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Domain name : PF00822.12_PMP22_Claudin
Domain size : 198
Domain Description : PMP-22/EMP/MP20/Claudin family
Domain gathering score : -20.0000
Domain trusted cutoff : -20.0000
Domain architecture : TM/SP [1 24; 91 198], non-TM/SP [25 90]
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Scores for complete sequences (score includes all domains):
Sequence                             Description        Score    E-value  N 
--------                             -----------        -----    ------- ---
gi|21687006|ref|NP_542375.1|         calcium channel,    -8.7      0.083   1
gi|21687012|ref|NP_542424.1|         calcium channel,    -8.7      0.083   1
gi|73947815|ref|XP_533601.2|         PREDICTED: simil    -8.9      0.085   1

Parsed for domains:
Sequence                             Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------                             ------- ----- -----    ----- -----      -----  -------
gi|21687006|ref|NP_542375.1|           1/1       7   196 ..     1   184 []    -8.7    0.083
gi|21687012|ref|NP_542424.1|           1/1       7   196 ..     1   184 []    -8.7    0.083
gi|73947815|ref|XP_533601.2|           1/1      61   206 ..     1   184 []    -8.9    0.085

Alignments of top-scoring domains:
gi|21687006|ref|NP_542375.1|: domain 1 of 1, from 7 to 196: score -8.7, E = 0.083
                   *->mlllLlgiivlhigwviLLfvsTiPtnqWkvsdyaGDniITAa....
                      ++l Ll+ +v+++ +++LL ++   t++W ++ ++G  iI  +++++
  gi|2168700     7    KALTLLS-SVFAVCGLGLLGIAVS-TDYW-LYLEEG--IILPQnqst 48   

                   ....aasagLWrnC...............ttqsctgqiscksfdSvlsln
                   + +   + gLWr C   ++++++  + + +   ++ ++s+++    ++  
  gi|2168700    49 evkmSLHSGLWRVCflageergrcftieyVMPMNSQMTSEST----VNVL 94   

                   saLqAvqALMiLSiiLgiislivfvfQLftmkkGgrfflkKariAmltGI
                     +++   +  +S+ + +i++i++ ++  +  +    f+        +GI
  gi|2168700    95 KMIRSATPFPLVSLFFMFIGFILSNIGHIRPHRTILAFV--------SGI 136  

                   iflvsgLCvlvAasIYTnriveefgnpltpYyvnqkyefGyayiLaWvAf
                   +f++sgL   v++ +Y + i +e  n+ +   +   y +G++++ a + f
  gi|2168700   137 FFILSGLSLVVGLVLYISSINDEMLNRTKDAETYFNYKYGWSFAFAAISF 186  

                   aLtfisGvlY<-*
                   +Lt  +Gv+    
  gi|2168700   187 LLTESAGVMS    196  

gi|21687012|ref|NP_542424.1|: domain 1 of 1, from 7 to 196: score -8.7, E = 0.083
                   *->mlllLlgiivlhigwviLLfvsTiPtnqWkvsdyaGDniITAa....
                      ++l Ll+ +v+++ +++LL ++   t++W ++ ++G  iI  +++++
  gi|2168701     7    KALTLLS-SVFAVCGLGLLGIAVS-TDYW-LYLEEG--IILPQnqst 48   

                   ....aasagLWrnC...............ttqsctgqiscksfdSvlsln
                   + +   + gLWr C   ++++++  + + +   ++ ++s+++    ++  
  gi|2168701    49 evkmSLHSGLWRVCflageergrcftieyVMPMNSQMTSEST----VNVL 94   

                   saLqAvqALMiLSiiLgiislivfvfQLftmkkGgrfflkKariAmltGI
                     +++   +  +S+ + +i++i++ ++  +  +    f+        +GI
  gi|2168701    95 KMIRSATPFPLVSLFFMFIGFILSNIGHIRPHRTILAFV--------SGI 136  

                   iflvsgLCvlvAasIYTnriveefgnpltpYyvnqkyefGyayiLaWvAf
                   +f++sgL   v++ +Y + i +e  n+ +   +   y +G++++ a + f
  gi|2168701   137 FFILSGLSLVVGLVLYISSINDEMLNRTKDAETYFNYKYGWSFAFAAISF 186  

                   aLtfisGvlY<-*
                   +Lt  +Gv+    
  gi|2168701   187 LLTESAGVMS    196  

gi|73947815|ref|XP_533601.2|: domain 1 of 1, from 61 to 206: score -8.9, E = 0.085
                   *->mlllLlgiivlhigwviLLfvsTiPtnqWkvsdyaGDniITAaaasa
                       +l Ll +++ ++ ++  +  sT     W v+ +         + + 
  gi|7394781    61    RSLALLTGSLGLVSIL--IALSTD---FWFVAMGPS------FTFHS 96   

                   gLWrnCttqsctgqiscksfdSvlslnsaLqAvqALMiLSiiLgiisliv
                   gLW   ++++   +  ++          a+q+  +L +LS++ ++i l++
  gi|7394781    97 GLWPKGVYNK---VADYIR---------ATQSLTILASLSVLVSVIFLVL 134  

                   fvfQLftmkkGgrfflkKariAmltGIiflvsgLCvlvAasIYTnrivee
                   + + L  +   gr  +         + + +++gL+++vA   YT+ + + 
  gi|7394781   135 SYIPLLSLPGHGRLIS---------SVTAFAAGLFAMVAMVVYTSERWNQ 175  

                   fgnpltpYyvnqkyefGyayiLaWvAfaLtfisGvlY<-*
                      p        +  f++++ L+Wv   L +  G l    
  gi|7394781   176 PHSPQ------VQTFFSWSFYLGWVSTVLLLCTGSLS    206  
