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Domain name : PF03381.7_CDC50
Domain size : 36
Domain Description : LEM3 (ligand-effect modulator 3) family / CDC50 family
Domain gathering score : -143.3000
Domain trusted cutoff : -124.6000
Domain architecture : non-TM/SP [1 453], TM [454 495]
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Example 1
gi|149751203|ref|XP_001489157.1| PREDICTED: similar to carbonic anhydrase XIV [Equus caballus] 336 (length) 297 324 .. (wrt seq) 460 495 .] (wrt HMM) 
No.of residues in non-TM/SP region : 0 [100%(over non-TM/SP length)]

Scores for sequence family classification:
Model        Description                                Score    E-value  N
--------     -----------                                -----    ------- ---
Carb_anhydrase  Eukaryotic-type carbonic anhydrase      298.7    1.2e-86   1
CDC50           LEM3 (ligand-effect modulator 3) fami    17.7    7.1e-05   1

Parsed for domains:
Model        Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------     ------- ----- -----    ----- -----      -----  -------
Carb_anhydrase    1/1      22   278 ..     1   280 []   298.7  1.2e-86
CDC50             1/1     297   325 ..   325   353 .]    17.7  7.1e-05

Alignments of top-scoring domains:
Carb_anhydrase: domain 1 of 1, from 22 to 278: score 298.7, E = 1.2e-86
                CS    -SSTTTSCCCH.......HHTSGGGGS.GGGGSSSSSBEEECGGCEE
                   *->WgYeegngpehhnnahPLWhklyPiAnGGnCqGeRQSPInIqtkkak
                      W+Ye   g +h       W+  yP ++      + QSPInIqt  + 
  gi|1497512    22    WTYEGPHGQDH-------WPASYPECG-----SNAQSPINIQTDSVT 56   

                CS ETTTEEEEEEETTGGEEE. EEEEESSSEEEEEETSSSSSEEEETTTSSS
                   yDPsLkpLslSYdaatake.feivNnGHsvqVefdDsddksvlsGGpLpg
                    DP L +L+  ++++  +e+  + NnGH+vq +++       l G  Lp 
  gi|1497512    57 FDPELPALQPHGYDKPGTEpLDMHNNGHTVQLSLPP---ALYLEG--LPQ 101  

                CS EEEEEEEEEEES..STTTS-SSEETTBB-SEEEEEEEEEGTGGSSHHHHT
                   pYRLkQfHFHWGGAssddqGSEHTVDGkkYaaELHLVHWNstKYssykeA
                    Y + Q+H+HWG  +    GSEH ++ k+ aaELH+VH+ s  Y s  eA
  gi|1497512   102 KYVAAQLHLHWG-QKGAPGGSEHQINSKATAAELHIVHYDSDSYDSLSEA 150  

                CS TSTTSEEEEEEEEEESS.SS-GGGHHHHHHGGGGCSTTTEEEECSEEGGG
                   vkkpDGLAVlGvFlkvGdykenpglqkvvDaLdsIktKGksatftnFDps
                   ++ p GLAVlG++ ++G  + np++   + +L +I++K+ +++ ++F++ 
  gi|1497512   151 AQRPQGLAVLGILIEAG-ETKNPAYEHILGHLHEIRHKDEKTSVPPFNVG 199  

                CS GSSSSCCGCGEEEEEEE-SSTTT-SSEEEEEESSSEEEEHHHHHHHCTSB
                   dLLPseeklrDYWtYpGSLTTPPltEsVtWiVlkepIsvSseQllkFRsL
                    LLP   +l  +++Y GSLTTPP++ sV W+V+    ++S eQl+k+   
  gi|1497512   200 ELLPP--QLGQFFRYNGSLTTPPCYQSVLWTVFNQRAQISMEQLEKLQET 247  

                CS SSCTTSSS-BB...-------B--TTT--EEESS   
                   lfsaegeeevpcdimvdNyRPtQPLkgRvVrAsF<-*
                   lfs ege+ +    +v+NyR +QPL++R+V AsF   
  gi|1497512   248 LFSTEGEPPEL---LVQNYRAPQPLNQRTVFASF    278  

CDC50: domain 1 of 1, from 297 to 325: score 17.7, E = 7.1e-05
                   *->lvVGglclvlgivfliihlikpRklgDps<-*
                      +vVG+lcl+l+++f++++++k R    +s   
  gi|1497512   297    IVVGCLCLLLAVYFIARKIRKKRLGSRKS    325  



Example 2
gi|164687437|ref|ZP_02211465.1| hypothetical protein CLOBAR_01078 [Clostridium bartlettii DSM 16795]gi|164603211|gb|EDQ96676.1| hypothetical protein CLOBAR_01078 [Clostridium bartlettii DSM 16795] 285 (length) 242 272 .. (wrt seq) 458 495 .] (wrt HMM) 
No.of residues in non-TM/SP region : 0 [100%(over non-TM/SP length)]

Scores for sequence family classification:
Model        Description                                Score    E-value  N
--------     -----------                                -----    ------- ---
Abi             CAAX amino terminal protease family      78.8    2.1e-21   1
CDC50           LEM3 (ligand-effect modulator 3) fami    17.8    6.7e-05   1

Parsed for domains:
Model        Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------     ------- ----- -----    ----- -----      -----  -------
Abi               1/1     131   220 ..     1   115 []    78.8  2.1e-21
CDC50             1/1     242   272 ..   323   353 .]    17.8  6.7e-05

Alignments of top-scoring domains:
Abi: domain 1 of 1, from 131 to 220: score 78.8, E = 2.1e-21
                   *->llilllvllaplaEElfFRGilltalerrlkkrytlfgpllaiiiss
                      + ++l+v+ ap+ EElfFR +l+ +++         f++++ +i+ss
  gi|1646874   131    ASFILTVISAPILEELFFRVVLFKRISKF-------FNVYIGMILSS 170  

                   liFallHlanalelgllliqpvlinwlqllytfllGlvlgllylrrtgsL
                   l+F++lH+++a                 +++++++G+   +lyl + +++
  gi|1646874   171 LLFGVLHMELA-----------------IVGAVIFGFANCILYL-KYRNI 202  

                   lapilvHalnNligfill<-*
                   l p+ vH+lnN+++ i     
  gi|1646874   203 LIPMTVHFLNNFLVSIHT    220  

CDC50: domain 1 of 1, from 242 to 272: score 17.8, E = 6.7e-05
                   *->aYlvVGglclvlgivfliihlikpRklgDps<-*
                      aYl+ G++ +++g +++i++++k Rk+ + +   
  gi|1646874   242    AYLILGAIVFIIGMILFIRFIVKNRKYIESD    272  



Example 3
gi|123422284|ref|XP_001306144.1| polymorphic outer membrane protein [Trichomonas vaginalis G3]gi|121887702|gb|EAX93214.1| polymorphic outer membrane protein, putative [Trichomonas vaginalis G3] 569 (length) 479 512 .. (wrt seq) 457 495 .] (wrt HMM) 
No.of residues in non-TM/SP region : 0 [100%(over non-TM/SP length)]

Scores for sequence family classification:
Model        Description                                Score    E-value  N
--------     -----------                                -----    ------- ---
Chlam_PMP       Chlamydia polymorphic membrane protei    41.6    4.9e-10   4
CDC50           LEM3 (ligand-effect modulator 3) fami    14.4    0.00065   1
DUF916          Bacterial protein of unknown function     7.7      0.049   1

Parsed for domains:
Model        Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------     ------- ----- -----    ----- -----      -----  -------
Chlam_PMP         1/4      72    96 ..     1    19 []    11.6    0.072
Chlam_PMP         2/4     108   125 ..     1    19 []    10.2     0.18
Chlam_PMP         3/4     133   151 ..     1    19 []     8.7     0.44
Chlam_PMP         4/4     171   188 ..     1    18 [.    11.1      0.1
CDC50             1/1     479   511 ..   322   353 .]    14.4  0.00065
DUF916            1/1     469   509 ..   327   368 .]     7.7    0.049

Alignments of top-scoring domains:
Chlam_PMP: domain 1 of 4, from 72 to 96: score 11.6, E = 0.072
                   *->ditFsgNsa......aggGGAiyas<-*
                       ++Fs+N a   ++ ag GGAi+ s   
  gi|1234222    72    KTEFSNNYAfcagsaAGIGGAIFIS    96   

Chlam_PMP: domain 2 of 4, from 108 to 125: score 10.2, E = 0.18
                   *->ditFsgNsaaggGGAiyas<-*
                      +i+F +N+a + GG+i +    
  gi|1234222   108    SIIFKKNEA-SVGGGIASL    125  

Chlam_PMP: domain 3 of 4, from 133 to 151: score 8.7, E = 0.44
                   *->ditFsgNsaaggGGAiyas<-*
                       +tFsgN+a + GGAiy +   
  gi|1234222   133    KVTFSGNTAFKYGGAIYYQ    151  

Chlam_PMP: domain 4 of 4, from 171 to 188: score 11.1, E = 0.1
                   *->ditFsgNsaaggGGAiya<-*
                      d+tF +N+a++ GGA+ a   
  gi|1234222   171    DCTFRNNAAYELGGAVAA    188  

CDC50: domain 1 of 1, from 479 to 511: score 14.4, E = 0.00065
                   *->IaYlvVGglclvlgivfliihli.kpRklgDps<-*
                      I++++VG++c  + i+++++++i ++Rk ++     
  gi|1234222   479    IIWIIVGCVCGAILIGLILAFFIiRSRKSNEEE    511  

DUF916: domain 1 of 1, from 469 to 509: score 7.7, E = 0.049
                   *->NqkaVtkkkkdnnWllyiiiglllllllllivyliwkrkkkk<-*
                      N     kk  +++W++ + +   +l+ l+l++++i+ rk ++   
  gi|1234222   469    NAANPRKK-TSIIWIIVGCVCGAILIGLILAFFIIRSRKSNE    509  



Example 4
gi|73981547|ref|XP_540298.2| PREDICTED: similar to carbonic anhydrase XIV precursor [Canis familiaris] 337 (length) 298 325 .. (wrt seq) 460 495 .] (wrt HMM) 
No.of residues in non-TM/SP region : 0 [100%(over non-TM/SP length)]

Scores for sequence family classification:
Model        Description                                Score    E-value  N
--------     -----------                                -----    ------- ---
Carb_anhydrase  Eukaryotic-type carbonic anhydrase      290.3    4.2e-84   1
CDC50           LEM3 (ligand-effect modulator 3) fami    13.7    0.00098   1
HAMP            HAMP domain                               9.1      0.099   1

Parsed for domains:
Model        Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------     ------- ----- -----    ----- -----      -----  -------
Carb_anhydrase    1/1      23   279 ..     1   280 []   290.3  4.2e-84
CDC50             1/1     298   326 ..   325   353 .]    13.7  0.00098
HAMP              1/1     294   318 ..     1    25 [.     9.1    0.099

Alignments of top-scoring domains:
Carb_anhydrase: domain 1 of 1, from 23 to 279: score 290.3, E = 4.2e-84
                CS    -SSTTTSCCCH.......HHTSGGGGS.GGGGSSSSSBEEECGGCEE
                   *->WgYeegngpehhnnahPLWhklyPiAnGGnCqGeRQSPInIqtkkak
                      W+Y    g +h       W+   P ++      + QSPI+Iqt  + 
  gi|7398154    23    WTYVGPHGQDH-------WPASHPECG-----SNAQSPIDIQTDSVT 57   

                CS ETTTEEEEEEETTGGEEE. EEEEESSSEEEEEETSSSSSEEEETTTSSS
                   yDPsLkpLslSYdaatake.feivNnGHsvqVefdDsddksvlsGGpLpg
                    DP L +L+l +++   +e+  + NnGH+vq +++       l G  Lp 
  gi|7398154    58 FDPELPALQLQGYDQPGTEpLDLHNNGHTVQLSLPP---TMYLEG--LPR 102  

                CS EEEEEEEEEEES..STTTS-SSEETTBB-SEEEEEEEEEGTGGSSHHHHT
                   pYRLkQfHFHWGGAssddqGSEHTVDGkkYaaELHLVHWNstKYssykeA
                    Y + Q+H+HWG      +GSEH ++G++ aaELH+VH+ s  Y s +eA
  gi|7398154   103 KYVAAQLHLHWG-ETGSLRGSEHQINGEATAAELHIVHYDSDSYDSLGEA 151  

                CS TSTTSEEEEEEEEEESS.SS-GGGHHHHHHGGGGCSTTTEEEECSEEGGG
                   vkkpDGLAVlGvFlkvGdykenpglqkvvDaLdsIktKGksatftnFDps
                   + kp GLAVlG++ +vG  + np +   +++L +I++K+++++ ++F++ 
  gi|7398154   152 APKPQGLAVLGILIEVG-EAKNPVYEHILSHLHEIRHKDQKTSVPPFNVG 200  

                CS GSSSSCCGCGEEEEEEE-SSTTT-SSEEEEEESSSEEEEHHHHHHHCTSB
                   dLLPseeklrDYWtYpGSLTTPPltEsVtWiVlkepIsvSseQllkFRsL
                    LLP   +l  +++Y GSLTTPP++ sV W+V+    ++S  Ql+++   
  gi|7398154   201 ELLPP--QLNQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEELQET 248  

                CS SSCTTSSS-BB...-------B--TTT--EEESS   
                   lfsaegeeevpcdimvdNyRPtQPLkgRvVrAsF<-*
                   lfs e e+ +    +v+NyR +QPL++R+V AsF   
  gi|7398154   249 LFSTEEEPSKL---LVRNYRAPQPLNQRTVFASF    279  

CDC50: domain 1 of 1, from 298 to 326: score 13.7, E = 0.00098
                   *->lvVGglclvlgivfliihlikpRklgDps<-*
                      + VG+lcl+l+++f++++++k R  + ++   
  gi|7398154   298    ILVGCLCLLLAVYFIARKIRKKRLGNRKT    326  

HAMP: domain 1 of 1, from 294 to 318: score 9.1, E = 0.099
                CS    HHHHHHHHHHHHHHHHHH-XXXXXX   
                   *->lllvllialllalllalllarrilr<-*
                      l++++l+++l +ll+++++ar i +   
  gi|7398154   294    LGVGILVGCLCLLLAVYFIARKIRK    318  



Example 5
gi|194036285|ref|XP_001924916.1| PREDICTED: similar to carbonic anhydrase 14 [Sus scrofa] 233 (length) 194 221 .. (wrt seq) 460 495 .] (wrt HMM) 
No.of residues in non-TM/SP region : 0 [100%(over non-TM/SP length)]

Scores for sequence family classification:
Model        Description                                Score    E-value  N
--------     -----------                                -----    ------- ---
Carb_anhydrase  Eukaryotic-type carbonic anhydrase      108.0    3.7e-31   1
CDC50           LEM3 (ligand-effect modulator 3) fami    14.5    0.00058   1
HAMP            HAMP domain                               9.1      0.099   1

Parsed for domains:
Model        Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------     ------- ----- -----    ----- -----      -----  -------
Carb_anhydrase    1/1      85   175 ..   185   280 .]   108.0  3.7e-31
CDC50             1/1     194   222 ..   325   353 .]    14.5  0.00058
HAMP              1/1     190   214 ..     1    25 [.     9.1    0.099

Alignments of top-scoring domains:
Carb_anhydrase: domain 1 of 1, from 85 to 175: score 108.0, E = 3.7e-31
                CS    TEEEECSEEGGGGSSSSCCGCGEEEEEEE-SSTTT-SSEEEEEESSS
                   *->GksatftnFDpsdLLPseeklrDYWtYpGSLTTPPltEsVtWiVlke
                      +++++ ++F++++LLP   +l  +++Y GSLTTPP++ sV W+V+  
  gi|1940362    85    DQRTSVPPFNVRGLLPP--LLAQFFRYNGSLTTPPCYQSVLWTVFNR 129  

                CS EEEEHHHHHHHCTSBSSCTTSSS-BB...-------B--TTT--EEESS 
                   pIsvSseQllkFRsLlfsaegeeevpcdimvdNyRPtQPLkgRvVrAsF<
                     ++S  Ql+k+   lfs e e+ +    +v+NyR +QPL++R V AsF 
  gi|1940362   130 RAQISMGQLEKLQEALFSTEEEPSQL---LVQNYRAPQPLNQRIVLASF  175  

                CS   
                   -*
                     
  gi|1940362     -    -    

CDC50: domain 1 of 1, from 194 to 222: score 14.5, E = 0.00058
                   *->lvVGglclvlgivfliihlikpRklgDps<-*
                      + VG+lcl+l+++f++++++k R  + +s   
  gi|1940362   194    ILVGCLCLLLAVYFIARKIRKKRLGNRKS    222  

HAMP: domain 1 of 1, from 190 to 214: score 9.1, E = 0.099
                CS    HHHHHHHHHHHHHHHHHH-XXXXXX   
                   *->lllvllialllalllalllarrilr<-*
                      l++++l+++l +ll+++++ar i +   
  gi|1940362   190    LGVGILVGCLCLLLAVYFIARKIRK    214  

