Acknowledgements

We thank Dr Peter Stephenson and Mrs Nan Keen who interpreted and Minnesota coded the ECG data, Professor John Mathers who advised on the interpretation of dietary data, Dr Charlotte Wright who converted growth data into standard deviation scores and advised on their interpretation, and Professor Stephanie Amiel who facilitated the carrying out of five health checks at King’s College Hospital, London.

Biochemical and haematological assays were carried out at the Spence Biochemical Genetics Laboratory and Department of Medicine, University of Newcastle and at the Department of Haematology, Freeman Hospital, Newcastle respectively. Ultrasonography of the carotid artery was carried out by Ann Harvey, Yasmin McGrady, and Dorothy Young in the Radiology Department of the Royal Victoria Infirmary, Newcastle. Food frequency questionnaires were analysed by the MRC Dunn Clinical Nutrition Centre, University of Cambridge.

Table A Representativeness of study sample by weight and social class at birth
 

Variable
No (%) of original cohort (n=1114)*
No (%) of study sample (n=347)*
Social class at birth  
I Professional
32 (2.9)
9 (2.6)
II Managerial
92 (8.3)
26 (7.5)
III Skilled manual
589 (52.9)
212 (61.1)
IV Semiskilled
165 (14.8)
44 (12.7)
V Unskilled
158 (14.2)
48 (13.8)
Unclassified
78 (7.0)
8 (2.3)
Birth weight  
<2.50 kg (5.5 lb)
42 (3.8)
11 (3.2)
<2.95 kg (6.5 lb)
192 (17.2)
63 (18.2)
<3.40 kg (7.5 lb)
388 (34.8)
106 (30.5)
<3.86 kg (8.5 lb)
316 (28.4)
109 (31.4)
<4.31 kg (9.5 lb)
136 (12.2)
46 (13.3)
>4.31 kg
34 (3.1)
11 (3.2)
Unknown
6 (0.5)
1 (0.3

*Excludes twins.