|854040 U61
6_35_Capsid Protein
Core Members : Average percent Identity : 28.2419236641221
EHV1_#44 gi|330836 capsid protein
EHV2_#26 gi|695198 capsid protein
EHV4_#44 gi|2605989 43 (capsid protein, component of intercapsomeric triplex)
HCMV_#100 gi|1780863 HCMVUL85
HSV1_#20 gi|59518 capsid protein
HSV2_#20 gi|1869840 capsid protein
VZV_#41 gi|60030 ORF41 (AA1-316)
EBV_#72 gi|1334901 BDLF1 late reading frame, poor homology to RF 41 VZV
HHV6_#66 gi|854035 U56 (probable capsid protein)
HHV7_#62 gi|1139659 putative capsid protein
MHV68_#24 gi|2317939 capsid protein
HVS2_#27 gi|60347 ORF 26; sim. to other HV
Additional Members : Average Identity to Core : 0
6_36_Capsid Maturation/DNA packaging
Core Members : Average percent Identity : 21.5293611111111
EHV1_#27 gi|330819 ORF 27
EHV2_#69 gi|695241 ORF 67A (role in capsid maturation/DNA packaging)
EHV4_#27 gi|2605970 27 (role in DNA packaging)
HCMV_#65 gi|1780829 HCMVUL51
HSV1_#36 gi|59532 UL33 DNA packaging
HSV2_#36 gi|1869856 UL33 (role in DNA packaging)
VZV_#25 gi|60015 ORF25 (AA1-156)
HHV6_#45 gi|854014 U35 (AKA XILF1; homologues: HCMV UL51, EHV1 27, VZV 25, HSV1 UL33)
HHV7_#40 gi|1139637 U35 gene product
6_37_Unknown
Core Members : Average percent Identity : 22.6166190476191
EHV2_#35 gi|695207 ORF 34
HCMV_#110 gi|1780873 HCMVUL95
EBV_#63 gi|1334894 BGLF3 reading frame
HHV6_#77 gi|854046 U67 (AKA 13R; homologues:HCMVUL95, HVS 34, EBV BGLF3 EHV1 48, VZV 46, HSV1 UL14)
HHV7_#71 gi|1139668 U67 gene product
MHV68_#32 gi|2317945 unknown
HVS2_#35 gi|60354 ORF 34; sim. to other HV
Additional Members : Average Identity to Core : 0
6_38_Virion Protein
Core Members : Average percent Identity : 19.3789545454546
EHV1_#28 gi|330820 virion protein
EHV2_#71 gi|695243 ORF 68
EHV4_#28 gi|2605971 28 (role in DNA packaging)
HCMV_#66 gi|1780830 HCMVUL52
HSV1_#35 gi|59533 UL32 ts mutant is deficient in DNA packaging
HSV2_#35 gi|1869855 UL32
VZV_#26 gi|60014 ORF26 (AA1-585)
EBV_#16 gi|1334849 BFLF1 reading frame, 2 NXT/S homologous to RF 26 in VZV and HFRF1 in
HHV6_#46 gi|854015 U36 (AKA XIRF1; sim to HCMV UL52, HVS 68, EBV BFLF1, EHV1 28, VZV 26 HSV1 UL32)
HHV7_#41 gi|1139638 putative virion protein
MHV68_#66 gi|2317960 glycoprotein
HVS2_#69 gi|60389 ORF 68; ECRF1; sim. to other HV
Additional Members : Average Identity to Core : 0
6_39_Unknown
Core Members : Average percent Identity : 23.1423636363636
EHV1_#29 gi|330821 ORF 29
EHV2_#72 gi|695244 ORF 69
EHV4_#29 gi|2605972 29
HCMV_#67 gi|1780831 HCMVUL53
HSV1_#34 gi|59531|gnl|PID|e312346 UL31
HSV2_#34 gi|1869854|gnl|PID|e304176 UL31
VZV_#27 gi|60016 ORF27 (AA1-333)
HHV6_#47 gi|854016 U37
HHV7_#42 gi|1139639 U37 gene product
MHV68_#67 gi|2317961 unknown
HVS2_#70 gi|60390 ORF 69; ECRF2; sim. to other HV
Additional Members : Average Identity to Core : 0