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The A20-dependent degradation of TRAF2 requires the membrane tethering activity of A20, but not its ubiquitin-modifying function. (A) Schematic representation of the A20 constructs (OTU, ovarian tumor; NZF, Npl4 zinc finger). Arrows indicate the location of the mutations. (B) The degradation of TRAF2 in 293Tcells expressing the indicated A20 variants was analyzed by pulse chase experiment. Asterisk indicates a non-specific protein. (C) Quantification of the experiment in (B).
