Table S12. Known motifs enriched in predicted enhancer regions. Motifs are from Xie et al., Nature 2005 Name Consensus Enhancer over-conservation Enhancer enrichment Promoter over-conservation Promoter enrichment AP-2ALPHA SCYNNNGGC 1.00E-300 1.00E-300 4.66E-05 STAT5A AWTTCY 1.00E-300 5.80E-220 3.83E-177 6.16E-31 TEF-1 GRRATG 1.00E-300 4.33E-65 5.75E-36 IY AWTTTCC 1.04E-279 2.06E-50 5.09E-36 9.98E-18 FOXO1 RWAAACAA 1.08E-270 6.63E-53 1.03E-43 HNF-3 TRTTTRYTYW 1.12E-247 4.51E-50 3.64E-21 MEIS1 TGACAG 3.92E-221 4.25E-05 1.88E-56 MYOD RNCAGGTG 3.84E-215 1.25E-94 4.19E-05 NF-AT WGGAAANW 1.57E-188 3.85E-60 7.83E-15 6.57E-24 TCF11 WNNATGAC 5.86E-181 5.69E-94 1.33E-31 AP-1 CTGASTCA 9.09E-174 1.00E-300 2.31E-43 1.14E-05 SRY KTWGTTT 3.09E-140 1.41E-10 2.05E-37 AP-4 GCAGCTGNY 2.92E-123 5.07E-05 4.77E-48 ER RNNNTGACCT 6.28E-112 6.10E-15 3.00E-35 GATA WGATAR 1.43E-109 PEA3 MGGAWGT 4.43E-105 3.71E-21 7.04E-282 6.15E-57 TCF-4 WTCAAAGS 7.02E-104 1.87E-11 1.71E-20 AML1 ACCACA 1.76E-96 2.89E-48 T3R MNTGWCCT 2.48E-95 2.16E-27 9.79E-09 TBP TATAAATW 5.39E-80 4.88E-32 NCX GTAAKTNG 3.35E-74 2.10E-19 SOX-5 ATTGTT 4.66E-74 4.02E-27 6.44E-17 NKX6-2 WADTAAWTA 6.53E-74 7.96E-14 DBP GTDTGCT 1.21E-72 2.18E-07 1.09E-05 NKX2-5 TYAAGTG 7.55E-72 4.13E-39 5.54E-12 CHX10 GCTAATTA 8.62E-70 1.17E-12 HOXA4 CYAATTWT 2.12E-69 9.41E-14 6.20E-05 NF-1 TGGNNNNNNGCCAA 1.45E-56 2.85E-99 1.39E-09 IRF1 AAGTGAA 1.23E-50 8.26E-19 9.56E-12 1.50E-14 NKX2-5 CWTAATTG 2.56E-50 4.83E-09 ELF-1 RNWMBAGGAART 1.87E-40 7.83E-07 7.46E-16 3.63E-07 TCF-1(P) GKCRGKTT 1.52E-36 2.04E-07 STAT1 CANTTCCS 9.86E-34 6.14E-05 3.26E-140 3.80E-119 C/EBPBETA KNTTGCNYAAY 9.27E-29 1.71E-32 1.12E-04 1.35E-04 OCTAMER ATGCAAATNA 3.15E-28 1.21E-23 1.09E-09 CRX KGRGATTANNNR 5.19E-28 2.22E-09 6.76E-04 CREB TGACGTMA 3.24E-27 5.64E-14 6.38E-123 5.41E-249 STAT TCCMAGAA 4.13E-27 6.70E-11 2.94E-08 8.08E-07 SF-1 TGRCCTTG 2.14E-25 5.11E-17 YY1 GCCATNTT 2.37E-21 2.65E-133 AREB6 WCAGGTGWNW 1.16E-17 3.38E-08 4.09E-10 NF-Y YSATTGGYY 3.54E-17 1.00E-300 5.94E-209 PBX-1 WTGATTGNT 7.86E-16 6.41E-06 RFX1 GTTRCYWNGYNAC 3.03E-15 5.23E-27 4.52E-09 C-REL SGGRNTTTCC 1.63E-14 4.04E-11 BACH2 SRTGAGTCANC 7.87E-14 1.56E-163 6.73E-09 E4BP4 RTTACRTAAY 9.31E-14 7.43E-10 TAL-1ALPHA/E47 AACAGATGKT 2.48E-12 PU.1 WGAGGAAG 2.84E-12 1.37E-14 POU3F2 ATTARCATAA 2.82E-10 1.42E-06 POU1F1 ATGAATAAWT 1.59E-09 6.04E-06 1.19E-04 RORALPHA2 TGACCTANWTW 2.93E-09 P65 GGGRATTTCC 7.63E-09 3.37E-04 1.03E-09 5.33E-04 CAC-BP GRGGSTGGG 4.39E-08 HNF-6 HWAAATCAATAW 7.46E-08 ELK-1 CCGGAART 1.27E-07 5.30E-165 1.00E-300 RP58 TCCAGATGTT 2.58E-07 MEF-2 YTAAAWATAGCY 1.19E-05 2.42E-05 2.16E-04 5.26E-04 AHR TNGCGTG 1.48E-05 3.31E-04 MYB GNCNGTT 2.03E-05 2.93E-19 AREB6 ABWCAGGTRNR 2.52E-05 IPF1 KGTCATTANNDC 3.98E-05 ATF-1 TGACGTCARRG 4.76E-05 1.65E-06 6.91E-09 4.34E-30 BRN-2 YKNATTWYSNATG 1.24E-04 MAZ GGGGAGGG 1.78E-04 5.23E-06 4.87E-07 LHX3 TTAATTAATT 3.50E-04 LEF1 CTTTGA 1.02205884431E-310 4.34E-13 1.17E-66