Chemical Inducers of Targeted Protein Degradation

Current position: Professor of molecular, cellular and developmental biology, chemistry, and pharmacology at Yale University

Education: Ph.D. in biochemistry in 1993 from Harvard University

Nonscientific interests: Squash, traveling and reading Harry Potter with my daughters

Originally trained as a protein biochemist, I have long been interested in the interface of chemistry and biology.  Initially focused on mechanism of action studies of biologically active natural products, my lab has more recently investigated new approaches to target the “undruggable proteome” using small molecules.  Given the “active-site centric” focus of many drug development efforts, our goal is to be able to control intracellular protein function irrespective of the class of protein targeted. These studies will hopefully lead to new bioactive research probes as well as impact current drug development strategy.

Read Crew's article on page 11178.