Antibiotic Treatment of Clostridium difficile Carrier Mice Triggers a Supershedder State, Spore-Mediated Transmission, and Severe Disease in Immunocompromised Hosts -- Lawley et al. 77 (9): 3661 Data Supplement - Supplemental material -- Infection and Immunity

Antibiotic Treatment of Clostridium difficile Carrier Mice Triggers a Supershedder State, Spore-Mediated Transmission, and Severe Disease in Immunocompromised Hosts
Infect. Immun. Lawley et al. 77: 3661

Supplemental material

Files in this Data Supplement:

Supplemental file 1 - Table S1. Data from 16S rRNA gene libraries from clindamycin-treated carrier mice.
MS Excel file, 103K.
Supplemental file 2 - Fig. S1. Genomic comparisons of a collection of C. difficile strains to isolates recovered from mouse feces and from an anesthetic chamber after transmission.
Fig. S2. Variable effects of long-term clindamycin treatment on the duration of the C. difficile supershedder state in mice.
Fig. S3. Supershedders efficiently transmit C. difficile to naive recipients.
Fig. S4. Pathological lesions within the kidneys and lungs of C. difficile-infected Myd88^-/- mice but not C. difficile-infected wild-type mice.
Zipped PDF file, 2.93 MB.
Supplemental file 3 - Legends for Fig. S1 through S4 and Table S1.
MS Word document, 24K.