Nitric Oxide Induces the Progression of Abdominal Aortic Aneurysms through the Matrix Metalloproteinase Inducer EMMPRIN
Am J Pathol Lizarbe et al. 175: 1421
Supplemental Material
This supplemental material includes supporting data for this study.
Files in this Data Supplement:
- Supplemental Figure 1 - A Verhoeff-van Gieson (VVG) staining of elastase in aortic sections from C57BL/6 (WT) and iNOS null mice collected at zero days and 15 days after elastase infusion.
- Supplemental Figure 2 - Lack of iNOS does not inhibit the expression of MMP-2 and MMP-9 in AAA.
- Supplemental Figure 3 - Lack of iNOS does not inhibit the expression of MMP-12 in AAA.
- Supplemental Figure 4 - Confocal microscopy detection of EMMPRIN in the aortas of 12 week old wild type mice injected with 5mM Spermidine-nonoate, 15 days after elastase infusion ((n=3 mice by triplicate).
- Supplemental Figure 5 - Exogenous administration of NO does not induce significant changes in the inflammatory response of elastase-infused mice.
- Supplemental Figure Legends
- Supplemental Table 1 - Characteristics of patients.