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Domain name : PF07365.4_Toxin_8
Domain size : 66
Domain gathering score : 25.0000
Domain architecture : TM/SP [1 21], non-TM/SP [22 66]
Total query sequences in database : 15
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gi|73808765|gb|AAZ85382.1|TeA21P, Conus textile
Toxin_8         Alpha conotoxin precursor                16.1      0.015   1
Toxin_8           1/1       1    38 []     1    66 []    16.1    0.015
Toxin_8: domain 1 of 1, from 1 to 38: score 16.1, E = 0.015
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                 sdGRn+aaka++++++++++
  gi|7380876     1    ---------------------------SDGRNDAAKASGLVSLTDRR 20   

                CS X-GCGSCCCHHH-CCCB-X   
                   kecCsdppcavsrpeyscG<-*
                   +ecCsdp+c++s+pe+ cG   
  gi|7380876    21 PECCSDPRCNSSHPEL-CG    38   

Score/E-value (less TMSP): 45.038/2.86240837588618e-10
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/58.954/-11.455 (18.561/16.1)


gi|110808193|sp|Q1L777.1|CXA1A_CONPR|Alpha-conotoxin PeIA, Conus pergrandis
Toxin_8  Alpha conotoxin precursor                       14.0      0.026   1
Toxin_8    1/1       1    38 []     1    66 []    14.0    0.026
Toxin_8: domain 1 of 1, from 1 to 38: score 14.0, E = 0.026
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                 +dGRnaaa+++ s+l+a + 
  gi|1108081     1    ---------------------------FDGRNAAANDKASDLVALTV 20   

                CS X-GCGSCCCHHH-CCCB-X   
                   kecCsdppcavsrpeyscG<-*
                   ++cCs+p+c v +pe+ cG   
  gi|1108081    21 RGCCSHPACSVNHPEL-CG    38   

Score/E-value (less TMSP): 42.938/1.22714133448645e-09
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/55.676/-11.455 (15.283/14.0)


gi|87242723|gb|ABD33869.1|alpha conotoxin Mr1.1, Conus marmoreus
Toxin_8  Alpha conotoxin precursor                       12.8      0.036   1
Toxin_8    1/1       1    38 []     1    66 []    12.8    0.036
Toxin_8: domain 1 of 1, from 1 to 38: score 12.8, E = 0.036
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                 sdGRnaaak++ s+l+a + 
  gi|8724272     1    ---------------------------SDGRNAAAKDKASDLVALTV 20   

                CS X-GCGSCCCHHH-CCCB-X   
                   kecCsdppcavsrpeyscG<-*
                   k+cCs+p+c v +p+  cG   
  gi|8724272    21 KGCCSHPACSVNNPDI-CG    38   

Score/E-value (less TMSP): 41.738/2.81923046454647e-09
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/55.601/-11.455 (15.208/12.8)


gi|87242709|gb|ABD33862.1|alpha conotoxin Qc1.5, Conus quercinus
Toxin_8  Alpha conotoxin precursor                       10.7      0.061   1
Toxin_8    1/1       1    38 [.     1    66 []    10.7    0.061
Toxin_8: domain 1 of 1, from 1 to 38: score 10.7, E = 0.061
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                 sdGRnaaa ++ s+li    
  gi|8724270     1    ---------------------------SDGRNAAADDKASDLIGLAV 20   

                CS X-GCGSCCCHHH-CCCB-X   
                   kecCsdppcavsrpeyscG<-*
                   ++cCs+p+c v +pe+ cG   
  gi|8724270    21 RGCCSNPACSVNHPEL-CG    38   

Score/E-value (less TMSP): 39.638/1.20863055866883e-08
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/53.445/-11.455 (13.052/10.7)


gi|88697630|gb|ABD48795.1|conotoxin Lp1.10, Conus leopardus
Toxin_8  Alpha conotoxin precursor                       15.0      0.021   1
Toxin_8    1/1       1    45 []     1    66 []    15.0    0.021
Toxin_8: domain 1 of 1, from 1 to 45: score 15.0, E = 0.021
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                  VVL         + AsdGRnaaa+ + ++lia + 
  gi|8869763     1    ------------VVL---------GPASDGRNAAANVKAPDLIALTV 26   

                CS X- GCGSCCCHHH-CCCB-X   
                   ke.cCsdppcavsrpeyscG<-*
                   +++cC++ pc   +p   cG   
  gi|8869763    27 RNdCCHNAPCRNNHPGI-CG    45   

Score/E-value (less TMSP): 37.221/6.45480415884032e-08
TMSP/non-TMSP/fixed score (recomputed/original total): -22.221/51.421/-11.455 (17.745/15.0)


gi|87242719|gb|ABD33867.1|alpha conotoxin Ac4.3b, Conus achatinus
Toxin_8         Alpha conotoxin precursor                -0.8        1.2   1
Toxin_8           1/1       1    42 [.     1    66 []    -0.8      1.2
Toxin_8: domain 1 of 1, from 1 to 42: score -0.8, E = 1.2
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                 sd Rnaa+++rq++l++s+i
  gi|8724271     1    ---------------------------SDVRNAAVHERQKELVPSKI 20   

                CS X-GCGSCC   CHHH-CCCB-X   
                   kecCsdpp...cavsrpeyscG<-*
                   ++cC++ p++ c+++ ++++c    
  gi|8724271    21 TTCCGYSPgtaCPSCMCTNTCK    42   

Score/E-value (less TMSP): 28.138/3.50056800703157e-05
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/42.831/-11.455 (2.438/-0.8)


gi|87242699|gb|ABD33857.1|alpha conotoxin Qca-L-1, Conus quercinus
Toxin_8  Alpha conotoxin precursor                        8.1       0.12   1
Toxin_8    1/1       1    38 [.     1    66 []     8.1     0.12
Toxin_8: domain 1 of 1, from 1 to 38: score 8.1, E = 0.12
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                 +dGRnaaa+++  +l+a + 
  gi|8724269     1    ---------------------------FDGRNAAANNKATDLMARTV 20   

                CS X-GCGSCCCHHH-CCCB-X   
                   kecCsdppcavsrpeyscG<-*
                   +  Csdppc +s+pe  cG   
  gi|8724269    21 RRFCSDPPCRISNPES-CG    38   

Score/E-value (less TMSP): 37.038/7.32776544221689e-08
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/49.025/-11.455 (8.632/8.1)


gi|62286493|sp|P69658.1|CXA1A_CONPU|Alpha-conotoxin PIA, Conus purpurascens
Toxin_8  Alpha conotoxin precursor                        4.6        0.3   1
Toxin_8    1/1       1    40 []     1    66 []     4.6      0.3
Toxin_8: domain 1 of 1, from 1 to 40: score 4.6, E = 0.3
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                 sdGR+aaa+++  +lia + 
  gi|6228649     1    ---------------------------SDGRDAAANDKATDLIALTA 20   

                CS X-  GCGSCCCHHH-CCCB-X   
                   ke..cCsdppcavsrpeyscG<-*
                   + ++cCs+p c+v +p+  cG   
  gi|6228649    21 RRdpCCSNPVCTVHNPQI-CG    40   

Score/E-value (less TMSP): 33.538/8.29042021561165e-07
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/46.956/-11.455 (6.563/4.6)


gi|87242725|gb|ABD33870.1|alpha conotoxin Pu1.2, Conus pulicarius
Toxin_8  Alpha conotoxin precursor                       -1.9        1.6   1
Toxin_8    1/1       1    39 [.     1    66 []    -1.9      1.6
Toxin_8: domain 1 of 1, from 1 to 39: score -1.9, E = 1.6
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                  dGRnaaa  ++s+l+a +i
  gi|8724272     1    ---------------------------LDGRNAAADFETSDLLAMTI 20   

                CS X- GCGSCCCHHH-CCCB-X   
                   ke.cCsdppcavsrpeyscG<-*
                   +++cCs+ppc   +  +++G   
  gi|8724272    21 RGgCCSYPPCI-ANNPLCGG    39   

Score/E-value (less TMSP): 27.038/7.50363175843017e-05
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/38.664/-11.455 (-1.729/-1.9)


gi|87242715|gb|ABD33865.1|alpha conotoxin Ac4.2, Conus achatinus
Toxin_8       Alpha conotoxin precursor                  -1.3        1.4   1
Toxin_8         1/1       1    41 []     1    66 []    -1.3      1.4
Toxin_8: domain 1 of 1, from 1 to 41: score -1.3, E = 1.4
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                 +dGRnaa+++r + ++    
  gi|8724271     1    ---------------------------FDGRNAAVNERAPWMVVTAT 20   

                CS X-GCGS  CCCHHH-CCCB-X   
                   kecCsd..ppcavsrpeyscG<-*
                   ++cC++++p+c ++ ++ scG   
  gi|8724271    21 TNCCGYtgPACHPCLCTQSCG    41   

Score/E-value (less TMSP): 27.638/4.95055074461123e-05
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/41.475/-11.455 (1.082/-1.3)


gi|87242711|gb|ABD33863.1|alpha conotoxin Qc1.6, Conus quercinus
Toxin_8  Alpha conotoxin precursor                        0.8       0.79   1
Toxin_8    1/1       1    38 []     1    66 []     0.8     0.79
Toxin_8: domain 1 of 1, from 1 to 38: score 0.8, E = 0.79
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                 +dGRnaaa+++ s+l+a   
  gi|8724271     1    ---------------------------FDGRNAAASDKASELMALAV 20   

                CS X-GCGSCCCHHH-CCCB-X   
                   kecCsdppcavsrpeyscG<-*
                   ++cCs+p ca  + +  cG   
  gi|8724271    21 RGCCSNPTCAGNNGNI-CG    38   

Score/E-value (less TMSP): 29.738/1.15475679698894e-05
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/43.278/-11.455 (2.885/0.8)


gi|73808763|gb|AAZ85381.1|LeD2P, Conus litteratus
Toxin_8  Alpha conotoxin precursor                        1.5       0.67   1
Toxin_8    1/1       1    39 [.     1    66 []     1.5     0.67
Toxin_8: domain 1 of 1, from 1 to 39: score 1.5, E = 0.67
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                 sdGRn+aa+++ s+lia   
  gi|7380876     1    ---------------------------SDGRNDAASNKASHLIALAV 20   

                CS X-GCGSCCCHHH-CCCB-X   
                   kecCsdppcavsrpeyscG<-*
                   ++cC + +ca  + e+++G   
  gi|7380876    21 RGCCARAACAGIHQELCGG    39   

Score/E-value (less TMSP): 30.438/7.10836189997678e-06
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/44.708/-11.455 (4.315/1.5)


gi|87242705|gb|ABD33860.1|alpha conotoxin Qc1.4a, Conus quercinus
Toxin_8  Alpha conotoxin precursor                        0.2       0.93   1
Toxin_8    1/1       1    38 [.     1    66 []     0.2     0.93
Toxin_8: domain 1 of 1, from 1 to 38: score 0.2, E = 0.93
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                 sdGRn aa+++ s+l+a  +
  gi|8724270     1    ---------------------------SDGRNTAANDKASDLMAL-R 19   

                CS X-GCGSCCCHHH-CCCB-X   
                   kecCsdppcavsrpeyscG<-*
                    +cCs+p c v +p+ ++G   
  gi|8724270    20 DGCCSNPSCSVNNPDICGG    38   

Score/E-value (less TMSP): 29.138/1.75028400647855e-05
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/43.988/-11.455 (3.595/0.2)


gi|73808761|gb|AAZ85380.1|LiC22P, Conus lividus
Toxin_8  Alpha conotoxin precursor                       -3.0        2.1   1
Toxin_8    1/1       1    37 [.     1    66 []    -3.0      2.1
Toxin_8: domain 1 of 1, from 1 to 37: score -3.0, E = 2.1
                CS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXX
                   *->MGMRMMFtVFLLVVLAtTVVsvtsdrAsdGRnaaakarqssliassi
                                                 sdGRn+aa+++ s+l+   +
  gi|7380876     1    ---------------------------SDGRNDAANDKASKLMVL-R 19   

                CS X-GCGSCCCHHH-CCCB-X   
                   kecCsdppcavsrpeyscG<-*
                    ecC +ppc++s+p++ c    
  gi|7380876    20 NECCDNPPCKSSNPDL-CD    37   

Score/E-value (less TMSP): 25.938/0.000160843866491821
TMSP/non-TMSP/fixed score (recomputed/original total): -28.938/40.197/-11.455 (-0.196/-3.0)


