BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing -- Martin et al. 76 (2): 327 Data Supplement - Data Supplement -- Molecular Pharmacology

BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing
Mol Pharmacol Martin et al. 76: 327

Data Supplement

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Data Supplement -
Figure S1. Sorafenib and Vorinostat interact to kill rodent pancreatic tumor cells. ...
Figure S2. Sorafenib and Vorinostat enhance Grp78/BiP association with CD95 in a FADD-dependent fashion. ...
Figure S3. Sorafenib and Vorinostat interact to increase PERK and eIF2a phosphorylation and decrease pro-BID levels....
Figure S4. Expression of dominant negative MEK1 and dominant negative AKT enhances the toxicity of sorafenib+vorinostat exposure...
Figure S5. Knock out of BAX and BAK abolishes sorafenib and HDACI combination toxicity. ...
Data Supplement - Complete Figure Legends.