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Domain name : PF01105.16_EMP24_GP25L
Domain size : 167
Domain gathering score : -16.0000
Domain gathering score(TMSP) : 13.82
Domain gathering score(non-TMSP) : -20.28
Domain architecture : TM/SP [142 167], non-TM/SP [1 141]
Total query sequences in database : 1029
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A5E4J1 A5E4J1_LODEL Putative uncharacterized protein [Lodderomyces elongisporus]
EMP24_GP25L  emp24/gp25L/p24 family/GOLD                -12.3     0.0013   1
EMP24_GP25L    1/1      53   292 ..     1   167 []   -12.3   0.0013
EMP24_GP25L: domain 1 of 1, from 53 to 292: score -12.3, E = 0.0013
                   *->altfelppgekeCFyEelkkkgtkvtgsYqVi...............
                      +    l+  +  C+  e + k + + ++   +++ ++++ +    ++
      A5E4J1    53    DKKSSLKNLQ-NCVSYETT-KKDIMFVTISNVeqftsqslnllildd 97   

                   ................didvtvkdPfdngkrvlykk....erkseGdftF
                   ++++ +++++ ++ ++ +   +++ ++   +vl +k+++++  s+++++ 
      A5E4J1    98 qgntlrnqqdigkfnrEVELLITNLESLKSIVLEEKreegKANSNNNVEE 147  

                   talesGeYkfCFsNefsktfs....sktVsfdid................
                    a+++    +CF+N +s   s + ++ + +f+++ + +++ ++++ +  +
      A5E4J1   148 IAKDTKMIHVCFDNVYS-DLSwsfqPRIFEFEVTvnikndiestdygmyr 196  

                   .......................kekldpalessirkLeeqlnsikreQk
                   +  +  +++++++++ + +  + + k+   +e  ++++ ++l ++ +  k
      A5E4J1   197 qyftylqdenskegqaeinamsfEAKMLL-VEMDLQTVVDKLLELDETLK 245  

                   ylrekREarhrntsEsTNsRVvwWSiiqllvlvgvsvfQvyyLKrFFe<-
                   +l+e  E   r+ +E++ s  ++ Si+ ++ +++ +++Q+ y K++    
      A5E4J1   246 LLME-NEFKLRDANEEIFSGYTLISIVLCVTILVCGLLQLIYFKFYLR   292  

                   *
                    
      A5E4J1     -   -    

TMSP/non-TMSP/fixed score (recomputed/original total): 18.449/-22.228/-9.473 (-13.252/-12.3)


A7NVB0 A7NVB0_VITVI Chromosome chr18 scaffold_1, whole genome shotgun sequence [Vitis vinifera]
EMP24_GP25L emp24/gp25L/p24 family/GOLD                 -13.3     0.0015   1
EMP24_GP25L   1/1       1    88 [.     1   167 []   -13.3   0.0015
EMP24_GP25L: domain 1 of 1, from 1 to 88: score -13.3, E = 0.0015
                   *->altfelppgekeCFyEelkkkgtkvtgsYqVididvtvkdPfdngkr
                                      e+  +                    +  g+ 
      A7NVB0     1    ---------------MEIM-R--------------------K--GQ- 8    

                   vlykkerkseGdftFtalesGeYkfCFsNefsktfssktVsfdid....k
                                                             d+d+  +k
      A7NVB0     9 ------------------------------------------DWDsvakK 16   

                   ekldpalessirkLeeqlnsikreQkylrekREarhrntsEsTNsRVvwW
                   ek+++ +e ++rkLe+ +n+i+++  +l+e REa +r++sE TNsRV+w+
      A7NVB0    17 EKIEG-VEFELRKLEGIVNAIHENIIFLKE-REAKMREVSETTNSRVAWF 64   

                   SiiqllvlvgvsvfQvyyLKrFFe<-*
                   S+++l+v+++v+++Q+++L++FF    
      A7NVB0    65 SLMSLGVCIVVAALQLWHLQHFFR    88   

TMSP/non-TMSP/fixed score (recomputed/original total): 50.8/-48.649/-15.797 (-13.646/-13.3)


B4DZH3 B4DZH3_HUMAN cDNA FLJ52032, highly similar to Transmembrane emp24 domain-containing protein 10 [Homo sapiens]
EMP24_GP25L emp24/gp25L/p24 family/GOLD                 -15.4     0.0021   1
EMP24_GP25L   1/1       1    88 [.     1   167 []   -15.4   0.0021
EMP24_GP25L: domain 1 of 1, from 1 to 88: score -15.4, E = 0.0021
                   *->altfelppgekeCFyEelkkkgtkvtgsYqVididvtvkdPfdngkr
                                       +k++                v++ +   + 
      B4DZH3     1    -----------------MKHG----------------VEAKN--YE- 11   

                   vlykkerkseGdftFtalesGeYkfCFsNefsktfssktVsfdidkekld
                    ++k e+                                         l+
      B4DZH3    12 EIAKVEK-----------------------------------------LK 20   

                   palessirkLeeqlnsikreQkylrekREarhrntsEsTNsRVvwWSiiq
                   p le ++r+Le++ +si ++  y++  RE+++r+t+EsTN+RV ++Si++
      B4DZH3    21 P-LEVELRRLEDLSESIVNDFAYMKK-REEEMRDTNESTNTRVLYFSIFS 68   

                   llvlvgvsvfQvyyLKrFFe<-*
                   ++ l+g + +Qv+yL+rFF+   
      B4DZH3    69 MFCLIGLATWQVFYLRRFFK    88   

TMSP/non-TMSP/fixed score (recomputed/original total): 43.922/-43.908/-15.797 (-15.783/-15.4)


B8C7C9 B8C7C9_THAPS Predicted protein [Thalassiosira pseudonana CCMP1335]
EMP24_GP25L  emp24/gp25L/p24 family/GOLD                 -9.1    0.00077   1
EMP24_GP25L    1/1      26   377 ..     1   167 []    -9.1  0.00077
EMP24_GP25L: domain 1 of 1, from 26 to 377: score -9.1, E = 0.00077
                   *->altfelppgekeCFyEelkkkgtkvtgsYqVi...............
                      +l++++p +++eC+yE + + g+++t s +V+++++ +     +++ 
      B8C7C9    26    PLSYTIPYHQEECLYERIATPGEHLTSSVFVVsgeelraavliegpv 72   

                   ..................................................
                    + + + ++++ +++++ ++  ++  +++ +   +++++++ ++ ++ + 
      B8C7C9    73 apadfdlqnehlgggtelqkfleryakegmkmfasgehgdsmqnvrpvrf 122  

                   ..didvt...........................................
                   ++ +d++ +++  ++   +++ ++ + ++++++++++++    ++ ++++
      B8C7C9   123 teMLDFEaeeevyddavaeqelpplhaggggrnrhteekavaaddyerrr 172  

                   .......................................vkdPfdngkrv
                   +++ +++ +++ + +++  + + ++++++++ +++++++ +  +   + +
      B8C7C9   173 eqklkrqveeevefdddfvklqmerrnkrggaggrerqqRRRLQ--EQAT 220  

                   lykkerkseGdftFtalesGeYkfCFsNefsktfssktVsfdid......
                   l  +  ++  + t+ ++ +G Y+ C       + ++  V++++++++  +
      B8C7C9   221 LMAG--EPY-QKTIEVQSPGWYRLCVRA----KVQTIEVEMELRksslyg 263  

                   .........................................kekldpale
                   + ++++++ ++ ++ + +++ ++  +++++ +   +++  ++e+l     
      B8C7C9   264 kvdprtghvpsledvevhseihqlfdkeddatiiaeeeaikDEDLSA-TR 312  

                   ssirkLeeqlnsikreQkylrekREarhrnt..sEsTNsRVvwWSiiqll
                   +++r Le+  ++i + Q  l e R   + +t +++  +s +v+  +++++
      B8C7C9   313 EQLRILERVYQDIISKQ--LEE-RRTWNWRTihNKHLYSHMVMGNLVETV 359  

                   vlvgvsvfQvyyLKrFFe<-*
                   + +g++++Qvy ++++F    
      B8C7C9   360 FYMGITGWQVYTIRKWFG    377  

TMSP/non-TMSP/fixed score (recomputed/original total): 22.506/-23.553/-9.473 (-10.520/-9.1)


C5M6J8 C5M6J8_CANTT Putative uncharacterized protein [Candida tropicalis MYA-3404]
EMP24_GP25L   emp24/gp25L/p24 family/GOLD                 4.5    9.6e-05   1
EMP24_GP25L     1/1       7   145 ..     1   167 []     4.5  9.6e-05
EMP24_GP25L: domain 1 of 1, from 7 to 145: score 4.5, E = 9.6e-05
                   *->altfelppgekeCFyEe..lkkkgtkvtgsYqVi....didvtvkdP
                           +p + ke +y  + +  ++ +++   q ++ ++++ + +k+ 
      C5M6J8     7    ----KIPNKDKEILYLSsiIS-ENMNFVSQIQCLhlskKLLI-LKS- 46   

                   fdngkrvlykkerkseGdftFtalesGeYkfCFsNefsktfssktVsfdi
                   +   k ++ +k+   + +     ++  + +  F N               
      C5M6J8    47 N--LK-MIMNKMVIVNLKLIYLINQVVNLRLMFEN--------------- 78   

                   dkekldpalessirkLeeqlnsikreQkylrekREarhrntsEsTNsRVv
                           + + ++k+e+ql+ +++  +y+++ R++r+++t++sT+sR+ 
      C5M6J8    79 --------MRKTVDKIEDQLDGLYKALQYYKT-RNNRNQATVQSTESRIY 119  

                   wWSiiqllvlvgvsvfQvyyLKrFFe<-*
                   ++Si+++l++vg++++Q+ +++ FF    
      C5M6J8   120 YFSIFEVLLMVGMAFLQITIVQLFFR    145  

TMSP/non-TMSP/fixed score (recomputed/original total): 40.295/-20.582/-15.797 (3.916/4.5)


Q019P7 Q019P7_OSTTA Emp24/gp25L/p24 family of membrane trafficking proteins (ISS) (Fragment) [Ostreococcus tauri]
EMP24_GP25L emp24/gp25L/p24 family/GOLD                  -3.0     0.0003   1
EMP24_GP25L   1/1       1   123 [.     1   167 []    -3.0   0.0003
EMP24_GP25L: domain 1 of 1, from 1 to 123: score -3.0, E = 0.0003
                   *->altfelppgekeCFyEelkkkgtkvtgsYqVididvtvkdPfdngkr
                                                                + gk 
      Q019P7     1    --------------------X---------------------ALGK- 5    

                   vlykkerkseGdftFtalesGeYkfCFsNefsktfs....sktVsfdid.
                           se +f+     +G+ + CF N  + + ++ + s  +   +d+
      Q019P7     6 --------SEHRFEYGLRKAGTIRTCFKNSGT-RDAgvrySASIGHRWDh 46   

                   ....kekldpalessirkLeeqlnsikreQkylrekREarhrntsEsTNs
                   ++ +  ++dp   ++++++e  ++++++e +y+++ R  r ++t++s N+
      Q019P7    47 ekatVKHIDP-TYERLNNVEAEVSKLMQEVRYHKT-RATRAMHTVKSVNA 94   

                   RVvwWSiiqllvlvgvsvfQvyyLKrFFe<-*
                   RV +WS+i+++v+v++s++Q y+++ +F    
      Q019P7    95 RVLRWSLIEAVVMVCASIYQFYHVQTLFM    123  

TMSP/non-TMSP/fixed score (recomputed/original total): 41.598/-28.664/-15.797 (-2.863/-3.0)


Q06IX6 Q06IX6_DANRE Transmembrane emp24 protein transport domain containing 7 (Fragment) [Danio rerio]
EMP24_GP25L emp24/gp25L/p24 family/GOLD                   0.8    0.00017   1
EMP24_GP25L   1/1       1   100 [.     1   167 []     0.8  0.00017
EMP24_GP25L: domain 1 of 1, from 1 to 100: score 0.8, E = 0.00017
                   *->altfelppgekeCFyEelkkkgtkvtgsYqVididvtvkdPfdngkr
                                   F  + + k  +v++++qV+      +dP      
      Q06IX6     1    -------------FSTFTH-K--TVYFDFQVG------DDPP----- 20   

                   vlykkerkseGdftFtalesGeYkfCFsNefsktfssktVsfdidkekld
                   ++ +++r       +ta                               l+
      Q06IX6    21 LFPNENR-------VTA-------------------------------LT 32   

                   palessirkLeeqlnsikreQkylrekREarhrntsEsTNsRVvwWSiiq
                   + +es++  ++e+l s+++ Q  +r  REa  r  +E+ NsRV++WS+ +
      Q06IX6    33 Q-MESACVSIHEALKSVMDYQTHFRL-REAQGRSRAEDLNSRVAFWSVGE 80   

                   llvlvgvsvfQvyyLKrFFe<-*
                   +l+l++vsv Qv  L++FF    
      Q06IX6    81 ALILLVVSVSQVLLLRSFFS    100  

TMSP/non-TMSP/fixed score (recomputed/original total): 42.762/-26.563/-15.797 (0.402/0.8)


Q2U2X9 Q2U2X9_ASPOR Predicted protein [Aspergillus oryzae]
EMP24_GP25L emp24/gp25L/p24 family/GOLD                  21.4    7.2e-06   1
EMP24_GP25L   1/1       1   124 [.     1   167 []    21.4  7.2e-06
EMP24_GP25L: domain 1 of 1, from 1 to 124: score 21.4, E = 7.2e-06
                   *->altfelppgekeCFyEelkkkgtkvtgsYqVididvtvkdPfdngkr
                      + t      +      +lk +   + ++  +         P+   k 
      Q2U2X9     1    MSTASATRDG----LRTLK-RYPSMFMELSTS--------PN--RK- 31   

                   vlykkerkseGdftFtalesGeYkfCFsNefsktfssktVsfdid.kekl
                           +   +  ++ ++               +     + +++ ++l
      Q2U2X9    32 -------CPKILWRWKVWMK---------------T----QYALEtLQQL 55   

                   dpalessirkLeeqlnsikreQkylrekREarhrntsEsTNsRVvwWSii
                        + +r+L+e+l ++k+eQ y+++ RE+ hrnt+EsTN+RV+wWSi+
      Q2U2X9    56 IV-SRLLVRRLSEALAQVKDEQSYIVV-RERVHRNTAESTNARVKWWSIF 103  

                   qllvlvgvsvfQvyyLKrFFe<-*
                   ql+vl+g ++fQv++LKrFFe   
      Q2U2X9   104 QLAVLIGEGIFQVWWLKRFFE    124  

TMSP/non-TMSP/fixed score (recomputed/original total): 64.724/-34.395/-9.473 (20.856/21.4)


nonTMSP insignificant hits/no hmmpfamresult hits (total %) :8/33 (41 4.0%)
