Supplemental Figure 1. Representative contour plots illustrating CBD effects upon spatiotemporal epileptiform burst features. (A) In the continued presence of Mg2+-free aCSF: (i) quiescent period between epileptiform burst events also showing hippocampal slice orientation, (ii) peak source in the absence of CBD (Supplemental video: mg_free.mpg) and (iii) peak source in the presence of CBD (100 μM; Supplemental video: mg_free_cbd.mpg). (B) In the continued presence of 100 μM 4-AP: (i) quiescent period between epileptiform burst events also showing hippocampal slice orientation, (ii) peak source in the absence of CBD (Supplemental video: 4ap.mpg) and (iii) peak source in the presence of CBD (100 μM; Supplemental video: 4ap_cbd.mpg). Note that supplemental video materials show two dimensional surface plots derived from the same recordings, slice orientations and amplitude scales (blue = sinks; red = sources) as still images shown in Supplemental Figure 1.
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