CAT-level p-values. ======================== This file lists the CAT-level p-values observed in the pairwise comparisons in the post-hoc analysis, for the 24 FragBag libraries, SGM, and the method of Zotenko et al. The numbers of proteins in each of the CAT-level categories are - Mainly-alpha: C A T no. of proteins 1 10 8 69 1 10 10 241 1 10 150 69 1 10 238 77 1 10 287 101 1 10 490 34 1 10 760 34 1 20 5 161 1 20 58 48 1 20 120 72 1 25 40 75 1 50 10 32 Mainly-beta: C A T no. of proteins 2 10 25 38 2 30 29 41 2 30 30 124 2 30 42 51 2 30 110 31 2 40 10 107 2 40 30 49 2 40 50 155 2 40 70 32 2 40 128 40 2 60 40 451 2 60 120 238 2 80 10 39 alpha + beta: C A T no. of proteins 3 10 20 96 3 10 100 32 3 10 129 31 3 10 450 56 3 20 20 311 3 30 70 245 3 30 160 39 3 30 200 57 3 30 300 32 3 30 390 44 3 30 420 58 3 30 450 45 3 30 1330 34 3 30 1490 39 3 40 30 87 3 40 50 1122 3 40 190 102 3 40 630 78 3 40 640 41 3 50 50 56 3 60 20 31 3 90 1150 45 The p-values are now reported, multiplied by 1000 (so that, e.g., 2 is actually 0.002). For FragBag libraries, N is the library size and k is the length of each fragment. FragBag library: N = 20, k = 5 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 7 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 2 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 1 0 0 0 2 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 213 0 0 0 0 3 0 0 0 0 0 0 0 3 30 390 1 0 7 0 0 0 0 0 0 0 0 0 3 30 420 159 3 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 100, k = 5 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 71 0 0 0 0 0 0 0 0 0 1 10 10 1 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 1 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 24 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 57 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 230 11 0 118 0 8 0 0 0 0 0 0 0 3 30 390 8 0 144 0 0 0 0 0 0 0 0 0 3 30 420 105 16 0 0 6 0 0 0 0 0 0 3 30 450 236 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 40, k = 6 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 47 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 3 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 7 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 1 0 0 0 0 0 0 2 40 30 1 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 14 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 9 0 0 1 0 3 0 0 0 0 0 0 0 3 30 390 2 0 3 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 300, k = 6 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 1 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 289 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 183 0 0 0 1 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 339 6 0 40 0 0 0 0 0 0 0 0 0 3 30 390 8 0 22 0 0 0 0 0 0 0 0 0 3 30 420 0 1 0 0 0 0 0 0 0 0 0 3 30 450 4 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 1 0 2 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 50, k = 7 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 2 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 1 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 1 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 5 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 63 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 24 0 0 7 0 1 0 0 0 0 0 0 0 3 30 390 0 0 15 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 250, k = 7 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 113 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 9 0 21 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 1 11 0 157 1 8 0 0 0 0 0 0 0 3 30 390 2 0 26 0 0 0 0 0 0 0 0 0 3 30 420 0 29 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 50, k = 9 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 0 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 106 0 0 0 0 1 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 21 0 0 0 2 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 3 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 70, k = 9 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 1 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 0 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 2 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 47 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 0 1 0 0 1 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 1 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 100, k = 9 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 5 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 0 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 16 0 0 0 0 1 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 0 0 0 2 0 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 200, k = 9 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 1 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 65 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 241 0 0 0 0 9 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 1 20 0 16 1 0 0 0 0 0 0 0 0 3 30 390 1 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 1 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 400, k = 9 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 6 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 8 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 4 0 34 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 0 2 0 1 0 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 1 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 600, k = 9 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 183 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 3 0 75 0 0 0 2 137 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 1 0 0 139 0 0 2 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 8 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 100, k = 10 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 2 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 13 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 200 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 26 0 0 0 0 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 1 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 200, k = 10 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 43 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 1 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 24 0 0 0 0 1 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 6 5 0 1 2 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 5 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 400, k = 10 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 1 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 311 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 22 0 44 0 0 0 0 37 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 1 6 0 9 2 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 2 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 2 1 2 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 600, k = 10 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 146 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 30 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 1 1 0 5 0 1 1 0 0 0 0 0 0 3 30 390 13 0 7 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 1 0 3 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 100, k = 11 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 9 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 200, k = 11 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 2 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 107 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 11 0 0 0 0 15 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 5 4 0 0 1 0 0 0 0 0 0 0 0 3 30 390 0 0 1 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 400, k = 11 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 67 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 28 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 0 10 0 0 0 0 0 0 0 0 0 0 0 3 30 390 1 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 10 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 600, k = 11 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 1 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 188 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 25 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 29 0 82 0 0 0 0 3 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 23 43 0 11 0 1 0 0 0 0 0 0 0 3 30 390 0 0 1 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 17 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 1 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 100, k = 12 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 1 1 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 1 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 0 0 0 0 1 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 1 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 1 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 200, k = 12 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 23 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 36 0 0 0 0 1 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 4 0 0 0 0 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 400, k = 12 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 3 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 1 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 15 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 8 0 20 0 0 0 0 1 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 4 3 0 0 0 0 0 0 0 0 0 0 0 3 30 390 0 0 1 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 1 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 FragBag library: N = 600, k = 12 Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 1 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 241 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 26 0 34 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 2 31 0 1 0 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 SGM Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 0 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150 Zotenko et al. Mainly-alpha proteins 1 1 1 1 1 1 1 1 1 1 1 1 10 10 10 10 10 10 10 20 20 20 25 50 8 10 150 238 287 490 760 5 58 120 40 10 1 10 8 0 0 0 0 0 0 0 0 0 0 0 1 10 10 0 0 0 0 0 0 0 0 0 0 1 10 150 0 0 0 0 0 0 0 0 0 1 10 238 0 0 0 0 0 0 0 0 1 10 287 0 0 0 0 0 0 0 1 10 490 0 0 0 0 0 0 1 10 760 0 0 0 0 0 1 20 5 0 0 0 0 1 20 58 0 0 0 1 20 120 0 0 1 25 40 0 1 50 10 Mainly-beta proteins 2 2 2 2 2 2 2 2 2 2 2 2 2 10 30 30 30 30 40 40 40 40 40 60 60 80 25 29 30 42 110 10 30 50 70 128 40 120 10 2 10 25 0 0 0 0 0 0 0 0 0 0 0 0 2 30 29 0 0 0 0 0 0 0 0 0 0 0 2 30 30 0 0 0 0 0 0 0 0 0 0 2 30 42 0 0 0 0 0 0 0 0 0 2 30 110 0 0 0 0 0 0 0 0 2 40 10 0 0 0 0 0 0 0 2 40 30 0 0 0 0 0 0 2 40 50 0 0 0 0 0 2 40 70 0 0 0 0 2 40 128 0 0 0 2 60 40 0 0 2 60 120 0 2 80 10 alpha + beta proteins 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 10 10 10 10 20 30 30 30 30 30 30 30 30 30 40 40 40 40 40 50 60 90 20 100 129 450 20 70 160 200 300 390 420 450 1330 1490 30 50 190 630 640 50 20 1150 3 10 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 129 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 10 450 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 20 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 70 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 160 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 300 0 0 0 0 0 0 0 0 0 0 0 0 0 3 30 390 0 0 0 0 0 0 0 0 0 0 0 0 3 30 420 0 0 0 0 0 0 0 0 0 0 0 3 30 450 0 0 0 0 0 0 0 0 0 0 3 30 1330 0 0 0 0 0 0 0 0 0 3 30 1490 0 0 0 0 0 0 0 0 3 40 30 0 0 0 0 0 0 0 3 40 50 0 0 0 0 0 0 3 40 190 0 0 0 0 0 3 40 630 0 0 0 0 3 40 640 0 0 0 3 50 50 0 0 3 60 20 0 3 90 1150