Supplementary material for Sandberg et al. (2000) Proc. Natl. Acad. Sci. USA 97 (20) 11038-11043.
Table 2.
Brain-region specific differences between mouse strainsGene name | Cb | Cx | Mb | Hp | Ag | Ec | Mf | Acc. no. | Gene name | Cb | Cx | Mb | Hp | Ag | Ec | Mf | Acc. no. |
Murine leukemia virus (pol) | ~49 | * | * | * | * | ~13 | A | AA087673 | Novel | = | = | = | 2.9 | * | 2.0 | * | AA289858 |
c-fos oncogene | ~11 | ~6 | = | = | A | A | A | V00727 | Phosphodiesterase I | = | = | * | 2.4 | = | = | A | AA059550 |
Novel | 8.4 | 8.4 | * | * | * | * | = | AA154646 | Novel | = | * | * | 2.4 | * | * | * | AA048853 |
Ataxia telangiectasia mutated | ~5 | * | * | * | * | * | * | U43678 | Kinesin heavy chain (Kif5b) | * | = | * | 1.8 | * | * | * | U86090 |
sim. Mito. enoyl-CoA hydratase (e-83) | 4.3 | * | = | = | = | = | = | AA270965 | Glutmate receptor 1 / AMPA1 | = | * | = | -1.9 | * | * | A | X57497 |
Novel | 4.2 | * | * | * | A | A | = | AA277082 | Nuclear factor I | * | * | * | -3.0 | * | * | A | ET63137 |
ADP-ribosylation factor 5 (ARF5) | 3.1 | * | * | * | * | * | A | D87902 | Novel | A | * | * | * | ~18 | * | A | W47728 |
sim. human beta tubulin 4 (e-35) | 2.2 | = | = | = | = | = | = | AA030364 | Phosphatidylethanolamine binding protein | * | * | * | * | 4.1 | 3.1 | * | W35778 |
Novel | 2.2 | * | = | * | * | * | * | AA276848 | sim.(MDG1) (e-109) | = | = | = | = | 3.2 | = | = | AA673251 |
Novel | 2.2 | = | * | * | * | = | = | AA530176 | Novel | = | = | = | = | 2 | = | = | AA237797 |
Novel | 2.2 | 1.9 | = | * | * | * | = | R75193 | Novel | = | = | = | * | -6.3 | * | A | C81189 |
Synaptotagmin 4 | 2.2 | = | = | * | * | * | A | U10355 | Acidic nuclear phosphoprotein pp32 | = | = | = | = | ~ -2 | * | A | U73478 |
Novel | 2 | * | * | * | * | 2.4 | = | C76063 | sim. to PI-4-phosphate 5-kinase (e-72) | = | = | = | = | -3.1 | = | A | AA623242 |
Novel | 1.9 | = | = | = | = | = | = | W34733 | Beta2-microglobulin (B2m) | * | * | * | * | * | ~19 | = | AA059700 |
T-complex testis-specific protein 1 | -1.9 | * | * | = | = | * | * | W15873 | sim. rat peroxisomal membrane protein | = | = | * | * | * | 2.1 | = | AA028386 |
Novel | -5.2 | * | * | * | * | * | A | AA023065 | Novel | * | * | * | * | * | 1.8 | = | AA198947 |
sim. Mito. NADH:ubiquitine oxidoreductase(e-108) | * | ~17 | * | * | * | * | = | W90880 | Alpha-globin | = | * | = | * | -2.8 | -2.7 | A | V00714 |
Neuronal Protein NP25 | * | ~15 | * | * | * | 2.2 | A | AA118297 | Alpha-globin | = | * | = | * | -3.1 | -2.1 | A | C77409 |
Novel | * | ~13 | * | * | * | * | A | AA288448 | Alpha-globin | = | * | * | * | * | -2.5 | A | C79775 |
Groucho-related gene 1 (Grg1) | A | 5.3 | * | = | = | * | = | U61362 | Novel | * | * | * | = | = | -2 | = | D18279 |
Myocyte specific enhancer factor 2 | A | 2.4 | A | ~9.8 | * | = | A | L13171 | Novel | * | * | * | = | = | -2.5 | * | D18376 |
Novel | * | 1.9 | * | 2.2 | 2.3 | * |
| AA035993 | SRY-box containing gene 11 | = | * | * | = | * | ~ -3 | = | AF009414 |
T-complex testis-specific protein 1 | * | * | -2.9 | = | * | * | * | M25825 | Novel | * | * | * | = | = | -6.3 | * | AA666918 |
Novel | * | * | -2.7 | * | = | * | * | R74815 | Novel | = | + | = | * | = | -7.6 | * | AA285607 |
Plasma glutathione peroxidase | + | * | ~ -9 | = | = | * | * | U13705 |
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Values represent fold change in comparisons of C57BL/6 to 129SvEv for cerebellum (Cb), cortex (Cx), midbrain (Mb), hippocampus (Hp), amygdala (Ag), and entorhinal cortex (Ec). Mf indicates a comparison between C57BL/6 and 129SvEv fibroblast samples. "A", absent or below the level of detectability; *, similar trend to that found in other brain regions; +, =1.8 fold change in the direction opposite to other brain regions; =, no change in expression level in the region for C57BL/6 compared to 129SvEv; Acc. no., accession number. Genes involved in transcription are in green, in vesicular transport/synaptic transmission in red, and signal transduction in blue. Several "novel" genes and genes with unknown function were also identified (black).