Unusual 1H NMR chemical shifts support (His) Cepsilon 1---H{middle dot}{middle dot}{middle dot}O==C H-bond: Proposal for reaction-driven ring flip mechanism in serine protease catalysis -- Data Supplement - Supplemental Data -- Proceedings of the National Academy of Sciences

Supplementary material for Ash et al. (2000) Proc. Natl. Acad. Sci. USA 97 (19), 10371-10376.

QuickTime Video Movie 1.
Video loop with sound effects for proposed model of reaction-driven imidazole ring flip mechanism in serine hydrolases containing the catalytic triad. We recommend that you enable the continuous looping option, if it is available on your video player program. Details of timing and exact geometries of reactants, product, and transition states are still largely unknown, and they should not be taken too literally, because the primary intent of the video is to teach and persuade viewers how the ring flip mechanism might achieve peptide hydrolysis based on classical mechanistic principles when combined with pure mechanical motion.