Effects of Growth Hormone and Free Fatty Acids on Insulin Sensitivity in Patients with Type 1 Diabetes
J Clin Endocrinol Metab Salgin et al. 94: 3297 Supplemental Data
Supplemental Data
Files in this Data Supplement:
- Supplemental Figure 1 - Endogenous glycerol production (glycerol Ra) per kg body weight, adjusted for plasma insulin levels, during the pre-clamp euglycaemic steady state period (07:30-08:00). Data are means ± 1 SEM. Repeated measures analysis showed differences in glycerol Ra across the four study visits (p
- Supplemental Figure 2 - Endogenous glucose production (glucose Ra) per kg body weight, adjusted for plasma insulin levels, during the pre-clamp euglycaemic steady state period (07:30-08:00). Data are means ± 1 SEM. Repeated measures analysis showed a trend towards differences in glucose Ra across the four study visits (p=0.06).
- Supplemental Figure 3 - Change (Δ) in endogenous glucose production (glucose Ra) from baseline (07:30-08:00) to the steady state of step 1 of the hyperinsulinaemic euglycaemic clamp (09:30-10:00) adjusted for the increase in plasma insulin levels. Data are means ± 1 SEM. Repeated measures analysis showed no differences in Δ glucose Ra across the four study visits (p=0.2).
- Supplemental Figure 4 - Change (Δ) in endogenous glucose production (glucose Ra) from baseline (07:30-08:00) to the steady state of step 2 of the hyperinsulinaemic euglycaemic clamp (11:30-12:00) adjusted for the increase in plasma insulin levels. Data are means ± 1 SEM. Repeated measures analysis showed no differences in Δ glucose Ra across the four study visits (p=0.6).
- Supplemental Figure 5 - Peripheral glucose uptake (glucose Rd) per kg FFM, adjusted for plasma insulin levels, during the pre-clamp euglycaemic steady state period (07:30-08:00). Data are means ± 1 SEM. Repeated measures analysis showed no differences in glucose Rd across the four study visits (p=0.3).
- Supplemental Figure 6 - Change (Δ) in peripheral glucose uptake (glucose Rd) from baseline (07:30-08:00) to the steady state of step 1 of the hyperinsulinaemic euglycaemic clamp (09:30-10:00) adjusted for the increase in plasma insulin levels. Data are means ± 1 SEM. Repeated measures analysis showed there was a trend towards differences in Δ glucose Rd across the four study visits (p=0.08).
- Supplemental Figure 7 - Change (Δ) in peripheral glucose uptake (glucose Rd) from baseline (07:30-08:00) to the steady state of step 2 of the hyperinsulinaemic euglycaemic clamp (11:30-12:00) adjusted for the increase in plasma insulin levels. Data are means ± 1 SEM. Repeated measures analysis showed that Δ glucose Rd changed across the four study visits (p=0.02).