The Carboxy-Terminal Tail of Human Cytomegalovirus (HCMV) US28 Regulates both Chemokine-Independent and Chemokine-Dependent Signaling in HCMV-Infected Cells -- Stropes et al. 83 (19): 10016 Data Supplement - Supplemental material -- The Journal of Virology

The Carboxy-Terminal Tail of Human Cytomegalovirus (HCMV) US28 Regulates both Chemokine-Independent and Chemokine-Dependent Signaling in HCMV-Infected Cells
J. Virol. Stropes et al. 83: 10016

Supplemental material

Files in this Data Supplement:

Supplemental file 1 - Fig. S1 (Restriction mapping and Southern hybridization confirm the integrity of the US28/FL1-314 mutant.)
Fig. S2 (US28-directed stimulation of Ca²⁺ release requires the amino-terminal ligand-binding domain.)
Fig. S3 (Determination of the EC50 for CCL5 and CX3CL1 induced Ca²⁺ signaling through US28.)
Fig. S4 (Agonist-independent US28 stimulated inositol phosphate accumulation requires Gq/11 proteins.)
Fig. S5 (US28 exhibits hyperactive signaling activity in βarrestin-deficient cells, indicating a failure to be regulated by the cellular desensitization machinery.)
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