Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice -- Data Supplement - Supplemental Fig. 7 -- Proceedings of the National Academy of Sciences

Supplementary material for Travis et al. (2000) Proc. Natl. Acad. Sci. USA 97 (1), 162-167.

Fig. 7.
Fast-scan cyclic voltammograms recorded during chemical degranulation of a vesicular monoamine transporter (VMAT2)^-/- mast cell. Electrochemical current sampled at peak oxidation potentials for both histamine (upper line) and 5-hydroxytryptamine (5-HT) (lower line) are shown. The false color plot shows a slight current drift without any sharp current transients. (Right) A cyclic voltammogram obtained during a postexperiment calibration of the electrode is shown. Thus, the electrode was functional in its response to histamine and serotonin, and the absence of signals during cyclic voltammetry at the cell surface is because 5-HT and histamine are not secreted.