Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging -- Ahmed et al. 177 (1): 311 Data Supplement - Supplemental Material -- American Journal of Pathology

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging
Am J Pathol Ahmed et al. 177: 311

Supplemental Material

This supplemental material includes supporting data for this study.

Files in this Data Supplement:

Supplemental Figure 1 - Neuronal PGRN scoring scheme. (544KB)
Supplemental Figure 2 - Granular cytoplasmic staining (GCS) scoring scheme. (2,386KB)
Supplemental Figure 3 - Microglial scoring scheme. (1,518KB)
Supplemental Figure 4 - Regional severity of granular cytoplasmic staining (GCS). (50KB)
Supplemental Figure 5 - Granular cytoplasmic staining (GCS) in 23 month old GRN-/- mice. (5,286KB)
Supplemental Figure 6 - TDP-43 is not abnormally phosphorylated at 409/410 in GRN-/- mice. (2,092KB)
Supplemental Figure 7 - Ultrastructural analysis of the habenula in old GRN-/- mice. (697KB)
Supplemental Figure 8 - Evidence of focal neuronal loss in 23 month old GRN-/- mice. (1,335KB)
Supplemental Figure 9 - Extra-neuronal lipofuscin in the thalamus of 23 month old GRN-/- mice. (3,490KB)
Supplemental Figure10 - PGRN is increased in cathepsin D knockout mouse model of lipofuscinosis. (343KB)
Supplemental Figure Legends - Full legends for Supplemental Figures 1-10. (30KB)
Supplemental Table 1 - The degree of neuronal PGRN immunoreactivity (IR) in different anatomical regions was analyzed in 12 month old GRN+/+ mice using a semi-quantitative scoring scheme. (40KB)