NOLC1, an Enhancer of Nasopharyngeal Carcinoma Progression, Is Essential for TP53 to Regulate MDM2 Expression
Am J Pathol Hwang et al. 175: 342
Supplemental Material
This supplemental material includes supporting data for this study.
Files in this Data Supplement:
- Supplemental Figure 1 - Determination of differential gene expression by complementary DNA (cDNA) microarray in NPC-TW04 and NNM cells. Microarray images show higher or lower expression of the genes in the NPC-TW04 cell line than in NNM cells. Arrow: the NOLC1 gene.
- Supplemental Figure 2 - Identification of NOLC1-regulated downstream genes in NPC-TW03 cells.
- Supplemental Figure 3 - Identification of NOLC1-regulated downstream genes in vivo. qRT-PCR analysis of the expression patterns of the TP53, TNF, and CASP1 genes in NPC-TW03 xenograft and shNOLC1-1-NPC-TW03 preserved xenograft tumor tissues.
- Supplemental Figure 4 - RT-PCR analysis of genes expressed in shNOLC1-1-NPC-TW03 cells.
- Supplemental Figure 5 - The effect of EBV infection on NOLC1 gene expression in NPC-TW cells.
- Supplemental Figure Legends
- Supplementary Table 1 - Selected genes were highly differentially expressed between NPC and NNM cells.
- Supplemental Table 2 - Full length mRNA of genes identified by screening phage lambdagt11 expression cDNA libraries from NPC.
