This file contains a list of COGs in the following format:
CSN_COG#_one line description of COG members
Average identity between core members (genes that are members due to congruent BeTs)
List of genes in COG core in this format:
[Virus_#gene number] [the sequence's PID number] [Genbank annotation] [add. annotation (op.)]
Average identity to the core members of the additional members
List of genes that are Additional Members of the COG
(due to non-congruent BeTs to Core members) Same format as core.
The COG# assigned each COG is arbitrary and not related to the number assigned any similar COGs at other CSNs. The "gene number" after the "#" was assigned for internal reference purposes.
COG Stringency Number for cores is 8
COG Stringency Number for addition is 8
8_1_DNA cleavage/transport
Core Members : Average percent Identity :24.3074545454545
EHV1_#32 gi|330824 virion protein
EHV2_#7 gi|695179 ORF 07
EHV4_#32 gi|2605976 32
HCMV_#70 gi|1780834 HCMVUL56
HSV1_#31 gi|59528|gnl|PID|e312343 UL28
HSV2_#31 gi|1869851|gnl|PID|e304174 UL28
VZV_#30 gi|60019 ORF30 (AA1-770)
EBV_#86 gi|1334915|gnl|PID|e24996 BALF3 reading frame
HHV6_#50 gi|854019 U40
HHV7_#45 gi|1139642 U40 gene product
MHV68_#7 gi|2317928 transport protein
HVS2_#8 gi|60328 transport protein
Additional Members : Average Identity to Core : 0
8_2_glycoprotein B
Core Members : Average percent Identity : 19.3601818181818
EHV1_#33 gi|330825 membrane glycoprotein B
EHV2_#8 gi|695180 glycoprotein B
EHV4_#33 gi|2605977 33
HCMV_#69 gi|1780833 Glycoprotein B (9)
HSV1_#30 gi|59527|gnl|PID|e312342 virion glycoprotein B
HSV2_#30 gi|1869850|gnl|PID|e304272 glycoprotein B
VZV_#31 gi|60020 ORF31 (AA1-868)
EBV_#85 gi|1334914 BALF4 late reading frame 9xNXT/S homologous to HSV1 glycoprotein B (P
HHV6_#49 gi|854018 U39, glycoprotein B
HHV7_#44 gi|1139641 glycoprotein B
MHV68_#8 gi|2317929 glycoprotein B
HVS2_#9 gi|60329 glycoprotein B
Additional Members : Average Identity to Core : 0
8_3_dUTPase
Core Members : Average percent Identity : 19.7846222222222
EHV1_#9 gi|330801 dUTPase
EHV2_#55 gi|695227 ORF 54
EHV4_#9 gi|2606026 9
HSV1_#54 gi|59550|gnl|PID|e312366 deoxyuridine triphosphatase
HSV2_#54 gi|1869874|gnl|PID|e304281 deoxyuridine triphosphatase
VZV_#8 gi|59997 ORF8 (AA1-396)
EBV_#31 gi|1334864 BLLF3 early reading frame (BLLF2 in Baer et al, 1984). Homologous to
IHV_#49 gi|331259 dUTPase
MHV68_#51 gi|2317954 dUTPase
HVS2_#55 gi|60375 dUTPase
Additional Members : Average Identity to Core : 0
8_4_virion protein kinase
Core Members : Average percent Identity : 17.2192846153846
EHV1_#49 gi|330840 virion protein kinase
EHV2_#37 gi|695209 virion protein kinase
EHV4_#49 gi|2605994 49
HCMV_#112 gi|1780876 Phosphotransferase? (13)
HSV1_#15 gi|59514|gnl|PID|e312327 protein kinase
HSV2_#15 gi|1869835|gnl|PID|e304164 protein kinase
VZV_#46 gi|60036 ORF 47 (AA1-510)
EBV_#62 gi|1334892|gnl|PID|e25030 BGLF4 early reading frame, homologous to RF 47 VZV
HHV6_#79 gi|854048 U69, ganciclovir kinase, phosphotransferase
HHV7_#73 gi|1139670 phosphotransferase
MHV68_#34 gi|2317947 kinase
HVS2_#37 gi|60357 tyrosine-specific protein kinase
Additional Members : Average Identity to Core : 0
8_5_unknown
Core Members : Average percent Identity : 20.7121550387597
EHV1_#55 gi|330846 ORF 55
EHV2_#43 gi|695215 ORF 42
EHV4_#55 gi|2606001 55
HCMV_#118 gi|1780882 HCMVUL103
HSV1_#9 gi|59508|gnl|PID|e312321 UL7
HSV2_#9 gi|1869829|gnl|PID|e304160 UL7
VZV_#52 gi|60042 ORF 53 (AA1-331)
EBV_#56 gi|1632797|gnl|PID|e25024 BBRF2 late reading frame, homologous to RF 53 VZV
HHV6_#85 gi|854054 U75
HHV7_#79 gi|1139676 U75 gene product
MHV68_#39 gi|2317980 unknown
HVS2_#43 gi|60363 ORF 42; sim. to other HV
Additional Members : Average Identity to Core : 0
8_6_capsid associated tegument protein
Core Members : Average percent Identity : 24.0343787878788
EHV1_#37 gi|330829 virion protein
EHV2_#19 gi|695191 tegument protein
EHV4_#37 gi|2605981 36
HCMV_#91 gi|1780854 HCMVUL77
HSV1_#27 gi|59525|gnl|PID|e312339 capsid associated tegument protein
HSV2_#27 gi|1869847|gnl|PID|e304271 capsid associated tegument protein
VZV_#34 gi|60023 ORF34 (AA1-579)
EBV_#79 gi|1334908 BVRF1 early reading frame, homologous to RF 34 VZV
HHV6_#60 gi|854029 U50
HHV7_#55 gi|1139652 viron protein
MHV68_#17 gi|2317973 tegument protein
HVS2_#20 gi|60340 ORF 19; sim. to other HV
Additional Members : Average Identity to Core : 0
8_7_protease/scaffold/assembly
Core Members : Average percent Identity : 23.9678409090909
EHV1_#36 gi|330827 protease
EHV2_#17 gi|695188 proteinase/capsid scaffold protein
EHV4_#36 gi|2605979 35
HCMV_#94 gi|1780857 HCMVUL80
HSV1_#28 gi|59526|gnl|PID|e312340 protease
HSV2_#28 gi|1869848|gnl|PID|e304172 protease
VZV_#33 gi|60022 ORF33 (AA1-605)
EBV_#80 gi|1334909 BVRF2 early reading frame, N-terminus homologous to RF 33 VZV
HHV6_#63 gi|854032 U53, protease-assembly protein
HHV7_#58 gi|1139655 protease
MHV68_#15 gi|2317972 capsid protein
HVS2_#18 gi|60339 ORF 17; similarity to other herpesviruses (HV)
Additional Members : Average Identity to Core : 0
8_8_capsid
Core Members : Average percent Identity : 28.2419236641221
EHV1_#44 gi|330836 capsid protein
EHV2_#26 gi|695198 capsid protein
EHV4_#44 gi|2605989 43
HCMV_#100 gi|1780863 HCMVUL85
HSV1_#20 gi|59518|gnl|PID|e312332 capsid protein
HSV2_#20 gi|1869840|gnl|PID|e304167 capsid protein
VZV_#41 gi|60030 ORF41 (AA1-316)
EBV_#72 gi|1334901 BDLF1 late reading frame, poor homology to RF 41 VZV
HHV6_#66 gi|854035 U56
HHV7_#62 gi|1139659 putative capsid protein
MHV68_#24 gi|2317939 capsid protein
HVS2_#27 gi|60347 ORF 26; sim. to other HV
Additional Members : Average Identity to Core : 0
8_9_major capsid protein
Core Members : Average percent Identity : 33.7684090909091
EHV1_#43 gi|330835 major capsid protein
EHV2_#25 gi|695197 capsid protein
EHV4_#43 gi|2605988 42
HCMV_#101 gi|1780864 Major capsid protein (12)
HSV1_#21 gi|59519|gnl|PID|e312333 major capsid protein
HSV2_#21 gi|1869841|gnl|PID|e304168 major capsid protein
VZV_#40 gi|60029 ORF40 (AA1-1396)
EBV_#73 gi|1334902 BcLF1 late reading frame, homologous to RF 40 VZV and major capsid pr
HHV6_#67 gi|854036 U57, major capsid protein
HHV7_#63 gi|1139660 major capsid protein
MHV68_#23 gi|2317938 major capsid protein
HVS2_#26 gi|60346 major capsid protein
Additional Members : Average Identity to Core : 0
8_10_DNA packaging
Core Members : Average percent Identity : 22.8097876712329
EHV1_#45 gi|330792 DNA packaging protein
EHV2_#29 gi|695201 ORF 29b; possible terminase; ORF 29a and 29b probably expressed as a s
EHV4_#45 gi|2605992 47/44
HCMV_#104 gi|1813970|gnl|PID|e298607 Conserved herpesvirus spliced gene
HSV1_#17 gi|59501|gnl|PID|e312331 UL15
HSV2_#17 gi|1869837|gnl|PID|e304165 UL15
VZV_#44 gi|60034 ORF45 (spliced to ORF42) (352 AA)
EBV_#65 gi|1632798|gnl|PID|e276433 probable DNA packaging protein
HHV6_#70 gi|854039 U60, late spliced gene(U60-66)
HHV7_#66 gi|1139663 late spliced gene
IHV_#62 gi|331210 terminase
MHV68_#26 gi|2317977 packaging protein
HVS2_#30 gi|60355 ORF 29; conserved spliced gene
Additional Members : Average Identity to Core : 19.4873255813954
EHV2_#34 gi|695206 ORF 29a; expression of ORF 29a and 29b is likely as a spliced mRNA
EBV_#64 gi|1334893 BGRF1 reading frame, homologous to RF 45 VZV and spliced HSV gene (Co
EBV_#69 TRANSLATE of: v01555 check: 1039 from: 129188 to: 130348
HHV6_#76 gi|854045 U66, late spliced gene (U60- 66)
MHV68_#31 gi|2317978 packaging protein
8_11_alkaline exonuclease
Core Members : Average percent Identity : 18.363303030303
EHV1_#50 gi|330841 deoxyribonuclease
EHV2_#38 gi|695210 deoxyribonuclease
EHV4_#50 gi|2605996 50
HCMV_#113 gi|1780877 DNase homologue
HSV1_#14 gi|59513|gnl|PID|e312326 deoxyribonuclease
HSV2_#14 gi|1869834|gnl|PID|e304266 deoxyribonuclease
VZV_#47 gi|60037 ORF 48 (AA1-551)
EBV_#61 gi|1334891 BGLF5 early reading frame, homologous to RF 48 VZV and alkaline exonu
HHV6_#80 gi|854049 U70, alkaline exonuclease
HHV7_#74 gi|1139671 alkaline exonuclease
MHV68_#35 gi|2317948 alkaline exonuclease
HVS2_#38 gi|60358 alkaline exonuclease
Additional Members : Average Identity to Core : 0
8_12_minor capsid protein
Core Members : Average percent Identity : 21.4712954545455
EHV1_#56 gi|330847 virion protein
EHV2_#44 gi|695216 minor capsid protein
EHV4_#56 gi|2606002 56
HCMV_#119 gi|1780884 HCMVUL104
HSV1_#8 gi|59506|gnl|PID|e312320 minor capsid protein
HSV2_#8 gi|1869828|gnl|PID|e304264 minor capsid protein
VZV_#53 gi|60043 ORF 54 (AA1-769)
EBV_#55 gi|1334884 BBRF1 late reading frame, homologous to RF 54 VZV
HHV6_#86 gi|854055 U76
HHV7_#80 gi|1139677 putative viron protein
MHV68_#40 gi|2317981 capsid protein
HVS2_#44 gi|60365 ORF 43; sim. to other HV
Additional Members : Average Identity to Core : 0
8_13_helicase/primase complex
Core Members : Average percent Identity : 26.7292380952381
EHV1_#57 gi|330848 encodes for a protein associated with a DNA helicase/primase complex;
EHV2_#45 gi|695217 DNA helicase-primase complex component
EHV4_#57 gi|2606003 57
HCMV_#120 gi|1780883 Homology to helicases
HSV1_#7 gi|59507|gnl|PID|e312319 UL5
HSV2_#7 gi|1869827|gnl|PID|e304159 UL5
VZV_#54 gi|60044 ORF 55 (AA1-881)
EBV_#54 gi|1334885 BBLF4 early reading frame, very good homology to RF55 VZV
HHV6_#87 gi|854056 old name HDRF2; helicase, part of helicase-primase complex, homologue
HHV7_#81 gi|1139678 helicase
IHV_#25 gi|331235 SFI helicase
MHV68_#41 gi|2317951 helicase-primase
HVS2_#45 gi|60364 helicase
Additional Members : Average Identity to Core : 0
8_14_uracil DNA glycosylase
Core Members : Average percent Identity : 28.7044242424243
EHV1_#61 gi|330852 uracil-DNA glycosylase
EHV2_#47 gi|695219 uracil DNA glycosylase
EHV4_#61 gi|2606008 61
HCMV_#131 gi|1780896 Homology to uracil-DNA glycosylase
HSV1_#4 gi|59503|gnl|PID|e312316 uracil-DNA glycosylase
HSV2_#4 gi|1869824|gnl|PID|e304157 uracil-DNA glycosylase
VZV_#58 gi|60048 ORF 59 (AA1-305)
EBV_#52 gi|1632795|gnl|PID|e25020 BKRF3 reading frame, homologous to RF 59 VZV
HHV6_#90 gi|854059 U81, uracil-DNA glycosylase
HHV7_#86 gi|1139683 uracil-DNA glycosylase
MHV68_#43 gi|2317983 uracil DNA glycosylase
HVS2_#47 gi|60367 uracil DNA glucosidase
Additional Members : Average Identity to Core : 0
8_15_unknown
Core Members : Average percent Identity : 28.6021732283465
EHV1_#38 gi|330830 ORF 37
EHV2_#20 gi|695192 ORF 20
EHV4_#38 gi|2605982 37
HCMV_#90 gi|1780853 HCMVUL76
HSV1_#26 gi|59523|gnl|PID|e312338 UL24
HSV2_#26 gi|1869846|gnl|PID|e304171 UL24
VZV_#35 gi|60024 ORF35 (AA1-258)
EBV_#78 gi|1334906 BXRF1 late reading frame, homologous to RF 35 VZV. Basic (core?) prot
HHV6_#59 gi|854028 U49
HHV7_#54 gi|1139651 U49 gene product
MHV68_#18 gi|2317974 unknown
HVS2_#21 gi|60342 ORF 20; sim. to other HV
Additional Members : Average Identity to Core : 0
8_16_glycoprotein M
Core Members : Average percent Identity : 26.0679696969697
EHV1_#52 gi|330843 membrane protein
EHV2_#40 gi|695212 glycoprotein M
EHV4_#52 gi|2605998 52
HCMV_#115 gi|1780879 Multiple hydrophobic domains
HSV1_#12 gi|59510|gnl|PID|e312324 virion glycoprotein M
HSV2_#12 gi|1869832|gnl|PID|e304162 virion glycoprotein M
VZV_#49 gi|60040 ORF 50 (AA1-435)
EBV_#59 gi|1334889 BBRF3 late reading frame
HHV6_#82 gi|854051 U72, integral membrane protein, glycoprotein M, gM
HHV7_#76 gi|1139673 glycoprotein M
MHV68_#37 gi|2317979 glycoprotein M
HVS2_#40 gi|60360 integral membrane protein
Additional Members : Average Identity to Core : 0
8_17_helicase/primase
Core Members : Average percent Identity : 20.5429848484849
EHV1_#7 gi|330799 encodes for a protein associated with a DNA helicase/primase complex;
EHV2_#57 gi|695229 DNA helicase-primase complex component
EHV4_#7 gi|2606017 7
HCMV_#84 gi|1780848|gnl|PID|e27270 Homology to HSV-1 protein required for DNA replication
HSV1_#56 gi|59552|gnl|PID|e312368 UL52
HSV2_#56 gi|1869876|gnl|PID|e304282 UL52
VZV_#6 gi|59995 ORF6 (AA1-1083)
EBV_#29 gi|1334862 BSLF1 reading frame, homologous to RF 6 VZV
HHV6_#53 gi|854022 U43, helicase-primase complex
HHV7_#48 gi|1139645 primase
MHV68_#53 gi|2317955 DNA replication protein
HVS2_#57 gi|60376 ORF 56; EDRF4; sim. to other HV
Additional Members : Average Identity to Core : 0
8_18_ribonucleotide reductase small subunit
Core Members : Average percent Identity : 41.78275
EHV1_#20 gi|330812 ribonucleotide reductase RR2
EHV2_#61 gi|695233 ribonucleotide reductase, small subunit
EHV4_#20 gi|2605963 20
HSV1_#43 gi|59540|gnl|PID|e312355 ribonucleotide reductase small subunit
HSV2_#43 gi|1869863|gnl|PID|e304277 ribonucleotide reductase small subunit
VZV_#18 gi|60007 ORF18 (AA1-306)
EBV_#24 gi|1334857 BaRF1 early reading frame, homologous to HSV 38K ribonucleotide reduc
MHV68_#58 gi|2317992 ribonucleotide reductase small
HVS2_#61 gi|60381 ribonucleotide reductase,small subunit
Additional Members : Average Identity to Core : 0
8_19_ribonucleotide reductase large subunit
Core Members : Average percent Identity : 20.6603257575758
EHV1_#21 gi|330813 ribonucleotide reductase RR1
EHV2_#62 gi|695234 ribonucleotide reductase, large subunit
EHV4_#21 gi|2605964 21
HCMV_#59 gi|1780823 Homology to large subunit of ribonucleotide reductase
HSV1_#42 gi|59539|gnl|PID|e312354 ribonucleotide reductase large subunit
HSV2_#42 gi|1869862|gnl|PID|e304181 ribonucleotide reductase large subunit
VZV_#19 gi|60008 ORF19 (AA1-775)
EBV_#23 gi|1334856 BORF2 early reading frame, 2 NXT/S. Homology HSV 140K ribonucleotide
HHV6_#38 gi|854007 U28, RR1
HHV7_#33 gi|1139630 ribonucleotide reductase, large subunit
MHV68_#59 gi|2317993 ribonucleotide reductase large
HVS2_#62 gi|60382 ribonucleotide reductase,large subunit
Additional Members : Average Identity to Core : 0
8_20_unknown
Core Members : Average percent Identity : 21.5293611111111
EHV1_#27 gi|330819 ORF 27
EHV2_#69 gi|695241 ORF 67A
EHV4_#27 gi|2605970 27
HCMV_#65 gi|1780829 HCMVUL51
HSV1_#36 gi|59532|gnl|PID|e312348 UL33
HSV2_#36 gi|1869856|gnl|PID|e304177 UL33
VZV_#25 gi|60015 ORF25 (AA1-156)
HHV6_#45 gi|854014 U35
HHV7_#40 gi|1139637 U35 gene product
Additional Members : Average Identity to Core : 0
8_21_virion protein
Core Members : Average percent Identity : 19.3789545454546
EHV1_#28 gi|330820 virion protein
EHV2_#71 gi|695243 ORF 68
EHV4_#28 gi|2605971 28
HCMV_#66 gi|1780830 HCMVUL52
HSV1_#35 gi|59533|gnl|PID|e312347 UL32
HSV2_#35 gi|1869855|gnl|PID|e304274 UL32
VZV_#26 gi|60014 ORF26 (AA1-585)
EBV_#16 gi|1334849 BFLF1 reading frame, 2 NXT/S homologous to RF 26 in VZV and HFRF1 in
HHV6_#46 gi|854015 U36
HHV7_#41 gi|1139638 putative virion protein
MHV68_#66 gi|2317960 glycoprotein
HVS2_#69 gi|60389 ORF 68; ECRF1; sim. to other HV
Additional Members : Average Identity to Core : 0
8_22_DNA polymerase
Core Members : Average percent Identity : 27.5661212121212
EHV1_#30 gi|330822 DNA polymerase
EHV2_#9 gi|695181 DNA polymerase replicative subunit
EHV4_#30 gi|2605974 30
HCMV_#68 gi|1780832 DNA polymerase (8)
HSV1_#33 gi|59530|gnl|PID|e312345 DNA polymerase
HSV2_#33 gi|1869853|gnl|PID|e304175 DNA polymerase
VZV_#28 gi|60017 ORF28 (AA1-1194)
EBV_#84 gi|1334913 BALF5 DNA polymerase (early), homologous to many DNA polymerases, CMV
HHV6_#48 gi|854017 U38, DNA polymerase
HHV7_#43 gi|1139640 DNA polymerase
MHV68_#9 gi|2317930 DNA polymerase
HVS2_#10 gi|60330 DNA polymerase
Additional Members : Average Identity to Core : 0
8_23_unknown
Core Members : Average percent Identity : 23.1423636363636
EHV1_#29 gi|330821 ORF 29
EHV2_#72 gi|695244 ORF 69
EHV4_#29 gi|2605972 29
HCMV_#67 gi|1780831 HCMVUL53
HSV1_#34 gi|59531|gnl|PID|e312346 UL31
HSV2_#34 gi|1869854|gnl|PID|e304176 UL31
VZV_#27 gi|60016 ORF27 (AA1-333)
HHV6_#47 gi|854016 U37
HHV7_#42 gi|1139639 U37 gene product
MHV68_#67 gi|2317961 unknown
HVS2_#70 gi|60390 ORF 69; ECRF2; sim. to other HV
Additional Members : Average Identity to Core : 0
8_24_single stranded DNA binding protein
Core Members : Average percent Identity : 27.1420909090909
EHV1_#31 gi|330823 single stranded DNA binding protein
EHV2_#6 gi|695178 single-stranded DNA binding protein
EHV4_#31 gi|2605975 31
HCMV_#71 gi|1780835 Major DNA binding protein
HSV1_#32 gi|59529|gnl|PID|e312344 UL29
HSV2_#32 gi|1869852|gnl|PID|e304273 UL29
VZV_#29 gi|60018 ORF29 (AA1-1204)
EBV_#87 gi|1334916 BALF2 early reading frame, homologous to RF 29 VZV and major DNA bind
HHV6_#51 gi|854020 U41, major DNA binding protein
HHV7_#46 gi|1139643 major DNA binding protein
MHV68_#6 gi|2317927 ssDNA binding protein
HVS2_#7 gi|60327 major ssDNA-binding protein
Additional Members : Average Identity to Core : 0
8_25_unknown
Core Members : Average percent Identity : 23.2209714285714
EHV1_#47 gi|330838 ORF 46
EHV2_#33 gi|695205 ORF 33
EHV4_#47 gi|2605991 46
HCMV_#109 gi|1780872 HCMVUL94
HSV1_#18 gi|59516|gnl|PID|e312329 UL16
VZV_#43 gi|60033 ORF44 (AA1-363)
EBV_#66 gi|1334895 BGLF2 late reading frame, poor homology to RF 44 VZV
HHV6_#75 gi|854044 U65
HHV7_#70 gi|1139667 U65 gene product
MHV68_#30 gi|2317944 unknown
HVS2_#34 gi|60353 ORF 33; sim. to other HV
Additional Members : Average Identity to Core : 0