Fig. 6. Impaired osmotic regulation in trpv4^-/- mice. (A) Impaired drinking of trpv4^-/- mice after systemic osmotic challenge with 0.5 M NaCl (i.p. administration): latency of drinking behavior. Initiation of drinking behavior was found to be significantly delayed in trpv4^-/- mice. (B) Response to chronic systemic administration of the ADH analogue, dDAVP: urine osmolality. Osmolality was determined in urine while mice received dDAVP. Urine was collected at the same time of bleeding. Note a urine osmolality of >3,500 milliosmol/kg in both genotypes, and the absence of significant differences.