--------------------------------------------------------------------------------
Domain name : PF01569.13_PAP2
Domain size : 177
Domain gathering score : 8.3000
Domain gathering score(TMSP) : 21.7
Domain gathering score(non-TMSP) : -3.92
Domain architecture : TM/SP [102 177], non-TM/SP [1 101]
Total query sequences in database : 5231
--------------------------------------------------------------------------------
A0AWQ1 A0AWQ1_ARTS2 Putative uncharacterized protein [Arthrobacter sp. FB24]
PAP2            PAP2 superfamily                         12.9    0.00051   1
PAP2              1/1      94   207 .]     1   177 []    12.9  0.00051
PAP2: domain 1 of 1, from 94 to 207: score 12.9, E = 0.00051
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT   
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgd...
                       ++ l+ +l+ +++l+ +       g p   P         wg  ++
      A0AWQ1    94    MLWTLGSSLLGCAILSIM-------GAPK--P--------VWGLvgg 123  

                CS -GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SS
                   stcsdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSF
                    +c                                   a  lvs+ +   
      A0AWQ1   124 ILCGIV--------------------------------ALILVSPIWK-- 139  

                CS S-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHH
                   PSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRv
                    SGHa++ + + ++++l +++            lgl +++ a lv++SRv
      A0AWQ1   140 ISGHAMTLGGATVSAVLMFGW------------LGLPFVVAAPLVCWSRV 177  

                CS HCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   ylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   yl  H   +V+aG++ G++ + + +++   ++    
      A0AWQ1   178 YLRDHSAPQVIAGFITGVVAFGASYTL---IVG    207  

TMSP/non-TMSP/fixed score (recomputed/original total): 28/-6.123/-9.474 (12.403/12.9)


A0QS82 A0QS82_MYCS2 PAP2 superfamily protein [Mycobacterium smegmatis str. MC2 155]
PAP2            PAP2 superfamily                         31.8    2.9e-06   1
PAP2              1/1     259   359 ..     1   177 []    31.8  2.9e-06
PAP2: domain 1 of 1, from 259 to 359: score 31.8, E = 2.9e-06
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      + ++  l l ++++l +    + +++                     
      A0QS82   259    TRGWGKLNLHSATALIDQ--GQASVNLVA------------------ 285  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                + PS+
      A0QS82   286 ---------------------------------------------AIPSL 290  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   Ha ++a +a fl++++ r            ++ ll+++ l ++++ vy  
      A0QS82   291 HAGLTAGVAAFLWYRVNR-----------KWRPLLVAYPLIMAFTLVYTA 329  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    Hy +D+l G++l+a++++++ +f++ ++    
      A0QS82   330 EHYVVDILLGWALAATVIFVFNRFHAFRRG    359  

TMSP/non-TMSP/fixed score (recomputed/original total): 51.595/-10.774/-9.474 (31.347/31.8)


A1RBF5 A1RBF5_ARTAT PAP2 superfamily domain protein [Arthrobacter aurescens TC1]
PAP2            PAP2 superfamily                         27.5    3.4e-05   1
PAP2              1/1     145   239 .]     1   177 []    27.5  3.4e-05
PAP2: domain 1 of 1, from 145 to 239: score 27.5, E = 3.4e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       +  +++al+ + ++ ++     ++++                    
      A1RBF5   145    GVTVMIIALIGGIGILAV--VSAFWKM-------------------- 169  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                   SG
      A1RBF5   170 ------------------------------------------------SG 171  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   Ha++  a+++++ l ++             ++l llll+  vg+SR+ l 
      A1RBF5   172 HASALSAAVVIAILMFGP------------AWLPLLLLVPAVGWSRLVLR 209  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                   +H   +V+aG+l G +++a   ++ r +     
      A1RBF5   210 AHTLAQVIAGSLFGGVVIAGLWWLLREWML    239  

TMSP/non-TMSP/fixed score (recomputed/original total): 45.568/-8.983/-9.474 (27.111/27.5)


A1SGZ0 A1SGZ0_NOCSJ Phosphoesterase, PA-phosphatase related [Nocardioides sp. JS614]
PAP2            PAP2 superfamily                         28.0    3.1e-05   1
PAP2              1/1     195   340 ..     1   177 []    28.0  3.1e-05
PAP2: domain 1 of 1, from 195 to 340: score 28.0, E = 3.1e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT  -
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgd..s
                       a   ++a+v + +l+++  + +l++ +   P f+a  +++ g ++ 
      A1SGZ0   195    DAYVGIAAFVWVWILGTA--TYYLIPSLG--P-FHAEPADFTGLphM 236  

                CS GGGHHHHHHCHHCHCCCHHCCHHHHT-- SS-B--TTCSSTTBS-SS-SS
                   tcsdlwyeellgyefycmagspgldrid.lfgsvlltsafalvseagpSF
                   + +d                   ++r+    +  l+++++    +   +F
      A1SGZ0   237 MIQDT------------------QARYLaQRDYLLVHPHAGDGFAQVSAF 268  

                CS S-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHH
                   PSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRv
                    S+H  ++a+++++++++  r           ++ ++l ++ + ++ ++v
      A1SGZ0   269 ASLHVGVTATILGLAWWHRLR-----------RTTIVLGVFLAGTMVATV 307  

                CS HCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   ylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   ylg+H+ +D+ aG++++a+  +l+ ++v+ +++   
      A1SGZ0   308 YLGWHFAVDIPAGLAIAAVAWWLAPRTVGVRRR    340  

TMSP/non-TMSP/fixed score (recomputed/original total): 44.604/-7.694/-9.474 (27.436/28.0)


A1SHK3 A1SHK3_NOCSJ Putative uncharacterized protein [Nocardioides sp. JS614]
PAP2            PAP2 superfamily                         21.4    0.00011   1
PAP2              1/1     194   332 ..     1   177 []    21.4  0.00011
PAP2: domain 1 of 1, from 194 to 332: score 21.4, E = 0.00011
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT -G
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgd.st
                       al++ +  v s +l+    l  +       P  +a + p+ +    
      A1SHK3   194    SALWVWILGVGSYYLVPS--LGPFA--SA--PEEFAGLRPTAISaTQ 234  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                   +  l  +                       ++l  +++    ++  +F S
      A1SHK3   235 VKYLAERA----------------------HFLADPHAGDAFVSISAFAS 262  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                   +H  f+ +++l++++y +r           ++ l+l+ +  +++ ++vy 
      A1SHK3   263 LHVGFTCTVLLVARYYRWR-----------RTTLALATFLSVTMVATVYF 301  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                   g+H+ +D +aG++l+ + + l +l v++ ++   
      A1SHK3   302 GWHFVVDDIAGVVLALAAFTLGRLMVYPVRN    332  

TMSP/non-TMSP/fixed score (recomputed/original total): 44.551/-14.261/-9.474 (20.816/21.4)


A1T4J6 A1T4J6_MYCVP Phosphoesterase, PA-phosphatase related [Mycobacterium vanbaalenii PYR-1]
PAP2            PAP2 superfamily                         30.5    6.7e-06   1
PAP2              1/1     251   351 ..     1   177 []    30.5  6.7e-06
PAP2: domain 1 of 1, from 251 to 351: score 30.5, E = 6.7e-06
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      a ++ +l l ++ +l +    + +++                     
      A1T4J6   251    ARGWRVLELHSASALIDQ--GQASVNLVA------------------ 277  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                + PS+
      A1T4J6   278 ---------------------------------------------AIPSL 282  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   Ha ++  +a+fl+ +l             +++ +l+++ l+++++ vy  
      A1T4J6   283 HAGLSLGIAVFLWTRLNN-----------VWRPVLVAYPLVMAFTLVYTA 321  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    Hy +D+l G+ll+a++ a+  lf rr +    
      A1T4J6   322 EHYVIDILLGWLLAAVVLAALWLFERRQAG    351  

TMSP/non-TMSP/fixed score (recomputed/original total): 48.447/-8.857/-9.474 (30.116/30.5)


A1UBJ7 A1UBJ7_MYCSK Phosphoesterase, PA-phosphatase related [Mycobacterium sp. KMS]
PAP2            PAP2 superfamily                         30.4    7.5e-06   1
PAP2              1/1     247   347 ..     1   177 []    30.4  7.5e-06
PAP2: domain 1 of 1, from 247 to 347: score 30.4, E = 7.5e-06
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                        ++  l l ++++l ++   + +++                     
      A1UBJ7   247    GRGWGKLNLHSATALLDA--GQASVNLVA------------------ 273  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                + PS+
      A1UBJ7   274 ---------------------------------------------AIPSL 278  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   Ha ++aa+a fl++++ r            ++ +l++++l+++++ vy  
      A1UBJ7   279 HAGMTAAIAAFLWHRVHR-----------GWRPVLVAYVLVMAFTLVYTA 317  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    Hy +D+l G++ +a+  ++  ++ ++++    
      A1UBJ7   318 EHYVIDILLGWAFAAVAVVALNRYDAWRRS    347  

TMSP/non-TMSP/fixed score (recomputed/original total): 48.676/-9.236/-9.474 (29.966/30.4)


A2DEI4 A2DEI4_TRIVA PAP2 superfamily protein [Trichomonas vaginalis G3]
PAP2     PAP2 superfamily                                20.3    0.00013   1
PAP2       1/1       5   111 ..     1   177 []    20.3  0.00013
PAP2: domain 1 of 1, from 5 to 111: score 20.3, E = 0.00013
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       +  + ++ +  +++      K ++ +    P               
      A2DEI4     5    CGPEANYTTCRLNGTKRD---KEFISW----P--------------- 29   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                   S 
      A2DEI4    30 ------------------------------------------------SA 31   

                CS HHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHHC
                   Haafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvyl
                   Ha+ a+++ +f+a++++   ++  + l     ++l+l+++++vg SR+ +
      A2DEI4    32 HATEAGSAGVFVAFFVQE-VFVDKnLLISFASAVLFLGFGVYVGGSRIKD 80   

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                    +H+p DV aG+l+Ga++ ++  +  ++      
      A2DEI4    81 FKHHPDDVTAGLLIGAGVSYFIWTNMKKKIF    111  

TMSP/non-TMSP/fixed score (recomputed/original total): 53.984/-24.676/-9.474 (19.834/20.3)


A2QIK7 A2QIK7_ASPNC Contig An04c0140, complete genome [Aspergillus niger CBS 513.88]
PAP2     PAP2 superfamily                                23.8    6.7e-05   1
PAP2       1/1      26   135 ..     1   177 []    23.8  6.7e-05
PAP2: domain 1 of 1, from 26 to 135: score 23.8, E = 6.7e-05
                CS    CCHHHHHHHHHHHHHHHH H HHHHCC-B--..HHHHHHHHHHHTT-
                   *->aalalllalvaslllngl.a.ylKllfgrpRApPhflavcqpdwgds
                        +  l +l+ + l  ++++++l+   ++                  
      A2QIK7    26    DCRTPLSVLANMHLSKTAsDhGLQVGQRF-K---------------- 55   

                CS GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS
                   tcsdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFP
                                                                     
      A2QIK7     - -------------------------------------------------- -    

                CS -HHHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklg.rllrlllgllllllallvglSRv
                      ++fa++f+l l+l  ++ ++++++  +++ll++++ l a lv+ SR+
      A2QIK7    56 ---TSFAGLFYLTLWLSGKLHIMDNRgEAWKTLLVMIPSLAATLVAVSRI 102  

                CS HCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   ylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   ++  H+p+DV+ G+llG+++a++ ++++++ l+   
      A2QIK7   103 MDARHHPFDVITGSLLGIICACISYRQYFPSLN    135  

TMSP/non-TMSP/fixed score (recomputed/original total): 74.305/-41.438/-9.474 (23.393/23.8)


A2W046 A2W046_9BURK Putative uncharacterized protein [Burkholderia cenocepacia PC184]
PAP2            PAP2 superfamily                         24.4    6.1e-05   1
PAP2              1/1      33   147 ..     1   177 []    24.4  6.1e-05
PAP2: domain 1 of 1, from 33 to 147: score 24.4, E = 6.1e-05
                CS    CCHHHHHHHHHHHHHHHH H HHHHCC-B--..HHHHHHHHHHHTT-
                   *->aalalllalvaslllngl.a.ylKllfgrpRApPhflavcqpdwgds
                      aa++ +l ++ ++++++++  y+   ++                   
      A2W046    33    AARWGVLLAAGMGVVGATkIlYAGCGIELAQ---------------- 63   

                CS GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS
                   tcsdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFP
                                                                ++   
      A2W046    64 --------------------------------------------FDFRVI 69   

                CS -HHHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklg.rllrlllgllllllallvglSRv
                   SGH++++++++++++  l+        r ++ + ++++l++++ ++ +Rv
      A2W046    70 SGHTMLSTSVWTVALSMLWQ-----AfRPGKAPGVAAGLAIGAITAVARV 114  

                CS HCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   ylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   +++ H    V++G+llGal+a+++l+ + + ++   
      A2W046   115 FDHSHTVPEVVVGWLLGALVALVFLRGYDGVRQ    147  

TMSP/non-TMSP/fixed score (recomputed/original total): 38.632/-5.253/-9.474 (23.905/24.4)


A3PV82 A3PV82_MYCSJ Phosphoesterase, PA-phosphatase related [Mycobacterium sp. JLS]
PAP2            PAP2 superfamily                         30.4    7.5e-06   1
PAP2              1/1     247   347 ..     1   177 []    30.4  7.5e-06
PAP2: domain 1 of 1, from 247 to 347: score 30.4, E = 7.5e-06
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                        ++  l l ++++l ++   + +++                     
      A3PV82   247    GRGWGKLNLHSATALLDA--GQASVNLVA------------------ 273  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                + PS+
      A3PV82   274 ---------------------------------------------AIPSL 278  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   Ha ++aa+a fl++++ r            ++ +l++++l+++++ vy  
      A3PV82   279 HAGMTAAIAAFLWHRVHR-----------GWRPVLVAYVLVMAFTLVYTA 317  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    Hy +D+l G++ +a+  ++  ++ ++++    
      A3PV82   318 EHYVIDILLGWAFAAVAVVALNRYDAWRRS    347  

TMSP/non-TMSP/fixed score (recomputed/original total): 48.676/-9.236/-9.474 (29.966/30.4)


A3VGN3 A3VGN3_9RHOB PA-phosphatase related phosphoesterase [Rhodobacterales bacterium HTCC2654]
PAP2     PAP2 superfamily                                55.9    1.5e-13   1
PAP2       1/1       1    93 [.     1   177 []    55.9  1.5e-13
PAP2: domain 1 of 1, from 1 to 93: score 55.9, E = 1.5e-13
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                       +             P               
      A3VGN3     1    -----------------M-------------P--------------- 2    

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                        ++v++a  SFPSG
      A3VGN3     3 -------------------------------------HGVDVATASFPSG 15   

                CS HHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHHC
                   Haafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvyl
                   H+++aa  +l la  l+r     g+ ++r + + l+++lal vg SRvyl
      A3VGN3    16 HSMMAAVTYLTLAVMLAR---LDGhTKVRVFFVSLAAILALAVGVSRVYL 62   

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                   gvH+psDVlaG+ lGa++a+lv l+ r+l +   
      A3VGN3    63 GVHWPSDVLAGWTLGAAWALLVWLIARWLER    93   

TMSP/non-TMSP/fixed score (recomputed/original total): 87.756/-16.478/-15.722 (55.556/55.9)


A4KSB3 A4KSB3_FRATU Putative uncharacterized protein [Francisella tularensis subsp. holarctica 257]
PAP2     PAP2 superfamily                                22.5    8.5e-05   1
PAP2       1/1       1    88 [.     1   177 []    22.5  8.5e-05
PAP2: domain 1 of 1, from 1 to 88: score 22.5, E = 8.5e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                       l  +K++                       
      A4KSB3     1    ---------------MCL--TKYSR---------------------- 8    

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                         + +    SFPSG
      A4KSB3     9 --------------------------------------INYNINNSFPSG 20   

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   Ha+f ++f+++++ ++p+            +++l++lla+lv  + +  +
      A4KSB3    21 HATFIFSFSVSMWILFPK------------YRWLWALLAFLVVVTQLLQY 58   

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    H+ sD+++G++lG +i++ ++  + + ++   
      A4KSB3    59 FHFVSDLIVGSMLGSIIGYYAAQSYTKKSQ    88   

TMSP/non-TMSP/fixed score (recomputed/original total): 50.665/-12.751/-15.722 (22.192/22.5)


A5FR61 A5FR61_DEHSB Putative uncharacterized protein [Dehalococcoides sp. BAV1]
PAP2            PAP2 superfamily                         20.5    0.00012   1
PAP2              1/1     103   196 .]     1   177 []    20.5  0.00012
PAP2: domain 1 of 1, from 103 to 196: score 20.5, E = 0.00012
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      ++ al++++v+s l+  +    ++f  +                   
      A5FR61   103    LIAALFAGFVSSVLFMIV----NFF--WK------------------ 125  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                   S 
      A5FR61   126 -----------------------------------------------ISV 128  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H+afa af+ +++ ++++             +l ++ll+  ++++Rvyl 
      A5FR61   129 HTAFASAFSSIALMLYGY------------SALGFMLLVPMMAWARVYLK 166  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    H   +V aGall+ ++++ v+ ++        
      A5FR61   167 EHTVGQVTAGALLAGTVIVTVFNIFNMVNI    196  

TMSP/non-TMSP/fixed score (recomputed/original total): 40.427/-10.78/-9.474 (20.173/20.5)


A5I753 A5I753_CLOBH PAP2 family protein [Clostridium botulinum A str. Hall]
PAP2            PAP2 superfamily                         21.5     0.0001   1
PAP2              1/1     180   298 ..     1   177 []    21.5   0.0001
PAP2: domain 1 of 1, from 180 to 298: score 21.5, E = 0.0001
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC -B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKllf.grpRApPhflavcqpdwgdst
                      ++l+++l   + l++       ++++g+    P              
      A5I753   180    HVLQVFLITPFYLMFHLQ--EVWYVnGH----P-------------- 206  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                                g   + + +a   ++   FPS
      A5I753   207 ----------------------------DGLARNLGPQAAAGVTLNCFPS 228  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                    H++ a+a +l++++   +           + + ++ ++ l v +S++yl
      A5I753   229 MHTSIAFAMFLVVLHEKDK-----------IFKYIWSFFCLSVVYSTMYL 267  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     H+++DV++G++l+++   l+ ++ ++      
      A5I753   268 EIHWIIDVFGGMVLAFVTVKLADFILAKGKI    298  

TMSP/non-TMSP/fixed score (recomputed/original total): 44.601/-14.096/-9.474 (21.031/21.5)


A5N676 A5N676_CLOK5 Predicted phosphatase [Clostridium kluyveri DSM 555]
PAP2            PAP2 superfamily                         26.4    4.1e-05   1
PAP2              1/1     152   298 ..     1   177 []    26.4  4.1e-05
PAP2: domain 1 of 1, from 152 to 298: score 26.4, E = 4.1e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B                    
                   *->aalalllalvaslllnglaylKllfgr....................
                      ++l++llal  s+++ +l   K++    +++  +    ++   + + 
      A5N676   152    FVLPVLLALYRSAIIMDL--KKMVRYTlsshilqvflitpfyltfhl 196  

                CS        --..HHHHHHHHHHHTT-GGGHHHHHHCHHCHCCCHHCCHHHH
                   .......pRApPhflavcqpdwgdstcsdlwyeellgyefycmagspgld
                   ++         P                                      
      A5N676   197 qevwyvlKH--P-------------------------------------- 206  

                CS T--SS-B--TTCSSTTBS-SS-SSS-HHHHHHHHHHHHHHHHCTTSSCCC
                   ridlfgsvlltsafalvseagpSFPSGHaafaaafalflalylprrlskl
                        g v +  ++a    +   FPS H++ ++a +l++++   +     
      A5N676   207 ----DGLVRHLATNAAAGTTLNCFPSMHTSISFAMFLLALREKNK----- 247  

                CS -CGS-EECHHHHCCHHHHHHHHHHHCTSS-HHHHCHHHCHCHCCCCHCHC
                   grllrlllgllllllallvglSRvylgvHypsDVlaGallGaliaalvll
                         l ++l+ ++ l + +S++yl  H+ +DV+aG+llG++   l+ l
      A5N676   248 ------LFKILFSFFCLSIIYSTLYLEIHWVLDVIAGMLLGYITVKLADL 291  

                CS HCCCGB-   
                   fvrrlld<-*
                   +  ++     
      A5N676   292 ILNKIKI    298  

TMSP/non-TMSP/fixed score (recomputed/original total): 48.654/-13.358/-9.474 (25.822/26.4)


A5VHW9 A5VHW9_LACRD Phosphoesterase, PA-phosphatase related [Lactobacillus reuteri DSM 20016]
PAP2           PAP2 superfamily                           9.1      0.001   1
PAP2             1/1      55   166 .]     1   177 []     9.1    0.001
PAP2: domain 1 of 1, from 55 to 166: score 9.1, E = 0.001
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      +a+++ll  +++++l     +   +  pR  P               
      A5VHW9    55    KAGPFLLIPGIGFILLSF--IRQRIDAPR--P--------------- 82   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-  SS-SSS
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvse..agpSFP
                                                 +   + ++l++++++g S P
      A5VHW9    83 ------------------------------YEKFPINPLIRRqkTGDSLP 102  

                CS -HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvy
                   S H  f+a++  +  l+l +           +lg++ll+la++ +++Rv 
      A5VHW9   103 SRHV-FSATVIAMCGLRLNL-----------ILGVILLVLAVVSAITRVI 140  

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                    gvH+p DV+ G++ G++++ + +l+         
      A5VHW9   141 GGVHFPRDVVIGFICGFICGSFLFLV------    166  

TMSP/non-TMSP/fixed score (recomputed/original total): 32.219/-14.094/-9.474 (8.651/9.1)


A6BZP5 A6BZP5_9PLAN Putative uncharacterized protein [Planctomyces maris DSM 8797]
PAP2     PAP2 superfamily                                19.8    0.00014   1
PAP2       1/1     227   370 ..     1   177 []    19.8  0.00014
PAP2: domain 1 of 1, from 227 to 370: score 19.8, E = 0.00014
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B                    
                   *->aalalllalvaslllnglaylKllfgr....................
                      ++  +++a va++++ ++     l++r+++ ++++ +    ++++  
      A6BZP5   227    TIPLFAAAWVAGAMFETI----PLVNRtgewgerslraiivgtppml 269  

                CS         --..HHHHHHHHHHHTT-GGGHHHHHHCHHCHCCCHHCCHHH
                   ........pRApPhflavcqpdwgdstcsdlwyeellgyefycmagspgl
                     +  ++  R  P                                     
      A6BZP5   270 amqlatgaSR--P------------------------------------- 280  

                CS HT--SS-B--TTCSSTTBS-SS-SSS-HHHHHHHHHHHHHHHHCTTSSCC
                   dridlfgsvlltsafalvseagpSFPSGHaafaaafalflalylprrlsk
                             +t ++ + +  +    SGH+ ++a  +l++a +  +    
      A6BZP5   281 --------GETTANAKWKPFQDNNGVSGHSFMGAIPFLAAAKVTDK---- 318  

                CS C-CGS-EECHHHHCCHHHHHHHHHHHCTSS-HHHHCHHHCHCHCCCCHCH
                   lgrllrlllgllllllallvglSRvylgvHypsDVlaGallGaliaalvl
                         +ll+l++++ + lv lSR+ +  Hyps+V+ G+ ++++   +v 
      A6BZP5   319 ------PLLKLAFYAGSTLVPLSRINDNRHYPSQVFLGWWMAWIATNAVD 362  

                CS CHCCCGB-   
                   lfvrrlld<-*
                    +  + ++   
      A6BZP5   363 ATQNPDRH    370  

TMSP/non-TMSP/fixed score (recomputed/original total): 33.855/-5.136/-9.474 (19.245/19.8)


A6CHG8 A6CHG8_9BACI Putative uncharacterized protein [Bacillus sp. SG-1]
PAP2           PAP2 superfamily                          36.6      1e-07   1
PAP2             1/1       1    90 [.     1   177 []    36.6    1e-07
PAP2: domain 1 of 1, from 1 to 90: score 36.6, E = 1e-07
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                       +                             
      A6CHG8     1    ----------------MI---------EQ------------------ 4    

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                              g+SFPSG
      A6CHG8     5 ------------------------------------------DGYSFPSG 12   

                CS HHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHHC
                   Haafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvyl
                   H+++++ f++++a++l r      + + r + +++l++l+ll+glSRvyl
      A6CHG8    13 HSMGSFIFYGAMAFALFR---LYDhTWSRVIGAAALMVLVLLIGLSRVYL 59   

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                   gvHypsD+l+G+l G ++ a+  l++  +     
      A6CHG8    60 GVHYPSDILGGFLAGGVWLAFSILVYTFIKG    90   

TMSP/non-TMSP/fixed score (recomputed/original total): 74.041/-22.114/-15.722 (36.205/36.6)


A6EJ49 A6EJ49_9SPHI Putative uncharacterized protein [Pedobacter sp. BAL39]
PAP2            PAP2 superfamily                          9.9    0.00089   1
PAP2              1/1      89   213 ..     1   177 []     9.9  0.00089
PAP2: domain 1 of 1, from 89 to 213: score 9.9, E = 0.00089
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT   
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgd...
                       + +l+l l++ ++l  l  l  l+g++R  P +   ++ +++ +  
      A6EJ49    89    MIPFLVLYLGIQNFLLFL--LNSLLGHLR--PLYELGLASRLHIgia 131  

                CS -GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SS
                   stcsdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSF
                   + ++ +   +l                                       
      A6EJ49   132 GKGMAYGCIPL--------------------------------------- 142  

                CS S-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHH
                   PSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRv
                        ++a  +alf++ly+          + l+l++l++++a l  ++R+
      A6EJ49   143 ----VSNAVGIALFFCLYFDQ--------RYLPLKILVVVWAGLLLYGRI 180  

                CS HCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   ylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   y g+ +p  +l G++lG +  +  +  +r +l+   
      A6EJ49   181 YTGWNFPDEILLGIFLGLTLSYSSFIAYRYYLN    213  

TMSP/non-TMSP/fixed score (recomputed/original total): 41.8/-22.956/-9.474 (9.370/9.9)


A6G8Z2 A6G8Z2_9DELT Putative uncharacterized protein [Plesiocystis pacifica SIR-1]
PAP2            PAP2 superfamily                         14.1     0.0004   1
PAP2              1/1      89   231 ..     1   177 []    14.1   0.0004
PAP2: domain 1 of 1, from 89 to 231: score 14.1, E = 0.0004
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--.. HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKllfgrpRAp.Phflavcqpdwgdst
                      +++a+l+a+ +++++  +  +   +  pRA++P              
      A6G8Z2    89    LLFAVLAAASVCAAVFLI--FPTTY--PRAAhP-------------- 117  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                         l++ +++ +v   +  +l + +    PS
      A6G8Z2   118 ----------------------LALLPDSPAVRELWRLRLADSPTNCLPS 145  

                CS HHHHHHHHHHHHHHHHCTT    SSCCC- CGS-EECHHHHCCHHHHHHH
                   GHaafaaafalflalylpr....rlsklg.rllrlllgllllllallvgl
                   +H a+a+++al+    + r + +r+s   ++++++ll++++l +a++v+l
      A6G8Z2   146 LHVALAWTLALVGTQPYTRaewsRRSGAVpSWAPPLLRGVALTWAAVVAL 195  

                CS HHHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   SRvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   +++   +Hy +DV  Ga++G++  +++++   + +    
      A6G8Z2   196 TTLTTKQHYVVDVPTGAAVGVFAWWAARRALPGEAT    231  

TMSP/non-TMSP/fixed score (recomputed/original total): 27.163/-4.155/-9.474 (13.534/14.1)


A6MJU9 A6MJU9_CALJA Lipid phosphate phosphohydrolase 2-like protein (Fragment) [Callithrix jacchus]
PAP2     PAP2 superfamily                                57.6    4.7e-14   1
PAP2       1/1       1    91 [.     1   177 []    57.6  4.7e-14
PAP2: domain 1 of 1, from 1 to 91: score 57.6, E = 4.7e-14
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                     +++          R                  
      A6MJU9     1    ---------------TEA----------R------------------ 4    

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                SF+SG
      A6MJU9     5 --------------------------------------------LSFYSG 10   

                CS HHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHHC
                   Haafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvyl
                   Ha+f++++++flaly+++rl++++ rllr++++++l+++al+vg++Rv++
      A6MJU9    11 HASFGMYCMVFLALYVQARLCWKWaRLLRPTVQFFLVAFALYVGYTRVSD 60   

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                   ++H++ DVlaG+l Gal+a l+ ++   +++   
      A6MJU9    61 HKHHWNDVLAGLLQGALVAGLTVRYISDFFK    91   

TMSP/non-TMSP/fixed score (recomputed/original total): 99.017/-26.039/-15.722 (57.256/57.6)


A6MKP2 A6MKP2_CALJA Lipid phosphate phosphohydrolase 2-like protein (Fragment) [Callithrix jacchus]
PAP2     PAP2 superfamily                                59.4    1.3e-14   1
PAP2       1/1       2    93 ..     1   177 []    59.4  1.3e-14
PAP2: domain 1 of 1, from 2 to 93: score 59.4, E = 1.3e-14
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                    ++++          R                  
      A6MKP2     2    --------------VTEA----------R------------------ 6    

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                SF+SG
      A6MKP2     7 --------------------------------------------LSFYSG 12   

                CS HHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHHC
                   Haafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvyl
                   Ha+f++++++flaly+++rl++++ rllr++++++l+++al+vg++Rv++
      A6MKP2    13 HASFGMYCMVFLALYVQARLCWKWaRLLRPTVQFFLVAFALYVGYTRVSD 62   

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                   ++H++ DVlaG+l Gal+a l+ ++   +++   
      A6MKP2    63 HKHHWNDVLAGLLQGALVAGLTVRYISDFFK    93   

TMSP/non-TMSP/fixed score (recomputed/original total): 99.017/-24.225/-15.722 (59.070/59.4)


A7FYS4 A7FYS4_CLOB1 PAP2 family protein [Clostridium botulinum A str. ATCC 19397]
PAP2            PAP2 superfamily                         21.5     0.0001   1
PAP2              1/1     180   298 ..     1   177 []    21.5   0.0001
PAP2: domain 1 of 1, from 180 to 298: score 21.5, E = 0.0001
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC -B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKllf.grpRApPhflavcqpdwgdst
                      ++l+++l   + l++       ++++g+    P              
      A7FYS4   180    HVLQVFLITPFYLMFHLQ--EVWYVnGH----P-------------- 206  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                                g   + + +a   ++   FPS
      A7FYS4   207 ----------------------------DGLARNLGPQAAAGVTLNCFPS 228  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                    H++ a+a +l++++   +           + + ++ ++ l v +S++yl
      A7FYS4   229 MHTSIAFAMFLVVLHEKDK-----------IFKYIWSFFCLSVVYSTMYL 267  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     H+++DV++G++l+++   l+ ++ ++      
      A7FYS4   268 EIHWIIDVFGGMVLAFVTVKLADFILAKGKI    298  

TMSP/non-TMSP/fixed score (recomputed/original total): 44.601/-14.096/-9.474 (21.031/21.5)


A7GIR4 A7GIR4_CLOBL PAP2 family protein [Clostridium botulinum F str. Langeland]
PAP2            PAP2 superfamily                         20.6    0.00012   1
PAP2              1/1     180   298 ..     1   177 []    20.6  0.00012
PAP2: domain 1 of 1, from 180 to 298: score 20.6, E = 0.00012
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC -B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKllf.grpRApPhflavcqpdwgdst
                      ++l+++l   + l++       ++++g+    P              
      A7GIR4   180    HVLQVFLITPFYLMFHLQ--EVWYVnGH----P-------------- 206  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                                g   + + +a   ++   FPS
      A7GIR4   207 ----------------------------DGLARNLGPQAAAGVTLNCFPS 228  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                    H++ a+a +l++++   +           + + ++ ++ l v +S++yl
      A7GIR4   229 MHTSIAFAMFLVVLHEKDK-----------IFKYIWSFFCLSVVYSTMYL 267  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     H+++DV++G++l+++   l  ++ ++      
      A7GIR4   268 EIHWIIDVFGGMVLAFVTVKLSDFILAKGKI    298  

TMSP/non-TMSP/fixed score (recomputed/original total): 43.668/-14.096/-9.474 (20.098/20.6)


A7JEA0 A7JEA0_FRATT Putative uncharacterized protein [Francisella tularensis subsp. tularensis FSC033]
PAP2          PAP2 superfamily                           22.8    8.1e-05   1
PAP2            1/1       1    88 [.     1   177 []    22.8  8.1e-05
PAP2: domain 1 of 1, from 1 to 88: score 22.8, E = 8.1e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                       l  +K++                       
      A7JEA0     1    ---------------MCL--TKYSR---------------------- 8    

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                         + +    SFPSG
      A7JEA0     9 --------------------------------------INYNINNSFPSG 20   

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   Ha+f ++f+++++ ++p+            +++l++lla+lv  + +  +
      A7JEA0    21 HATFIFSFSVSMWILFPK------------YRWLWALLAFLVVVTQLLQY 58   

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    H+ sD+++G++lG +i++ ++  + + ++   
      A7JEA0    59 FHFVSDLIVGLMLGSIIGYYAAQSYTKKSQ    88   

TMSP/non-TMSP/fixed score (recomputed/original total): 50.921/-12.751/-15.722 (22.448/22.8)


A7N4N0 A7N4N0_VIBHB Putative uncharacterized protein [Vibrio harveyi ATCC BAA-1116]
PAP2         PAP2 superfamily                            18.1    0.00019   1
PAP2           1/1       1    90 [.     1   177 []    18.1  0.00019
PAP2: domain 1 of 1, from 1 to 90: score 18.1, E = 0.00019
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                 +++ +           +R  P               
      A7N4N0     1    -----------MNYEGIR---------QR--P--------------- 10   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                           + +  SFPS 
      A7N4N0    11 ---------------------------------------DKSGNDSFPSN 21   

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H+a+a+a a+ l+l++++            +gl +++++ lvg +Rv   
      A7N4N0    22 HTANAFASATNLYLRYGW-----------EAGLPAYGVVTLVGVGRVEAK 60   

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                   +Hy+ DVlaGa+lG+l a+++   +   ++   
      A7N4N0    61 KHYWRDVLAGAALGTLSAYVFTDAYDENVQ    90   

TMSP/non-TMSP/fixed score (recomputed/original total): 48.631/-15.213/-15.722 (17.696/18.1)


A7YU93 A7YU93_FRATU Putative uncharacterized protein [Francisella tularensis subsp. holarctica FSC022]
PAP2     PAP2 superfamily                                25.6    4.8e-05   1
PAP2       1/1       1    88 [.     1   177 []    25.6  4.8e-05
PAP2: domain 1 of 1, from 1 to 88: score 25.6, E = 4.8e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                       l  +K++                       
      A7YU93     1    ---------------MCL--IKYSR---------------------- 8    

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                         + +    SFPSG
      A7YU93     9 --------------------------------------INYNINNSFPSG 20   

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   Ha+f ++f+++++ ++p+            +++l++lla+lv ++ +  +
      A7YU93    21 HATFIFSFSVSMWILFPK------------YRWLWALLAFLVVITQLLQY 58   

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    H+ sD+++G++lG +i++ ++  + + ++   
      A7YU93    59 FHFVSDLIVGSMLGSIIGYYAAQSYTKKSQ    88   

TMSP/non-TMSP/fixed score (recomputed/original total): 52.513/-11.518/-15.722 (25.273/25.6)


A8GFS6 A8GFS6_SERP5 Putative uncharacterized protein [Serratia proteamaculans 568]
PAP2            PAP2 superfamily                         12.9    0.00051   1
PAP2              1/1      79   199 ..     1   177 []    12.9  0.00051
PAP2: domain 1 of 1, from 79 to 199: score 12.9, E = 0.00051
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      aa++l +  + + +l +   + +++     pP               
      A8GFS6    79    AAMQLTALGAGAVYLLWP--TTMAY-----PP--------------- 103  

                CS GHHHHHHCHHCHCCCHHCCHHHHT-- SS-B--TTCSSTTBS-SS-SSS-
                   sdlwyeellgyefycmagspgldrid.lfgsvlltsafalvseagpSFPS
                                           + +  +s+ l  a  +v+      PS
      A8GFS6   104 ------------------------DSgVGVSSKLLAALTQVDSLQNCLPS 129  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                   +H a++ +++ +l+ + ++           +  +ll+l+al +++S + l
      A8GFS6   130 LHMALTVLAVWALSCRQRK-----------VRTALLILWALAIAFSILQL 168  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     H  +D++ Gall++l ++lv++   ++++   
      A8GFS6   169 RRHLLVDLVSGALLAFLAGWLVQRKQSWRRN    199  

TMSP/non-TMSP/fixed score (recomputed/original total): 34.388/-12.53/-9.474 (12.384/12.9)


A8SE50 A8SE50_9FIRM Putative uncharacterized protein [Faecalibacterium prausnitzii M21/2]
PAP2     PAP2 superfamily                                 9.8    0.00089   1
PAP2       1/1      84   210 ..     1   177 []     9.8  0.00089
PAP2: domain 1 of 1, from 84 to 210: score 9.8, E = 0.00089
                CS    CCHHHHHHHHHHHHHHHHHHHHH CC-B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKl.lfgrpRApPhflavcqpdwgdst
                      + + ++ ++ ++l++  +  l ++l   +R  P              
      A8SE50    84    LCMTMFSGMTFCLIVYMI--LPNgLE--LR--P-------------- 110  

                CS GGHHHHHHCHHC H CCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SS
                   csdlwyeellgy.e.fycmagspgldridlfgsvlltsafalvseagpSF
                         e l ++++   +m                  +  +  ++a    
      A8SE50   111 ----AVETLGRDnPaLRIM------------------QLLWKADAAVNVC 138  

                CS S-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHH
                   PSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRv
                   PS H + +a+ a ++++   +        +++l ++l++++a+l++lS+v
      A8SE50   139 PSIHCQSSACMAMAFSHSKLA-------EGKPLRKVLAWVWAALICLSTV 181  

                CS HCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   ylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   +  +H  +DV+ G     ++a+++l +v+r+++   
      A8SE50   182 FTKQHSVIDVACG----LAVAFVWLPVVYRPAR    210  

TMSP/non-TMSP/fixed score (recomputed/original total): 34.846/-16.042/-9.474 (9.330/9.8)


A8SGW1 A8SGW1_9FIRM Putative uncharacterized protein [Faecalibacterium prausnitzii M21/2]
PAP2            PAP2 superfamily                         24.8    5.5e-05   1
PAP2              1/1      63   178 .]     1   177 []    24.8  5.5e-05
PAP2: domain 1 of 1, from 63 to 178: score 24.8, E = 5.5e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC   -B--..HHHHHHHHHHHTT
                   *->aalalllalvaslllnglaylKllf...grpRApPhflavcqpdwgd
                      + +  + ++++ +l+ +     ll ++ ++pR  P            
      A8SGW1    63    FMVLIARSVFVPGLVFWG--GTLLRsrlHFPR--P------------ 93   

                CS -GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-S  S-
                   stcsdlwyeellgyefycmagspgldridlfgsvlltsafalvsea..gp
                                                    +  ++ ++lv   ++g 
      A8SGW1    94 ---------------------------------YEQPGFTPLVAKEsrGH 110  

                CS SSS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHH
                   SFPSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglS
                   S+PS Ha ++aa++ +++ly++             +g +++++all++  
      A8SGW1   111 SMPSRHA-LSAAVLAAVWLYFYP-----------AAGCVMVGIALLICCL 148  

                CS HHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   RvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   Rv  gvH+  DV+ G++lG++ +a+ +++         
      A8SGW1   149 RVLTGVHHVRDVVCGFALGFALGAAGMWLL-----    178  

TMSP/non-TMSP/fixed score (recomputed/original total): 39.998/-6.152/-9.474 (24.372/24.8)


A9GA33 A9GA33_SORC5 Putative uncharacterized protein [Sorangium cellulosum 'So ce 56']
PAP2            PAP2 superfamily                         28.1      3e-05   1
PAP2              1/1     238   338 ..     1   177 []    28.1    3e-05
PAP2: domain 1 of 1, from 238 to 338: score 28.1, E = 3e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      + ++++++ v+s + +g   +K++f      P               
      A9GA33   238    LDGGFFWGCVSSVVQAGG-AMKDVF------P--------------- 262  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                   S+
      A9GA33   263 ------------------------------------------------SL 264  

                CS HHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHHC
                   Haafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvyl
                   H+  aa ++++l+ ++++     ++ ++  +l++++++++ ++  S++ l
      A9GA33   265 HT--AAPLWFALYTFHRA-----RtDRRLFWLAVVAAFFSMNIIVSTMLL 307  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                    +Hy +DV+aG++l+a+ a+l+ ++vr+      
      A9GA33   308 RWHYAVDVVAGVFLAAGTAWLTPRLVRWEEG    338  

TMSP/non-TMSP/fixed score (recomputed/original total): 55.402/-18.236/-9.474 (27.692/28.1)


A9WIY1 A9WIY1_CHLAA Putative uncharacterized protein [Chloroflexus aurantiacus J-10-fl]
PAP2            PAP2 superfamily                         17.8     0.0002   1
PAP2              1/1     121   213 .]     1   177 []    17.8   0.0002
PAP2: domain 1 of 1, from 121 to 213: score 17.8, E = 0.0002
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       +la+l+++++++l++    + l+++                     
      A9WIY1   121    PLLAMLVSVAVMNLISFF--INLFWKI-------------------- 145  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                   S 
      A9WIY1   146 ------------------------------------------------SI 147  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H+a  +++a++++ ylp+            lg+++++ a++ g++R+   
      A9WIY1   148 HSASIGSCATLASIYLPA------------LGGICWIAAVVLGWARLRTR 185  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    H   +V+aG+ l++l+ + v+++++ +     
      A9WIY1   186 NHTLMQVIAGISLAVLCVLGVYRLFGLI--    213  

TMSP/non-TMSP/fixed score (recomputed/original total): 42.442/-15.554/-9.474 (17.414/17.8)


B0DCJ7 B0DCJ7_LACBS Predicted protein [Laccaria bicolor S238N-H82]
PAP2        PAP2 superfamily                             33.2      1e-06   1
PAP2          1/1       1   116 [.     1   177 []    33.2    1e-06
PAP2: domain 1 of 1, from 1 to 116: score 33.2, E = 1e-06
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                       +          R                  
      B0DCJ7     1    -----------------M----------R------------------ 2    

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                             +++SFPSG
      B0DCJ7     3 -----------------------------------------DGFRSFPSG 11   

                CS HHHHHHHHHHHHHHHCTT                        SSCCC- C
                   Haafaaafalflalylpr........................rlsklg.r
                   H+++++a ++fl++yl+++ +  +++++  ++  +  +++ +   ++++ 
      B0DCJ7    12 HSSLSFAGLGFLSFYLAGklhlfdkrghavrslfpfissgirLTYERNgT 61   

                CS GS-EECHHHHCCHHHHHHHHHHHCTSS-HHHHCHHHCHCHCCCCHCHCHC
                   llrlllgllllllallvglSRvylgvHypsDVlaGallGaliaalvllfv
                    ++ +l l +++ a+lv++SR +++ H+++DVl+G+++G++ a++ ++++
      B0DCJ7    62 QGKAWLSLTPFAGAALVAISRTMDYRHHWHDVLVGSIIGTVLAYFSYRQY 111  

                CS CCGB-   
                   rrlld<-*
                   ++ l    
      B0DCJ7   112 YPSLS    116  

TMSP/non-TMSP/fixed score (recomputed/original total): 71.276/-22.837/-15.722 (32.717/33.2)


B0MGB0 B0MGB0_9FIRM Putative uncharacterized protein [Anaerostipes caccae DSM 14662]
PAP2            PAP2 superfamily                         12.8    0.00052   1
PAP2              1/1      81   213 ..     1   177 []    12.8  0.00052
PAP2: domain 1 of 1, from 81 to 213: score 12.8, E = 0.00052
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B      --..HHHHHHHHHH
                   *->aalalllalvaslllnglaylKllfgr......pRApPhflavcqpd
                       +  +l+ ++++ ll+ +  +  +f    +++  R  P         
      B0MGB0    81    IGKEHLYRFLVGDLLSRV--ICGIFFVmvpttlAR--P--------- 114  

                CS HTT-GGGHHHHHHCHHCHCCCHHCCHH HHT--SS-B--TTCSSTTBS-S
                   wgdstcsdlwyeellgyefycmagspg.ldridlfgsvlltsafalvsea
                                      +++ + +++++              + v+++
      B0MGB0   115 -------------------EITGTGIWdQM----------LNLVYTVDPS 135  

                CS S-SSS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHH
                   gpSFPSGHaafaaafalflalylprrlsklgrllrlllgllllllallvg
                      FPS H  +++++++  +   +          +l+++ +  ++a+lv+
      B0MGB0   136 ANLFPSIHCLVSWFCYVGIRGQKKV---------PLWYQRFSCVFAVLVC 176  

                CS HHHHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lSRvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   +S+    +Hy++D+++G+ll+ ++ ++ +++ + l     
      B0MGB0   177 ISTQVTKQHYIIDLIGGILLAEAMYLVGQKTDWYLKL    213  

TMSP/non-TMSP/fixed score (recomputed/original total): 26.98/-5.267/-9.474 (12.239/12.8)


B0NDM1 B0NDM1_EUBSP Putative uncharacterized protein [Clostridium scindens ATCC 35704]
PAP2            PAP2 superfamily                         15.1    0.00034   1
PAP2              1/1      81   213 ..     1   177 []    15.1  0.00034
PAP2: domain 1 of 1, from 81 to 213: score 15.1, E = 0.00034
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B      --..HHHHHHHHHH
                   *->aalalllalvaslllnglaylKllfgr......pRApPhflavcqpd
                       +  +++ +v + +l+ +     ++    ++++ R  P    v++ d
      B0NDM1    81    QGEEHCFRFVTADMLSRI--VSGIIFIllpttnVR--P----VLAGD 119  

                CS HTT-GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS
                   wgdstcsdlwyeellgyefycmagspgldridlfgsvlltsafalvseag
                   ++                                 +v l +  + ++e+ 
      B0NDM1   120 DI---------------------------------FVKLLGMIYSIDEPT 136  

                CS -SSS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHH
                   pSFPSGHaafaaafalflalylprrlsklgrllrlllgllllllallvgl
                   + FPS H  +++++++  + +            ++ ++++  ++allv+ 
      B0NDM1   137 RLFPSIHCLVSWFCYIGIRGRENI---------PKAYRAFSCIFALLVCV 177  

                CS HHHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   SRvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   S+    +Hy++D ++G++++ l  +l++++ + + +   
      B0NDM1   178 STQLTKQHYIIDAFGGIAIAELTYWLAFHTQAYRGP    213  

TMSP/non-TMSP/fixed score (recomputed/original total): 29.694/-5.627/-9.474 (14.593/15.1)


B1IFG5 B1IFG5_CLOBK PAP2 family protein [Clostridium botulinum B1 str. Okra]
PAP2            PAP2 superfamily                         20.0    0.00014   1
PAP2              1/1     180   298 ..     1   177 []    20.0  0.00014
PAP2: domain 1 of 1, from 180 to 298: score 20.0, E = 0.00014
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC -B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKllf.grpRApPhflavcqpdwgdst
                      ++l+++l   + l++       ++++g+    P              
      B1IFG5   180    HVLQVFLITPFYLMFHLQ--EVWYVnGH----P-------------- 206  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                                g   + + +a   ++   FPS
      B1IFG5   207 ----------------------------DGLARNLGPQAAAGVTLNCFPS 228  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                    H++ a+a +l++++   +           + + ++ ++ l v +S++yl
      B1IFG5   229 MHTSIAFAMFLVVLHEKDK-----------IFKYIWSFFCLSVVYSTMYL 267  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     H+++DV++G++l+++   l  ++  +      
      B1IFG5   268 EIHWIIDVFGGMVLAFVTVKLSDFILSKGKI    298  

TMSP/non-TMSP/fixed score (recomputed/original total): 43.107/-14.096/-9.474 (19.537/20.0)


B1L208 B1L208_CLOBM PAP2 family protein [Clostridium botulinum A3 str. Loch Maree]
PAP2            PAP2 superfamily                         20.9    0.00012   1
PAP2              1/1     180   298 ..     1   177 []    20.9  0.00012
PAP2: domain 1 of 1, from 180 to 298: score 20.9, E = 0.00012
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC -B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKllf.grpRApPhflavcqpdwgdst
                      ++l+++l   + l++       ++++g+    P              
      B1L208   180    HVLQVFLITPFYLMFHLQ--EVWYVnGH----P-------------- 206  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                                g   + + +a   ++   FPS
      B1L208   207 ----------------------------DGLARNLGPQAAAGVTLNCFPS 228  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                    H++ a+a +l++++   +           + + ++ ++ l v +S++yl
      B1L208   229 MHTSIAFAMFLVALHEKDK-----------IFKYIWSFFCLSVVYSTMYL 267  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     H+++DV++G++l+++   l+ ++ ++      
      B1L208   268 EIHWIIDVFGGMVLAFVTVKLADFILAKGKI    298  

TMSP/non-TMSP/fixed score (recomputed/original total): 43.989/-14.096/-9.474 (20.419/20.9)


B1Q9R6 B1Q9R6_CLOBO PAP2 family protein [Clostridium botulinum NCTC 2916]
PAP2            PAP2 superfamily                         21.5     0.0001   1
PAP2              1/1     180   298 ..     1   177 []    21.5   0.0001
PAP2: domain 1 of 1, from 180 to 298: score 21.5, E = 0.0001
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC -B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKllf.grpRApPhflavcqpdwgdst
                      ++l+++l   + l++       ++++g+    P              
      B1Q9R6   180    HVLQVFLITPFYLMFHLQ--EVWYVnGH----P-------------- 206  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                                g   + + +a   ++   FPS
      B1Q9R6   207 ----------------------------DGLARNLGPQAAAGVTLNCFPS 228  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                    H++ a+a +l++++   +           + + ++ ++ l v +S++yl
      B1Q9R6   229 MHTSIAFAMFLVVLHEKDK-----------IFKYIWSFFCLSVVYSTMYL 267  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     H+++DV++G++l+++   l+ ++ ++      
      B1Q9R6   268 EIHWIIDVFGGMVLAFVTVKLADFILAKGKI    298  

TMSP/non-TMSP/fixed score (recomputed/original total): 44.601/-14.096/-9.474 (21.031/21.5)


B1QI28 B1QI28_CLOBO PAP2 family protein [Clostridium botulinum Bf]
PAP2            PAP2 superfamily                         21.4     0.0001   1
PAP2              1/1     180   298 ..     1   177 []    21.4   0.0001
PAP2: domain 1 of 1, from 180 to 298: score 21.4, E = 0.0001
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC -B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKllf.grpRApPhflavcqpdwgdst
                      ++l+++l   + l++       ++++g+    P              
      B1QI28   180    HVLQVFLITPFYLMFHLQ--EVWYVnGH----P-------------- 206  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                                g   + + +a   ++   FPS
      B1QI28   207 ----------------------------DGLARNLGPQAAAGVTLNCFPS 228  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                    H++ a+a +l++++   +           + + ++ ++ l v +S++yl
      B1QI28   229 MHTSIAFAMFLVVLHEKDK-----------IFKYIWSFFCLSVVYSTMYL 267  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     H+++DV+aG++l+++   l  ++ ++      
      B1QI28   268 EIHWIIDVFAGMVLAFVTVKLSDFILAKGKI    298  

TMSP/non-TMSP/fixed score (recomputed/original total): 44.54/-14.096/-9.474 (20.970/21.4)


B2G5E8 B2G5E8_LACRJ Putative uncharacterized protein [Lactobacillus reuteri JCM 1112]
PAP2           PAP2 superfamily                           9.1      0.001   1
PAP2             1/1      55   166 .]     1   177 []     9.1    0.001
PAP2: domain 1 of 1, from 55 to 166: score 9.1, E = 0.001
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      +a+++ll  +++++l     +   +  pR  P               
      B2G5E8    55    KAGPFLLIPGIGFILLSF--IRQRIDAPR--P--------------- 82   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-  SS-SSS
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvse..agpSFP
                                                 +   + ++l++++++g S P
      B2G5E8    83 ------------------------------YEKFPINPLIRRqkTGDSLP 102  

                CS -HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvy
                   S H  f+a++  +  l+l +           +lg++ll+la++ +++Rv 
      B2G5E8   103 SRHV-FSATVIAMCGLRLNL-----------ILGVILLVLAVVSAITRVI 140  

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                    gvH+p DV+ G++ G++++ + +l+         
      B2G5E8   141 GGVHFPRDVVIGFICGFICGSFLFLV------    166  

TMSP/non-TMSP/fixed score (recomputed/original total): 32.219/-14.094/-9.474 (8.651/9.1)


B3JER4 B3JER4_9BACE Putative uncharacterized protein [Bacteroides coprocola DSM 17136]
PAP2            PAP2 superfamily                         28.1      3e-05   1
PAP2              1/1     184   316 ..     1   177 []    28.1    3e-05
PAP2: domain 1 of 1, from 184 to 316: score 28.1, E = 3e-05
                CS    CCHHHHHHHHHHHHHHHH H HHHHCC-B                  
                   *->aalalllalvaslllngl.a.ylKllfgr..................
                      a+ ++++ ++ +  +n+  ++ + ++f+ ++   ++++ +++   + 
      B3JER4   184    AGPQFYFPAIGMDKVNACiFpAIGDYFNTndylipgpgfehgffyql 230  

                CS         --..HHHHHHHHHHHTT-GGGHHHHHHCHHCHCCCHHCCHHH
                   ........pRApPhflavcqpdwgdstcsdlwyeellgyefycmagspgl
                    + +++ + R  P                                     
      B3JER4   231 veasqevgER--P------------------------------------- 241  

                CS HT--SS-B--TTCSSTTBS-SS-SSS-HHHHHHHHHHHHHHHHCTTSSCC
                   dridlfgsvlltsafalvseagpSFPSGHaafaaafalflalylprrlsk
                                          +FPS H   ++ ++++++++ ++    
      B3JER4   242 ---------------------TAAFPSSHVGISTIVMIMAWRVNKK---- 266  

                CS C-CGS-EECHHHHCCHHHHHHHHHHHCTSS-HHHHCHHHCHCHCCCCHCH
                   lgrllrlllgllllllallvglSRvylgvHypsDVlaGallGaliaalvl
                           l+ +l+++ +l + ++vy  +Hy +D ++G++ ++++  l+ 
      B3JER4   267 --------LAYVLAPFYILLCCATVYIQAHYLIDAIVGFVSAFFVYQLAT 308  

                CS CHCCCGB-   
                   lfvrrlld<-*
                   l ++r++    
      B3JER4   309 LMYKRWFI    316  

TMSP/non-TMSP/fixed score (recomputed/original total): 41.168/-4.135/-9.474 (27.559/28.1)


B4HBL8 B4HBL8_DROPE GL23307 [Drosophila persimilis]
PAP2          PAP2 superfamily                           54.4    4.3e-13   1
PAP2            1/1      65   225 ..     1   177 []    54.4  4.3e-13
PAP2: domain 1 of 1, from 65 to 225: score 54.4, E = 4.3e-13
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..  HHHHHHHHHHHTT-
                   *->aalalllalvaslllnglaylKllfgrpRAp..Phflavcqpdwgds
                          + ++++a++l+++l  +K+++g   Ap  P             
      B4HBL8    65    SQATFSFGFIATFLTTEL--AKHVVGAAAAPflP------------- 96   

                CS GGGHHHHHHCHHC H CCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-S
                   tcsdlwyeellgy.e.fycmagspgldridlfgsvlltsafalvseagpS
                              g++  ++ +++                 ++++ +++++ 
      B4HBL8    97 -----------GLpAaHERQHQ---------------LLGPPERRPVRG- 119  

                CS SS-HHHHHHHHHHHHHHHHCTT                            
                   FPSGHaafaaafalflalylpr............................
                             af+l+ + +l+ ++++  ++ ++++++++   + + +  +
      B4HBL8   120 ----------AFLLLQSQHLGPpnpraarelperpqqsqlllhvpagllr 159  

                CS    SSCCC- CGS-EECHHHHCCHHHHHHHHHHHCTSS-HHHHCHHHCHC
                   ...rlsklg.rllrlllgllllllallvglSRvylgvHypsDVlaGallG
                    +    +++ r+lr++l++lll+ al+v+lSRv +++H++sDVlaGa+lG
      B4HBL8   160 aqcVQGRGSiRVLRHILQFLLLMAALCVSLSRVADYWHHWSDVLAGAVLG 209  

                CS HCCCCHCHCHCCCGB-   
                   aliaalvllfvrrlld<-*
                   ++ aa+++ +v+ +l+   
      B4HBL8   210 VVYAAITAIYVGDMLR    225  

TMSP/non-TMSP/fixed score (recomputed/original total): 75.473/-12.269/-9.474 (53.730/54.4)


B5CRB3 B5CRB3_9FIRM Putative uncharacterized protein [Ruminococcus lactaris ATCC 29176]
PAP2           PAP2 superfamily                           8.9     0.0011   1
PAP2             1/1      77   222 ..     1   177 []     8.9   0.0011
PAP2: domain 1 of 1, from 77 to 222: score 8.9, E = 0.0011
                CS    CCHHHHHHHHHHHHHHHH H H HHHCC-B           --..HH
                   *->aalalllalvaslllngl.a.y.lKllfgr...........pRApPh
                      a+++l++ +  ++++  l a + + + +     +  ++++++R  P 
      B5CRB3    77    AVVFLYFFFTDVQGFYKLaAiSfAGMTIFLiictffpngqdLR--P- 120  

                CS HHHHHHHHHTT-GGGHHHHHHCHHCH CCCHHCCHHHHT--SS-B--TTC
                   flavcqpdwgdstcsdlwyeellgye.fycmagspgldridlfgsvllts
                                            + f+ +++           +v+   
      B5CRB3   121 -------------------------VvFERENM-----------FVDAVR 134  

                CS SSTTBS-SS-SSS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHH
                   afalvseagpSFPSGHaafaaafalflalylprrlsklgrllrlllglll
                     + ++     FPS+H  f  ++a ++ + + +       ++ + + + +
      B5CRB3   135 VLYRTDTCTNVFPSLHV-FNSLCACIAIHESEK------VRTHKAVCISA 177  

                CS CCHHHHHHHHHHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lllallvglSRvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   ++la l+ l++++l +H  +DV+++a+++++   +v+   +++++   
      B5CRB3   178 YVLAGLIILATMFLKQHSVLDVIGAAVMAFVLYQIVYAPGKKRVP    222  

TMSP/non-TMSP/fixed score (recomputed/original total): 23.057/-5.278/-9.474 (8.305/8.9)


B5CV94 B5CV94_9BACE Putative uncharacterized protein [Bacteroides plebeius DSM 17135]
PAP2            PAP2 superfamily                         21.7      1e-04   1
PAP2              1/1     186   318 ..     1   177 []    21.7    1e-04
PAP2: domain 1 of 1, from 186 to 318: score 21.7, E = 1e-04
                CS    CCHHHHHHHHHHHHHHHH H HHHHCC-B     --..HHHHHHHHH
                   *->aalalllalvaslllngl.a.ylKllfgr.....pRApPhflavcqp
                      a+ ++++ ++ +  +n+ +++ + ++f+ ++   p   P        
      B5CV94   186    AGPQFYFPAIGMDKVNACdFpAIGDYFNDntfllPG--P-------- 222  

                CS HHTT-GGGHHHHHHCHHCHCCCHHCCHHHHT-- SS-B--TTCSSTTBS-
                   dwgdstcsdlwyeellgyefycmagspgldrid.lfgsvlltsafalvse
                                                  ++++f+  l+  ++++  +
      B5CV94   223 ------------------------------GYEhGFFYNLVEASQEVGER 242  

                CS SS-SSS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHH
                   agpSFPSGHaafaaafalflalylprrlsklgrllrlllgllllllallv
                   +  +FPS H   ++ ++++++++ ++            l+ +l+++ +l 
      B5CV94   243 PTAAFPSSHVGISTIVMIMAWRVNRK------------LAYILFPFYVLL 280  

                CS HHHHHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   glSRvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   + ++vy  +Hy +D l+G++ ++++  l+ l ++r++    
      B5CV94   281 CCATVYIQAHYLIDSLVGLITAFFVYQLATLMYKRWFI    318  

TMSP/non-TMSP/fixed score (recomputed/original total): 37.659/-7.042/-9.474 (21.143/21.7)


B5Y7H8 B5Y7H8_COPPD PAP2 superfamily protein [Coprothermobacter proteolyticus DSM 5265]
PAP2            PAP2 superfamily                         29.3    1.6e-05   1
PAP2              1/1     112   204 ..     1   177 []    29.3  1.6e-05
PAP2: domain 1 of 1, from 112 to 204: score 29.3, E = 1.6e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      +   ++++l++++++n     K +f+                     
      B5Y7H8   112    LTSTMGIGLGICGFINLF--WKVSFHT-------------------- 136  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                     
      B5Y7H8     - -------------------------------------------------- -    

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                    a+ a+a ++f++  +++              +llll++l++g+SR+ lg
      B5Y7H8   137 FASSAMATMFFMVTSSWW------------SLVLLLLVSLVIGWSRIRLG 174  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                   vH p +Vl G+llG++  +l++  +++ +    
      B5Y7H8   175 VHTPMQVLIGFLLGIFLPILCAMSYLGGFL    204  

TMSP/non-TMSP/fixed score (recomputed/original total): 57.574/-19.185/-9.474 (28.915/29.3)


B6FV92 B6FV92_9CLOT Putative uncharacterized protein [Clostridium nexile DSM 1787]
PAP2           PAP2 superfamily                          17.1    0.00023   1
PAP2             1/1      81   209 ..     1   177 []    17.1  0.00023
PAP2: domain 1 of 1, from 81 to 209: score 17.1, E = 0.00023
                CS    CCHHHHHHHHHHHHHHHHHHHHH CC-B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKl.lfgrpRApPhflavcqpdwgdst
                      +  +l++++ + l+++++    ++  + +R  P              
      B6FV92    81    LSAFLCIGMTIFLIFSTI----YpNGQILR--P-------------- 107  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT-- SS-B--TTCSSTTBS-SS-SSS
                   csdlwyeellgyefycmagspgldrid.lfgsvlltsafalvseagpSFP
                                          ++ ++++ +v+l  + +  + +   FP
      B6FV92   108 -----------------------TTFEhDNIFVDLVKQLYRADTPTNIFP 134  

                CS -HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvy
                   S+H       a ++  +++r       ++  +++ + l+l+ l+ lS+++
      B6FV92   135 SLHV-YNSIGACIAIMHSQR------LKEYRWIQYASLVLGGLIILSTMF 177  

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   l +H  +DV+++ ++++++  lv++  ++ ++   
      B6FV92   178 LKQHSVIDVVGAGAMAVICYQLVYVAAFKKQP    209  

TMSP/non-TMSP/fixed score (recomputed/original total): 36.466/-10.361/-9.474 (16.631/17.1)


B6TM35 B6TM35_MAIZE Putative uncharacterized protein [Zea mays]
PAP2     PAP2 superfamily                                21.2    0.00011   1
PAP2       1/1       1    83 [.     1   177 []    21.2  0.00011
PAP2: domain 1 of 1, from 1 to 83: score 21.2, E = 0.00011
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                      ++                             
      B6TM35     1    ---------------MYV---------AV------------------ 5    

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                           s+ ++SFPSG
      B6TM35     6 ----------------------------------------SADHWSFPSG 15   

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H++ a+++a fla    r             + +l+l+a+ ++ SRv lg
      B6TM35    16 HSSRAFLVASFLAAGGFR------------PREALFLWAAATSASRVLLG 53   

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    Hy +DV+aGa+lG++ a++  l+ + + +   
      B6TM35    54 RHYVLDVVAGACLGVFEAWVSILLLGFMCA    83   

TMSP/non-TMSP/fixed score (recomputed/original total): 55.547/-18.962/-15.722 (20.863/21.2)


B6YVD2 B6YVD2_THEON Membrane-bound phosphoesterase [Thermococcus onnurineus NA1]
PAP2            PAP2 superfamily                         16.4    0.00027   1
PAP2              1/1     108   226 ..     1   177 []    16.4  0.00027
PAP2: domain 1 of 1, from 108 to 226: score 16.4, E = 0.00027
                CS    CCHHHHHHHHHHHHHHHHH H HHH CC-B--..HHHHHHHHHHHTT
                   *->aalalllalvaslllngla.y.lKl.lfgrpRApPhflavcqpdwgd
                      +++ +ll++ +++ +  +++ ++ + +++     P            
      B6YVD2   108    LFIRYLLSYTVAGSIYLIVhVhAPHlVYNL----P------------ 138  

                CS -GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SS
                   stcsdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSF
                                                      + s     ++  +  
      B6YVD2   139 ----------------------------------GYISESTYLTRQEFVL 154  

                CS S-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHH
                   PSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRv
                   PS+H +fa+   + l++y +             +g+ l++l  l+ ++++
      B6YVD2   155 PSLHNTFAMVNIITLWRYRKE-----------KIGATLIVLNSLIPFTTL 193  

                CS HCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   ylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   +lg+H++ D++ G++l++++  l++ +  rl++   
      B6YVD2   194 FLGHHWIYDIITGMVLAVIVSRLTAGYSPRLPA    226  

TMSP/non-TMSP/fixed score (recomputed/original total): 37.316/-11.956/-9.474 (15.886/16.4)


B7H327 B7H327_ACIB3 Bacitracin transport permease protein BCRC [Acinetobacter baumannii AB307-0294]
PAP2         PAP2 superfamily                            21.7    9.8e-05   1
PAP2           1/1       1    88 [.     1   177 []    21.7  9.8e-05
PAP2: domain 1 of 1, from 1 to 88: score 21.7, E = 9.8e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                      g+     ++++    P               
      B7H327     1    ---------------MGV--GTTFIEH-A--P--------------- 12   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                SFPS 
      B7H327    13 -------------------------------------------TASFPSN 19   

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H     ++al+ +++ ++           ++g++ll+l+++v++SR+ylg
      B7H327    20 HMLIFSTIALSYLFAQRK-----------MIGIILLFLSFVVAWSRIYLG 58   

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                   vH+p+D+l++++++ l+  + ++f+  +     
      B7H327    59 VHFPLDMLGAFIVALLVNTAGYYFWNVYGT    88   

TMSP/non-TMSP/fixed score (recomputed/original total): 59.596/-22.481/-15.722 (21.393/21.7)


B7LSF7 B7LSF7_ESCF3 Putative membrane protein, putative Acid phosphatase/Vanadium-dependent haloperoxidase [Escherichia fergusonii ATC
PAP2            PAP2 superfamily                         19.0    0.00016   1
PAP2              1/1      80   202 ..     1   177 []    19.0  0.00016
PAP2: domain 1 of 1, from 80 to 202: score 19.0, E = 0.00016
                CS    CCHHHHHHHHHHHHHHHHHH HHHCC-B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglay.lKllfgrpRApPhflavcqpdwgdst
                      +a+a+ l++++++l+  l +++ +++      P              
      B7LSF7    80    LARAMQLSALVAGLFYLL-WpTTMHY------P-------------- 105  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-S   
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpS...
                                              +f+      ++++   a  S+++
      B7LSF7   106 ---------------------------SFDQMGISAGALNRLIAIDSsqn 128  

                CS  SS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHH
                   .FPSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglS
                    FPS+Ha    a+ l++++++++       ++  +l l  +++a+ +++S
      B7LSF7   129 cFPSLHA----ALTLLAVWAIAK-------KGNRWLTLMSVVWAIAIAFS 167  

                CS HHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   RvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                    + l  H ++D+++Gall+ ++++++++  +r ++   
      B7LSF7   168 ILQLRRHLFIDLVGGALLASICGWICATCEKRKTQ    202  

TMSP/non-TMSP/fixed score (recomputed/original total): 39.129/-11.191/-9.474 (18.464/19.0)


B7R5A3 B7R5A3_9EURY Membrane-bound phosphoesterase, PAP2 superfamily [Thermococcus sp. AM4]
PAP2            PAP2 superfamily                         12.2    0.00058   1
PAP2              1/1      87   200 ..     1   177 []    12.2  0.00058
PAP2: domain 1 of 1, from 87 to 200: score 12.2, E = 0.00058
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      ++++ + +++++l+ +++    ++++     P               
      B7R5A3    87    LVIYSICGAIYTLVHVYA--PHYVYNL----P--------------- 112  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                    +++    +   +  PS+
      B7R5A3   113 -------------------------------GFYPDRTYLTQQEFVLPSL 131  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H ++aa+  ++l+ y +            l++ l+++l  lv ++++ lg
      B7R5A3   132 HNTVAAFNIIILWKYRRE-----------LTAKLIIALNSLVPFATLLLG 170  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                   +H++ D l G++l+++++ lv     r +    
      B7R5A3   171 HHWIYDALSGIVLAVIVGRLVEGKKIRVPS    200  

TMSP/non-TMSP/fixed score (recomputed/original total): 31.957/-10.779/-9.474 (11.704/12.2)


B7UQC1 B7UQC1_ECO27 Predicted protein [Escherichia coli O127
PAP2            PAP2 superfamily                         17.5    0.00022   1
PAP2              1/1      72   198 ..     1   177 []    17.5  0.00022
PAP2: domain 1 of 1, from 72 to 198: score 17.5, E = 0.00022
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      ++++l+ ++ +s+l++g+  + ll+      P               
      B7UQC1    72    HLRWLARSMQISALVAGV--FYLLW------P--------------- 95   

                CS GHHHHHHCHHCHCCCHHCCHH HHT-- SS-B--TTCSSTTBS-SS-SSS
                   sdlwyeellgyefycmagspg.ldrid.lfgsvlltsafalvseagpSFP
                                + m+    +++ i  ++ + l  ++  + +     FP
      B7UQC1    96 -------------TTMHYPSFdQMGISaGALNRLIAIDSSQNC-----FP 127  

                CS -HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvy
                   S+Ha    a+ l++++++++       ++  +l l  +++a+ +++S + 
      B7UQC1   128 SLHA----ALTLLAVWAIAK-------KGNRWLTLMSVVWAIAIAFSILQ 166  

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   l  H ++D+++Gall+ ++++++++  +r ++   
      B7UQC1   167 LRRHLFIDLVGGALLASICGWICATCEKRKTQ    198  

TMSP/non-TMSP/fixed score (recomputed/original total): 39.129/-12.638/-9.474 (17.017/17.5)


B7WUB6 B7WUB6_COMTE Putative uncharacterized protein [Comamonas testosteroni KF-1]
PAP2            PAP2 superfamily                         11.6    0.00064   1
PAP2              1/1     103   229 ..     1   177 []    11.6  0.00064
PAP2: domain 1 of 1, from 103 to 229: score 11.6, E = 0.00064
                CS    CCHHHHHHHHHHHHHHHH H H HHHCC-B--..HHHHHHHHHHHTT
                   *->aalalllalvaslllngl.a.y.lKllfgrpRApPhflavcqpdwgd
                        +++l++l+++l+++  +a+  + +++++    P            
      B7WUB6   103    GKRQVLATLICGLVFVLFpAnLaFDRVIPEVE--P------------ 135  

                CS -GGGHHHHHHCHHC H CCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-
                   stcsdlwyeellgy.e.fycmagspgldridlfgsvlltsafalvseagp
                                y+  f  m                       v+ ++ 
      B7WUB6   136 -------------YrSiFSTM---------------------FFVDQPHN 151  

                CS SSS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHH
                   SFPSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglS
                     PS+H   +a+  l+ + + +        ++r  l +l++l+++ ++ S
      B7WUB6   152 LLPSLHIVYTALTCLAICQAQWP-------RGRRALCVLMVLWSVAICAS 194  

                CS HHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   RvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   ++  ++H+ +DV+ ++ll a+ ++l +    ++++   
      B7WUB6   195 TMLVHQHHVLDVVTALLLTAVLCVLIRPADVPPQP    229  

TMSP/non-TMSP/fixed score (recomputed/original total): 31.128/-10.514/-9.474 (11.140/11.6)


B8XSI8 B8XSI8_PIG Phosphatidic acid phosphatase type 2C isoform 2 [Sus scrofa]
PAP2     PAP2 superfamily                                57.9    3.9e-14   1
PAP2       1/1       4   136 ..     1   177 []    57.9  3.9e-14
PAP2: domain 1 of 1, from 4 to 136: score 57.9, E = 3.9e-14
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       ++++ll ++++l+++    +  l+      P               
      B8XSI8     4    RWVFVLLDVLCVLVASLP--FTILTFVNA--P--------------- 31   

                CS GHHHHHHCHHC H CCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS
                   sdlwyeellgy.e.fycmagspgldridlfgsvlltsafalvseagpSFP
                             y+ +fyc                    ++ + ++ +p   
      B8XSI8    32 ----------YkRgFYCG-------------------DDSIRYPYRPDTI 52   

                CS -HHHHHHHHHHHHHHHHCTT  SSCCC- CGS-EECHHHHCCHHHHHHHH
                   SGHaafaaafalflalylpr..rlsklg.rllrlllgllllllallvglS
                     H  +a+ + ++ + +l+ + rl++++ rllr++++++l+++al+vg++
      B8XSI8    53 -THGLMAGVIITATVILLYVqaRLCWKWaRLLRPTVQFFLVAFALYVGYT 101  

                CS HHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   RvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   Rv++++H++sDVl+G+l Gal+a l+ ++   +++   
      B8XSI8   102 RVSDHKHHWSDVLVGLLQGALVASLTVRYISDFFK    136  

TMSP/non-TMSP/fixed score (recomputed/original total): 86.82/-19.987/-9.474 (57.359/57.9)


B9BKE2 B9BKE2_9BURK Membrane protein, PAP2 family [Burkholderia multivorans CGD2]
PAP2          PAP2 superfamily                           15.6    0.00031   1
PAP2            1/1       1   104 [.     1   177 []    15.6  0.00031
PAP2: domain 1 of 1, from 1 to 104: score 15.6, E = 0.00031
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       al  +  +++++  ++l             P               
      B9BKE2     1    MALVGATKILYAGCGVAL-------------P--------------- 19   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                            + ++ + SG
      B9BKE2    20 -----------------------------------------AFDFRMISG 28   

                CS HHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHHC
                   Haafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvyl
                   H++++++++++++  l+        r +  + ++++l+++++++ +Rv++
      B9BKE2    29 HTMLSTSVWTVALAMLWH-----AfRPGSAPGVAAGLAIGAVTAVARVFD 73   

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     H    V+aG+llGal+a+++ + + r ++   
      B9BKE2    74 DSHTVPEVIAGWLLGALVAIVFVRAYVRAPK    104  

TMSP/non-TMSP/fixed score (recomputed/original total): 36.651/-12.031/-9.474 (15.146/15.6)


B9C4E7 B9C4E7_9BURK Membrane protein, PAP2 family [Burkholderia multivorans CGD2M]
PAP2          PAP2 superfamily                           15.6    0.00031   1
PAP2            1/1       1   104 [.     1   177 []    15.6  0.00031
PAP2: domain 1 of 1, from 1 to 104: score 15.6, E = 0.00031
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       al  +  +++++  ++l             P               
      B9C4E7     1    MALVGATKILYAGCGVAL-------------P--------------- 19   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                            + ++ + SG
      B9C4E7    20 -----------------------------------------AFDFRMISG 28   

                CS HHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHHC
                   Haafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvyl
                   H++++++++++++  l+        r +  + ++++l+++++++ +Rv++
      B9C4E7    29 HTMLSTSVWTVALAMLWH-----AfRPGSAPGVAAGLAIGAVTAVARVFD 73   

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     H    V+aG+llGal+a+++ + + r ++   
      B9C4E7    74 DSHTVPEVIAGWLLGALVAIVFVRAYVRAPK    104  

TMSP/non-TMSP/fixed score (recomputed/original total): 36.651/-12.031/-9.474 (15.146/15.6)


B9DZQ1 B9DZQ1_CLOK1 Putative uncharacterized protein [Clostridium kluyveri NBRC 12016]
PAP2            PAP2 superfamily                         26.4    4.1e-05   1
PAP2              1/1     152   298 ..     1   177 []    26.4  4.1e-05
PAP2: domain 1 of 1, from 152 to 298: score 26.4, E = 4.1e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B                    
                   *->aalalllalvaslllnglaylKllfgr....................
                      ++l++llal  s+++ +l   K++    +++  +    ++   + + 
      B9DZQ1   152    FVLPVLLALYRSAIIMDL--KKMVRYTlsshilqvflitpfyltfhl 196  

                CS        --..HHHHHHHHHHHTT-GGGHHHHHHCHHCHCCCHHCCHHHH
                   .......pRApPhflavcqpdwgdstcsdlwyeellgyefycmagspgld
                   ++         P                                      
      B9DZQ1   197 qevwyvlKH--P-------------------------------------- 206  

                CS T--SS-B--TTCSSTTBS-SS-SSS-HHHHHHHHHHHHHHHHCTTSSCCC
                   ridlfgsvlltsafalvseagpSFPSGHaafaaafalflalylprrlskl
                        g v +  ++a    +   FPS H++ ++a +l++++   +     
      B9DZQ1   207 ----DGLVRHLATNAAAGTTLNCFPSMHTSISFAMFLLALREKNK----- 247  

                CS -CGS-EECHHHHCCHHHHHHHHHHHCTSS-HHHHCHHHCHCHCCCCHCHC
                   grllrlllgllllllallvglSRvylgvHypsDVlaGallGaliaalvll
                         l ++l+ ++ l + +S++yl  H+ +DV+aG+llG++   l+ l
      B9DZQ1   248 ------LFKILFSFFCLSIIYSTLYLEIHWVLDVIAGMLLGYITVKLADL 291  

                CS HCCCGB-   
                   fvrrlld<-*
                   +  ++     
      B9DZQ1   292 ILNKIKI    298  

TMSP/non-TMSP/fixed score (recomputed/original total): 48.654/-13.358/-9.474 (25.822/26.4)


B9LCZ2 B9LCZ2_CHLSY Putative uncharacterized protein [Chloroflexus sp. Y-400-fl]
PAP2            PAP2 superfamily                         17.8     0.0002   1
PAP2              1/1     121   213 .]     1   177 []    17.8   0.0002
PAP2: domain 1 of 1, from 121 to 213: score 17.8, E = 0.0002
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       +la+l+++++++l++    + l+++                     
      B9LCZ2   121    PLLAMLVSVAVMNLISFF--INLFWKI-------------------- 145  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                   S 
      B9LCZ2   146 ------------------------------------------------SI 147  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H+a  +++a++++ ylp+            lg+++++ a++ g++R+   
      B9LCZ2   148 HSASIGSCATLASIYLPA------------LGGICWIAAVVLGWARLRTR 185  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    H   +V+aG+ l++l+ + v+++++ +     
      B9LCZ2   186 NHTLMQVIAGISLAVLCVLGVYRLFGLI--    213  

TMSP/non-TMSP/fixed score (recomputed/original total): 42.442/-15.554/-9.474 (17.414/17.8)


B9LQY6 B9LQY6_HALLT Phosphoesterase PA-phosphatase related [Halorubrum lacusprofundi ATCC 49239]
PAP2            PAP2 superfamily                         27.9    3.1e-05   1
PAP2              1/1     146   267 ..     1   177 []    27.9  3.1e-05
PAP2: domain 1 of 1, from 146 to 267: score 27.9, E = 3.1e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      a++ +l+++v++ +   +  + +++      P               
      B9LQY6   146    AIGLVLYTVVLAYGPRNV--MPDMV-T----P--------------- 170  

                CS GHHHHHHCHHC HCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   sdlwyeellgy.efycmagspgldridlfgsvlltsafalvseagpSFPS
                            ++ +++  ++                  + ++ ea   FPS
      B9LQY6   171 ---------LLfTHNPGIM----------------ALTGEINEATNVFPS 195  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                   +H++++ ++ +f++l  +           +l+  +++ la+ v ++++yl
      B9LQY6   196 LHTSLSVTVGTFAVLTRRE---------YPLWTPIAAWLAVSVVIATMYL 236  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                   g H+ +DV++G +l+ +  +l +++v        
      B9LQY6   237 GIHWLTDVIGGTALALGAVYLSYRLVDEDGS    267  

TMSP/non-TMSP/fixed score (recomputed/original total): 41.43/-4.522/-9.474 (27.434/27.9)


B9XCQ8 B9XCQ8_9BACT PAP2 family protein [bacterium Ellin514]
PAP2            PAP2 superfamily                         12.1    0.00059   1
PAP2              1/1     133   284 ..     1   177 []    12.1  0.00059
PAP2: domain 1 of 1, from 133 to 284: score 12.1, E = 0.00059
                CS    CCHHHHHHHHHHHH  HHHHHHHHHCC-B                  
                   *->aalalllalvasll..lnglaylKllfgr..................
                      ++ +l+++l+  +l++l++l   K+++g  +  + +  + +  + ++
      B9XCQ8   133    FFPYLAFSLITYFLgnLDVL--KKFFVGLftiyglgflgysllpasg 177  

                CS                --..HHHHHHHHHHHTT-GGGHHHHHHCHHCHCCC
                   ...............pRApPhflavcqpdwgdstcsdlwyeellgyefyc
                   ++    ++ + + ++++   ++ ++ +   ++s++ d             
      B9XCQ8   178 phiamadrftipltgWC---FTKWNAALVVHGSNGVDV------------ 212  

                CS HHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-HHHHHHHHHHHHHHHH
                   magspgldridlfgsvlltsafalvseagpSFPSGHaafaaafalflaly
                                                  FPS+H a++a++++f +++
      B9XCQ8   213 -------------------------------FPSLHCAVTAFLLFFDRRH 231  

                CS CTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCTSS-HHHHCHHHCHCH
                   lprrlsklgrllrlllgllllllallvglSRvylgvHypsDVlaGallGa
                    p+                ll+  l  +lS++yl +Hy +DVl G++l+ 
      B9XCQ8   232 CPK------------RFKCLLIPCLGLWLSTIYLRYHYTIDVLCGFALAG 269  

                CS CCCCHCHCHCCCGB-   
                   liaalvllfvrrlld<-*
                   +  +l+ +f ++ +    
      B9XCQ8   270 FALWLANKFPLKSTT    284  

TMSP/non-TMSP/fixed score (recomputed/original total): 25.943/-5.02/-9.474 (11.449/12.1)


B9XDY8 B9XDY8_9BACT Phosphoesterase PA-phosphatase related protein [bacterium Ellin514]
PAP2            PAP2 superfamily                         27.8    3.2e-05   1
PAP2              1/1      99   214 ..     1   177 []    27.8  3.2e-05
PAP2: domain 1 of 1, from 99 to 214: score 27.8, E = 3.2e-05
                CS    CCHHHHHHHHHHHHHHHH H H HHHCC-B--..HHHHHHHHHHHTT
                   *->aalalllalvaslllngl.a.y.lKllfgrpRApPhflavcqpdwgd
                       +l  ++++++  +  +  ++ ++ +l g+ R               
      B9XDY8    99    VVLVGGIGFLLFPAELAYaVpKnIGYLPGMFR--------------- 130  

                CS -GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SS
                   stcsdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSF
                                                          ++    +   +
      B9XDY8   131 --------------------------------------LADALNLTYNLM 142  

                CS S-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHH
                   PSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRv
                   PS+H a++  + +++al++++           + ++ll+ +a+ ++ S++
      B9XDY8   143 PSLHVALSVVCIGAFALRIAG-----------IGKVLLWSWAIAIAASTL 181  

                CS HCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   ylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                     ++H+ +DVl G+ lG++   lv+l  + +++   
      B9XDY8   182 LTHQHHLLDVLTGFGLGVAGLRLVYLKRANFSK    214  

TMSP/non-TMSP/fixed score (recomputed/original total): 45.099/-8.254/-9.474 (27.371/27.8)


C0FX50 C0FX50_9FIRM Putative uncharacterized protein [Roseburia inulinivorans DSM 16841]
PAP2          PAP2 superfamily                           13.6    0.00044   1
PAP2            1/1      44   173 ..     1   177 []    13.6  0.00044
PAP2: domain 1 of 1, from 44 to 173: score 13.6, E = 0.00044
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT  -
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgd..s
                      +++a+l++ + ++l+  +  +    +++R  P      + +++++ +
      C0FX50    44    KLCAMLFTGMTVFLVIST--IYPNGHYLR--P------AYFEHNniF 80   

                CS GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS
                   tcsdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFP
                     +++w                                 + ++ +   FP
      C0FX50    81 IQMVKW--------------------------------LYATDTPTNLFP 98   

                CS -HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvy
                   S H  ++ a+ +++++           +  + ++   ++l++l+ lS+++
      C0FX50    99 SVHVFNSIAVNIAVWHSDNF-------KKNKAVRYGSAVLMVLIILSTMF 141  

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   l +H  +DV+ G++l++++  +v+++ +  +    
      C0FX50   142 LKQHSVFDVVTGMVLAVFMYSVVYTTNWAAVT    173  

TMSP/non-TMSP/fixed score (recomputed/original total): 29.697/-7.117/-9.474 (13.106/13.6)


C0HJ36 C0HJ36_MAIZE Putative uncharacterized protein [Zea mays]
PAP2     PAP2 superfamily                                34.4    4.5e-07   1
PAP2       1/1      11   112 ..     1   177 []    34.4  4.5e-07
PAP2: domain 1 of 1, from 11 to 112: score 34.4, E = 4.5e-07
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       ++++ + ++ ++ + ++      f  p   P               
      C0HJ36    11    DFCWYKIPVLDCQQFLTV------F--PL--P--------------- 32   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                     
      C0HJ36     - -------------------------------------------------- -    

                CS HHHHHHHHHHHHHHHCTT  SSCCC- CGS-EECHHHHCCHHHHHHHHHH
                   Haafaaafalflalylpr..rlsklg.rllrlllgllllllallvglSRv
                      +++a ++fl+lyl ++ + + + +++++l++++l+llla lvg SRv
      C0HJ36    33 ---GSFAGLGFLSLYLSGkiKAFNRQgHVAKLCIVILPLLLASLVGVSRV 79   

                CS HCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   ylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                    ++ H++ DV++G l+G+++a+l++l +++++    
      C0HJ36    80 DDYRHHWEDVFVGGLIGFIMAVLCYLHFFPPPY    112  

TMSP/non-TMSP/fixed score (recomputed/original total): 85.892/-42.404/-9.474 (34.014/34.4)


C0ULT2 C0ULT2_9ACTO PAP2 superfamily protein [Gordonia bronchialis DSM 43247]
PAP2            PAP2 superfamily                         25.4      5e-05   1
PAP2              1/1     187   366 ..     1   177 []    25.4    5e-05
PAP2: domain 1 of 1, from 187 to 366: score 25.4, E = 5e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..H               
                   *->aalalllalvaslllnglaylKllfgrpRApP...............
                      a++ +++++va+ +l+ +     ++  p ApP    + +  +  + +
      C0ULT2   187    AWRRYAACFVATSFLGLI--GYTMV--PAAPPwaaakctaadvvdyp 229  

                CS                              HHHHHHHHHHTT    -GGGH
                   .............................hflavcqpdwgd....stcsd
                   +++    ++ ++ +++  ++ ++++++   +  + + ++ +  + ++ s 
      C0ULT2   230 rdpacmyqeagpvegnllgdvepthpgaaPYVERISSRGWNflgiAMASS 279  

                CS HHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-HHH
                   lwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSGHa
                   l                                   + s    + PS+Ha
      C0ULT2   280 L------------------------------VEVGQGKSNLVAAIPSLHA 299  

                CS HHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCTSS
                   afaaafalflalylprrlsklgrllrlllgllllllallvglSRvylgvH
                    +++++alf++ ++++           l + l++++ l ++++ vy   H
      C0ULT2   300 GLSMLLALFMWPRVKA-----------LGKTLFMAYPLAMAFALVYTAEH 338  

                CS -HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   ypsDVlaGallGaliaalvllfvrrlld<-*
                   y +D+l G+ l+a+++a++ ++ r +l    
      C0ULT2   339 YVFDILLGWGLAAIVIAAYHVIDRTWLI    366  

TMSP/non-TMSP/fixed score (recomputed/original total): 39.614/-5.511/-9.474 (24.629/25.4)


C0UXS5 C0UXS5_9BACT PAP2 superfamily protein [Thermobaculum terrenum ATCC BAA-798]
PAP2            PAP2 superfamily                         17.0    0.00024   1
PAP2              1/1     200   302 ..     1   177 []    17.0  0.00024
PAP2: domain 1 of 1, from 200 to 302: score 17.0, E = 0.00024
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      +++  +l+ +  ++++      +l+++    P               
      C0UXS5   200    LIRDIVLSQLHFGGMSLS----MLIKHGN--P--------------- 225  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                               +y +                             ++PS+
      C0UXS5   226 ------------NYVA-----------------------------AMPSL 234  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   Haa  +++++f ++++++             + ++ll+ +  ++S vy g
      C0UXS5   235 HAAYPTLVFVFSLFHWRK------------FAPIALLYCFGLWFSIVYIG 272  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    Hy +D laG++++++ + +v l++r l +   
      C0UXS5   273 DHYVIDTLAGIAYAVVSFTIVSLIYRYLEK    302  

TMSP/non-TMSP/fixed score (recomputed/original total): 35.787/-9.681/-9.474 (16.632/17.0)


C0YXJ8 C0YXJ8_LACRE Phosphatidylglycerophosphatase B [Lactobacillus reuteri MM2-3]
PAP2           PAP2 superfamily                           9.1      0.001   1
PAP2             1/1      55   166 .]     1   177 []     9.1    0.001
PAP2: domain 1 of 1, from 55 to 166: score 9.1, E = 0.001
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      +a+++ll  +++++l     +   +  pR  P               
      C0YXJ8    55    KAGPFLLIPGIGFILLSF--IRQRIDAPR--P--------------- 82   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-  SS-SSS
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvse..agpSFP
                                                 +   + ++l++++++g S P
      C0YXJ8    83 ------------------------------YEKFPINPLIRRqkTGDSLP 102  

                CS -HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvy
                   S H  f+a++  +  l+l +           +lg++ll+la++ +++Rv 
      C0YXJ8   103 SRHV-FSATVIAMCGLRLNL-----------ILGVILLVLAVVSAITRVI 140  

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                    gvH+p DV+ G++ G++++ + +l+         
      C0YXJ8   141 GGVHFPRDVVIGFICGFICGSFLFLV------    166  

TMSP/non-TMSP/fixed score (recomputed/original total): 32.219/-14.094/-9.474 (8.651/9.1)


C1B9R3 C1B9R3_RHOOB Hypothetical membrane protein [Rhodococcus opacus B4]
PAP2            PAP2 superfamily                         18.4    0.00018   1
PAP2              1/1     189   295 ..     1   177 []    18.4  0.00018
PAP2: domain 1 of 1, from 189 to 295: score 18.4, E = 0.00018
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                        ++ +++++++ + +++    +++ +  + P               
      C1B9R3   189    DSVGRVAGFGFGVVPTDV--STRWL-EAQSNP--------------- 217  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                + PS+
      C1B9R3   218 -------------------------------------------VAALPSL 224  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   Haafa ++a++l+ + +           l+ ++ll+++ + +++  vy g
      C1B9R3   225 HAAFALLVAVALWPFAKN----------LWSRALLVAYPVAMAFVLVYGG 264  

                CS SS-HHHHCHH HCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaG.allGaliaalvllfvrrlld<-*
                    Hy +DVlaG a lG +i ++ ++  r  +    
      C1B9R3   265 EHYVVDVLAGwAYLGLAILLARAWESRTATS    295  

TMSP/non-TMSP/fixed score (recomputed/original total): 31.434/-4.036/-9.474 (17.924/18.4)


C1FLY6 C1FLY6_CLOBJ PAP2 family protein [Clostridium botulinum A2 str. Kyoto]
PAP2            PAP2 superfamily                         21.5     0.0001   1
PAP2              1/1     180   298 ..     1   177 []    21.5   0.0001
PAP2: domain 1 of 1, from 180 to 298: score 21.5, E = 0.0001
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC -B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKllf.grpRApPhflavcqpdwgdst
                      ++l+++l   + l++       ++++g+    P              
      C1FLY6   180    HVLQVFLITPFYLMFHLQ--EVWYVnGH----P-------------- 206  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                                g   + + +a   ++   FPS
      C1FLY6   207 ----------------------------DGLARNLGPQAAAGVTLNCFPS 228  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                    H++ a+a +l++++   +           + + ++ ++ l v +S++yl
      C1FLY6   229 MHTSIAFAMFLVVLHEKDK-----------IFKYIWSFFCLSVVYSTMYL 267  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     H+++DV++G++l+++   l+ ++ ++      
      C1FLY6   268 EIHWIIDVFGGMVLAFVTVKLADFILAKGKI    298  

TMSP/non-TMSP/fixed score (recomputed/original total): 44.601/-14.096/-9.474 (21.031/21.5)


C2DRX1 C2DRX1_ECOLX Putative uncharacterized protein [Escherichia coli 83972]
PAP2            PAP2 superfamily                         17.5    0.00022   1
PAP2              1/1      72   198 ..     1   177 []    17.5  0.00022
PAP2: domain 1 of 1, from 72 to 198: score 17.5, E = 0.00022
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      ++++l+ ++ +s+l++g+  + ll+      P               
      C2DRX1    72    HLRWLARSMQISALVAGV--FYLLW------P--------------- 95   

                CS GHHHHHHCHHCHCCCHHCCHH HHT-- SS-B--TTCSSTTBS-SS-SSS
                   sdlwyeellgyefycmagspg.ldrid.lfgsvlltsafalvseagpSFP
                                + m+    +++ i  ++ + l  ++  + +     FP
      C2DRX1    96 -------------TTMHYPSFdQMGISaGALNRLIAIDSSQNC-----FP 127  

                CS -HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvy
                   S+Ha    a+ l++++++++       ++  +l l  +++a+ +++S + 
      C2DRX1   128 SLHA----ALTLLAVWAIAK-------KGNRWLTLMSVVWAIAIAFSILQ 166  

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   l  H ++D+++Gall+ ++++++++  +r ++   
      C2DRX1   167 LRRHLFIDLVGGALLASICGWICATCEKRKTQ    198  

TMSP/non-TMSP/fixed score (recomputed/original total): 39.129/-12.638/-9.474 (17.017/17.5)


C2F076 C2F076_LACRE Phosphatidylglycerophosphatase B [Lactobacillus reuteri SD2112]
PAP2           PAP2 superfamily                          10.2    0.00084   1
PAP2             1/1      55   166 .]     1   177 []    10.2  0.00084
PAP2: domain 1 of 1, from 55 to 166: score 10.2, E = 0.00084
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      +a+++ll  +++++l     +   +  pR  P               
      C2F076    55    KAGPFLLIPGIGFILLSF--IRQRIDAPR--P--------------- 82   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                       yee                               l   +g S PS 
      C2F076    83 ----YEE------------------------FSINPLILRQKTGDSLPSR 104  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H  f+a++  +  l+l +           +lg++ll+la++ +++Rv  g
      C2F076   105 HV-FSATVIAMCGLRLNL-----------ILGVILLVLAVVSAITRVIGG 142  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                   vH+p DV+ G++ G++++ + +l+         
      C2F076   143 VHFPRDVVIGFICGFICGSFLFLV------    166  

TMSP/non-TMSP/fixed score (recomputed/original total): 32.219/-13.014/-9.474 (9.731/10.2)


C2F396 C2F396_LACRE Phosphatidylglycerophosphatase B [Lactobacillus reuteri MM4-1A]
PAP2           PAP2 superfamily                           9.1      0.001   1
PAP2             1/1      55   166 .]     1   177 []     9.1    0.001
PAP2: domain 1 of 1, from 55 to 166: score 9.1, E = 0.001
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      +a+++ll  +++++l     +   +  pR  P               
      C2F396    55    KAGPFLLIPGIGFILLSF--IRQRIDAPR--P--------------- 82   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-  SS-SSS
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvse..agpSFP
                                                 +   + ++l++++++g S P
      C2F396    83 ------------------------------YEKFPINPLIRRqkTGDSLP 102  

                CS -HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvy
                   S H  f+a++  +  l+l +           +lg++ll+la++ +++Rv 
      C2F396   103 SRHV-FSATVIAMCGLRLNL-----------ILGVILLVLAVVSAITRVI 140  

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                    gvH+p DV+ G++ G++++ + +l+         
      C2F396   141 GGVHFPRDVVIGFICGFICGSFLFLV------    166  

TMSP/non-TMSP/fixed score (recomputed/original total): 32.219/-14.094/-9.474 (8.651/9.1)


C2GQA2 C2GQA2_LACRE Phosphatidylglycerophosphatase B [Lactobacillus reuteri CF48-3A]
PAP2           PAP2 superfamily                          10.2    0.00084   1
PAP2             1/1      55   166 .]     1   177 []    10.2  0.00084
PAP2: domain 1 of 1, from 55 to 166: score 10.2, E = 0.00084
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      +a+++ll  +++++l     +   +  pR  P               
      C2GQA2    55    KAGPFLLIPGIGFILLSF--IRQRIDAPR--P--------------- 82   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                       yee                               l   +g S PS 
      C2GQA2    83 ----YEE------------------------FSINPLILRQKTGDSLPSR 104  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H  f+a++  +  l+l +           +lg++ll+la++ +++Rv  g
      C2GQA2   105 HV-FSATVIAMCGLRLNL-----------ILGVILLVLAVVSAITRVIGG 142  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                   vH+p DV+ G++ G++++ + +l+         
      C2GQA2   143 VHFPRDVVIGFICGFICGSFLFLV------    166  

TMSP/non-TMSP/fixed score (recomputed/original total): 32.219/-13.014/-9.474 (9.731/10.2)


C3KUU2 C3KUU2_CLOB6 PAP2 family protein [Clostridium botulinum Ba4 str. 657]
PAP2            PAP2 superfamily                         21.4     0.0001   1
PAP2              1/1     180   298 ..     1   177 []    21.4   0.0001
PAP2: domain 1 of 1, from 180 to 298: score 21.4, E = 0.0001
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC -B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKllf.grpRApPhflavcqpdwgdst
                      ++l+++l   + l++       ++++g+    P              
      C3KUU2   180    HVLQVFLITPFYLMFHLQ--EVWYVnGH----P-------------- 206  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                                g   + + +a   ++   FPS
      C3KUU2   207 ----------------------------DGLARNLGPQAAAGVTLNCFPS 228  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                    H++ a+a +l++++   +           + + ++ ++ l v +S++yl
      C3KUU2   229 MHTSIAFAMFLVVLHEKDK-----------IFKYIWSFFCLSVVYSTMYL 267  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     H+++DV+aG++l+++   l  ++ ++      
      C3KUU2   268 EIHWIIDVFAGMVLAFVTVKLSDFILAKGKI    298  

TMSP/non-TMSP/fixed score (recomputed/original total): 44.54/-14.096/-9.474 (20.970/21.4)


C4G6B6 C4G6B6_ABIDE Putative uncharacterized protein [Abiotrophia defectiva ATCC 49176]
PAP2         PAP2 superfamily                             9.0      0.001   1
PAP2           1/1      95   212 ..     1   177 []     9.0    0.001
PAP2: domain 1 of 1, from 95 to 212: score 9.0, E = 0.001
                CS    CCHHHHHHHHHHHHHHHH H HHHHCC-B--..HHHHHHHHHHHTT-
                   *->aalalllalvaslllngl.a.ylKllfgrpRApPhflavcqpdwgds
                      a  + ll++++   +n+ +  ++  +++r                  
      C4G6B6    95    AKTICLLCFLLIPTTNVRpEvGAEGIWNRVM---------------- 125  

                CS GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS
                   tcsdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFP
                                                       ++ +++++a+  FP
      C4G6B6   126 ------------------------------------IHLYNTDAADNLFP 139  

                CS -HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvy
                   S H  ++++++++++              +++++++ ll+a+ v++S++ 
      C4G6B6   140 SIHCLTSWFCYIAVRKNKNI---------PKPYVWFSLLFAISVCISTLT 180  

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                     +H ++DV++G+ l+ +  ++v++ + ++ +   
      C4G6B6   181 TKQHVIVDVIGGVGLAEGSYFVVKYGFTGFYE    212  

TMSP/non-TMSP/fixed score (recomputed/original total): 29.697/-11.71/-9.474 (8.513/9.0)


C4LGU7 C4LGU7_CORK4 Putative membrane protein [Corynebacterium kroppenstedtii DSM 44385]
PAP2            PAP2 superfamily                         27.5    3.4e-05   1
PAP2              1/1     278   412 ..     1   177 []    27.5  3.4e-05
PAP2: domain 1 of 1, from 278 to 412: score 27.5, E = 3.4e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC   -B             --..
                   *->aalalllalvaslllnglaylKllf...gr.............pRAp
                       + a++++ +a ++l++    K++ ++ +r+ + ++++ ++ +p   
      C4LGU7   278    RLTAHAWSQIAPFGLAEG--VKDFQdgaRRearadgptlgpvePV-- 320  

                CS HHHHHHHHHHHTT-GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TT
                   Phflavcqpdwgdstcsdlwyeellgyefycmagspgldridlfgsvllt
                   P                                           +   + 
      C4LGU7   321 P-------------------------------------------VGEGPL 327  

                CS CSSTTBS-SS-SSS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHH
                   safalvseagpSFPSGHaafaaafalflalylprrlsklgrllrlllgll
                     +  +s    + PS+Ha  +++fa+fl  + ++            +g +
      C4LGU7   328 AKAQASSNLVSAIPSLHAGITMYFATFLFSRRRW-----------KWGSV 366  

                CS HCCHHHHHHHHHHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   llllallvglSRvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   +l++al++g++ v+   Hy +D++ G+ l+a++ ++  ++  r+++   
      C4LGU7   367 ALIYALTMGFALVFFAEHYVFDIILGWTLAAAVPLVQTWWMSRRRE    412  

TMSP/non-TMSP/fixed score (recomputed/original total): 40.394/-3.941/-9.474 (26.979/27.5)


C4Z0A6 C4Z0A6_EUBE2 Phosphatidylglycerophosphatase [Eubacterium eligens ATCC 27750]
PAP2        PAP2 superfamily                             19.7    0.00014   1
PAP2          1/1      91   203 .]     1   177 []    19.7  0.00014
PAP2: domain 1 of 1, from 91 to 203: score 19.7, E = 0.00014
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      +  +++l+ + s++l+ +  +   +   R  P               
      C4Z0A6    91    LTSKFILTPFTSFILVSV--IRKCIDAKR--P--------------- 118  

                CS GHHHHHHCHHCH CCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   sdlwyeellgye.fycmagspgldridlfgsvlltsafalvseagpSFPS
                             ye+++++                      +    g S+PS
      C4Z0A6   119 ----------YEkYNIK-------------------PLFIKETKGESMPS 139  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                    H    +++ ++++ +l+            ++g+++lll++ ++ SRv  
      C4Z0A6   140 RHV---FSITIIAMCWLYV---------SVPVGIIMLLLVAIMSASRVLA 177  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                   gvH+  DV+aG+++G++++++ l++         
      C4Z0A6   178 GVHFVRDVVAGFAVGIICGIAGLWLI-----    203  

TMSP/non-TMSP/fixed score (recomputed/original total): 40.488/-11.806/-9.474 (19.208/19.7)


C4Z6G9 C4Z6G9_EUBE2 Putative uncharacterized protein [Eubacterium eligens ATCC 27750]
PAP2            PAP2 superfamily                         15.1    0.00034   1
PAP2              1/1      82   213 ..     1   177 []    15.1  0.00034
PAP2: domain 1 of 1, from 82 to 213: score 15.1, E = 0.00034
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B   --..HHHHHHHHHHHTT
                   *->aalalllalvaslllnglaylKllfgr...pRApPhflavcqpdwgd
                       +++++l+l+++  l+ +  + ++++ + ++R  P            
      C4Z6G9    82    EFIQFALSLIIGMSLSLT--ICMIYPNgltLR--P------------ 112  

                CS -GGGHHHHHHCHHC H CCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-
                   stcsdlwyeellgy.e.fycmagspgldridlfgsvlltsafalvseagp
                               +y +++ c                    a + ++ +  
      C4Z6G9   113 ------------DYiPdNFCG---------------KIINALYTIDTSTN 135  

                CS SSS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHH
                   SFPSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglS
                    FPS H     +++ f++l+ ++       ++ ++++ l  +l +l++l+
      C4Z6G9   136 VFPSIHV-YNSLAVNFALLRCKA------LKGHIITKTLSSILCILICLA 178  

                CS HHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   RvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   +v+l +H  +DV+++++l ++  ++ +++ + +l+   
      C4Z6G9   179 TVFLKQHSVVDVIGAIILYIVLYIFIYVIDYSRLK    213  

TMSP/non-TMSP/fixed score (recomputed/original total): 31.512/-7.504/-9.474 (14.534/15.1)


C5A5X7 C5A5X7_THEGJ Membrane-bound phosphoesterase, PAP2 superfamily [Thermococcus gammatolerans EJ3]
PAP2            PAP2 superfamily                          9.5    0.00095   1
PAP2              1/1     118   231 ..     1   177 []     9.5  0.00095
PAP2: domain 1 of 1, from 118 to 231: score 9.5, E = 0.00095
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      ++ + + + v++++ +++    ++++     P               
      C5A5X7   118    LITYSICGTVYTFAHVYA--PHYVYHL----P--------------- 143  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                    +++    +   +  PS+
      C5A5X7   144 -------------------------------GFYPDRTYLTQQEFVLPSL 162  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H ++aa+  ++l+ y +            l + l+++l  lv ++++ lg
      C5A5X7   163 HNTVAAFNIIILWKYRRE-----------LKAKLIIALNSLVPFATLLLG 201  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                   +H++ D l G++l+++++ +v     + +    
      C5A5X7   202 HHWIYDALSGIALAMVVGKMVEGRKIHVPS    231  

TMSP/non-TMSP/fixed score (recomputed/original total): 31.897/-13.361/-9.474 (9.062/9.5)


C5CUS0 C5CUS0_VARPS Phosphoesterase, PA-phosphatase related [Variovorax paradoxus S110]
PAP2            PAP2 superfamily                         15.4    0.00032   1
PAP2              1/1      93   224 ..     1   177 []    15.4  0.00032
PAP2: domain 1 of 1, from 93 to 224: score 15.4, E = 0.00032
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      +   ++++l +++l  +   l l++ +    P               
      C5CUS0    93    FRELVVYGLWIGALCLTG--LGLFYFW----P--------------- 118  

                CS GHHHHHHCHHC H CCCHHCCHH HHT--SS-B--TTCSSTTBS-SS-SS
                   sdlwyeellgy.e.fycmagspg.ldridlfgsvlltsafalvseagpSF
                           + +++      g+pg ++               +v++ag + 
      C5CUS0   119 --------TQIpPlAIDVSGYPGfAM-------------LQGVDAAGNAC 147  

                CS S-HHHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHH
                   PSGHaafaaafalflalylprrlsklg.rllrlllgllllllallvglSR
                   PS H     a+a+f a +l     +l++ +++ +l+l+ +l+ + +++S+
      C5CUS0   148 PSMHV----AVAIFTAIRLDH---VLReARTPVFLRLANWLWFAAIAYST 190  

                CS HHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   +   +H  +D laGallG+++a+  l++     +   
      C5CUS0   191 LAVKQHVVLDALAGALLGMAFALPSLRWRPEGMR    224  

TMSP/non-TMSP/fixed score (recomputed/original total): 33.361/-9.012/-9.474 (14.875/15.4)


Q0A887 Q0A887_ALHEH Phosphoesterase, PA-phosphatase related [Alkalilimnicola ehrlichii MLHE-1]
PAP2            PAP2 superfamily                         30.4    7.1e-06   1
PAP2              1/1      29   121 ..     1   177 []    30.4  7.1e-06
PAP2: domain 1 of 1, from 29 to 121: score 30.4, E = 7.1e-06
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                        +++ ++l+ +l+ln     K ++  +                   
      Q0A887    29    GDGPVWYTLMGALVLNPG--WKGAVASLQ------------------ 55   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                     
      Q0A887     - -------------------------------------------------- -    

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                     ++ +a++++++ +lp+            l  lll+l+ll++lSRv lg
      Q0A887    56 --MGLTALVGIALAWLPG------------LSPLLLPLVLLIALSRVVLG 91   

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    HypsD l+G ++G++ a l l+++   ++   
      Q0A887    92 LHYPSDGLVGGIIGYGLARLSLWLYPAATP    121  

TMSP/non-TMSP/fixed score (recomputed/original total): 69.454/-29.922/-9.474 (30.058/30.4)


Q0C4K7 Q0C4K7_HYPNA Putative membrane protein [Hyphomonas neptunium ATCC 15444]
PAP2            PAP2 superfamily                         22.7    8.2e-05   1
PAP2              1/1      83   199 ..     1   177 []    22.7  8.2e-05
PAP2: domain 1 of 1, from 83 to 199: score 22.7, E = 8.2e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       +la+++a +a +++  l     ++   R  P               
      Q0C4K7    83    PLLAYGFAWGADQIFRSL----IYV--SR--P--------------- 106  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                      ++alv++a  S  SG
      Q0C4K7   107 -----------------------------------DAALVHVASASSSSG 121  

                CS HHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHHC
                   Haafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvyl
                     ++ ++++++l  +  +   +++++l   ++ ++++ll+l  g +R+ l
      Q0C4K7   122 LPSTFGLVFGALFGVALW---MKNdSLQARIALAVCFLLMLAGGAARIVL 168  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                   g H+ s++l  ++lG+l a ++ ++++r+ +   
      Q0C4K7   169 GGHWLSQMLPSFALGILLAGIAVWVFGRIEA    199  

TMSP/non-TMSP/fixed score (recomputed/original total): 38.156/-6.407/-9.474 (22.275/22.7)


Q0FHX9 Q0FHX9_9RHOB PA-phosphatase related phosphoesterase [Roseovarius sp. HTCC2601]
PAP2            PAP2 superfamily                         22.2    9.1e-05   1
PAP2              1/1       1    76 [.     1   177 []    22.2  9.1e-05
PAP2: domain 1 of 1, from 1 to 76: score 22.2, E = 9.1e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                             +++a+++l+ +    l+  + R                  
      Q0FHX9     1    -------MMAAVTYLTLA--VMLARTEKR------------------ 20   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                     
      Q0FHX9     - -------------------------------------------------- -    

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                                +++++           +l++ ++lla+lvg SRvylg
      Q0FHX9    21 -------------RRIRA-----------FLVIMAALLAALVGTSRVYLG 46   

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                   vH+psDVlaG+ lGa++a+ v+l+ r+l++   
      Q0FHX9    47 VHWPSDVLAGWSLGAAWALGVALLARWLAR    76   

TMSP/non-TMSP/fixed score (recomputed/original total): 70.53/-32.96/-15.722 (21.848/22.2)


Q0RYB1 Q0RYB1_RHOSR Putative uncharacterized protein [Rhodococcus jostii RHA1]
PAP2            PAP2 superfamily                         16.3    0.00027   1
PAP2              1/1     106   198 .]     1   177 []    16.3  0.00027
PAP2: domain 1 of 1, from 106 to 198: score 16.3, E = 0.00027
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       ++a+ +a +a+ll+ g+  +  ++++                    
      Q0RYB1   106    ELIAFTAAGFATLLAIGI--ITSVVRWKV------------------ 132  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                   S 
      Q0RYB1   133 ------------------------------------------------SV 134  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H+a++a + ++l+l++              +++l+l+    +g+SRv lg
      Q0RYB1   135 HTAVSAGITVILMLAVSP------------IWVLALACTPAIGWSRVRLG 172  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    H   +V++Ga++Ga+ia  ++ ++        
      Q0RYB1   173 DHTTGQVIVGAFVGAVIAGGTYALFT----    198  

TMSP/non-TMSP/fixed score (recomputed/original total): 32.705/-7.339/-9.474 (15.892/16.3)


Q0TI04 Q0TI04_ECOL5 Putative dual specificity phosphatase [Escherichia coli 536]
PAP2          PAP2 superfamily                           19.1    0.00016   1
PAP2            1/1       1    91 [.     1   177 []    19.1  0.00016
PAP2: domain 1 of 1, from 1 to 91: score 19.1, E = 0.00016
                CS    CCHHHHHHHHHHHHHHHHHHHHH CC-B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKl.lfgrpRApPhflavcqpdwgdst
                                   ++++l + +l+lf      P              
      Q0TI04     1    -------------MTGWL-FSQLeLFDL----P-------------- 15   

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                                                   PS
      Q0TI04    16 --------------------------------------------YNQSPS 21   

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                   +H +++++++  ++ +l+            +++ ++ ++ ll+++S++  
      Q0TI04    22 LHIILCWLLWRHFRQHLAV-----------RWRKVCGGWFLLIAISTLTT 60   

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                   ++H+++DV+ G+++G+li ++v ++ r+  +   
      Q0TI04    61 WQHHFIDVITGLAVGMLIDWMVPVDRRWNYQ    91   

TMSP/non-TMSP/fixed score (recomputed/original total): 56.635/-22.162/-15.722 (18.751/19.1)


Q1EB11 Q1EB11_COCIM Putative uncharacterized protein [Coccidioides immitis]
PAP2            PAP2 superfamily                         13.8    0.00043   1
PAP2              1/1       1    94 [.     1   177 []    13.8  0.00043
PAP2: domain 1 of 1, from 1 to 94: score 13.8, E = 0.00043
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                 + + ++l                             
      Q1EB11     1    -----------MSGSAAL----------------------------- 7    

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                               ++FPS 
      Q1EB11     8 -------------------------------------------EYGFPST 14   

                CS HHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHHC
                   Haafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvyl
                   H+++a ++++++++ l    ++ +++  +  l++ll++++  + l+R+y+
      Q1EB11    15 HSTNAVSVVVYAMHNLNS-AASAFsPTSKAALQFLLFIYGTSIVLGRLYC 63   

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                   g+H ++DV+aG llGal +++ + + + + +   
      Q1EB11    64 GMHGFLDVVAGCLLGALLGFIQCSYGAAIDA    94   

TMSP/non-TMSP/fixed score (recomputed/original total): 58.031/-28.909/-15.722 (13.400/13.8)


Q1GR63 Q1GR63_SPHAL Putative uncharacterized protein [Sphingopyxis alaskensis]
PAP2            PAP2 superfamily                         14.7    0.00037   1
PAP2              1/1     186   332 ..     1   177 []    14.7  0.00037
PAP2: domain 1 of 1, from 186 to 332: score 14.7, E = 0.00037
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..H     HHHHHHHHHH
                   *->aalalllalvaslllnglaylKllfgrpRApP.....hflavcqpdw
                      +++ l++a+++++ l++l     ++      P  ++  + a   p++
      Q1GR63   186    HFRTLVVAVLLMQSLGAL----SYL--VA--PaigpfIYEAGIDPTI 224  

                CS TT -GGGHHHHHHCHHCHCCCHHCCHHHHT-- SS-B--TTCSSTTBS-S
                   gd.stcsdlwyeellgyefycmagspgldrid.lfgsvlltsafalvsea
                     +++ +   y+                     + gs +  ++   +  +
      Q1GR63   225 TPgQLSMLEFYRQ------------------SvSQGSAWIAQHGSTHFTV 256  

                CS S- SSS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHH
                   gp.SFPSGHaafaaafalflalylprrlsklgrllrlllgllllllallv
                   g  ++PS+Haa+a++f+lf++ + +             l  l+ +l +++
      Q1GR63   257 GLaAMPSLHAAGAFLFWLFAWKHGRI------------LLPLYSILLFFI 294  

                CS HHHHHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   glSRvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                     + +   +Hy +D+ +G++l++++ +l+ +fvr   d   
      Q1GR63   295 LVTSIASRWHYAIDIPVGIALAWGCVWLAERFVRTAND    332  

TMSP/non-TMSP/fixed score (recomputed/original total): 29.043/-5.487/-9.474 (14.082/14.7)


Q24K58 Q24K58_ORENI Glucose-6-phosphatase (Fragment) [Oreochromis niloticus]
PAP2     PAP2 superfamily                                12.6    0.00053   1
PAP2       1/1       3    90 .]     1   177 []    12.6  0.00053
PAP2: domain 1 of 1, from 3 to 90: score 12.6, E = 0.00053
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B  --..HHHHHHHHHHHTT-
                   *->aalalllalvaslllnglaylKllfgr..pRApPhflavcqpdwgds
                       + a+++a v   ++++l    l++ r++++  P             
      Q24K58     3    SGHAMGAAGVWYVMVTAL----LSIARekQC--P------------- 30   

                CS GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS
                   tcsdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFP
                                                                     
      Q24K58     - -------------------------------------------------- -    

                CS -HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvy
                               +l++++ +          + l++l+ l+ l+v+ SRvy
      Q24K58    31 ------------SLLYRFLY----------IGLWMLMGLVELVVCVSRVY 58   

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   + +H+p++V+aG++ G+l+a++v +  + +++   
      Q24K58    59 MAAHFPHQVIAGIITGTLVAEVVSKEKWIYSA    90   

TMSP/non-TMSP/fixed score (recomputed/original total): 51.186/-29.442/-9.474 (12.270/12.6)


Q2A2J6 Q2A2J6_FRATH Putative uncharacterized protein [Francisella tularensis subsp. holarctica LVS]
PAP2     PAP2 superfamily                                22.5    8.5e-05   1
PAP2       1/1       1    88 [.     1   177 []    22.5  8.5e-05
PAP2: domain 1 of 1, from 1 to 88: score 22.5, E = 8.5e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                                       l  +K++                       
      Q2A2J6     1    ---------------MCL--TKYSR---------------------- 8    

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                         + +    SFPSG
      Q2A2J6     9 --------------------------------------INYNINNSFPSG 20   

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   Ha+f ++f+++++ ++p+            +++l++lla+lv  + +  +
      Q2A2J6    21 HATFIFSFSVSMWILFPK------------YRWLWALLAFLVVVTQLLQY 58   

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    H+ sD+++G++lG +i++ ++  + + ++   
      Q2A2J6    59 FHFVSDLIVGSMLGSIIGYYAAQSYTKKSQ    88   

TMSP/non-TMSP/fixed score (recomputed/original total): 50.665/-12.751/-15.722 (22.192/22.5)


Q2G5H1 Q2G5H1_NOVAD Phosphoesterase, PA-phosphatase related [Novosphingobium aromaticivorans DSM 12444]
PAP2            PAP2 superfamily                         21.4    0.00011   1
PAP2              1/1     167   315 ..     1   177 []    21.4  0.00011
PAP2: domain 1 of 1, from 167 to 315: score 21.4, E = 0.00011
                CS    CCHHHHHHHHHHHHHHHHHHHHH CC-B              --..H
                   *->aalalllalvaslllnglaylKl.lfgr..............pRApP
                      +  + ll ++a+  l+ +  +   +f+  + +++    + +  R +P
      Q2G5H1   167    LPPKRLLHFIAAYSLTLT--ITVaVFPLfpaegpyvyyniplER-AP 210  

                CS HHHHHHHHHHTT-GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTC
                   hflavcqpdwgdstcsdlwyeellgyefycmagspgldridlfgsvllts
                    +l++++p + +   + l                          +  +  
      Q2G5H1   211 -YLDRLFPWETGIKIEKL--------------------------RLGYLR 233  

                CS SSTTBS-SS-SSS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHH
                   afalvseagpSFPSGHaafaaafalflalylprrlsklgrllrlllglll
                   +   + ++  SFPS Ha ++a ++++++l + +            +++ +
      Q2G5H1   234 DVTSEAAGLVSFPSFHA-ASAILLGWASLSWLW------------VRGPI 270  

                CS CCHHHHHHHHHHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lllallvglSRvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   lll +++ +S++ +g+Hy +D+++G++l+a++++++ +  ++ ++   
      Q2G5H1   271 LLLNAVMLFSTIVCGAHYLVDLIGGVVLAAGVIYWTGRCCQHNAN    315  

TMSP/non-TMSP/fixed score (recomputed/original total): 46.437/-16.181/-9.474 (20.782/21.4)


Q3A8D1 Q3A8D1_PELCD Putative uncharacterized protein [Pelobacter carbinolicus DSM 2380]
PAP2            PAP2 superfamily                         21.3    0.00011   1
PAP2              1/1     203   325 ..     1   177 []    21.3  0.00011
PAP2: domain 1 of 1, from 203 to 325: score 21.3, E = 0.00011
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B   --..HHHHHHHHHHHTT
                   *->aalalllalvaslllnglaylKllfgr...pRApPhflavcqpdwgd
                      ++  ++ a+  s+l+n +    +  ++++ +R               
      Q3A8D1   203    LFPTAGPAFYNSELFNLA--GTHCAKMqqlLR--------------- 232  

                CS -GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SS
                   stcsdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSF
                                                     +  +++ +  ++  ++
      Q3A8D1   233 -------------------------------LYMDGQVTQNGLMPGTMAM 251  

                CS S-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHH
                   PSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRv
                   PS+H  +++ ++  la+ ++r            + ++ +++ l v+ S+v
      Q3A8D1   252 PSLHVGLMGIAVWQLAHIWRR------------TLWVTIPWFLMVWMSTV 289  

                CS HCTSS-HHHHCHH   HCHCHCCCCHCHCHCCCGB-   
                   ylgvHypsDVlaG...allGaliaalvllfvrrlld<-*
                   +lg+Hy +D ++G   +++++lia + ++++  +     
      Q3A8D1   290 MLGWHYVLDGIGGiivIAIAMLIARIIFCVWSFFGV    325  

TMSP/non-TMSP/fixed score (recomputed/original total): 40.124/-9.837/-9.474 (20.813/21.3)


Q3DCZ4 Q3DCZ4_STRAG PAP2 family protein [Streptococcus agalactiae CJB111]
PAP2          PAP2 superfamily                           26.0    4.5e-05   1
PAP2            1/1      17   123 .]     1   177 []    26.0  4.5e-05
PAP2: domain 1 of 1, from 17 to 123: score 26.0, E = 4.5e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       +++ +++++a  ++         + +pR  P               
      Q3DCZ4    17    ILIIPAVGFIALSYIRKR------LDFPR--P--------------- 40   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                       ye                         ++       +  g+S+PS 
      Q3DCZ4    41 ----YEK------------------------WNIKPLIYKDTEGRSMPSR 62   

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H   a++++  l++y+ +             g+++l+l++l ++ Rv  g
      Q3DCZ4    63 HVFSATMISMCLLRYYVY------------FGIVCLILSVLLAICRVIAG 100  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                   vHyp DV++G+l+G + ++        l+    
      Q3DCZ4   101 VHYPKDVIVGYLIGLILGL-------CLFI    123  

TMSP/non-TMSP/fixed score (recomputed/original total): 39.133/-4.13/-9.474 (25.529/26.0)


Q3Z8A9 Q3Z8A9_DEHE1 PAP2 family protein [Dehalococcoides ethenogenes 195]
PAP2            PAP2 superfamily                         21.9    9.5e-05   1
PAP2              1/1     103   196 .]     1   177 []    21.9  9.5e-05
PAP2: domain 1 of 1, from 103 to 196: score 21.9, E = 9.5e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      ++ al++++v+s l+  +    ++f  +                   
      Q3Z8A9   103    LIAALFAGFVSSVLFMIV----NFF--WK------------------ 125  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                   S 
      Q3Z8A9   126 -----------------------------------------------ISV 128  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H+afa af+ +++ ++++             +l ++ll+  ++++Rvyl 
      Q3Z8A9   129 HTAFASAFFSIALVLYGY------------SALGFVLLVPMMAWARVYLK 166  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    H   +V aGall+ ++++ v+ ++        
      Q3Z8A9   167 EHTVGQVTAGALLAGTVIVTVFNIFNMVNL    196  

TMSP/non-TMSP/fixed score (recomputed/original total): 41.81/-10.78/-9.474 (21.556/21.9)


Q3ZXH6 Q3ZXH6_DEHSC PAP2 family protein [Dehalococcoides sp. CBDB1]
PAP2            PAP2 superfamily                         20.5    0.00012   1
PAP2              1/1     103   196 .]     1   177 []    20.5  0.00012
PAP2: domain 1 of 1, from 103 to 196: score 20.5, E = 0.00012
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      ++ al++++v+s l+  +    ++f  +                   
      Q3ZXH6   103    LIAALFAGFVSSVLFMIV----NFF--WK------------------ 125  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                   S 
      Q3ZXH6   126 -----------------------------------------------ISV 128  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H+afa af+ +++ ++++             +l ++ll+  ++++Rvyl 
      Q3ZXH6   129 HTAFASAFSSIALMLYGY------------SALGFMLLVPMMAWARVYLK 166  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    H   +V aGall+ ++++ v+ ++        
      Q3ZXH6   167 EHTVGQVTAGALLAGTVIVTVFNIFNMVNI    196  

TMSP/non-TMSP/fixed score (recomputed/original total): 40.427/-10.78/-9.474 (20.173/20.5)


Q4SP12 Q4SP12_TETNG Chromosome 15 SCAF14542, whole genome shotgun sequence. (Fragment) [Tetraodon nigroviridis]
PAP2            PAP2 superfamily                         32.3    1.9e-06   1
PAP2              1/1     381   476 ..     1   177 []    32.3  1.9e-06
PAP2: domain 1 of 1, from 381 to 476: score 32.3, E = 1.9e-06
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                        + l l l++  +ln l  + l+f  +   P               
      Q4SP12   381    SSCLLQLLLFLHSALNSL--FALVF--LL--P--------------- 406  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                     
      Q4SP12     - -------------------------------------------------- -    

                CS HHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHHC
                   Haafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvyl
                              l +yl+ r  ++g  +lr+l+++ l+++++++glSRv++
      Q4SP12   407 -----------LQFYLQSRFTWRGaAWLRPLTQFTLIMMSFYTGLSRVSD 445  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                   ++H+p+DVlaG++ Gal+a+ v +fv  l++   
      Q4SP12   446 HKHHPTDVLAGFVQGALVAYCVVFFVSDLFK    476  

TMSP/non-TMSP/fixed score (recomputed/original total): 73.911/-32.507/-9.474 (31.930/32.3)


Q4SW03 Q4SW03_TETNG Chromosome 3 SCAF13699, whole genome shotgun sequence [Tetraodon nigroviridis]
PAP2           PAP2 superfamily                          55.7    1.8e-13   1
PAP2             1/1      61   190 ..     1   177 []    55.7  1.8e-13
PAP2: domain 1 of 1, from 61 to 190: score 55.7, E = 1.8e-13
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       +   +l++++  +++    lK +++++R                  
      Q4SW03    61    GLDVICLCIASIPFFACE--LKTVTPYQR------------------ 87   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                               g+++  s+    ++ + + P  
      Q4SW03    88 ----------------------------GFFCGDSTITYPYVEREAIPDS 109  

                CS HHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHHC
                   Haafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvyl
                     ++++ + + l +yl++rls++g rllr+l+++ll+++a+++gl+R+++
      Q4SW03   110 LLIAGGIVITGLTFYLQARLSWRGaRLLRPLIQFLLVMIAIYTGLTRISD 159  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                   + H+psDVl G++ G l a++v+++   +++   
      Q4SW03   160 YRHHPSDVLTGFIQGGLTAYWVAFYISSMFK    190  

TMSP/non-TMSP/fixed score (recomputed/original total): 86.882/-22.24/-9.474 (55.168/55.7)


Q4YWD7 Q4YWD7_PLABE Putative uncharacterized protein (Fragment) [Plasmodium berghei]
PAP2            PAP2 superfamily                         15.5    0.00031   1
PAP2              1/1     107   241 ..     1   177 []    15.5  0.00031
PAP2: domain 1 of 1, from 107 to 241: score 15.5, E = 0.00031
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT -G
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgd.st
                       ++  ++ l++   +  +  + +++  p+  P    +cqp  +++++
      Q4YWD7   107    MFIRIAIILGSIYSIRSI--FIYVTTIPC--P--VPTCQPLVNNgFL 147  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                      +                           + + + fa v+e      S
      Q4YWD7   148 QNIY---------------------------SIYLIVFAKVYECTDLIIS 170  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                   GH+ + +++++f +ly+ +          l+++l++ll++++  l  +  
      Q4YWD7   171 GHT-CFTTLFVFTWLYYEK---------NLFIKLIILLYSIYLYLLIIIS 210  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     Hy +DVl G++ G +i++++ ++v   ++   
      Q4YWD7   211 RFHYTVDVLLGIFFGSTIFIFYHWLVDIAAK    241  

TMSP/non-TMSP/fixed score (recomputed/original total): 29.736/-5.286/-9.474 (14.976/15.5)


Q54UH9 Q54UH9_DICDI Putative uncharacterized protein [Dictyostelium discoideum]
PAP2            PAP2 superfamily                         28.2    2.9e-05   1
PAP2              1/1     298   425 ..     1   177 []    28.2  2.9e-05
PAP2: domain 1 of 1, from 298 to 425: score 28.2, E = 2.9e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHH CC-B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKl.lfgrpRApPhflavcqpdwgdst
                      +a  + + +++  l++++   K+ l+++ R  P              
      Q54UH9   298    LATEFTYLALLLSLVSQI--PKRfLWRF-R--P-------------- 325  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                                  +++  a  + + +  SFPS
      Q54UH9   326 -------------------------------YMVKRAKTVKKDMTSSFPS 344  

                CS HHHHHHHHHHHHHHHHCTTSSCCC- CGS-EECHHHHCCHHHHHHHHHHH
                   GHaafaaafalflalylprrlsklg.rllrlllgllllllallvglSRvy
                     a ++a ++ ++  ++  +  +    ++r++  ll+++ +ll +++R+ 
      Q54UH9   345 R-AVTCAVVYSYAIIWIVTYYDDYDiTVVRWWMPLLFIGSILLSSFARIN 393  

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   lgvHypsD ++G++ G+l++++   f +       
      Q54UH9   394 LGVHYPSDCVGGVIQGTLVCVIGTAFRKIDIL    425  

TMSP/non-TMSP/fixed score (recomputed/original total): 42.626/-5.416/-9.474 (27.736/28.2)


Q6BK22 Q6BK22_DEBHA DEHA2F25520p [Debaryomyces hansenii]
PAP2            PAP2 superfamily                         28.1    3.1e-05   1
PAP2              1/1     237   385 ..     1   177 []    28.1  3.1e-05
PAP2: domain 1 of 1, from 237 to 385: score 28.1, E = 3.1e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      a+  +++a+++ ++++++  +  +f  p ApP               
      Q6BK22   237    ALKLYAFAMGLQNVASVM--THIVF--PNAPP--------------- 264  

                CS GHHHHHHCHHC  H CCCHHCCHHHHT-- SS-B--TTCSSTTBS-SS-S
                   sdlwyeellgy..e.fycmagspgldrid.lfgsvlltsafalvseagpS
                       y + +g +++++y m+ + gl+   +   s  + s  +  s  + +
      Q6BK22   265 ---LYIHYYGEtkVpDYDMIYADGLSKPGtRLPSTIYQSIYYANSNKFAA 311  

                CS SS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHH
                   FPSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSR
                    PS H+++a + +lf+++y++            +l++l +++ l+ ++S+
      Q6BK22   312 IPSIHSTTAVMTFLFVSYYSRN----------SVLKFLSFAFLLFEWWST 351  

                CS HHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   +yl +Hy++D+++G+++ + i  +  ++ +++++   
      Q6BK22   352 LYLEHHYRLDLFVGLIYSICIYTFLIHWKKGFTK    385  

TMSP/non-TMSP/fixed score (recomputed/original total): 43.148/-6.214/-9.474 (27.460/28.1)


Q6DAY9 Q6DAY9_ERWCT Putative membrane protein [Pectobacterium atrosepticum]
PAP2            PAP2 superfamily                         12.1    0.00058   1
PAP2              1/1      95   203 ..     1   177 []    12.1  0.00058
PAP2: domain 1 of 1, from 95 to 203: score 12.1, E = 0.00058
                CS    CCHHHHHHHHHHHHHHHH H H HHHCC-B--..HHHHHHHHHHHTT
                   *->aalalllalvaslllngl.a.y.lKllfgrpRApPhflavcqpdwgd
                        l++  ++v+ +++++  + + l+ll + +   P            
      Q6DAY9    95    VYLIFPTTMVYPQVVGDDiSaRlLQLLQRIDS--P------------ 127  

                CS -GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SS
                   stcsdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSF
                                                                     
      Q6DAY9   128 ----------------------------------------------QNCL 131  

                CS S-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHH
                   PSGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRv
                   PS+H a++ +++ +++   ++           +  +l++l+++ +++S +
      Q6DAY9   132 PSLHIALTVLAVWAMSDSQQK-----------VKTGLYFLWGAAIAFSIL 170  

                CS HCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   ylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                    l  H ++D++ Ga+l+ ++++++l+          
      Q6DAY9   171 QLRRHLFIDLVTGAMLAGIVGWIFLRSREAVKV    203  

TMSP/non-TMSP/fixed score (recomputed/original total): 27.376/-6.188/-9.474 (11.714/12.1)


Q7NV94 Q7NV94_CHRVO Putative uncharacterized protein [Chromobacterium violaceum]
PAP2            PAP2 superfamily                         12.3    0.00057   1
PAP2              1/1      82   202 ..     1   177 []    12.3  0.00057
PAP2: domain 1 of 1, from 82 to 202: score 12.3, E = 0.00057
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       a++l++ ++ + +l     + l++     pP              +
      Q7NV94    82    RAMQLCALAAGAVFLLCP--TTLAY-----PP-------------IV 108  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                    d w++e                             f+ ++ ++   PS+
      Q7NV94   109 GDGWHAEA-------------------------LRVFLRFDTPHNCLPSL 133  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H a++a+ a +l+   +r           l  +l+l++al + ++ + l 
      Q7NV94   134 HGALTALSAWALWAGRRR-----------LRSWLALAWALAILFAVIQLR 172  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                    H ++D+ aG++lG l+++l+++    +     
      Q7NV94   173 RHLFIDLSAGVALGLLCGLLAARPATVFNF    202  

TMSP/non-TMSP/fixed score (recomputed/original total): 25.914/-4.626/-9.474 (11.814/12.3)


Q7RM56 Q7RM56_PLAYO Putative uncharacterized protein PY02331 [Plasmodium yoelii yoelii]
PAP2            PAP2 superfamily                         14.3    0.00039   1
PAP2              1/1     144   278 ..     1   177 []    14.3  0.00039
PAP2: domain 1 of 1, from 144 to 278: score 14.3, E = 0.00039
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT -G
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgd.st
                       ++  ++ l++   +  +  + +++  p+  P    +cqp  +++++
      Q7RM56   144    MFIRIAIILGSIYSIRSI--FIYVTTIPC--P--VYTCQPLVNNgFL 184  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                      +                           + + + fa v+e      S
      Q7RM56   185 QNLY---------------------------SIYLIVFAKVYECTDLIIS 207  

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHC
                   GHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvyl
                   GH+ + +++++f +ly+ +          l+++l++ll++++  l  +  
      Q7RM56   208 GHT-CFTTLFVFTWLYYEK---------NLFIKLIILLYSIYLYLLIIIS 247  

                CS TSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   gvHypsDVlaGallGaliaalvllfvrrlld<-*
                     Hy +DVl G++ G +i++++ ++    ++   
      Q7RM56   248 RFHYTVDVLLGIFFGSTIFIFYHWLLDVAAK    278  

TMSP/non-TMSP/fixed score (recomputed/original total): 27.946/-4.68/-9.474 (13.792/14.3)


Q8A381 Q8A381_BACTN Phosphoesterase, PA-phosphatase [Bacteroides thetaiotaomicron]
PAP2            PAP2 superfamily                         25.9    4.5e-05   1
PAP2              1/1     216   316 ..     1   177 []    25.9  4.5e-05
PAP2: domain 1 of 1, from 216 to 316: score 25.9, E = 4.5e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      ++ + ++  ++   l++    + +    R  P               
      Q8A381   216    LLPGPGYQHGFFYSLVEG--SQQVG--ER--P--------------- 241  

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                                +FPS 
      Q8A381   242 -------------------------------------------TAAFPSS 248  

                CS HHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHHCT
                   HaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvylg
                   H   ++ +++++++ +++            l + l+++  l + ++vy  
      Q8A381   249 HVGISTILMIMAWRGSKK------------LFACLIPFYMLLCGATVYIQ 286  

                CS SS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   vHypsDVlaGallGaliaalvllfvrrlld<-*
                   +Hy +D ++G++ ++l  +++ + ++++++   
      Q8A381   287 AHYVIDAIVGFFSAFLLYVVATWMFKKWFA    316  

TMSP/non-TMSP/fixed score (recomputed/original total): 40.158/-5.154/-9.474 (25.530/25.9)


Q8FHY1 Q8FHY1_ECOL6 Putative uncharacterized protein [Escherichia coli O6]
PAP2            PAP2 superfamily                         17.5    0.00022   1
PAP2              1/1      76   202 ..     1   177 []    17.5  0.00022
PAP2: domain 1 of 1, from 76 to 202: score 17.5, E = 0.00022
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                      ++++l+ ++ +s+l++g+  + ll+      P               
      Q8FHY1    76    HLRWLARSMQISALVAGV--FYLLW------P--------------- 99   

                CS GHHHHHHCHHCHCCCHHCCHH HHT-- SS-B--TTCSSTTBS-SS-SSS
                   sdlwyeellgyefycmagspg.ldrid.lfgsvlltsafalvseagpSFP
                                + m+    +++ i  ++ + l  ++  + +     FP
      Q8FHY1   100 -------------TTMHYPSFdQMGISaGALNRLIAIDSSQNC-----FP 131  

                CS -HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvy
                   S+Ha    a+ l++++++++       ++  +l l  +++a+ +++S + 
      Q8FHY1   132 SLHA----ALTLLAVWAIAK-------KGNRWLTLMSVVWAIAIAFSILQ 170  

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   l  H ++D+++Gall+ ++++++++  +r ++   
      Q8FHY1   171 LRRHLFIDLVGGALLASICGWICATCEKRKTQ    202  

TMSP/non-TMSP/fixed score (recomputed/original total): 39.129/-12.638/-9.474 (17.017/17.5)


Q8K3T9 Q8K3T9_CAVPO Glucose-6-phosphatase (Fragment) [Cavia porcellus]
PAP2     PAP2 superfamily                                16.4    0.00026   1
PAP2       1/1       2   103 .]     1   177 []    16.4  0.00026
PAP2: domain 1 of 1, from 2 to 103: score 16.4, E = 0.00026
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B--..HHHHHHHHHHHTT-GG
                   *->aalalllalvaslllnglaylKllfgrpRApPhflavcqpdwgdstc
                       +   +++  ++ l+ +              P               
      Q8K3T9     2    VLDTDYYSNSSVPLIKQF-------------P--------------- 20   

                CS GHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-H
                   sdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPSG
                                                         +++e+gp+ PSG
      Q8K3T9    21 --------------------------------------VTCETGPGSPSG 32   

                CS HHHHHHHHHHHHHHHCTT     SSCCC- CGS-EECHHHHCCHHHHHHH
                   Haafaaafalflalylpr.....rlsklg.rllrlllgllllllallvgl
                   Ha+++a ++++++    +  +++++s+ g r+l  +l+l ++++ l+v+l
      Q8K3T9    33 HAMGTAGVYYVMVTSTLAifrgkKKSTYGfRCLNVVLWLGYWAVQLNVCL 82   

                CS HHHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   SRvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   SR+yl +H+p++V+aG+l G+                  
      Q8K3T9    83 SRIYLAAHFPHQVVAGVLSGI---------------    103  

TMSP/non-TMSP/fixed score (recomputed/original total): 32.468/-6.992/-9.474 (16.002/16.4)


Q8PUA6 Q8PUA6_METMA Conserved protein [Methanosarcina mazei]
PAP2            PAP2 superfamily                         38.3      3e-08   1
PAP2              1/1      14   117 ..     1   177 []    38.3    3e-08
PAP2: domain 1 of 1, from 14 to 117: score 38.3, E = 3e-08
                CS    CCHHHHHHHHHHHHHHHHHH HHHCC-B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglay.lKllfgrpRApPhflavcqpdwgdst
                       +   ++ l   ++l    +  K +   +   P              
      Q8PUA6    14    NGESGFFKLPDREILESF-RlQKVFP--DS--P-------------- 41   

                CS GGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-SS-SSS-
                   csdlwyeellgyefycmagspgldridlfgsvlltsafalvseagpSFPS
                                                                ++FPS
      Q8PUA6    42 ---------------------------------------------FGFPS 46   

                CS HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCC HHHHHHHHHHH
                   GHaafaaafalflalylprrlsklgrllrlllglllll.lallvglSRvy
                   GH a+++a+++ +++++             ++++ l++ ++ll+++SR+y
      Q8PUA6    47 GHVALTTALWGGASRVFNS-----------RTAGRLAPmVVLLMAFSRMY 85   

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   lg H+  DV++Ga+lG +  +++ +f + +l+   
      Q8PUA6    86 LGRHFLGDVIGGAALGLTLLVVFTYFLKSPLK    117  

TMSP/non-TMSP/fixed score (recomputed/original total): 57.93/-10.566/-9.474 (37.890/38.3)


Q8T0D6 Q8T0D6_DROME LD09836p [Drosophila melanogaster]
PAP2           PAP2 superfamily                          18.1     0.0002   1
PAP2             1/1     125   244 ..     1   177 []    18.1   0.0002
PAP2: domain 1 of 1, from 125 to 244: score 18.1, E = 0.0002
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC-B        --..HHHHHHHH
                   *->aalalllalvaslllnglaylKllfgr........pRApPhflavcq
                       ++ ll+  ++ l + ++  +K+ +++++    ++pR +P       
      Q8T0D6   125    VLRVLLVITFFKLETMTA--FKREIHEeelwlyknPR-RP------- 161  

                CS HHHTT-GGGHHHHHHCHHCHCCCHHCCHHHHT--SS-B--TTCSSTTBS-
                   pdwgdstcsdlwyeellgyefycmagspgldridlfgsvlltsafalvse
                                                             +  ++   
      Q8T0D6   162 ------------------------------------------DIVRGGEL 169  

                CS SS-SSS-HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHH
                   agpSFPSGHaafaaafalflalylprrlsklgrllrlllgllllllallv
                    ++          a f++  a+y++       r++rl++++++l++allv
      Q8T0D6   170 LFW-------VIVAPFLVTIAFYWYT------RDRRLCIAVIPLFIALLV 206  

                CS HHHHHHCTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   glSRvylgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   + SR  +++H++ DV  G l+G + +++ ++++++      
      Q8T0D6   207 AVSRTCDYHHHWQDVTIGGLIGLFAGYISYTQYYPSIF    244  

TMSP/non-TMSP/fixed score (recomputed/original total): 54.375/-27.329/-9.474 (17.572/18.1)


Q97LC9 Q97LC9_CLOAB Predicted phosphatase [Clostridium acetobutylicum]
PAP2           PAP2 superfamily                          24.2    6.2e-05   1
PAP2             1/1     176   294 ..     1   177 []    24.2  6.2e-05
PAP2: domain 1 of 1, from 176 to 294: score 24.2, E = 6.2e-05
                CS    CCHHHHHHHHHHHHHHHHHHHHHCC -B--..HHHHHHHHHHHTT-G
                   *->aalalllalvaslllnglaylKllf.grpRApPhflavcqpdwgdst
                      ++++ +l   +  ++       ++++g+    P              
      Q97LC9   176    HVFQIFLISPFYVIFHLQ--EVWFVnGH----P-------------- 202  

                CS GGHHHHHHCHHCHCCCHHCCHHHHT-- SS-B--TTCSSTTBS-SS-SSS
                   csdlwyeellgyefycmagspgldrid.lfgsvlltsafalvseagpSFP
                                             d l  ++ +++a   +   +pS+ 
      Q97LC9   203 --------------------------DmLLRHYSYRQAYGSTLNCFPSM- 225  

                CS -HHHHHHHHHHHHHHHHCTTSSCCC-CGS-EECHHHHCCHHHHHHHHHHH
                   SGHaafaaafalflalylprrlsklgrllrlllgllllllallvglSRvy
                     H++ a+a++l+l++   +           l + ++ ++ l v +S++y
      Q97LC9   226 --HTSIAFAAFLLLLREKNL-----------LFKSIWGFFCLSVIYSTMY 262  

                CS CTSS-HHHHCHHHCHCHCCCCHCHCHCCCGB-   
                   lgvHypsDVlaGallGaliaalvllfvrrlld<-*
                   l  H+ +DVl+G++l++    l+ +++++l++   
      Q97LC9   263 LEIHWAIDVLGGLILAFCSVKLTDFVFAKLQP    294  

TMSP/non-TMSP/fixed score (recomputed/original total): 54.305/-21.112/-9.474 (23.719/24.2)


nonTMSP insignificant hits/no hmmpfamresult hits (total %) :108/19 (127 2.4%)
