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Domain name : PF08294.3_TIM21
Domain size : 157
Domain gathering score : -20.3000
Domain gathering score(TMSP) : 0.19
Domain gathering score(non-TMSP) : -10.88
Domain architecture : TM/SP [1 36], non-TM/SP [37 157]
Total query sequences in database : 118
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A8Q3A7 A8Q3A7_MALGO Putative uncharacterized protein [Malassezia globosa CBS 7966]
TIM21      TIM21                                        -10.6    4.3e-05   1
TIM21        1/1     121   258 ..     1   157 []   -10.6  4.3e-05
TIM21: domain 1 of 1, from 121 to 258: score -10.6, E = 4.3e-05
                   *->KvkeattftfyfiiVlgGvGvtGlviYlifsELFSpsgdtqiFNrAv
                      K+++ t +t+ + ++ +G  +t ++ Y++fsELF++ ++t i+N+A 
      A8Q3A7   121    KAARVTVNTSRLFVITFGATLTFVIGYALFSELFAQNSPTVIYNEAC 167  

                   erveeneevrdlLqCnDgvtkGeri...........KayGEetrrgRWtR
                   +++e+   v++ L       ++ r +++ ++ +++ + +   +++ R   
      A8Q3A7   168 KLIEKSDKVHAHL------LEPYRFqtsltdfrsdySPLNPPSHPHR--P 209  

                   NRpivStreyd.kdGveHlrMrFHVeGSekrkeGtVhlElvesddsgqye
                    ++  Str  d++ G e ++++F V++           + ++ +  g + 
      A8Q3A7   210 SQTVHSTRYMDpRTGHEMMVLHFFVQS-----------RDKDEPL-GYWQ 247  

                   FrylyVevDvpgekrIylednr<-*
                   + +             ++ + r   
      A8Q3A7   248 YARSS-----------IITGGR    258  

TMSP/non-TMSP/fixed score (recomputed/original total): 34.714/-36.295/-9.607 (-11.188/-10.6)


C0S2Y0 C0S2Y0_PARBP Import inner membrane translocase subunit tim-21, mitochondrial [Paracoccidioides brasiliensis Pb03]
TIM21       TIM21                                       -14.5    8.9e-05   1
TIM21         1/1      74   148 .]     1   157 []   -14.5  8.9e-05
TIM21: domain 1 of 1, from 74 to 148: score -14.5, E = 8.9e-05
                   *->KvkeattftfyfiiVlgGvGvtGlviYlifsELFSpsgdtqiFNrAv
                      K+++at+++++f i+++G         ++ +E+F+p+++t+ FNrA 
      C0S2Y0    74    KAARATQQSANFLIIVIG---------AVMTEVFAPDSKTRNFNRAA 111  

                   erveeneevrdlLqCnDgvtkGeriKayGEetrrgRWtRNRpivStreyd
                   +r++e+ ++++lL      +++ +i ayGE++  ++WtRNRpi+      
      C0S2Y0   112 DRIKEDSRCIELL------GDKNKIRAYGETSW-NKWTRNRPIA------ 148  

                   kdGveHlrMrFHVeGSekrkeGtVhlElvesddsgqyeFrylyVevDvpg
                                                                     
      C0S2Y0     - -------------------------------------------------- -    

                   ekrIylednr<-*
                                
      C0S2Y0     - ----------    -    

TMSP/non-TMSP/fixed score (recomputed/original total): 22.331/-27.499/-9.607 (-14.775/-14.5)


C3Y8L0 C3Y8L0_BRAFL Putative uncharacterized protein (Fragment) [Branchiostoma floridae]
TIM21    TIM21                                           10.3    7.7e-07   1
TIM21      1/1      99   177 .]     1   157 []    10.3  7.7e-07
TIM21: domain 1 of 1, from 99 to 177: score 10.3, E = 7.7e-07
                   *->KvkeattftfyfiiVlgGvGvtGlviYlifsELFSpsgdtqiFNrAv
                      Kv ea+++++y++iV++GvGv G+++Y+i +ELFS  + + i+ +A 
      C3Y8L0    99    KVVEAGKDVTYLGIVIFGVGVMGVLFYAIGRELFSGGSINGIYTDAM 145  

                   erveeneevrdlLqCnDgvtkGeriKayGEetrrgRWtRNRpivStreyd
                    r+++neev+ +L        G +i+++GEetrrgR    R++       
      C3Y8L0   146 NRCKDNEEVKVAL--------GTPIAGFGEETRRGR----RRH------- 176  

                   kdGveHlrMrFHVeGSekrkeGtVhlElvesddsgqyeFrylyVevDvpg
                                                  +                  
      C3Y8L0   177 -------------------------------P------------------ 177  

                   ekrIylednr<-*
                                
      C3Y8L0     - ----------    -    

TMSP/non-TMSP/fixed score (recomputed/original total): 64.641/-45.091/-9.607 (9.943/10.3)


Q2H2T5 Q2H2T5_CHAGB Putative uncharacterized protein [Chaetomium globosum]
TIM21    TIM21                                           38.9    3.1e-09   1
TIM21      1/1      88   171 .]     1   157 []    38.9  3.1e-09
TIM21: domain 1 of 1, from 88 to 171: score 38.9, E = 3.1e-09
                   *->KvkeattftfyfiiVlgGvGvtGlviYlifsELFSpsgdtqiFNrAv
                      K ++a+++tf+f+ V+ Gv++tG+v Y++ sE+FSp+++t++FNrAv
      Q2H2T5    88    KTGRAAQQTFNFGMVVVGVVLTGGVGYVLYSEVFSPDSKTTYFNRAV 134  

                   erveeneevrdlLqCnDgvtkGeriKayGEetrrgRWtRNRpivStreyd
                   +r+++++++ +lL      ++G++i a+GEet+ ++W+R+Rp        
      Q2H2T5   135 DRIRKDPRCLELL------GDGKKITAFGEETH-NKWRRARP-------- 169  

                   kdGveHlrMrFHVeGSekrkeGtVhlElvesddsgqyeFrylyVevDvpg
                                                            l+       
      Q2H2T5   170 -----------------------------------------LA------- 171  

                   ekrIylednr<-*
                                
      Q2H2T5     - ----------    -    

TMSP/non-TMSP/fixed score (recomputed/original total): 59.307/-11.175/-9.607 (38.525/38.9)


Q5KL41 Q5KL41_CRYNE Expressed protein [Filobasidiella neoformans]
TIM21      TIM21                                         -8.2    2.7e-05   1
TIM21        1/1     100   240 ..     1   157 []    -8.2  2.7e-05
TIM21: domain 1 of 1, from 100 to 240: score -8.2, E = 2.7e-05
                   *->KvkeattftfyfiiVlgGvGvtGlviYlifsELFSpsgdtqiFNrAv
                      K  ++t++t++++++l+G+ +++++ +++ +ELF+  +++ +++ A 
      Q5KL41   100    KLVRTTQQTGNLTVILFGGALFVVLTFALTTELFAKNSPSVLYSHAI 146  

                   erve.eneevrdlL...qCnDgvtkGeriKayGEetrrgRWtRNRpivSt
                   ++++++n    +lL++ +   ++++++++        rg      p+ ++
      Q5KL41   147 DMIRgSNALDAYLLpplKFTHSPHSSAPV--------RGS-----PPIAH 183  

                   reydk..dGveHlrMrFHVeGSekrkeGtVhlElvesddsgqyeFrylyV
                   + + ++++G++Hl+  F + G          +  +e + s+     + +V
      Q5KL41   184 TFIRNptSGKDHLVISFWIHG---------RAKDEEETLSWIKQGWRSAV 224  

                   evDvpgekrIylednr<-*
                        g    + e+++   
      Q5KL41   225 AWGKEGMDMLVGEKPE    240  

TMSP/non-TMSP/fixed score (recomputed/original total): 41.021/-40.175/-9.607 (-8.761/-8.2)


Q5REP2 TI21L_PONAB TIM21-like protein, mitochondrial [Pongo abelii]
TIM21           TIM21                                   -12.5    6.1e-05   1
TIM21             1/1     100   168 ..     1   157 []   -12.5  6.1e-05
TIM21: domain 1 of 1, from 100 to 168: score -12.5, E = 6.1e-05
                   *->KvkeattftfyfiiVlgGvGvtGlviYlifsELFSpsgdtqiFNrAv
                      Kvkea+++++y+i+Vl+G+++tG+++Y+if+ELFS+s++++i++rA+
      Q5REP2   100    KVKEAGRDFTYLIVVLFGISITGGLFYTIFKELFSSSSPSKIYGRAL 146  

                   erveeneevrdlLqCnDgvtkGeriKayGEetrrgRWtRNRpivStreyd
                   e++++++e                          gR              
      Q5REP2   147 EKCRSHPE--------------------------GR-------------- 156  

                   kdGveHlrMrFHVeGSekrkeGtVhlElvesddsgqyeFrylyVevDvpg
                                ++           +  +sd         ++       
      Q5REP2   157 -------------SS-----------HRPRSDV--------IA------- 167  

                   ekrIylednr<-*
                            r   
      Q5REP2   168 ---------R    168  

TMSP/non-TMSP/fixed score (recomputed/original total): 71.843/-75.027/-9.607 (-12.791/-12.5)


Q8CCM6 TI21L_MOUSE TIM21-like protein, mitochondrial [Mus musculus]
TIM21    TIM21                                           28.3    2.4e-08   1
TIM21      1/1      98   249 .]     1   157 []    28.3  2.4e-08
TIM21: domain 1 of 1, from 98 to 249: score 28.3, E = 2.4e-08
                   *->KvkeattftfyfiiVlgGvGvtGlviYlifsELFSpsgdtqiFNrAv
                      Kv+ea+++++y+i+Vl+GvG+tG+++Y+if+ELF +s+++ i+++A+
      Q8CCM6    98    KVREAGRDVSYLIVVLFGVGLTGGLLYAIFKELFFSSSPNIIYGKAL 144  

                   erveeneevrdlLqCnDgvtkGeriKayGEetrrgRWtRNRpivS.trey
                    ++++++ev  l      +  G r +++       +     p +S ++++
      Q8CCM6   145 GKCRTHPEVSFLM-----IVLGRRCASL------LK-----PMLScFSVF 178  

                   dkdGveHl......rMrFHVeGSekrkeGtVh....lElvesddsgqyeF
                     +   H ++++ ++ +F V  S +  +G+ h++ +  l ++ +   + +
      Q8CCM6   179 RSHSLMHFdpgtvsYIHFSVVLSAPASSGLRHpsykTILNQNVAKRVESW 228  

                   rylyVevDvpgekrI..ylednr<-*
                   ++l   + ++   rI+++l ++    
      Q8CCM6   229 QRLH--LGHYIVYRIqgILCGPQ    249  

TMSP/non-TMSP/fixed score (recomputed/original total): 70.046/-32.741/-9.607 (27.698/28.3)


nonTMSP insignificant hits/no hmmpfamresult hits (total %) :7/1 (8 6.8%)
