>Ap-drosha
KKKWSRSAPSDIYYKKPDDD---SEVTFGNKIALDICDEFENTLGKRVSKMNENKPVHC-
KPRKVNVNVRKH--VCSGNGSSTSDEDEDDE-----KENSTLKELDRKCSHPDRLHSELW
YNEFGEMNDGPMCKCSVKSQRSGIRHNIYVGEGPFEPCLPNSNNSDKLFHYRITITPPTN
FLLKCPTVIECNESKYTFEGFSLLSHYPIPILPTCKVIRFNTNYAILYIEEKIPDNFIVK
ELQLFYDYLFKDILELVDLDLHG----IGNKNGCPQFHFMPRFVKDLSDNGKEVLSMNEV
LKYLLKSNKLLFEESSLSALQEMPMNEWQNIVDEYKGMIVTNPGTKPYSIRVDQLDRDSV
NEATEK-------NVNDGYPVLVHFGIRPPQLSYAGNP-DYQKGWRDYVKFRHLLANMPK
PSFEDKRKLEIKERALQEMRSHNKMKRGVTAAVSSKGFFKTGLMCDIVQHAMLLPVLVCH
FRFHKSLEYLEDTIEYKFKNKYLLQLALTHPSYRENFGTNPDHARNTLTNCGIRQPEYGD
RRIHYMNTRKRGINTLINIMSRFGKKSEMESNIMHNERLEFLGDAVVEFVSSIHLFNMFP
DIEEGGLATFRAAIVQNQHLAVLAKTLKLDDFMLYAHGSDLCHDSELKHAMANCFEALMG
ALFLDGGIEVADRVFGKTFYRDSPEYLDIWVNYPRHPLQQQEPEGDRKWIKKLPLLQKLT
NFEDSIGIKFTHIRLLARAFTDRSVGFTNLTLGSNQRLEFLGDTVLQLIASDYLYKYFPE
HHEGHLSLLRSSLVNNRTQSVVCDDLGMVSYALYAN--P----KAELKTKDRADLLEAFL
GALYIDKGLTFCQAFCNVCFFPRLHDFILKQDWNDPKSKLQQCCLTLRSVDGGEPDIPVY
KVIEC--MGPTNGRKYTVAVYFKSVRLSQATGHSIQRAEMNAANSALEVSKDLFPQLDHQ
RRAISRSLN
>Am-drosha
RKVWTRTAPADLYYTRDENN---PKIMRGTQKLHELCELFKKILLDRAAAARALQPPYEP
PPRKTRARLCKH--KSEACSSSSSDSDSSMD-----EDDRTMEELMAKKQHPQRLHPEMW
FNDPGEMNDGPLCRCSAKSRRSGIRHGIYAGEGAINKCDLNSNNADKLYHYRITISPPTN
FLTKTPTIIKHDEHEFIFEGFSMLSHFPLVKLPTCKVIRFNIEYTILYIDEKLPENFIIR
ELDFFQTYLFKEVLELIDFDLQA----AQNKSGCGQFHFMPRFVRDLADNGQEILSMNEV
LNYLIKSSKLLIDPDDLPRLVEMPQYKWQNFADEVKGMIVTFPGKKPCSVRVDQLDRNQT
DQPP----------GVIAYPEIVHFGIRPPQLSYAGNA-DYQKAWRDYVKFRHLLANMPK
PSFEDKRKLEAKENKLQELRTQSKMKRDVTVDVSSEGFYRTGIMCDIVQHAMLIPVLVCH
LRFHKSLDNLERTLGYEFKNRYLLQLALTHPSYRENFGTNPDHARNSLTNCGIRQPEYGD
RRIHYMNTRKRGINTLINIMSRFGARTETESSIAHNERLEFLGDAVVEFLTSIHLFHMFP
DLEEGGLATYRAAIVQNQHLAVLAKKLNLEEYMLYAHGSDLCHDLELRHAMANCFEALMG
SLFLDGGIEVADRVFGETLFKDEEDLAKVWVNYPKHPLQEQEPTGDRQWIPSFELLQKLT
KFEESIGIEFTHIRLLARAFTDRSIGYTNLTLGSNQRLEFLGDTVLQLIVSEYLYKYFPE
HHEGHLSLLRSSLVNNKTQAVVCDDLGMTQYALYGN--P----KAELKTKDRADLLEAFL
GALYVDKGLEYCRVFCDVCFFPRLQDFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPVY
KVIEC--KGPTNTRVYTVAVYFQGKRLAKASGHSIQEAEMNSAKEALEKSQDLFPQLDHQ
KRVIAKS-M
>Nv-drosha
RKIWTRTAPADLYYSRDEKN---NKLMKATGKLVQLCDDFKKILIDRASSARELQPPYEA
PARKNRARLCRH--KSEACSSSSSDSDDSVD-----EDDRTMEELMAKKQHPQRLHPEMW
FNDPGEMNDGPLCRCSAKSRRSGIRHGIYAGEGAIEKCDSHTNNADKLYHYRITISPPTN
FLTKTPTIIKHDEHEFIFEGFSMFSHFPLVKLPTCKVIRFNIEYTILYMEEKMPENFTIQ
ELDYFQDYLFNEILELVDFDLQA----AQDKKGCAQFHFMPRFVRDLPDNGQEILSMNEV
LSYLIKCSTLLIDPDELPKLVEMPQFQWQNFADEVKGMVVTYPGKKPCSVRVDQLDRNQA
DQPP----------GVIAYPEIVHFGIRPPQLSYAEIPSDYQRAWRDYVKFRHLLANMPK
PSFEDKRKLEAKENKLQELRTQSKMKRDVTVDVTSEGFYRTGIMCDIVQHAMLIPVLVCH
LRFHKSLDMLEQTLDYKFKNRYLLQLALTHPSYRENFGTNPDHARNSLTNCGIRQPEYGD
RRIHYMNTRKRGINTLINIMSRFGAKKETESSIAHNERLEFLGDAVVEFLTSIHLFHMFP
DLEEGGLATYRAAIVQNQHLAVLAKKLNLEQYMLYAHGSDLCHDLELRHAMANCFEALMG
ALFLDGGIRIADTVFGETLFKNESDLLNIWVNYPKHPLQEQEPTGDRQWIPSFELLQKLT
KFEEGIGVEFSHIRLLARAFTDRSIGYTNLTLGSNQRLEFLGDTVLQLIVSEYLYKFFPE
HHEGHLSLLRSSLVNNKTQAVVCDDLGMTQYALYGN--P----KAELKTKDRADLLEAFL
GALYVDKGLLHCQVFCNVCFFPRLQDFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPVY
KVIEC--KGPTNTRVYTVAVYFQGKRLAKASGHSIQEAEMNSAKEALEKSQDLFPQLDHQ
KRVIAKS-M
>Tc-drosha
KNIWTRSTPSDLYYRKDESN---ARVTRATKRLTQLCDKFNDCLVMRAAKVNKLKPKYEP
PPRKNRARLCKH--KSEESSSSGSSEEELTD-----EEDCTMEELQRKQQHPDRLHPEMW
YNDPGEMNDGPLCRCSIKSRKSGIRHGIYPGEKHLEKCVPDSNNAERLYHYRITISPPTN
FLIKTPTIIHYDEHEFIFEGFSMFSHFPLEKLPTCKVIRFNIEYTILYIEEKIPDNFTVR
ELDLFHDYLFREILELVDLDFKA----AGDVDGCSQFHFMPRFVRELPDNGKEILAMNEV
LQYLLDSSVSLIEEKDLEDMIKMTQYEWQSYADEIKGMVVTYPGKKPCSVRVDQLDRNID
LQKP----------GDYKFPEIVHFGIRPPQLSYAGNP-DYQKAWRDYVKFRHLLANMSK
PTFEDKRKLESKENKLQEMRTQGKMKRDITVAVSAEGFYRTGIMCDIIQHAMLIPVLVCH
LRFHHSLNILEESVNYKFKNRALLQLALTHPSYRENFGTNPDHARNSLTNCGIRQPEYGD
RRIHYMNTRKRGINTLINIMSRFGKQQETESNITHNERLEFLGDAVVEFLSSIHLFYTFP
DLEEGGLATYRAAIVQNQHLAVLAKTLKLDQFMLYAHGSDLCHDLELRHAMANCFEALMG
ALFLDGGINVVDRVFSETLFKVNPDLLEVWMNLPPHPLQEQEPTGDREWIPKFELLQNLT
KFEESVGLQFNHIRLLARAFTDRSVGYTNLTLGSNQRLEFLGDTVLQLIASEYLYKYFPE
HHEGHLSLLRSSLVNNRTQAVVCDDLGMSNYAVYNN--P----KAELKTKDRADLLEAFI
GALYVDQGLEFCEVFCQVTLFPRLQDFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPVY
KSVVCFTNSEVNTRVYTVAVYFRGRRLASAMGHSIQQAEMNAAKKALEISQDLFPQLDHQ
KRVIAKS-M
>Ag-drosha
RTLWVRSSPAELYYKRVS-D----KVVESTARLDALCTLFEEELIKRAERIRATQTPYNP
PPRKRKMKMCRH--KHDKCSSSSESSDEEME----FEDECSMEELTAKIKHPLRLHVDLW
YNDPGEMNDGPLCRCSARSRRTGIRHGKYPGEEGFPKCIPNSNNADKLYHYRITISPPTN
FLTKTPTIIKHDQHEFLFEGFSLLAHEPIGELPTCKVIRFNIEYTILYIEEQMPENFTIR
ELNLFDRYLFRELLELVDFTVQPS--GSGEDSSCPCYHFLPRFVRDLPDNGKEVLAMSEV
LRYLLDNSGPLVPPDMLKEMMDMSQNEWQDYVDYVKGMVVSNPGMKPCSVRVDQLDRNVG
DVPEANAI----DENGLVHPVIVHFGIRPPQLSYAGNP-EYQKAWREYIKFRHLIANMSK
PSFEDKRKLEAKENRLLEMRMQGRMKRNITIAVSAKAFHRTGIMCDMVQHAMLIPVLTGH
LRFHRSLNVLERYIGYTFTNRYTLQLALTHPSYKENFGTNPDHARNSLTNCGIRQPEYGD
RKIHYMNTRKRGINTLISIMSRFGKEHETDSNITHNERLEFLGDAVVEFITSIHLFHMFP
DLEEGGLATYRAAIVQNQHLAVLAKKLHLEEFMLYAHGSDLCHELELRHALANCFEALMG
ALLLDGGIEVADRVFAYALFQEDDTLRGIWVNYPSHPLQEQEPLGDRHHIDSFEMLKTLT
RFEDSIGVQFNHIRLLARAFTDRSIGFTNLTLGSNQRLEFLGDTVLQLICSEYLYRHFPE
HHEGHLSLLRSSLVNNRTQAVVCDDLGMTQYAVYSN--P----KADLKTKDRADLLEAFL
GALYVDKGLEYCEMFCHVCLFPRLQDFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPVY
KVIEC--TGPTNTRVYSVAVYFRGKRLACADGHSIQQAEMNAAKQALENSKDLFPQLDHQ
RRVIAQS-L
>Dm-drosha
VESWVRSSPAELYYERTKSE----NEVRGRARLQKLCTLFDEELLQRAKRVREKLPVYVP
PPRKARRRVCKHKHKSEACSSSSSSDDDSDEDAFKIEQDCCMEELSRKVQHPQRVHADLW
HNDAGEMNDGPLCRCSAKSRRIGIRHGIYPGETGYKLCDPNSNNAGKLFHYRISISPPTN
FLTKTPTIIKHDEHEFLFEGFSLLSHVRLSDLPVCKVIRFNIEYTIEYEEEKMPENFTIH
ELDIFFKYLFHELLELVDFNLMPNLPSGNVEESCPAFHFFPRFVRDLPDNGKEVLAMVEV
LRYLLDNSAQLVERQQLLHLNQISQSEWQNYVDFIKGMLVTKPGYKPCSLRVDQLDRNNS
DLPECVD-----RETGISHPAIVHFGICHPQLSYAGNP-EYQKAWREYVKYRHLMANMSK
PSFKDKRKLEEKEQRLQEMRTQGRMKRNITVAISSEGFYRTGIMCDVVQHAMLIPVLTGH
LRFHKSLDLLEESIGYRFKNRYLLQLALTHPSYKENYGTNPDHARNSLTNCGIRQPEYGD
RKIHYMNTRKRGINTLVSIMSRFGKEHETVSNITHNERLEFLGDAVVEFLSSIHLFFMFP
ELEEGGLATYRAAIVQNQHLALLAKKLQLEEFMLYAHGSDLCHELELRHAMANCFEALMG
ALLLDGGIKVADEVFTDALFRQDEKLLSIWKNLPEHPLQEQEPLGDRSCIDSYRVLKELT
KFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDTVLQLICSEYLYRHFPE
HHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYAN--P----KADLKTKDRADLLEAFL
GALYVDKGLLYCEQFCHVCLFPRLQLFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPYY
KVVEA--SGPTNTRVYKVAVYFRSKRLATSSGSSIQQAEMNAAKQALENSRDLFPQLDHQ
KRVIAKS-I
>Ph-drosha
NKVWIRSAPAYCYYERDPND---LRRMKPTPKLDELCERFKYELVDRGKRIRDGQTLKCP
APIKPKQKLCKH--KSQICSSSDDSESENSDE--SDDVNDMMEELQRKQKHPYRLHSELW
YNDPGEMNDGPLCRCSAKARRSGIRHGFYAGENQKICCDVKSNNAGNLYCYRITISPPTN
FLTRTPTIINYDDHEFIFEGFSLISHYPIQKLPTCKVIRFNIEYIILYVEEKLPENFSIL
ELDLFYEYVFKEILELVDFDLKN----SSHPENCPQFHFMPRFVRELPDNGRELLPMCEV
LKYLLSSNKKLIEDGTLDSLHKMTSSEWQDFADLVKGMVVTNPGMKPCSLRVDQLDRDTD
ESVKKKENAKSCSMENYYYPEIVHFGIRPPQLSYAGNP-EYQRAWRKYVKFRHLLANMPK
PTAEDKQKLAAKENSLHSMRAHSKMKRDVTVTVSSKGFYQTGLMCDVVQHAMLIPVLVCH
LRFHRSLVVLEEKINYKFKNKFLLQLALTHPSYRENFGTNSDHARNSLTNCGIRQPQYGD
RRIHYMNTRKRGINTLISIMSRFGRKNETQSNIYHNERLEFLGDAVVEFITSIHLFHIFR
DLEEGGLATYRAALVQNQHLSVLAKKLNLDEFMLYAHGSDLCHDLELKHAMANCFEALMG
ALFLDGGIESADKVFGMTLYGDDEDCSDVWFNYPPHPLQEQEPLGDRKWISHFPLLQNLT
KFEEATGIEFKHIRLLARAFTDRSVGYTNLTLGSNQRLEFLGDSVLQLIASEYLYKYFPE
HHEGHLSLLRSSLVNNKTQSVVCDDLGMTQYAVYAN--P----KVELKVKDRADLLEAFL
GALYVDNGLDICRVFCDVCFFPRLQIFIMNQDWNDPKSKLQQCCLTLRTMDNVEPDIPIY
KVVEC--KGPTNTRVYTVAVYFRNKRLAKATGHSIQQAEMNAAQKAMEVSGPLFPQLDHQ
KRVIAKS-L
>Hs-drosha
KPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEP
PKTKLDEDLESS--SESECESDEDSTCSSS-S--DSEVFDVIAEIKRKKAHPDRLHDELW
YNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTN
FLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVK
GLELFSLFLFRDILELYDWNLKGPL-FEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQI
LLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQF
N--P----------DVITFPIIVHFGIRPAQLSYAGDP-QYQKLWKSYVKLRHLLANSPK
VKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHH
IRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGD
RKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFP
SLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIG
AVYLEGSLEEAKQLFGRLLFN-DPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLT
EFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPD
HHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITND--K-TKRPVALRTKTLADLLESFI
AALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRT-EGKEPDIPLY
KTLQT--VGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKY--NFPQMAHQ
KRFIERK-Y
>Ci-drosha
KK-WK----SDITLTRHQ--QVKSST--IVKKLLESSKNLNLTLGEYIDQTEPSI-----
----PNFALGK--LKRAIESGVDLDTEHEGNE--VDHAGELMSSIRKLKAHKDRLHEELW
YNEPGQANDGPLCRCSSGSRDKGIRHNIYPGEVPTAPYDPMKNNIGKMHHYRITVGPAVN
YMISQPTTIEYSGHDYMFEGFSIFSDEPLDKIPLCDIIRFHIRYTIYLIEETPPESFCIR
GLDLFDEYLFREVLELYDWQGDTP-PSEALAKNKRKFRFFPRFVRSLPDNGKEILSLCKV
LEYLLDSDKPLVDEKDLDWLMKCSHDEWLDHTDAIRGSIVTHPGKRPSSLRVDQLDRYDR
KPVESTT--QHCPQVDERYPMIIHFGIRPANLSYAGDP-TYQRIWRAYLKQRHLMANSPK
VKQSDKKKLRERENALQKIKRAKDMQREVTVELSSHGFRRTGLRSDVCQHAMLLPVLSHH
LRYHLCLRTLEKKIGYEFKERKWLSHAMNHPSCQMNFGLNPDHVRNTLSNCGLRLPRYGD
SSIHYKYTRKRGITTLIRIMARLGQQRPVLSPIEHNERLEFLGDAVVGYFTSVHLFLLFP
DLSEGALTTFRTVLVNNQHLALLAERLQLDEFMLYAHGPDLCRKADLRHAMANCFEALMG
AIYMEAGLERAQRLFGEFLWE-TEALQRVWRSLPLHQLQEEEPVSDRRCIKDVPILQKLT
KFEDSIGVKFNHIRLLAKAFTWRNVHENILTHGHNQRLEFLGDSVCNLVASAYLFKLYPT
HHEGHLTLLRATVVNGRTQSLVATELGMPEYVICTLDNDSTERVPEWREKNLADLLEAFV
AALFIDKGLKYVKTFMKICFFPRLKEFILTQEWNDPKSCLQQCCLTLRQ-EGKEPQLPTY
EISHQ--TGPSHSRKYVVTVHFKGEEIGKGTGESIQRAERNAARTALNQ--YNFPQLEWQ
RRYVAEK-H