Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors -- Moura et al. 53 (12): 4968 Data Supplement - Supplemental material -- Antimicrobial Agents and Chemotherapy

Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors
Antimicrob. Agents Chemother. Moura et al. 53: 4968

Supplemental material

Files in this Data Supplement:

Supplemental file 1 - Table S1, showing susceptibility of plasmepsin single KO lines to protease inhibitors and chloroquine, and Table S2, showing susceptibility of plasmepsin multiple KO lines to protease inhibitors and chloroquine; Figure S1, showing chemical structures of compounds tested in the study; Figure S2, showing localization of PM V-mRFP and PM X-mRFP in live fluorescent trophozoite and schizont stage parasites; Fig. S3, showing results of an isobologram analysis of several different combinations of aspartic and cysteine protease inhibitors; Fig. S4, showing a sampling of Giemsa-stained images of parasites after 24 h of treatment with compounds tested at the time of protein harvest.
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