Text file with the 20 alignments used in this study. Alignment 1 of 20 file name: vertebrate_globins.NgB.aa.dialign.nex #NEXUS begin data; dimensions ntax=68 nchar=220; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb ------------------MEKVQGEMEIERWERNEEMSDAEKKMIQETWNTVYAKCEDVGVSLLIRFFVNFPSAKHYFSQF-KHMEDP-------LEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLLGVLLEVLAE-EYTNEF-SPP-EVQRAWAKMKSLICTHVTAAYKEVGWVQY-PNSTM---------- Anolis_GbY --------------------------------KAGKMTDLDRRHIREIWTAAFENPEENGRLVIIRFFSDYPASKQYFKTVP----TD-------GDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFD-DLLGRT-FTP-EKRVSWEKFFQVIQEEVEAAYDR---------------------- Anolis_HbA -----------------------------------MLTEDDKNHIRAIWGHVSSNPELYGAEALTRLFAAHHTTKTYFPHY--DMSP------------GSAQIKAHGKKVVEAITQAVNNLDD---IAGALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIA-AHNRGP-LKP-EFILALDKCFTSIGRVLIAQYR----------------------- Anolis_HbB ---------------------------------MVHWTAEEKQLI--ANCWSKVDIGQIGGDALACLLCVYPWTQRFFPDF-GNLSNA-------AAICANAKVKAHGKKVLTAFGEAVKNLDN---IKDTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLA-AHFGKD-FTP-ACHAAYQKLVNSVAHGLSRRYH----------------------- Anolis_Mb ----------------------------------MELSDQEWQKVIDIWGKVEPEIPAYGQMVILRLFEQHPETQEKFDKF-KNLKSL-------DEMKNSEDLKKHGTIVLTALGKILKQKRQ---HEAELAPLAQSHATKHKI-PVKYLEFISEVIVGVIA-EKRSAD-FGA-ESQAAMRKALELFRNDMDRKYKELGFQG----------------- Arctic_lamprey_Hb1 -------------------------MPIVDSGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVKFFTSTPAAQEFFPKF-KGMTSA-------DQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGD------------AGFEKLMSMICILLRSAY------------------------ Arctic_lamprey_Hb2 -------------------------MPIVDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIKFFTSNPAAQEFFPKF-QGLTSA-------DQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTVLPGD------------AGLEKLMSMICILLKSSY------------------------ Arctic_lamprey_Hb4 -------------------------MPIEDSGSKPDFSDDEKKAIKDSWSGVYSEYESTSSEILIKFFVDNPSAQDFFPKF-KDLDSE-------EKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVA-EKNDGS-FSD-SARSAWEKLLTYICISLKVAY------------------------ Chicken_Cygb ------------------MEKVQGEMEIERWERSEEISDAEKKVIQETWSRVYANCEDVGVSILIRFFVNFPSAKQYFSQF-KHMDDT-------LEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIA-EAYGND-FTP-EAHGAWTKMRTLIYTHVTAAYKEAGWVSY-PSATL---------- Chicken_GbE ----------------------------------MSFSEAEVQSARGAWEKMYVDAEDNGTAVLVRMFTEHPDTKSYFTHF-KGMDSA-------EEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLME-EKFGGD-C-----KASFEKVTNEICTHLTNIYKEAGW------------------- Chicken_HbA ----------------------------------MVLSAADKNNVKGIFTKIAGHAEEYGAETLERMFTTYPPTKTYFPHF--DLSH------------GSAQIKGHGKKVVAALIEAANHIDD---IAGTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVA-IHHPAA-LTP-EVHASLDKFLCAVGTVLTAKYR----------------------- Chicken_HbB ---------------------------------MVHWSAEEKQLI--TSVWSKVNVEECGAEALARLLIVYPWTQRFFASF-GNLSSP-------TAIMGNPRVRAHGKKVLSSFGEAVKNLDN---IKNTYAKLSELHCDKLHV-DPENFRLLGDILIIVLA-SHFARD-FTP-ACQFAWQKLVNVVAHALARKYH----------------------- Chicken_Mb ----------------------------------MGLSDQEWQQVLTIWGKVEADIAGHGHEVLMRLFHDHPETLDRFDKF-KGLKTP-------DQMKGSEDLKKHGATVLTQLGKILKQKGN---HESELKPLAQTHATKHKI-PVKYLEFISEVIIKVIA-EKHAAD-FGA-DSQAAMKKALELFRNDMASKYKEFGFQG----------------- Finch_Cygb ------------------MEKVQGEMEIERWERSEEISDAEKKVIQEIWSRVYANCEDVGVSILIRFFVNFPSAKQYFSQF-KHMEDP-------LEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIA-EEYPND-FTP-EAHGAWTKMKTLIYTHVTAAYKEVGWAQY-PTATL---------- Finch_GbE ----------------------------------MSLSEAEVQSARGAWEKIYVDAEDNGTAVLVRMFTEHPDTKSYFPHF-KGMDSA-------EEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLME-EKFGGD-C-----KASFEKVTNEICTHLNNIYKEEGW------------------- Finch_HbA ----------------------------------MVLSAGDKSNVKAVFGKIGGQADEYGADALERMFATYPQTKTYFPHF--DLGK------------GSAQVKGHGKKVAAALVEAANNVDD---LAGALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVA-TRNPSL-LTP-EVHASLDKFLCAVGTVLTAKYR----------------------- Finch_HbB ---------------------------------MVHWSAEEKQLI--ASVWGRVSVEECGAEALARLLIVYPWTQRFFSDF-GNLSSP-------TAIVGNPKVRAHGKKVLTSFGEAIKNLDN---LKGTYSKLSELHCDKLHV-DPENFRLLGDILVIVLA-AHFTKE-FTP-ACQATWQKLVGVVAHALARKYH----------------------- Finch_Mb ----------------------------------MGLSDQEWQQVLTVWGKVESDLAGHGHQILMRLFQDHPETLDRFEKF-KGLKTP-------DAMKGSEDLKKHGVTVLTQLGKILKAKGN---HEAELKPLAQTHATKHKI-PVKYLEFISEVIIKVLA-EKHAAD-FGA-DAQAAMKKALELFRNDMATKYKEFGFQG----------------- Frog_Cygb ------------------MEKVQGENDMERWERLEEITESERGVIKETWARVYANCEDVGVSILIRFFVNFPSAKQHFSQF-KHMEDP-------LEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIA-EEYAKD-FTP-DVQLAWNKLRSHLYSHVLSAYKEAGWTQY-PSNSV---------- Frog_GbY ---------------------------------MADLTGADIENINEVWSKIYANPEESGRTVVISLFLTYPQTKIYFKNL-KNISTL-------QEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFK-EALGSG-FTP-EQSKSWEKLFSITYKYLESCYANTDS------------------- Frog_HbA1 ----------------------------------MHLTADDKKHIKAIWPSVAAHGDKYGGEALHRMFMCAPKTKTYFPDF--DFSE------------HSKHILAHGKKVSDALNEACNHLDN---IAGCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVA-IHFPKQ-FDP-ATHKALDKFLVSVSNVLTSKYR----------------------- Frog_HbB ---------------------------------MVNLTAKERQLI--TGTWSKICAKTLGKQALGSMLYTYPWTQRYFSSF-GNLSSI-------EAIFHNAAVATHGEKVLTSIGEAIKHMDD---IKGYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMA-QTLQED-FTP-ELQAAFEKLFAAIADALGKGYH----------------------- Frog_NgB -------------------------------MEKDQLSGPQKELIRESWQTVSQDQLHHGTVLFSSDIFQLKSGLYWSSEVP----REclirvvhQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKH-RAVGV-KLESFNTVGESLLFALE-SCLGDA-FTS-DTREAWSLLYANVVQSMSRGWHRDSQEQREgi------------- Hagfish_Hb1 -------------------------MPITDQGPLPTLSEGDKKAIRESWPQIYQNFEQTGLVVLLEFLQKNPGAQQSFPKF-SATKC---------NLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTIR-GK------------AAYEKLFSIICTLLRSSYDE---------------------- Hagfish_Hb2 msah----------------------------GIARTTEGERAAVRASWAVLMKDYEHAGVQILDKFFKANPAAKPFFTKM-KDLHTL-------EDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVtDPQYFMILSQTILDEV--EKRNGG-LSG-EGKSGWHKVMTIICKMLKSKY------------------------ Hagfish_Hb3 -------------------------MPITDHGQPPTLSEGDKKAIRESWPQIYKNFEQNSLAVLLEFLKKFPKAQDSFPKF-SAKKS---------HLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTMG-GK------------AAYEKLFSIIATLLRSTYDA---------------------- Hagfish_Hb4 -------------------------MPITDQRPLPTLSEGEKKAIKESWPQIYQNFEQTSLDVLIEFLQKFPEAQDSFPKF-SAKKC---------HLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTIR-GK------------AAYEKLFSIICTLLRSSYDE---------------------- Houndshark_HbA ----------------------------------MAFTACEKQTIGKIAQVLAKSPEAYGAECLARLFVTHPGSKSYFEYK--DYSA------------AGAKVQVHGGKVIRAVVKAAEHVDD---LHSHLETLALTHGKKLLV-DPQNFPMLSECIIVTLA-THLTE--FSP-DTHCAVDKLLSAICQELSSRYR----------------------- Houndshark_HbB ---------------------------------MVHWTQEERDEI--SKTFQGTDMKTVVTQALDRMFKVYPWTNRYFQKR-TDFRSS-----------------IHAGIVVGALQDAVKHMDD---VKTLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELA-YLRKDC-FTP-HIQGIWDKFFEVVIDAISKQYH----------------------- Houndshark_Mb M--------------------------------------VDWEKVNSVWSAVESDLTAIGQNILLRLFEQYPESQNHFPKF-KNKSLG-------E-LKDTADIKAQADTVLSALGNIVKKKGS---HSQPVKALAATHITTHKI-PPHYFTKITTIAVDVLS-EMYPSE-MNA-QVQAAFSGAFKIICSDIEKEYKAANFQG----------------- Human_Cygb ------------------MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVRFFVNFPSAKQYFSQF-KHMEDP-------LEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVA-EEFASD-FPP-ETQRAWAKLRGLIYSHVTAAYKEVGWVQqvPNATtppatlpssgp Human_HbA ----------------------------------MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF--DLSH------------GSAQVKGHGKKVADALTNAVAHVDD---MPNALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLA-AHLPAE-FTP-AVHASLDKFLASVSTVLTSKYR----------------------- Human_HbB ---------------------------------MVHLTPEEKSAV--TALWGKVNVDEVGGEALGRLLVVYPWTQRFFESF-GDLSTP-------DAVMGNPKVKAHGKKVLGAFSDGLAHLDN---LKGTFATLSELHCDKLHV-DPENFRLLGNVLVCVLA-HHFGKE-FTP-PVQAAYQKVVAGVANALAHKYH----------------------- Human_Mb ----------------------------------MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIRLFKGHPETLEKFDKF-KHLKSE-------DEMKASEDLKKHGATVLTALGGILKKKGH---HEAEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQ-SKHPGD-FGA-DAQGAMNKALELFRKDMASNYKELGFQG----------------- Human_NgB ------------------------------------MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSP-------EDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGV-KLSSFSTVGESLLYMLE-KCLGPA-FTP-ATRAAWSQLYGAVVQAMSRGWDGE--------------------- Medaka_Cygb_1 m--------------------ERKQGEVDHLERSRPLTDKERVMIQDSWAKVYQNCDDAGVAILVRLFVNFPSSKQYFSQF-KHIEDA-------EELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLG-EAYPQV-MTA-EVASAWTNLLAILCCSIKAVYEELGWPHL-SNSTs---------- Medaka_Cygb_2 MSCREsppppsPPPQMLGVQR--GECE-DRPERAEPLSDAEMEIIQHTWGHVYKNCEDVGVSVLIRFFVNFPSAKQYFSQF-QDMQDP-------EEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLS-EDFPEF-FTA-EVQLVWTKLMAAVYWHVTGAYTEVGWLQV-SSSAV---------- Medaka_HbA ---------------------------------KMSLSAKDKAAVKAFWAKVSGQADAIGSDALSRMLVVYPQTKTYFAHW-KDLSP------------GSAPVKKHGKTVMGGIADAVGKIDD---ISSGLLNLSELHAFTLRV-DPTNFKILSHNILVVMA-IMFPQD-FTP-EVHVALDKFLAAVSLALSEKYR----------------------- Medaka_HbB ---------------------------------MVEWTEQERSII--TNIFGNLDYEDVGSKALSRCLIVYPWTQRYFASF-GNLYNA-------EAIKTNPNIAAHGTKVLHGLDRAVKNMDN---IKATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIA-AKLGSA-FSP-EIQATFQKFLAVVVSALGRQYH----------------------- Medaka_Mb M--------------------------------------ADYDMVLKHWGPVEADYNTHGNLVLTRLFHEYPETQKLFPKF-AGIAKG-------D-MAGNAALSAHGATVLKKLGELLKARGN---HGAILKPLANSHATKHKI-PINNFRLITEVIGKVMA-EKAGLD-AAG---QQALRSVMAGIIAEIEADYKELGFAG----------------- Medaka_NgB ---------------------------------MEKLSGKDKELIRGSWESLGKNKVPHGVIMFSRLFELDPALLSLFNYN-TNCGST-------QDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKH-QAVGV-STQSFAVVGESLLYMLQ-CSLGQA-YTA-ALSQAWLNMYSIVVAAMSRGWAKNGEDKAD--------------- Platypus_GbY ---------------------------------MVQVTDVEKANIQSIWSKMMENLEKNGIDIFTRLFREYPETKKYFKNIP----LE-------GNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQ-DYLGPC-YTP-EIAESFQKLQSSLYDQVVITYLHSGSD------------------ Platypus_HbA ----------------------------------MGLTDGEKKEVAALWANVSGHEEEFGAEALDRLFLSFPPTKTYFPHF--ELSQ------------GSAQVKAHGKKVADALTTAVAHLDD---LDSTLSALSDLHAHKLRV-DPINFKLLAHCILVVVA-RHLPAE-FTP-SAHAALDKFLSKVATVLTSKYR----------------------- Platypus_HbB ---------------------------------MVHLSGGEKSAV--TNLWGKVNINELGGEALGRLLVVYPWTQRFFEAF-GDLSSA-------GAVMGNPKVKAHGAKVLTSFGDALKNLDD---LKGTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLA-RHFSKD-FSP-EVQAAWQKLVSGVAHALGHKYH----------------------- Platypus_HbW ---------------------------------MVNWTSEEKHAI--VSIWGKVDIEETGANALSRLLVVYPWTQRYFSAF-GNLSSP-------TAIVGNPRVRAHGKKVLTSFGEAVKDLDH---VKSNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLA-ATLGKD-FTP-EAQAAWQKLVGVVASALSSQYH----------------------- Platypus_Mb ----------------------------------MGLSDGEWQLVLKVWGKVEGDLPGHGQEVLIRLFKTHPETLEKFDKF-KGLKTE-------DEMKASADLKKHGGTVLTALGNILKKKGQ---HEAELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQ-SKHSAD-FGA-DAQAAMGKALELFRNDMAAKYKEFGFQG----------------- Platypus_NgB -------------------------------MENGRLSGPEQELIRESWRSVNSNPLEHGMILFTRLFDLEPDLLPLFQYNCRQFSSP-------RDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKH-KAIGV-KLSSFSTVGESLLFMLE-KCLGPA-FSP-ATREAWTRLYTAMVHAMSRGWGGE--------------------- Port_Jackson_shark_Mb M--------------------------------------TEWEHVNKVWAVVEPDIPAVGLAILLRLFKEHKETKDLFPKF-KEIPVQ-------Q-LGNNEDLRKHGVTVLRALGNILKQKGK---HSTNVKELADTHINKHKI-PPKNFVLITNIAVKVLT-EMYPSD-MTG-PMQESFSKVFTVICSDLETLYKEANFQG----------------- Sea_lamprey_Hb1a -------------------------MPIVDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIKFFTSNPAAQAFFPKF-QGLTSA-------DQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTVLPGD------------AGLEKLMSMICILLRSSY------------------------ Sea_lamprey_Hb1b -------------------------MPIVDSGSVSPLSDAEKNKIRAAWDLVYKDYEKTGVDILVKFFTGTPAAQAFFPKF-KGLTTA-------DDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTTAPGD------------AGFEKLMSMICILLSSAY------------------------ Sea_lamprey_Hb2 -------------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVKFFTSTPAAQEFFPKF-KGLTTA-------DQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGD------------AGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb3 -------------------------MPIVDSGSVAPLSAAEKTKIRSAWAPVYSNYETTGVDILVKFFTSTPAAQEFFPKF-KGLTTA-------DQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGD------------AGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb5 -------------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYSTYETSGVDILVKFFTSTPAAQEFFPKF-KGLTTA-------DQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGD------------AGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb_PMII -------------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVKFFTSTPAAQEFFPKF-KGLTTA-------DQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGD------------AGFEKLMSMICILLRSAY------------------------ Stingray_HbB ---------------------------------MVKLSEDQEHYI--KGVWKDVDHKQITAKALERVFVVYPWTTRLFSKL-QGLFSA-------NDIG----VQQHADKVQRALG---EAIDDLKKVEINFQNLSGKH-QEIGV-DTQNFKLLGQTFMVELA-LHYKKT-FRP-KEHAAAYKFFRLVAEALSSNYH----------------------- Stingray_HbA ----------------------------------MVLSSQNKKAIEELGNLIKANAEAWGADALARLFELHPQTKTYFSKF-SGFEA------------CNEQVKKHGKRVMNALADATHHLDN---LHLHLEDLARKHGENLLV-DPHNFHLFADCIVVTLA-VNLQA--FTP-VTHCAVDKFLELVAYELSSCYR----------------------- Tetraodon_Cygb_1 ------------------MERMQRDGEVDHVEQPGPLTEKEKVMIQDSWAKVFQSCDDAGVAILVRFFVNFPSSKQFFKDF-KHMEEP-------EEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLG-EAFTEI-ITA-EVASAWTKLLANMCCGIAAVYKEAGWTEL-SSSve---------- Tetraodon_Cygb_2 MSHRE------PPPPQLAVQRRDVDGQ-DGPERAEPLSDTEREMIRDAWGHVYKNCEDVGVSILIRFFVNFPSAKQYFSQF-QDMEEP-------EEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLC-EDFPEF-FTA-DVQLVWSKLMATVYWHVTGAYTDVGWLQV-SSSAV---------- Tetraodon_HbA ---------------------------------MTSLSTKDKETVRAFWAKVASNREEIGASALCRLLSVYPQTKTYFSHW-KDQSP------------NSASAKKHGITIMNAVGDAVSKIDD---LKTGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIA-IMYPAD-FTP-EVHVAMDKFLASLALALSEKYR----------------------- Tetraodon_HbB ---------------------------------MVVWTDQERAII--DNIFSNLDYEDVGSKALIRCLIVYPWTQRYFSSF-GNLYNA-------EAIRNNPNVAKHGVTVLHGLDRALKNMDN---IKEEY----KKHSEKLHV-DPDNFKLLSDCLTVVIA-GKLGSK-FTP-EYQAALQKFLAVVVSALGRQYH----------------------- Tetraodon_Mb M--------------------------------------GDFDMVLKFWGPVEADYSAHGGMVLTRLFTENPETQQLFPKF-VGIAQS-------E-LAGNAAVSAHGATVLKKLGELLKAKGN---HAAILQPLANSHATKHKI-PIKNFKLIAEVIGKVMA-EKAGLD-TAG---QQALRNIMATIIADIDATYKELGFS------------------ Tetraodon_NgB ---------------------------------MEKLSSKDKELIRGSWDSLGKNKVPHGVILFSRLFELDPELLNLFHYT-TNCGST-------QDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKH-QAVGV-KPQSFAMVGESLLYMLQ-CSLGQA-YTA-SLRQAWLNMYSVVVASMSRGWAKNGEDKAD--------------- Zebrafish_Cygb_1 ---------------------MEGDGGVQLTQSPDSLTEEDVCVIQDTWKPVYAERDNAGVAVLVRFFTNFPSAKQYFEHF-RELQDP-------AEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLV-EAFPQC-FSPaEVQSSWSKLMGILYWQMNRVYAEVGWENSKk-------------- Zebrafish_Cygb_2 ------------------MEKEREDEETEGRERPEPLTDVERGIIKDTWARVYASCEDVGVTILIRFFVNFPSAKQYFSQF-QDMEDP-------EEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILA-EEFGEC-FTP-EVQTSWSKLMAALYWHITGAYTEVGWVKL-SSSAV---------- Zebrafish_HbA ----------------------------------MSLSDTDKAVVKAIWAKISPKADEIGAEALARMLTVYPQTKTYFSHW-ADLSP------------GSGPVKKHGKTIMGAVGEAVSKIDD---LVGGLAALSELHAFKLRV-DPANFKILSHNVIVVIA-MLFPAD-FTP-EVHVSVDKFFNNLALALSEKYR----------------------- Zebrafish_HbB ---------------------------------MVEWTDAERTAI--LGLWGKLNIDEIGPQALSRCLIVYPWTQRYFATF-GNLSSP-------AAIMGNPKVAAHGRTVMGGLERAIKNMDN---VKNTYAALSVMHSEKLHV-DPDNFRLLADCITVCAA-MKFGQAgFNA-DVQEAWQKFLAVVVSALCRQYH----------------------- Zebrafish_Mb M--------------------------------------ADHDLVLKCWGAVEADYAANGGEVLNRLFKEYPDTLKLFPKF-SGISQG-------D-LAGSPAVAAHGATVLKKLGELLKAKGD---HAALLKPLANTHANIHKV-ALNNFRLITEVLVKVMA-EKAGLD-AAG---QGALRRVMDAVIGDIDGYYKEIGFAG----------------- Zebrafish_NgB ---------------------------------MEKLSEKDKGLIRDSWESLGKNKVPHGIVLFTRLFELDPALLTLFSYS-TNCGDA-------PECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKH-QAVGV-NTQSFALVGESLLYMLQ-SSLGPA-YTT-SLRQAWLTMYSIVVSAMTRGWAKNGEHKSN--------------- ; end; Alignment 2 of 20 file name: vertebrate_globins.NgB.aa.kalign.nex #NEXUS begin data; dimensions ntax=68 nchar=228; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb ----------------MEKVQGEME-IERWERNEE--MSDAEKKMIQETWNTVYAKCEDVGVSLLIR-FFVNFPSAK--HYFSQFKHM---EDPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLL-GVLLEVLAEEYTNE-FSPP-EVQRA---------WAKMKSLICTHVTAAYKEVGWVQY------PNSTM----- Anolis_GbY -------------------------------KAGK--MTDLDRRHIREIWTAAFENPEENGRLVIIR-FFSDYPASK--QY---FKTV---PTDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLGRT-F-TP-EKRVS---------WEKFFQVIQEEVEAAYDR---------------------- Anolis_HbA ----------------------------------M--LTEDDKNHIRAIWGHVSSNPELYGAEALTR-LFAAHHTTK--TYFPHY-DM---S-----PGSAQIKAHGKKVVEAITQAVNNLDD---IAGALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNRGP-L-KP-EFILA---------LDKCFTSIGRVLIAQYR----------------------- Anolis_HbB --------------------------------MVH--WTAEEKQLIANCWSKV--DIGQIGGDALAC-LLCVYPWTQ--RFFPDFGNL---SNAAAICANAKVKAHGKKVLTAFGEAVKNLDN---IKDTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFGKD-F-TP-ACHAA---------YQKLVNSVAHGLSRRYH----------------------- Anolis_Mb ---------------------------------ME--LSDQEWQKVIDIWGKVEPEIPAYGQMVILR-LFEQHPETQ--EKFDKFKNL---KSLDEMKNSEDLKKHGTIVLTALGKILKQKRQ---HEAELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSAD-F-GA-ESQAA---------MRKALELFRNDMDRKYKELGFQG----------------- Arctic_lamprey_Hb1 ------------MP--IVDSGSVAP------------LSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQ--EFFPKFKGM---TSADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAG---------FEKLMSMICILLRSAY------------------------ Arctic_lamprey_Hb2 ------------MP--IVDSGSVPA------------LTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQ--EFFPKFQGL---TSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTVL------------PGDAG---------LEKLMSMICILLKSSY------------------------ Arctic_lamprey_Hb4 ------------MP--IEDSGSKPD------------FSDDEKKAIKDSWSGVYSEYESTSSEILIK-FFVDNPSAQ--DFFPKFKDL---DSEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVA------------EKNDGSFSDSARSAWEKLLTYICISLKVAY------------------------ Chicken_Cygb ----------------MEKVQGEME-IERWERSEE--ISDAEKKVIQETWSRVYANCEDVGVSILIR-FFVNFPSAK--QYFSQFKHM---DDTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGND-F-TP-EAHGA---------WTKMRTLIYTHVTAAYKEAGWVSY------PSATL----- Chicken_GbE ---------------------------------MS--FSEAEVQSARGAWEKMYVDAEDNGTAVLVR-MFTEHPDTK--SYFTHFKGM---DSAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEK-----F-GG-DCKAS---------FEKVTNEICTHLTNIYKEAGW------------------- Chicken_HbA ---------------------------------MV--LSAADKNNVKGIFTKIAGHAEEYGAETLER-MFTTYPPTK--TYFPHF-DL---S-----HGSAQIKGHGKKVVAALIEAANHIDD---IAGTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHPAA-L-TP-EVHAS---------LDKFLCAVGTVLTAKYR----------------------- Chicken_HbB --------------------------------MVH--WSAEEKQLITSVWSKV--NVEECGAEALAR-LLIVYPWTQ--RFFASFGNL---SSPTAIMGNPRVRAHGKKVLSSFGEAVKNLDN---IKNTYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFARD-F-TP-ACQFA---------WQKLVNVVAHALARKYH----------------------- Chicken_Mb ---------------------------------MG--LSDQEWQQVLTIWGKVEADIAGHGHEVLMR-LFHDHPETL--DRFDKFKGL---KTPDQMKGSEDLKKHGATVLTQLGKILKQKGN---HESELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAAD-F-GA-DSQAA---------MKKALELFRNDMASKYKEFGFQG----------------- Finch_Cygb ----------------MEKVQGEME-IERWERSEE--ISDAEKKVIQEIWSRVYANCEDVGVSILIR-FFVNFPSAK--QYFSQFKHM---EDPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPND-F-TP-EAHGA---------WTKMKTLIYTHVTAAYKEVGWAQY------PTATL----- Finch_GbE ---------------------------------MS--LSEAEVQSARGAWEKIYVDAEDNGTAVLVR-MFTEHPDTK--SYFPHFKGM---DSAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEK-----F-GG-DCKAS---------FEKVTNEICTHLNNIYKEEGW------------------- Finch_HbA ---------------------------------MV--LSAGDKSNVKAVFGKIGGQADEYGADALER-MFATYPQTK--TYFPHF-DL---G-----KGSAQVKGHGKKVAAALVEAANNVDD---LAGALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNPSL-L-TP-EVHAS---------LDKFLCAVGTVLTAKYR----------------------- Finch_HbB --------------------------------MVH--WSAEEKQLIASVWGRV--SVEECGAEALAR-LLIVYPWTQ--RFFSDFGNL---SSPTAIVGNPKVRAHGKKVLTSFGEAIKNLDN---LKGTYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFTKE-F-TP-ACQAT---------WQKLVGVVAHALARKYH----------------------- Finch_Mb ---------------------------------MG--LSDQEWQQVLTVWGKVESDLAGHGHQILMR-LFQDHPETL--DRFEKFKGL---KTPDAMKGSEDLKKHGVTVLTQLGKILKAKGN---HEAELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAAD-F-GA-DAQAA---------MKKALELFRNDMATKYKEFGFQG----------------- Frog_Cygb ----------------MEKVQGEND-MERWERLEE--ITESERGVIKETWARVYANCEDVGVSILIR-FFVNFPSAK--QHFSQFKHM---EDPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAKD-F-TP-DVQLA---------WNKLRSHLYSHVLSAYKEAGWTQY------PSNSV----- Frog_GbY --------------------------------MAD--LTGADIENINEVWSKIYANPEESGRTVVIS-LFLTYPQTK--IYFKNLKNI---STLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALGSG-F-TP-EQSKS---------WEKLFSITYKYLESCYANTDS------------------- Frog_HbA1 ---------------------------------MH--LTADDKKHIKAIWPSVAAHGDKYGGEALHR-MFMCAPKTK--TYFPDF-DF---S-----EHSKHILAHGKKVSDALNEACNHLDN---IAGCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFPKQ-F-DP-ATHKA---------LDKFLVSVSNVLTSKYR----------------------- Frog_HbB --------------------------------MVN--LTAKERQLITGTWSKI--CAKTLGKQALGS-MLYTYPWTQ--RYFSSFGNL---SSIEAIFHNAAVATHGEKVLTSIGEAIKHMDD---IKGYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQED-F-TP-ELQAA---------FEKLFAAIADALGKGYH----------------------- Frog_NgB --------------------------------MEKDQLSGPQKELIRESWQTVSQDQLHHGTVLFSSDIFQLKSGLYWSSEVPR--ECLIRVVHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKH-RAVGV-KLESFNTVGESLLFALESCLGDA-F-TS-DTREA---------WSLLYANVVQSMSRGWHRDSQEQR--EGI----------- Hagfish_Hb1 ------------MP--ITDQGPLPT------------LSEGDKKAIRESWPQIYQNFEQTGLVVLLE-FLQKNPGAQ--QSFPKF----S-ATKCNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTI-------------RGKAA---------YEKLFSIICTLLRSSYDE---------------------- Hagfish_Hb2 --------------------MSAHG-IAR--------TTEGERAAVRASWAVLMKDYEHAGVQILDK-FFKANPAAK--PFFTKMKDL---HTLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKRNGGL---SG-EGKSG---------WHKVMTIICKMLKSKY------------------------ Hagfish_Hb3 ------------MP--ITDHGQPPT------------LSEGDKKAIRESWPQIYKNFEQNSLAVLLE-FLKKFPKAQ--DSFPKF----S-AKKSHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTM-------------GGKAA---------YEKLFSIIATLLRSTYDA---------------------- Hagfish_Hb4 ------------MP--ITDQRPLPT------------LSEGEKKAIKESWPQIYQNFEQTSLDVLIE-FLQKFPEAQ--DSFPKF----S-AKKCHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTI-------------RGKAA---------YEKLFSIICTLLRSSYDE---------------------- Houndshark_HbA ---------------------------------MA--FTACEKQTIGKIAQVLAKSPEAYGAECLAR-LFVTHPGSK--SYF---------EYKDYSAAGAKVQVHGGKVIRAVVKAAEHVDD---LHSHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHLTE--F-SP-DTHCA---------VDKLLSAICQELSSRYR----------------------- Houndshark_HbB --------------------------------MVH--WTQEERDEISKTFQGT--DMKTVVTQALDR-MFKVYPWTN--RYFQKRTDF-------------RSSIHAGIVVGALQDAVKHMDD---VKTLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRKDC-F-TP-HIQGI---------WDKFFEVVIDAISKQYH----------------------- Houndshark_Mb ---------------------------------M------VDWEKVNSVWSAVESDLTAIGQNILLR-LFEQYPESQ--NHFPKFKN----KSLGELKDTADIKAQADTVLSALGNIVKKKGS---HSQPVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPSE-M-NA-QVQAA---------FSGAFKIICSDIEKEYKAANFQG----------------- Human_Cygb ----------------MEKVPGEME-IERRERSEE--LSEAERKAVQAMWARLYANCEDVGVAILVR-FFVNFPSAK--QYFSQFKHM---EDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFASD-F-PP-ETQRA---------WAKLRGLIYSHVTAAYKEVGWVQQVPNATTPPATLPSSGP Human_HbA ---------------------------------MV--LSPADKTNVKAAWGKVGAHAGEYGAEALER-MFLSFPTTK--TYFPHF-DL---S-----HGSAQVKGHGKKVADALTNAVAHVDD---MPNALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLPAE-F-TP-AVHAS---------LDKFLASVSTVLTSKYR----------------------- Human_HbB --------------------------------MVH--LTPEEKSAVTALWGKV--NVDEVGGEALGR-LLVVYPWTQ--RFFESFGDL---STPDAVMGNPKVKAHGKKVLGAFSDGLAHLDN---LKGTFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFGKE-F-TP-PVQAA---------YQKVVAGVANALAHKYH----------------------- Human_Mb ---------------------------------MG--LSDGEWQLVLNVWGKVEADIPGHGQEVLIR-LFKGHPETL--EKFDKFKHL---KSEDEMKASEDLKKHGATVLTALGGILKKKGH---HEAEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPGD-F-GA-DAQGA---------MNKALELFRKDMASNYKELGFQG----------------- Human_NgB -------------------------------------MERPEPELIRQSWRAVSRSPLEHGTVLFAR-LFALEPDLL--PLFQY--NCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGV-KLSSFSTVGESLLYMLEKCLGPA-F-TP-ATRAA---------WSQLYGAVVQAMSRGWDGE--------------------- Medaka_Cygb_1 ----------------MER--KQGE-VDHLERSRP--LTDKERVMIQDSWAKVYQNCDDAGVAILVR-LFVNFPSSK--QYFSQFKHI---EDAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQV-M-TA-EVASA---------WTNLLAILCCSIKAVYEELGWPHL------SNSTS----- Medaka_Cygb_2 MSCRESPPPPSPPPQMLGVQRGECE--DRPERAEP--LSDAEMEIIQHTWGHVYKNCEDVGVSVLIR-FFVNFPSAK--QYFSQFQDM---QDPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPEF-F-TA-EVQLV---------WTKLMAAVYWHVTGAYTEVGWLQV------SSSAV----- Medaka_HbA --------------------------------KMS--LSAKDKAAVKAFWAKVSGQADAIGSDALSR-MLVVYPQTK--TYFAHWKDL---S-----PGSAPVKKHGKTVMGGIADAVGKIDD---ISSGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFPQD-F-TP-EVHVA---------LDKFLAAVSLALSEKYR----------------------- Medaka_HbB --------------------------------MVE--WTEQERSIITNIFGNL--DYEDVGSKALSR-CLIVYPWTQ--RYFASFGNL---YNAEAIKTNPNIAAHGTKVLHGLDRAVKNMDN---IKATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLGSA-F-SP-EIQAT---------FQKFLAVVVSALGRQYH----------------------- Medaka_Mb ---------------------------------M------ADYDMVLKHWGPVEADYNTHGNLVLTR-LFHEYPETQ--KLFPKFAG----IAKGDMAGNAALSAHGATVLKKLGELLKARGN---HGAILKPLANSHATKHKI-PINNFRLITEVIGKVMAEK--AG-L-DA-AGQQA---------LRSVMAGIIAEIEADYKELGFAG----------------- Medaka_NgB --------------------------------MEK--LSGKDKELIRGSWESLGKNKVPHGVIMFSR-LFELDPALL--SLFNYNTNC---GSTQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKH-QAVGV-STQSFAVVGESLLYMLQCSLGQA-Y-TA-ALSQA---------WLNMYSIVVAAMSRGWAKNGEDKA--D------------- Platypus_GbY --------------------------------MVQ--VTDVEKANIQSIWSKMMENLEKNGIDIFTR-LFREYPETK--KYFKNI------PLEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLGPC-Y-TP-EIAES---------FQKLQSSLYDQVVITYLHSGSD------------------ Platypus_HbA ---------------------------------MG--LTDGEKKEVAALWANVSGHEEEFGAEALDR-LFLSFPPTK--TYFPHF-EL---S-----QGSAQVKAHGKKVADALTTAVAHLDD---LDSTLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLPAE-F-TP-SAHAA---------LDKFLSKVATVLTSKYR----------------------- Platypus_HbB --------------------------------MVH--LSGGEKSAVTNLWGKV--NINELGGEALGR-LLVVYPWTQ--RFFEAFGDL---SSAGAVMGNPKVKAHGAKVLTSFGDALKNLDD---LKGTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFSKD-F-SP-EVQAA---------WQKLVSGVAHALGHKYH----------------------- Platypus_HbW --------------------------------MVN--WTSEEKHAIVSIWGKV--DIEETGANALSR-LLVVYPWTQ--RYFSAFGNL---SSPTAIVGNPRVRAHGKKVLTSFGEAVKDLDH---VKSNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLGKD-F-TP-EAQAA---------WQKLVGVVASALSSQYH----------------------- Platypus_Mb ---------------------------------MG--LSDGEWQLVLKVWGKVEGDLPGHGQEVLIR-LFKTHPETL--EKFDKFKGL---KTEDEMKASADLKKHGGTVLTALGNILKKKGQ---HEAELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSAD-F-GA-DAQAA---------MGKALELFRNDMAAKYKEFGFQG----------------- Platypus_NgB --------------------------------MENGRLSGPEQELIRESWRSVNSNPLEHGMILFTR-LFDLEPDLL--PLFQY--NCRQFSSPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKH-KAIGV-KLSSFSTVGESLLFMLEKCLGPA-F-SP-ATREA---------WTRLYTAMVHAMSRGWGGE--------------------- Port_Jackson_shark_Mb ---------------------------------M------TEWEHVNKVWAVVEPDIPAVGLAILLR-LFKEHKETK--DLFPKFKE----IPVQQLGNNEDLRKHGVTVLRALGNILKQKGK---HSTNVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPSD-M-TG-PMQES---------FSKVFTVICSDLETLYKEANFQG----------------- Sea_lamprey_Hb1a ------------MP--IVDSGSVPA------------LTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQ--AFFPKFQGL---TSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTVL------------PGDAG---------LEKLMSMICILLRSSY------------------------ Sea_lamprey_Hb1b ------------MP--IVDSGSVSP------------LSDAEKNKIRAAWDLVYKDYEKTGVDILVK-FFTGTPAAQ--AFFPKFKGL---TTADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTTA------------PGDAG---------FEKLMSMICILLSSAY------------------------ Sea_lamprey_Hb2 ------------MP--IVDTGSVAP------------LSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQ--EFFPKFKGL---TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAG---------FEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb3 ------------MP--IVDSGSVAP------------LSAAEKTKIRSAWAPVYSNYETTGVDILVK-FFTSTPAAQ--EFFPKFKGL---TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAG---------FEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb5 ------------MP--IVDTGSVAP------------LSAAEKTKIRSAWAPVYSTYETSGVDILVK-FFTSTPAAQ--EFFPKFKGL---TTADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAG---------FEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb_PMII ------------MP--IVDTGSVAP------------LSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQ--EFFPKFKGL---TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAG---------FEKLMSMICILLRSAY------------------------ Stingray_HbB --------------------------------MVK--LSEDQEHYIKGVWKDV--DHKQITAKALER-VFVVYPWTT--RLFSKLQGL-F------SANDIGVQQHADKVQRALGEAIDDLKK---VEINFQNLSGKH-QEIGV-DTQNFKLLGQTFMVELALHYKKT-F-RP-KEHAA---------AYKFFRLVAEALSSNYH----------------------- Stingray_HbA ---------------------------------MV--LSSQNKKAIEELGNLIKANAEAWGADALAR-LFELHPQTK--TYFSKFSGF-E-------ACNEQVKKHGKRVMNALADATHHLDN---LHLHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNLQA--F-TP-VTHCA---------VDKFLELVAYELSSCYR----------------------- Tetraodon_Cygb_1 ----------------MERMQRDGE-VDHVEQPGP--LTEKEKVMIQDSWAKVFQSCDDAGVAILVR-FFVNFPSSK--QFFKDFKHM---EEPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTEI-I-TA-EVASA---------WTKLLANMCCGIAAVYKEAGWTEL------SSSVE----- Tetraodon_Cygb_2 MSHREPPPPQ------LAVQRRDVDGQDGPERAEP--LSDTEREMIRDAWGHVYKNCEDVGVSILIR-FFVNFPSAK--QYFSQFQDM---EEPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPEF-F-TA-DVQLV---------WSKLMATVYWHVTGAYTDVGWLQV------SSSAV----- Tetraodon_HbA --------------------------------MTS--LSTKDKETVRAFWAKVASNREEIGASALCR-LLSVYPQTK--TYFSHWKDQ---S-----PNSASAKKHGITIMNAVGDAVSKIDD---LKTGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYPAD-F-TP-EVHVA---------MDKFLASLALALSEKYR----------------------- Tetraodon_HbB --------------------------------MVV--WTDQERAIIDNIFSNL--DYEDVGSKALIR-CLIVYPWTQ--RYFSSFGNL---YNAEAIRNNPNVAKHGVTVLHGLDRALKNMDN---IKEEYKK----HSEKLHV-DPDNFKLLSDCLTVVIAGKLGSK-F-TP-EYQAA---------LQKFLAVVVSALGRQYH----------------------- Tetraodon_Mb ---------------------------------M------GDFDMVLKFWGPVEADYSAHGGMVLTR-LFTENPETQ--QLFPKFVG----IAQSELAGNAAVSAHGATVLKKLGELLKAKGN---HAAILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEK--AG-L-DT-AGQQA---------LRNIMATIIADIDATYKELGFS------------------ Tetraodon_NgB --------------------------------MEK--LSSKDKELIRGSWDSLGKNKVPHGVILFSR-LFELDPELL--NLFHYTTNC---GSTQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKH-QAVGV-KPQSFAMVGESLLYMLQCSLGQA-Y-TA-SLRQA---------WLNMYSVVVASMSRGWAKNGEDKA--D------------- Zebrafish_Cygb_1 -------------------MEGDGG-VQLTQSPDS--LTEEDVCVIQDTWKPVYAERDNAGVAVLVR-FFTNFPSAK--QYFEHFREL---QDPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQC-F-SPAEVQSS---------WSKLMGILYWQMNRVYAEVGW---------ENSKK----- Zebrafish_Cygb_2 ----------------MEKEREDEE-TEGRERPEP--LTDVERGIIKDTWARVYASCEDVGVTILIR-FFVNFPSAK--QYFSQFQDM---EDPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGEC-F-TP-EVQTS---------WSKLMAALYWHITGAYTEVGWVKL------SSSAV----- Zebrafish_HbA ---------------------------------MS--LSDTDKAVVKAIWAKISPKADEIGAEALAR-MLTVYPQTK--TYFSHWADL---S-----PGSGPVKKHGKTIMGAVGEAVSKIDD---LVGGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFPAD-F-TP-EVHVS---------VDKFFNNLALALSEKYR----------------------- Zebrafish_HbB --------------------------------MVE--WTDAERTAILGLWGKL--NIDEIGPQALSR-CLIVYPWTQ--RYFATFGNL---SSPAAIMGNPKVAAHGRTVMGGLERAIKNMDN---VKNTYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGF-NA-DVQEA---------WQKFLAVVVSALCRQYH----------------------- Zebrafish_Mb ---------------------------------M------ADHDLVLKCWGAVEADYAANGGEVLNR-LFKEYPDTL--KLFPKFSG----ISQGDLAGSPAVAAHGATVLKKLGELLKAKGD---HAALLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEK--AG-L-DA-AGQGA---------LRRVMDAVIGDIDGYYKEIGFAG----------------- Zebrafish_NgB --------------------------------MEK--LSEKDKGLIRDSWESLGKNKVPHGIVLFTR-LFELDPALL--TLFSYSTNC---GDAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKH-QAVGV-NTQSFALVGESLLYMLQSSLGPA-Y-TT-SLRQA---------WLTMYSIVVSAMTRGWAKNGEHKS--N------------- ; end; Alignment 3 of 20 file name: vertebrate_globins.NgB.aa.mafft_einsi.nex #NEXUS begin data; dimensions ntax=68 nchar=213; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb -ME---------------KVQGEMEIERWERNEEMSDAEKKMIQETWNTVYAKCEDVGVSLLIR-FFVNFPSAK--HYFSQFKHM-EDPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLL-GVLLEVLAEEYTNE-FSPPEVQRAWAKMKSLICTHVTAAYKEVGWVQYPNSTM----------- Anolis_GbY ------------------------------KAGKMTDLDRRHIREIWTAAFENPEENGRLVIIR-FFSDYPASK--QYF---KTV-PTDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLGRT-FT-PEKRVSWEKFFQVIQEEVEAAYDR---------------------- Anolis_HbA -M--------------------------------LTEDDKNHIRAIWGHVSSNPELYGAEALTR-LFAAHHTTK--TYFPHY-DM-SP-----GSAQIKAHGKKVVEAITQAVNNLDDIA---GALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNRGP-LK-PEFILALDKCFTSIGRVLIAQYR----------------------- Anolis_HbB MVH-------------------------------WTAEEKQLIANCWSKV--DIGQIGGDALAC-LLCVYPWTQ--RFFPDFGNL-SNAAAICANAKVKAHGKKVLTAFGEAVKNLDNIK---DTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFGKD-FT-PACHAAYQKLVNSVAHGLSRRYH----------------------- Anolis_Mb -ME-------------------------------LSDQEWQKVIDIWGKVEPEIPAYGQMVILR-LFEQHPETQ--EKFDKFKNL-KSLDEMKNSEDLKKHGTIVLTALGKILKQKRQHE---AELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSAD-FG-AESQAAMRKALELFRNDMDRKYKELGFQG----------------- Arctic_lamprey_Hb1 -MP----------------------IVDSGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQ--EFFPKFKGM-TSADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Arctic_lamprey_Hb2 -MP----------------------IVDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQ--EFFPKFQGL-TSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTV-----------LPGDAGLEKLMSMICILLKSSY------------------------ Arctic_lamprey_Hb4 -MP----------------------IEDSGSKPDFSDDEKKAIKDSWSGVYSEYESTSSEILIK-FFVDNPSAQ--DFFPKFKDL-DSEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKNDGS-FS-DSARSAWEKLLTYICISLKVAY------------------------ Chicken_Cygb -ME---------------KVQGEMEIERWERSEEISDAEKKVIQETWSRVYANCEDVGVSILIR-FFVNFPSAK--QYFSQFKHM-DDTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGND-FT-PEAHGAWTKMRTLIYTHVTAAYKEAGWVSYPSATL----------- Chicken_GbE -MS-------------------------------FSEAEVQSARGAWEKMYVDAEDNGTAVLVR-MFTEHPDTK--SYFTHFKGM-DSAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFG------GDCKASFEKVTNEICTHLTNIYKEAGW------------------- Chicken_HbA -MV-------------------------------LSAADKNNVKGIFTKIAGHAEEYGAETLER-MFTTYPPTK--TYFPHF-DL-SH-----GSAQIKGHGKKVVAALIEAANHIDDIA---GTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHPAA-LT-PEVHASLDKFLCAVGTVLTAKYR----------------------- Chicken_HbB MVH-------------------------------WSAEEKQLITSVWSKV--NVEECGAEALAR-LLIVYPWTQ--RFFASFGNL-SSPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNIK---NTYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFARD-FT-PACQFAWQKLVNVVAHALARKYH----------------------- Chicken_Mb -MG-------------------------------LSDQEWQQVLTIWGKVEADIAGHGHEVLMR-LFHDHPETL--DRFDKFKGL-KTPDQMKGSEDLKKHGATVLTQLGKILKQKGNHE---SELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAAD-FG-ADSQAAMKKALELFRNDMASKYKEFGFQG----------------- Finch_Cygb -ME---------------KVQGEMEIERWERSEEISDAEKKVIQEIWSRVYANCEDVGVSILIR-FFVNFPSAK--QYFSQFKHM-EDPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPND-FT-PEAHGAWTKMKTLIYTHVTAAYKEVGWAQYPTATL----------- Finch_GbE -MS-------------------------------LSEAEVQSARGAWEKIYVDAEDNGTAVLVR-MFTEHPDTK--SYFPHFKGM-DSAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFG------GDCKASFEKVTNEICTHLNNIYKEEGW------------------- Finch_HbA -MV-------------------------------LSAGDKSNVKAVFGKIGGQADEYGADALER-MFATYPQTK--TYFPHF-DL-GK-----GSAQVKGHGKKVAAALVEAANNVDDLA---GALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNPSL-LT-PEVHASLDKFLCAVGTVLTAKYR----------------------- Finch_HbB MVH-------------------------------WSAEEKQLIASVWGRV--SVEECGAEALAR-LLIVYPWTQ--RFFSDFGNL-SSPTAIVGNPKVRAHGKKVLTSFGEAIKNLDNLK---GTYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFTKE-FT-PACQATWQKLVGVVAHALARKYH----------------------- Finch_Mb -MG-------------------------------LSDQEWQQVLTVWGKVESDLAGHGHQILMR-LFQDHPETL--DRFEKFKGL-KTPDAMKGSEDLKKHGVTVLTQLGKILKAKGNHE---AELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAAD-FG-ADAQAAMKKALELFRNDMATKYKEFGFQG----------------- Frog_Cygb -ME---------------KVQGENDMERWERLEEITESERGVIKETWARVYANCEDVGVSILIR-FFVNFPSAK--QHFSQFKHM-EDPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAKD-FT-PDVQLAWNKLRSHLYSHVLSAYKEAGWTQYPSNSV----------- Frog_GbY -MA------------------------------DLTGADIENINEVWSKIYANPEESGRTVVIS-LFLTYPQTK--IYFKNLKNI-STLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALGSG-FT-PEQSKSWEKLFSITYKYLESCYANTDS------------------- Frog_HbA1 -MH-------------------------------LTADDKKHIKAIWPSVAAHGDKYGGEALHR-MFMCAPKTK--TYFPDF-DF-SE-----HSKHILAHGKKVSDALNEACNHLDNIA---GCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFPKQ-FD-PATHKALDKFLVSVSNVLTSKYR----------------------- Frog_HbB MVN-------------------------------LTAKERQLITGTWSKI--CAKTLGKQALGS-MLYTYPWTQ--RYFSSFGNL-SSIEAIFHNAAVATHGEKVLTSIGEAIKHMDDIK---GYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQED-FT-PELQAAFEKLFAAIADALGKGYH----------------------- Frog_NgB -ME----------------------------KDQLSGPQKELIRESWQTVSQDQLHHGTVLFSSDIFQLKSGLYWSSEVPRECLIRVVHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKH-RAVGV-KLESFNTVGESLLFALESCLGDA-FT-SDTREAWSLLYANVVQSMSRGWHRDSQEQREGI------------- Hagfish_Hb1 -MP----------------------ITDQGPLPTLSEGDKKAIRESWPQIYQNFEQTGLVVLLE-FLQKNPGAQ--QSFPKFS---ATKCNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTI------------RGKAAYEKLFSIICTLLRSSYDE---------------------- Hagfish_Hb2 -MS-------------------------AHGIARTTEGERAAVRASWAVLMKDYEHAGVQILDK-FFKANPAAK--PFFTKMKDL-HTLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKRNGG--LS-GEGKSGWHKVMTIICKMLKSKY------------------------ Hagfish_Hb3 -MP----------------------ITDHGQPPTLSEGDKKAIRESWPQIYKNFEQNSLAVLLE-FLKKFPKAQ--DSFPKFS---AKKSHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTM------------GGKAAYEKLFSIIATLLRSTYDA---------------------- Hagfish_Hb4 -MP----------------------ITDQRPLPTLSEGEKKAIKESWPQIYQNFEQTSLDVLIE-FLQKFPEAQ--DSFPKFS---AKKCHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTI------------RGKAAYEKLFSIICTLLRSSYDE---------------------- Houndshark_HbA -MA-------------------------------FTACEKQTIGKIAQVLAKSPEAYGAECLAR-LFVTHPGSK--SYF-EYKDY-SA-----AGAKVQVHGGKVIRAVVKAAEHVDDLH---SHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHL-TE-FS-PDTHCAVDKLLSAICQELSSRYR----------------------- Houndshark_HbB MVH-------------------------------WTQEERDEISKTFQGT--DMKTVVTQALDR-MFKVYPWTN--RYFQKRTDF-RS----------SIHAGIVVGALQDAVKHMDDVK---TLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRKDC-FT-PHIQGIWDKFFEVVIDAISKQYH----------------------- Houndshark_Mb -M-----------------------------------VDWEKVNSVWSAVESDLTAIGQNILLR-LFEQYPESQ--NHFPKFKNK-SLGE-LKDTADIKAQADTVLSALGNIVKKKGSHS---QPVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPSE-MN-AQVQAAFSGAFKIICSDIEKEYKAANFQG----------------- Human_Cygb -ME---------------KVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVR-FFVNFPSAK--QYFSQFKHM-EDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFASD-FP-PETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATTPPATLPSSGP Human_HbA -MV-------------------------------LSPADKTNVKAAWGKVGAHAGEYGAEALER-MFLSFPTTK--TYFPHF-DL-SH-----GSAQVKGHGKKVADALTNAVAHVDDMP---NALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLPAE-FT-PAVHASLDKFLASVSTVLTSKYR----------------------- Human_HbB MVH-------------------------------LTPEEKSAVTALWGKV--NVDEVGGEALGR-LLVVYPWTQ--RFFESFGDL-STPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLK---GTFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFGKE-FT-PPVQAAYQKVVAGVANALAHKYH----------------------- Human_Mb -MG-------------------------------LSDGEWQLVLNVWGKVEADIPGHGQEVLIR-LFKGHPETL--EKFDKFKHL-KSEDEMKASEDLKKHGATVLTALGGILKKKGHHE---AEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPGD-FG-ADAQGAMNKALELFRKDMASNYKELGFQG----------------- Human_NgB ----------------------------------MERPEPELIRQSWRAVSRSPLEHGTVLFAR-LFALEPDLL--PLFQYNCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGV-KLSSFSTVGESLLYMLEKCLGPA-FT-PATRAAWSQLYGAVVQAMSRGWDGE--------------------- Medaka_Cygb_1 -ME-----------------RKQGEVDHLERSRPLTDKERVMIQDSWAKVYQNCDDAGVAILVR-LFVNFPSSK--QYFSQFKHI-EDAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQV-MT-AEVASAWTNLLAILCCSIKAVYEELGWPHLSNSTS----------- Medaka_Cygb_2 -MSCRESPPPPSPPPQMLGVQRGECEDRPERAEPLSDAEMEIIQHTWGHVYKNCEDVGVSVLIR-FFVNFPSAK--QYFSQFQDM-QDPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPEF-FT-AEVQLVWTKLMAAVYWHVTGAYTEVGWLQVSSSAV----------- Medaka_HbA KMS-------------------------------LSAKDKAAVKAFWAKVSGQADAIGSDALSR-MLVVYPQTK--TYFAHWKDL-SP-----GSAPVKKHGKTVMGGIADAVGKIDDIS---SGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFPQD-FT-PEVHVALDKFLAAVSLALSEKYR----------------------- Medaka_HbB MVE-------------------------------WTEQERSIITNIFGNL--DYEDVGSKALSR-CLIVYPWTQ--RYFASFGNL-YNAEAIKTNPNIAAHGTKVLHGLDRAVKNMDNIK---ATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLGSA-FS-PEIQATFQKFLAVVVSALGRQYH----------------------- Medaka_Mb -M-----------------------------------ADYDMVLKHWGPVEADYNTHGNLVLTR-LFHEYPETQ--KLFPKFAGI-AKGD-MAGNAALSAHGATVLKKLGELLKARGNHG---AILKPLANSHATKHKI-PINNFRLITEVIGKVMAEKAGLD----AAGQQALRSVMAGIIAEIEADYKELGFAG----------------- Medaka_NgB -ME------------------------------KLSGKDKELIRGSWESLGKNKVPHGVIMFSR-LFELDPALL--SLFNYNTNC-GSTQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKH-QAVGV-STQSFAVVGESLLYMLQCSLGQA-YT-AALSQAWLNMYSIVVAAMSRGWAKNGEDKAD--------------- Platypus_GbY -MV------------------------------QVTDVEKANIQSIWSKMMENLEKNGIDIFTR-LFREYPETK--KYF---KNI-PLEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLGPC-YT-PEIAESFQKLQSSLYDQVVITYLHSGSD------------------ Platypus_HbA -MG-------------------------------LTDGEKKEVAALWANVSGHEEEFGAEALDR-LFLSFPPTK--TYFPHF-EL-SQ-----GSAQVKAHGKKVADALTTAVAHLDDLD---STLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLPAE-FT-PSAHAALDKFLSKVATVLTSKYR----------------------- Platypus_HbB MVH-------------------------------LSGGEKSAVTNLWGKV--NINELGGEALGR-LLVVYPWTQ--RFFEAFGDL-SSAGAVMGNPKVKAHGAKVLTSFGDALKNLDDLK---GTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFSKD-FS-PEVQAAWQKLVSGVAHALGHKYH----------------------- Platypus_HbW MVN-------------------------------WTSEEKHAIVSIWGKV--DIEETGANALSR-LLVVYPWTQ--RYFSAFGNL-SSPTAIVGNPRVRAHGKKVLTSFGEAVKDLDHVK---SNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLGKD-FT-PEAQAAWQKLVGVVASALSSQYH----------------------- Platypus_Mb -MG-------------------------------LSDGEWQLVLKVWGKVEGDLPGHGQEVLIR-LFKTHPETL--EKFDKFKGL-KTEDEMKASADLKKHGGTVLTALGNILKKKGQHE---AELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSAD-FG-ADAQAAMGKALELFRNDMAAKYKEFGFQG----------------- Platypus_NgB -ME----------------------------NGRLSGPEQELIRESWRSVNSNPLEHGMILFTR-LFDLEPDLL--PLFQYNCRQFSSPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKH-KAIGV-KLSSFSTVGESLLFMLEKCLGPA-FS-PATREAWTRLYTAMVHAMSRGWGGE--------------------- Port_Jackson_shark_Mb -M-----------------------------------TEWEHVNKVWAVVEPDIPAVGLAILLR-LFKEHKETK--DLFPKFKEI-PVQQ-LGNNEDLRKHGVTVLRALGNILKQKGKHS---TNVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPSD-MT-GPMQESFSKVFTVICSDLETLYKEANFQG----------------- Sea_lamprey_Hb1a -MP----------------------IVDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQ--AFFPKFQGL-TSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTV-----------LPGDAGLEKLMSMICILLRSSY------------------------ Sea_lamprey_Hb1b -MP----------------------IVDSGSVSPLSDAEKNKIRAAWDLVYKDYEKTGVDILVK-FFTGTPAAQ--AFFPKFKGL-TTADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTT-----------APGDAGFEKLMSMICILLSSAY------------------------ Sea_lamprey_Hb2 -MP----------------------IVDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQ--EFFPKFKGL-TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb3 -MP----------------------IVDSGSVAPLSAAEKTKIRSAWAPVYSNYETTGVDILVK-FFTSTPAAQ--EFFPKFKGL-TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb5 -MP----------------------IVDTGSVAPLSAAEKTKIRSAWAPVYSTYETSGVDILVK-FFTSTPAAQ--EFFPKFKGL-TTADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb_PMII -MP----------------------IVDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQ--EFFPKFKGL-TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Stingray_HbB MVK-------------------------------LSEDQEHYIKGVWKDV--DHKQITAKALER-VFVVYPWTT--RLFSKLQGL-FSA----NDIGVQQHADKVQRALGEAIDDLKKVE---INFQNLSGKH-QEIGV-DTQNFKLLGQTFMVELALHYKKT-FR-PKEHAAAYKFFRLVAEALSSNYH----------------------- Stingray_HbA -MV-------------------------------LSSQNKKAIEELGNLIKANAEAWGADALAR-LFELHPQTK--TYFSKFSGF-EA-----CNEQVKKHGKRVMNALADATHHLDNLH---LHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNL-QA-FT-PVTHCAVDKFLELVAYELSSCYR----------------------- Tetraodon_Cygb_1 -ME---------------RMQRDGEVDHVEQPGPLTEKEKVMIQDSWAKVFQSCDDAGVAILVR-FFVNFPSSK--QFFKDFKHM-EEPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTEI-IT-AEVASAWTKLLANMCCGIAAVYKEAGWTELSSSVE----------- Tetraodon_Cygb_2 -MSHREPPPPQ----LAVQRRDVDGQDGPERAEPLSDTEREMIRDAWGHVYKNCEDVGVSILIR-FFVNFPSAK--QYFSQFQDM-EEPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPEF-FT-ADVQLVWSKLMATVYWHVTGAYTDVGWLQVSSSAV----------- Tetraodon_HbA MTS-------------------------------LSTKDKETVRAFWAKVASNREEIGASALCR-LLSVYPQTK--TYFSHWKDQ-SP-----NSASAKKHGITIMNAVGDAVSKIDDLK---TGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYPAD-FT-PEVHVAMDKFLASLALALSEKYR----------------------- Tetraodon_HbB MVV-------------------------------WTDQERAIIDNIFSNL--DYEDVGSKALIR-CLIVYPWTQ--RYFSSFGNL-YNAEAIRNNPNVAKHGVTVLHGLDRALKNMDNIK---EEYKK----HSEKLHV-DPDNFKLLSDCLTVVIAGKLGSK-FT-PEYQAALQKFLAVVVSALGRQYH----------------------- Tetraodon_Mb -M-----------------------------------GDFDMVLKFWGPVEADYSAHGGMVLTR-LFTENPETQ--QLFPKFVGI-AQSE-LAGNAAVSAHGATVLKKLGELLKAKGNHA---AILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEKAGLD----TAGQQALRNIMATIIADIDATYKELGFS------------------ Tetraodon_NgB -ME------------------------------KLSSKDKELIRGSWDSLGKNKVPHGVILFSR-LFELDPELL--NLFHYTTNC-GSTQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKH-QAVGV-KPQSFAMVGESLLYMLQCSLGQA-YT-ASLRQAWLNMYSVVVASMSRGWAKNGEDKAD--------------- Zebrafish_Cygb_1 -ME------------------GDGGVQLTQSPDSLTEEDVCVIQDTWKPVYAERDNAGVAVLVR-FFTNFPSAK--QYFEHFREL-QDPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQC-FSPAEVQSSWSKLMGILYWQMNRVYAEVGWENSKK-------------- Zebrafish_Cygb_2 -ME---------------KEREDEETEGRERPEPLTDVERGIIKDTWARVYASCEDVGVTILIR-FFVNFPSAK--QYFSQFQDM-EDPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGEC-FT-PEVQTSWSKLMAALYWHITGAYTEVGWVKLSSSAV----------- Zebrafish_HbA -MS-------------------------------LSDTDKAVVKAIWAKISPKADEIGAEALAR-MLTVYPQTK--TYFSHWADL-SP-----GSGPVKKHGKTIMGAVGEAVSKIDDLV---GGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFPAD-FT-PEVHVSVDKFFNNLALALSEKYR----------------------- Zebrafish_HbB MVE-------------------------------WTDAERTAILGLWGKL--NIDEIGPQALSR-CLIVYPWTQ--RYFATFGNL-SSPAAIMGNPKVAAHGRTVMGGLERAIKNMDNVK---NTYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGFN-ADVQEAWQKFLAVVVSALCRQYH----------------------- Zebrafish_Mb -M-----------------------------------ADHDLVLKCWGAVEADYAANGGEVLNR-LFKEYPDTL--KLFPKFSGI-SQGD-LAGSPAVAAHGATVLKKLGELLKAKGDHA---ALLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEKAGLD----AAGQGALRRVMDAVIGDIDGYYKEIGFAG----------------- Zebrafish_NgB -ME------------------------------KLSEKDKGLIRDSWESLGKNKVPHGIVLFTR-LFELDPALL--TLFSYSTNC-GDAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKH-QAVGV-NTQSFALVGESLLYMLQSSLGPA-YT-TSLRQAWLTMYSIVVSAMTRGWAKNGEHKSN--------------- ; end; Alignment 4 of 20 file name: vertebrate_globins.NgB.aa.mafft_ginsi.nex #NEXUS begin data; dimensions ntax=68 nchar=212; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb ME---------------KVQGEMEIERWERNEEMSDAEKKMIQETWNTVYAKCEDVGVSLLIR-FFVNFPSAK--HYFSQFKHM-EDPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLL-GVLLEVLAEEYTNE-FSPPEVQRAWAKMKSLICTHVTAAYKEVGWVQ-----------YPNSTM Anolis_GbY KA-----------------------------GKMTDLDRRHIREIWTAAFENPEENGRLVIIR-FFSDYPASK--QYF---KTV-PTDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLGRT-FT-PEKRVSWEKFFQVIQEEVEAAYDR---------------------- Anolis_HbA M--------------------------------LTEDDKNHIRAIWGHVSSNPELYGAEALTR-LFAAHHTTK--TYFPHY-DM-SP-----GSAQIKAHGKKVVEAITQAVNNLDDIA---GALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNRGP-LK-PEFILALDKCFTSIGRVLIAQYR----------------------- Anolis_HbB MV------------------------------HWTAEEKQLIANCWSKV--DIGQIGGDALAC-LLCVYPWTQ--RFFPDFGNL-SNAAAICANAKVKAHGKKVLTAFGEAVKNLDNIK---DTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFGKD-FT-PACHAAYQKLVNSVAHGLSRRYH----------------------- Anolis_Mb M-------------------------------ELSDQEWQKVIDIWGKVEPEIPAYGQMVILR-LFEQHPETQ--EKFDKFKNL-KSLDEMKNSEDLKKHGTIVLTALGKILKQKRQHE---AELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSAD-FG-AESQAAMRKALELFRNDMDRKYKELGFQG----------------- Arctic_lamprey_Hb1 MP----------------------IVDSGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQ--EFFPKFKGM-TSADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Arctic_lamprey_Hb2 MP----------------------IVDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQ--EFFPKFQGL-TSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTV-----------LPGDAGLEKLMSMICILLKSSY------------------------ Arctic_lamprey_Hb4 MP----------------------IEDSGSKPDFSDDEKKAIKDSWSGVYSEYESTSSEILIK-FFVDNPSAQ--DFFPKFKDL-DSEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKNDGS-FS-DSARSAWEKLLTYICISLKVAY------------------------ Chicken_Cygb ME---------------KVQGEMEIERWERSEEISDAEKKVIQETWSRVYANCEDVGVSILIR-FFVNFPSAK--QYFSQFKHM-DDTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGND-FT-PEAHGAWTKMRTLIYTHVTAAYKEAGWVS-----------YPSATL Chicken_GbE M-------------------------------SFSEAEVQSARGAWEKMYVDAEDNGTAVLVR-MFTEHPDTK--SYFTHFKGM-DSAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFG------GDCKASFEKVTNEICTHLTNIYKEAGW------------------- Chicken_HbA M-------------------------------VLSAADKNNVKGIFTKIAGHAEEYGAETLER-MFTTYPPTK--TYFPHF-DL-SH-----GSAQIKGHGKKVVAALIEAANHIDDIA---GTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHPAA-LT-PEVHASLDKFLCAVGTVLTAKYR----------------------- Chicken_HbB MV------------------------------HWSAEEKQLITSVWSKV--NVEECGAEALAR-LLIVYPWTQ--RFFASFGNL-SSPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNIK---NTYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFARD-FT-PACQFAWQKLVNVVAHALARKYH----------------------- Chicken_Mb M-------------------------------GLSDQEWQQVLTIWGKVEADIAGHGHEVLMR-LFHDHPETL--DRFDKFKGL-KTPDQMKGSEDLKKHGATVLTQLGKILKQKGNHE---SELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAAD-FG-ADSQAAMKKALELFRNDMASKYKEFGFQG----------------- Finch_Cygb ME---------------KVQGEMEIERWERSEEISDAEKKVIQEIWSRVYANCEDVGVSILIR-FFVNFPSAK--QYFSQFKHM-EDPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPND-FT-PEAHGAWTKMKTLIYTHVTAAYKEVGWAQ-----------YPTATL Finch_GbE M-------------------------------SLSEAEVQSARGAWEKIYVDAEDNGTAVLVR-MFTEHPDTK--SYFPHFKGM-DSAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFG------GDCKASFEKVTNEICTHLNNIYKEEGW------------------- Finch_HbA M-------------------------------VLSAGDKSNVKAVFGKIGGQADEYGADALER-MFATYPQTK--TYFPHF-DL-GK-----GSAQVKGHGKKVAAALVEAANNVDDLA---GALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNPSL-LT-PEVHASLDKFLCAVGTVLTAKYR----------------------- Finch_HbB MV------------------------------HWSAEEKQLIASVWGRV--SVEECGAEALAR-LLIVYPWTQ--RFFSDFGNL-SSPTAIVGNPKVRAHGKKVLTSFGEAIKNLDNLK---GTYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFTKE-FT-PACQATWQKLVGVVAHALARKYH----------------------- Finch_Mb M-------------------------------GLSDQEWQQVLTVWGKVESDLAGHGHQILMR-LFQDHPETL--DRFEKFKGL-KTPDAMKGSEDLKKHGVTVLTQLGKILKAKGNHE---AELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAAD-FG-ADAQAAMKKALELFRNDMATKYKEFGFQG----------------- Frog_Cygb ME---------------KVQGENDMERWERLEEITESERGVIKETWARVYANCEDVGVSILIR-FFVNFPSAK--QHFSQFKHM-EDPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAKD-FT-PDVQLAWNKLRSHLYSHVLSAYKEAGWTQ-----------YPSNSV Frog_GbY MA------------------------------DLTGADIENINEVWSKIYANPEESGRTVVIS-LFLTYPQTK--IYFKNLKNI-STLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALGSG-FT-PEQSKSWEKLFSITYKYLESCYANTDS------------------- Frog_HbA1 M-------------------------------HLTADDKKHIKAIWPSVAAHGDKYGGEALHR-MFMCAPKTK--TYFPDF-DF-SE-----HSKHILAHGKKVSDALNEACNHLDNIA---GCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFPKQ-FD-PATHKALDKFLVSVSNVLTSKYR----------------------- Frog_HbB MV------------------------------NLTAKERQLITGTWSKI--CAKTLGKQALGS-MLYTYPWTQ--RYFSSFGNL-SSIEAIFHNAAVATHGEKVLTSIGEAIKHMDDIK---GYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQED-FT-PELQAAFEKLFAAIADALGKGYH----------------------- Frog_NgB ME----------------------------KDQLSGPQKELIRESWQTVSQDQLHHGTVLFSSDIFQLKSGLYWSSEVPRECLIRVVHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKH-RAVGV-KLESFNTVGESLLFALESCLGDA-FT-SDTREAWSLLYANVVQSMSRGWHRDSQEQREGI------------- Hagfish_Hb1 MP----------------------ITDQGPLPTLSEGDKKAIRESWPQIYQNFEQTGLVVLLE-FLQKNPGAQ--QSFPKFS---ATKCNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTI------------RGKAAYEKLFSIICTLLRSSYDE---------------------- Hagfish_Hb2 MS-------------------------AHGIARTTEGERAAVRASWAVLMKDYEHAGVQILDK-FFKANPAAK--PFFTKMKDL-HTLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKRNGG--LS-GEGKSGWHKVMTIICKMLKSKY------------------------ Hagfish_Hb3 MP----------------------ITDHGQPPTLSEGDKKAIRESWPQIYKNFEQNSLAVLLE-FLKKFPKAQ--DSFPKFS---AKKSHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTM------------GGKAAYEKLFSIIATLLRSTYDA---------------------- Hagfish_Hb4 MP----------------------ITDQRPLPTLSEGEKKAIKESWPQIYQNFEQTSLDVLIE-FLQKFPEAQ--DSFPKFS---AKKCHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTI------------RGKAAYEKLFSIICTLLRSSYDE---------------------- Houndshark_HbA M-------------------------------AFTACEKQTIGKIAQVLAKSPEAYGAECLAR-LFVTHPGSK--SYF-EYKDY-SA-----AGAKVQVHGGKVIRAVVKAAEHVDDLH---SHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHLTE--FS-PDTHCAVDKLLSAICQELSSRYR----------------------- Houndshark_HbB MV------------------------------HWTQEERDEISKTFQGT--DMKTVVTQALDR-MFKVYPWTN--RYFQKRTDF-RS----------SIHAGIVVGALQDAVKHMDDVK---TLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRKDC-FT-PHIQGIWDKFFEVVIDAISKQYH----------------------- Houndshark_Mb M-----------------------------------VDWEKVNSVWSAVESDLTAIGQNILLR-LFEQYPESQ--NHFPKFKNK-SLGE-LKDTADIKAQADTVLSALGNIVKKKGSHS---QPVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPSE-MN-AQVQAAFSGAFKIICSDIEKEYKAANFQG----------------- Human_Cygb ME---------------KVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVR-FFVNFPSAK--QYFSQFKHM-EDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFASD-FP-PETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATTPPATLPSSGP Human_HbA M-------------------------------VLSPADKTNVKAAWGKVGAHAGEYGAEALER-MFLSFPTTK--TYFPHF-DL-SH-----GSAQVKGHGKKVADALTNAVAHVDDMP---NALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLPAE-FT-PAVHASLDKFLASVSTVLTSKYR----------------------- Human_HbB MV------------------------------HLTPEEKSAVTALWGKV--NVDEVGGEALGR-LLVVYPWTQ--RFFESFGDL-STPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLK---GTFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFGKE-FT-PPVQAAYQKVVAGVANALAHKYH----------------------- Human_Mb M-------------------------------GLSDGEWQLVLNVWGKVEADIPGHGQEVLIR-LFKGHPETL--EKFDKFKHL-KSEDEMKASEDLKKHGATVLTALGGILKKKGHHE---AEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPGD-FG-ADAQGAMNKALELFRKDMASNYKELGFQG----------------- Human_NgB ME---------------------------------RPEPELIRQSWRAVSRSPLEHGTVLFAR-LFALEPDLL--PLFQYNCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGV-KLSSFSTVGESLLYMLEKCLGPA-FT-PATRAAWSQLYGAVVQAMSRGWDGE--------------------- Medaka_Cygb_1 ME---------------RKQ--GEVDHLERSRPLTDKERVMIQDSWAKVYQNCDDAGVAILVR-LFVNFPSSK--QYFSQFKHI-EDAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQV-MT-AEVASAWTNLLAILCCSIKAVYEELGWPH-----------LSNSTS Medaka_Cygb_2 MSCRESPPPPSPPPQMLGVQRGECEDRPERAEPLSDAEMEIIQHTWGHVYKNCEDVGVSVLIR-FFVNFPSAK--QYFSQFQDM-QDPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPEF-FT-AEVQLVWTKLMAAVYWHVTGAYTEVGWLQ-----------VSSSAV Medaka_HbA KM------------------------------SLSAKDKAAVKAFWAKVSGQADAIGSDALSR-MLVVYPQTK--TYFAHWKDL-SP-----GSAPVKKHGKTVMGGIADAVGKIDDIS---SGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFPQD-FT-PEVHVALDKFLAAVSLALSEKYR----------------------- Medaka_HbB MV------------------------------EWTEQERSIITNIFGNL--DYEDVGSKALSR-CLIVYPWTQ--RYFASFGNL-YNAEAIKTNPNIAAHGTKVLHGLDRAVKNMDNIK---ATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLGSA-FS-PEIQATFQKFLAVVVSALGRQYH----------------------- Medaka_Mb M-----------------------------------ADYDMVLKHWGPVEADYNTHGNLVLTR-LFHEYPETQ--KLFPKFAGI-AKGD-MAGNAALSAHGATVLKKLGELLKARGNHG---AILKPLANSHATKHKI-PINNFRLITEVIGKVMAEKAGLD----AAGQQALRSVMAGIIAEIEADYKELGFAG----------------- Medaka_NgB ME------------------------------KLSGKDKELIRGSWESLGKNKVPHGVIMFSR-LFELDPALL--SLFNYNTNC-GSTQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKH-QAVGV-STQSFAVVGESLLYMLQCSLGQA-YT-AALSQAWLNMYSIVVAAMSRGWAKNGEDKAD--------------- Platypus_GbY MV------------------------------QVTDVEKANIQSIWSKMMENLEKNGIDIFTR-LFREYPETK--KYF---KNI-PLEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLGPC-YT-PEIAESFQKLQSSLYDQVVITYLHSG------------------SD Platypus_HbA M-------------------------------GLTDGEKKEVAALWANVSGHEEEFGAEALDR-LFLSFPPTK--TYFPHF-EL-SQ-----GSAQVKAHGKKVADALTTAVAHLDDLD---STLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLPAE-FT-PSAHAALDKFLSKVATVLTSKYR----------------------- Platypus_HbB MV------------------------------HLSGGEKSAVTNLWGKV--NINELGGEALGR-LLVVYPWTQ--RFFEAFGDL-SSAGAVMGNPKVKAHGAKVLTSFGDALKNLDDLK---GTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFSKD-FS-PEVQAAWQKLVSGVAHALGHKYH----------------------- Platypus_HbW MV------------------------------NWTSEEKHAIVSIWGKV--DIEETGANALSR-LLVVYPWTQ--RYFSAFGNL-SSPTAIVGNPRVRAHGKKVLTSFGEAVKDLDHVK---SNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLGKD-FT-PEAQAAWQKLVGVVASALSSQYH----------------------- Platypus_Mb M-------------------------------GLSDGEWQLVLKVWGKVEGDLPGHGQEVLIR-LFKTHPETL--EKFDKFKGL-KTEDEMKASADLKKHGGTVLTALGNILKKKGQHE---AELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSAD-FG-ADAQAAMGKALELFRNDMAAKYKEFGFQG----------------- Platypus_NgB ME----------------------------NGRLSGPEQELIRESWRSVNSNPLEHGMILFTR-LFDLEPDLL--PLFQYNCRQFSSPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKH-KAIGV-KLSSFSTVGESLLFMLEKCLGPA-FS-PATREAWTRLYTAMVHAMSRGWGGE--------------------- Port_Jackson_shark_Mb M-----------------------------------TEWEHVNKVWAVVEPDIPAVGLAILLR-LFKEHKETK--DLFPKFKEI-PVQQ-LGNNEDLRKHGVTVLRALGNILKQKGKHS---TNVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPSD-MT-GPMQESFSKVFTVICSDLETLYKEANFQG----------------- Sea_lamprey_Hb1a MP----------------------IVDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQ--AFFPKFQGL-TSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTV-----------LPGDAGLEKLMSMICILLRSSY------------------------ Sea_lamprey_Hb1b MP----------------------IVDSGSVSPLSDAEKNKIRAAWDLVYKDYEKTGVDILVK-FFTGTPAAQ--AFFPKFKGL-TTADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTT-----------APGDAGFEKLMSMICILLSSAY------------------------ Sea_lamprey_Hb2 MP----------------------IVDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQ--EFFPKFKGL-TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb3 MP----------------------IVDSGSVAPLSAAEKTKIRSAWAPVYSNYETTGVDILVK-FFTSTPAAQ--EFFPKFKGL-TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb5 MP----------------------IVDTGSVAPLSAAEKTKIRSAWAPVYSTYETSGVDILVK-FFTSTPAAQ--EFFPKFKGL-TTADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb_PMII MP----------------------IVDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQ--EFFPKFKGL-TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Stingray_HbB MV------------------------------KLSEDQEHYIKGVWKDV--DHKQITAKALER-VFVVYPWTT--RLFSKLQGL-FSA----NDIGVQQHADKVQRALGEAIDDLKKVE---INFQNLSGKH-QEIGV-DTQNFKLLGQTFMVELALHYKKT-FR-PKEHAAAYKFFRLVAEALSSNYH----------------------- Stingray_HbA M-------------------------------VLSSQNKKAIEELGNLIKANAEAWGADALAR-LFELHPQTK--TYFSKFSGF-EA-----CNEQVKKHGKRVMNALADATHHLDNLH---LHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNLQA--FT-PVTHCAVDKFLELVAYELSSCYR----------------------- Tetraodon_Cygb_1 ME---------------RMQRDGEVDHVEQPGPLTEKEKVMIQDSWAKVFQSCDDAGVAILVR-FFVNFPSSK--QFFKDFKHM-EEPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTEI-IT-AEVASAWTKLLANMCCGIAAVYKEAGWTE-----------LSSSVE Tetraodon_Cygb_2 MSHREPPPP----QLAVQRRDVDGQDGPERAEPLSDTEREMIRDAWGHVYKNCEDVGVSILIR-FFVNFPSAK--QYFSQFQDM-EEPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPEF-FT-ADVQLVWSKLMATVYWHVTGAYTDVGWLQ-----------VSSSAV Tetraodon_HbA MT------------------------------SLSTKDKETVRAFWAKVASNREEIGASALCR-LLSVYPQTK--TYFSHWKDQ-SP-----NSASAKKHGITIMNAVGDAVSKIDDLK---TGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYPAD-FT-PEVHVAMDKFLASLALALSEKYR----------------------- Tetraodon_HbB MV------------------------------VWTDQERAIIDNIFSNL--DYEDVGSKALIR-CLIVYPWTQ--RYFSSFGNL-YNAEAIRNNPNVAKHGVTVLHGLDRALKNMDNIK---EEYKK----HSEKLHV-DPDNFKLLSDCLTVVIAGKLGSK-FT-PEYQAALQKFLAVVVSALGRQYH----------------------- Tetraodon_Mb M-----------------------------------GDFDMVLKFWGPVEADYSAHGGMVLTR-LFTENPETQ--QLFPKFVGI-AQSE-LAGNAAVSAHGATVLKKLGELLKAKGNHA---AILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEKAGLD----TAGQQALRNIMATIIADIDATYKELGFS------------------ Tetraodon_NgB ME------------------------------KLSSKDKELIRGSWDSLGKNKVPHGVILFSR-LFELDPELL--NLFHYTTNC-GSTQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKH-QAVGV-KPQSFAMVGESLLYMLQCSLGQA-YT-ASLRQAWLNMYSVVVASMSRGWAKNGEDKAD--------------- Zebrafish_Cygb_1 ME------------------GDGGVQLTQSPDSLTEEDVCVIQDTWKPVYAERDNAGVAVLVR-FFTNFPSAK--QYFEHFREL-QDPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQC-FSPAEVQSSWSKLMGILYWQMNRVYAEVGW--------------ENSKK Zebrafish_Cygb_2 ME---------------KEREDEETEGRERPEPLTDVERGIIKDTWARVYASCEDVGVTILIR-FFVNFPSAK--QYFSQFQDM-EDPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGEC-FT-PEVQTSWSKLMAALYWHITGAYTEVGWVK-----------LSSSAV Zebrafish_HbA M-------------------------------SLSDTDKAVVKAIWAKISPKADEIGAEALAR-MLTVYPQTK--TYFSHWADL-SP-----GSGPVKKHGKTIMGAVGEAVSKIDDLV---GGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFPAD-FT-PEVHVSVDKFFNNLALALSEKYR----------------------- Zebrafish_HbB MV------------------------------EWTDAERTAILGLWGKL--NIDEIGPQALSR-CLIVYPWTQ--RYFATFGNL-SSPAAIMGNPKVAAHGRTVMGGLERAIKNMDNVK---NTYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGFN-ADVQEAWQKFLAVVVSALCRQYH----------------------- Zebrafish_Mb M-----------------------------------ADHDLVLKCWGAVEADYAANGGEVLNR-LFKEYPDTL--KLFPKFSGI-SQGD-LAGSPAVAAHGATVLKKLGELLKAKGDHA---ALLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEKAGLD----AAGQGALRRVMDAVIGDIDGYYKEIGFAG----------------- Zebrafish_NgB ME------------------------------KLSEKDKGLIRDSWESLGKNKVPHGIVLFTR-LFELDPALL--TLFSYSTNC-GDAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKH-QAVGV-NTQSFALVGESLLYMLQSSLGPA-YT-TSLRQAWLTMYSIVVSAMTRGWAKNGEHKSN--------------- ; end; Alignment 5 of 20 file name: vertebrate_globins.NgB.aa.mafft_linsi.nex #NEXUS begin data; dimensions ntax=68 nchar=213; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb -ME---------------KVQGEMEIERWERNEEMSDAEKKMIQETWNTVYAKCEDVGVSLLIR-FFVNFPSAK--HYFSQFKHM-EDPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLL-GVLLEVLAEEYTNE-FSPPEVQRAWAKMKSLICTHVTAAYKEVGWVQYPNSTM----------- Anolis_GbY ------------------------------KAGKMTDLDRRHIREIWTAAFENPEENGRLVIIR-FFSDYPASK--QYF---KTV-PTDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLGRT-FT-PEKRVSWEKFFQVIQEEVEAAYDR---------------------- Anolis_HbA -M--------------------------------LTEDDKNHIRAIWGHVSSNPELYGAEALTR-LFAAHHTTK--TYFPHY-DM-SP-----GSAQIKAHGKKVVEAITQAVNNLDDIA---GALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNRGP-LK-PEFILALDKCFTSIGRVLIAQYR----------------------- Anolis_HbB MVH-------------------------------WTAEEKQLIANCWSKV--DIGQIGGDALAC-LLCVYPWTQ--RFFPDFGNL-SNAAAICANAKVKAHGKKVLTAFGEAVKNLDNIK---DTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFGKD-FT-PACHAAYQKLVNSVAHGLSRRYH----------------------- Anolis_Mb -ME-------------------------------LSDQEWQKVIDIWGKVEPEIPAYGQMVILR-LFEQHPETQ--EKFDKFKNL-KSLDEMKNSEDLKKHGTIVLTALGKILKQKRQHE---AELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSAD-FG-AESQAAMRKALELFRNDMDRKYKELGFQG----------------- Arctic_lamprey_Hb1 -MP----------------------IVDSGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQ--EFFPKFKGM-TSADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Arctic_lamprey_Hb2 -MP----------------------IVDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQ--EFFPKFQGL-TSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTV-----------LPGDAGLEKLMSMICILLKSSY------------------------ Arctic_lamprey_Hb4 -MP----------------------IEDSGSKPDFSDDEKKAIKDSWSGVYSEYESTSSEILIK-FFVDNPSAQ--DFFPKFKDL-DSEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKNDGS-FS-DSARSAWEKLLTYICISLKVAY------------------------ Chicken_Cygb -ME---------------KVQGEMEIERWERSEEISDAEKKVIQETWSRVYANCEDVGVSILIR-FFVNFPSAK--QYFSQFKHM-DDTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGND-FT-PEAHGAWTKMRTLIYTHVTAAYKEAGWVSYPSATL----------- Chicken_GbE -MS-------------------------------FSEAEVQSARGAWEKMYVDAEDNGTAVLVR-MFTEHPDTK--SYFTHFKGM-DSAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFG------GDCKASFEKVTNEICTHLTNIYKEAGW------------------- Chicken_HbA -MV-------------------------------LSAADKNNVKGIFTKIAGHAEEYGAETLER-MFTTYPPTK--TYFPHF-DL-SH-----GSAQIKGHGKKVVAALIEAANHIDDIA---GTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHPAA-LT-PEVHASLDKFLCAVGTVLTAKYR----------------------- Chicken_HbB MVH-------------------------------WSAEEKQLITSVWSKV--NVEECGAEALAR-LLIVYPWTQ--RFFASFGNL-SSPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNIK---NTYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFARD-FT-PACQFAWQKLVNVVAHALARKYH----------------------- Chicken_Mb -MG-------------------------------LSDQEWQQVLTIWGKVEADIAGHGHEVLMR-LFHDHPETL--DRFDKFKGL-KTPDQMKGSEDLKKHGATVLTQLGKILKQKGNHE---SELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAAD-FG-ADSQAAMKKALELFRNDMASKYKEFGFQG----------------- Finch_Cygb -ME---------------KVQGEMEIERWERSEEISDAEKKVIQEIWSRVYANCEDVGVSILIR-FFVNFPSAK--QYFSQFKHM-EDPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPND-FT-PEAHGAWTKMKTLIYTHVTAAYKEVGWAQYPTATL----------- Finch_GbE -MS-------------------------------LSEAEVQSARGAWEKIYVDAEDNGTAVLVR-MFTEHPDTK--SYFPHFKGM-DSAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFG------GDCKASFEKVTNEICTHLNNIYKEEGW------------------- Finch_HbA -MV-------------------------------LSAGDKSNVKAVFGKIGGQADEYGADALER-MFATYPQTK--TYFPHF-DL-GK-----GSAQVKGHGKKVAAALVEAANNVDDLA---GALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNPSL-LT-PEVHASLDKFLCAVGTVLTAKYR----------------------- Finch_HbB MVH-------------------------------WSAEEKQLIASVWGRV--SVEECGAEALAR-LLIVYPWTQ--RFFSDFGNL-SSPTAIVGNPKVRAHGKKVLTSFGEAIKNLDNLK---GTYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFTKE-FT-PACQATWQKLVGVVAHALARKYH----------------------- Finch_Mb -MG-------------------------------LSDQEWQQVLTVWGKVESDLAGHGHQILMR-LFQDHPETL--DRFEKFKGL-KTPDAMKGSEDLKKHGVTVLTQLGKILKAKGNHE---AELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAAD-FG-ADAQAAMKKALELFRNDMATKYKEFGFQG----------------- Frog_Cygb -ME---------------KVQGENDMERWERLEEITESERGVIKETWARVYANCEDVGVSILIR-FFVNFPSAK--QHFSQFKHM-EDPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAKD-FT-PDVQLAWNKLRSHLYSHVLSAYKEAGWTQYPSNSV----------- Frog_GbY -MA------------------------------DLTGADIENINEVWSKIYANPEESGRTVVIS-LFLTYPQTK--IYFKNLKNI-STLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALGSG-FT-PEQSKSWEKLFSITYKYLESCYANTDS------------------- Frog_HbA1 -MH-------------------------------LTADDKKHIKAIWPSVAAHGDKYGGEALHR-MFMCAPKTK--TYFPDF-DF-SE-----HSKHILAHGKKVSDALNEACNHLDNIA---GCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFPKQ-FD-PATHKALDKFLVSVSNVLTSKYR----------------------- Frog_HbB MVN-------------------------------LTAKERQLITGTWSKI--CAKTLGKQALGS-MLYTYPWTQ--RYFSSFGNL-SSIEAIFHNAAVATHGEKVLTSIGEAIKHMDDIK---GYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQED-FT-PELQAAFEKLFAAIADALGKGYH----------------------- Frog_NgB -ME----------------------------KDQLSGPQKELIRESWQTVSQDQLHHGTVLFSSDIFQLKSGLYWSSEVPRECLIRVVHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKH-RAVGV-KLESFNTVGESLLFALESCLGDA-FT-SDTREAWSLLYANVVQSMSRGWHRDSQEQREGI------------- Hagfish_Hb1 -MP----------------------ITDQGPLPTLSEGDKKAIRESWPQIYQNFEQTGLVVLLE-FLQKNPGAQ--QSFPKFS---ATKCNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTI------------RGKAAYEKLFSIICTLLRSSYDE---------------------- Hagfish_Hb2 -MS-------------------------AHGIARTTEGERAAVRASWAVLMKDYEHAGVQILDK-FFKANPAAK--PFFTKMKDL-HTLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKRNGG--LS-GEGKSGWHKVMTIICKMLKSKY------------------------ Hagfish_Hb3 -MP----------------------ITDHGQPPTLSEGDKKAIRESWPQIYKNFEQNSLAVLLE-FLKKFPKAQ--DSFPKFS---AKKSHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTM------------GGKAAYEKLFSIIATLLRSTYDA---------------------- Hagfish_Hb4 -MP----------------------ITDQRPLPTLSEGEKKAIKESWPQIYQNFEQTSLDVLIE-FLQKFPEAQ--DSFPKFS---AKKCHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTI------------RGKAAYEKLFSIICTLLRSSYDE---------------------- Houndshark_HbA -MA-------------------------------FTACEKQTIGKIAQVLAKSPEAYGAECLAR-LFVTHPGSK--SYF-EYKDY-SA-----AGAKVQVHGGKVIRAVVKAAEHVDDLH---SHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHL-TE-FS-PDTHCAVDKLLSAICQELSSRYR----------------------- Houndshark_HbB MVH-------------------------------WTQEERDEISKTFQGT--DMKTVVTQALDR-MFKVYPWTN--RYFQKRTDF-RS----------SIHAGIVVGALQDAVKHMDDVK---TLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRKDC-FT-PHIQGIWDKFFEVVIDAISKQYH----------------------- Houndshark_Mb -M-----------------------------------VDWEKVNSVWSAVESDLTAIGQNILLR-LFEQYPESQ--NHFPKFKNK-SLGE-LKDTADIKAQADTVLSALGNIVKKKGSHS---QPVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPSE-MN-AQVQAAFSGAFKIICSDIEKEYKAANFQG----------------- Human_Cygb -ME---------------KVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVR-FFVNFPSAK--QYFSQFKHM-EDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFASD-FP-PETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATTPPATLPSSGP Human_HbA -MV-------------------------------LSPADKTNVKAAWGKVGAHAGEYGAEALER-MFLSFPTTK--TYFPHF-DL-SH-----GSAQVKGHGKKVADALTNAVAHVDDMP---NALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLPAE-FT-PAVHASLDKFLASVSTVLTSKYR----------------------- Human_HbB MVH-------------------------------LTPEEKSAVTALWGKV--NVDEVGGEALGR-LLVVYPWTQ--RFFESFGDL-STPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLK---GTFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFGKE-FT-PPVQAAYQKVVAGVANALAHKYH----------------------- Human_Mb -MG-------------------------------LSDGEWQLVLNVWGKVEADIPGHGQEVLIR-LFKGHPETL--EKFDKFKHL-KSEDEMKASEDLKKHGATVLTALGGILKKKGHHE---AEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPGD-FG-ADAQGAMNKALELFRKDMASNYKELGFQG----------------- Human_NgB ----------------------------------MERPEPELIRQSWRAVSRSPLEHGTVLFAR-LFALEPDLL--PLFQYNCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGV-KLSSFSTVGESLLYMLEKCLGPA-FT-PATRAAWSQLYGAVVQAMSRGWDGE--------------------- Medaka_Cygb_1 -ME-----------------RKQGEVDHLERSRPLTDKERVMIQDSWAKVYQNCDDAGVAILVR-LFVNFPSSK--QYFSQFKHI-EDAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQV-MT-AEVASAWTNLLAILCCSIKAVYEELGWPHLSNSTS----------- Medaka_Cygb_2 -MSCRESPPPPSPPPQMLGVQRGECEDRPERAEPLSDAEMEIIQHTWGHVYKNCEDVGVSVLIR-FFVNFPSAK--QYFSQFQDM-QDPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPEF-FT-AEVQLVWTKLMAAVYWHVTGAYTEVGWLQVSSSAV----------- Medaka_HbA KMS-------------------------------LSAKDKAAVKAFWAKVSGQADAIGSDALSR-MLVVYPQTK--TYFAHWKDL-SP-----GSAPVKKHGKTVMGGIADAVGKIDDIS---SGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFPQD-FT-PEVHVALDKFLAAVSLALSEKYR----------------------- Medaka_HbB MVE-------------------------------WTEQERSIITNIFGNL--DYEDVGSKALSR-CLIVYPWTQ--RYFASFGNL-YNAEAIKTNPNIAAHGTKVLHGLDRAVKNMDNIK---ATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLGSA-FS-PEIQATFQKFLAVVVSALGRQYH----------------------- Medaka_Mb -M-----------------------------------ADYDMVLKHWGPVEADYNTHGNLVLTR-LFHEYPETQ--KLFPKFAGI-AKGD-MAGNAALSAHGATVLKKLGELLKARGNHG---AILKPLANSHATKHKI-PINNFRLITEVIGKVMAEKAGLD----AAGQQALRSVMAGIIAEIEADYKELGFAG----------------- Medaka_NgB -ME------------------------------KLSGKDKELIRGSWESLGKNKVPHGVIMFSR-LFELDPALL--SLFNYNTNC-GSTQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKH-QAVGV-STQSFAVVGESLLYMLQCSLGQA-YT-AALSQAWLNMYSIVVAAMSRGWAKNGEDKAD--------------- Platypus_GbY -MV------------------------------QVTDVEKANIQSIWSKMMENLEKNGIDIFTR-LFREYPETK--KYF---KNI-PLEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLGPC-YT-PEIAESFQKLQSSLYDQVVITYLHSGSD------------------ Platypus_HbA -MG-------------------------------LTDGEKKEVAALWANVSGHEEEFGAEALDR-LFLSFPPTK--TYFPHF-EL-SQ-----GSAQVKAHGKKVADALTTAVAHLDDLD---STLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLPAE-FT-PSAHAALDKFLSKVATVLTSKYR----------------------- Platypus_HbB MVH-------------------------------LSGGEKSAVTNLWGKV--NINELGGEALGR-LLVVYPWTQ--RFFEAFGDL-SSAGAVMGNPKVKAHGAKVLTSFGDALKNLDDLK---GTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFSKD-FS-PEVQAAWQKLVSGVAHALGHKYH----------------------- Platypus_HbW MVN-------------------------------WTSEEKHAIVSIWGKV--DIEETGANALSR-LLVVYPWTQ--RYFSAFGNL-SSPTAIVGNPRVRAHGKKVLTSFGEAVKDLDHVK---SNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLGKD-FT-PEAQAAWQKLVGVVASALSSQYH----------------------- Platypus_Mb -MG-------------------------------LSDGEWQLVLKVWGKVEGDLPGHGQEVLIR-LFKTHPETL--EKFDKFKGL-KTEDEMKASADLKKHGGTVLTALGNILKKKGQHE---AELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSAD-FG-ADAQAAMGKALELFRNDMAAKYKEFGFQG----------------- Platypus_NgB -ME----------------------------NGRLSGPEQELIRESWRSVNSNPLEHGMILFTR-LFDLEPDLL--PLFQYNCRQFSSPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKH-KAIGV-KLSSFSTVGESLLFMLEKCLGPA-FS-PATREAWTRLYTAMVHAMSRGWGGE--------------------- Port_Jackson_shark_Mb -M-----------------------------------TEWEHVNKVWAVVEPDIPAVGLAILLR-LFKEHKETK--DLFPKFKEI-PVQQ-LGNNEDLRKHGVTVLRALGNILKQKGKHS---TNVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPSD-MT-GPMQESFSKVFTVICSDLETLYKEANFQG----------------- Sea_lamprey_Hb1a -MP----------------------IVDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQ--AFFPKFQGL-TSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTV-----------LPGDAGLEKLMSMICILLRSSY------------------------ Sea_lamprey_Hb1b -MP----------------------IVDSGSVSPLSDAEKNKIRAAWDLVYKDYEKTGVDILVK-FFTGTPAAQ--AFFPKFKGL-TTADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTT-----------APGDAGFEKLMSMICILLSSAY------------------------ Sea_lamprey_Hb2 -MP----------------------IVDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQ--EFFPKFKGL-TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb3 -MP----------------------IVDSGSVAPLSAAEKTKIRSAWAPVYSNYETTGVDILVK-FFTSTPAAQ--EFFPKFKGL-TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb5 -MP----------------------IVDTGSVAPLSAAEKTKIRSAWAPVYSTYETSGVDILVK-FFTSTPAAQ--EFFPKFKGL-TTADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb_PMII -MP----------------------IVDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQ--EFFPKFKGL-TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY------------------------ Stingray_HbB MVK-------------------------------LSEDQEHYIKGVWKDV--DHKQITAKALER-VFVVYPWTT--RLFSKLQGL-FSA----NDIGVQQHADKVQRALGEAIDDLKKVE---INFQNLSGKH-QEIGV-DTQNFKLLGQTFMVELALHYKKT-FR-PKEHAAAYKFFRLVAEALSSNYH----------------------- Stingray_HbA -MV-------------------------------LSSQNKKAIEELGNLIKANAEAWGADALAR-LFELHPQTK--TYFSKFSGF-EA-----CNEQVKKHGKRVMNALADATHHLDNLH---LHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNL-QA-FT-PVTHCAVDKFLELVAYELSSCYR----------------------- Tetraodon_Cygb_1 -ME---------------RMQRDGEVDHVEQPGPLTEKEKVMIQDSWAKVFQSCDDAGVAILVR-FFVNFPSSK--QFFKDFKHM-EEPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTEI-IT-AEVASAWTKLLANMCCGIAAVYKEAGWTELSSSVE----------- Tetraodon_Cygb_2 -MSHREPPPPQ----LAVQRRDVDGQDGPERAEPLSDTEREMIRDAWGHVYKNCEDVGVSILIR-FFVNFPSAK--QYFSQFQDM-EEPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPEF-FT-ADVQLVWSKLMATVYWHVTGAYTDVGWLQVSSSAV----------- Tetraodon_HbA MTS-------------------------------LSTKDKETVRAFWAKVASNREEIGASALCR-LLSVYPQTK--TYFSHWKDQ-SP-----NSASAKKHGITIMNAVGDAVSKIDDLK---TGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYPAD-FT-PEVHVAMDKFLASLALALSEKYR----------------------- Tetraodon_HbB MVV-------------------------------WTDQERAIIDNIFSNL--DYEDVGSKALIR-CLIVYPWTQ--RYFSSFGNL-YNAEAIRNNPNVAKHGVTVLHGLDRALKNMDNIK---EEYKK----HSEKLHV-DPDNFKLLSDCLTVVIAGKLGSK-FT-PEYQAALQKFLAVVVSALGRQYH----------------------- Tetraodon_Mb -M-----------------------------------GDFDMVLKFWGPVEADYSAHGGMVLTR-LFTENPETQ--QLFPKFVGI-AQSE-LAGNAAVSAHGATVLKKLGELLKAKGNHA---AILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEKAGLD----TAGQQALRNIMATIIADIDATYKELGFS------------------ Tetraodon_NgB -ME------------------------------KLSSKDKELIRGSWDSLGKNKVPHGVILFSR-LFELDPELL--NLFHYTTNC-GSTQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKH-QAVGV-KPQSFAMVGESLLYMLQCSLGQA-YT-ASLRQAWLNMYSVVVASMSRGWAKNGEDKAD--------------- Zebrafish_Cygb_1 -ME------------------GDGGVQLTQSPDSLTEEDVCVIQDTWKPVYAERDNAGVAVLVR-FFTNFPSAK--QYFEHFREL-QDPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQC-FSPAEVQSSWSKLMGILYWQMNRVYAEVGWENSKK-------------- Zebrafish_Cygb_2 -ME---------------KEREDEETEGRERPEPLTDVERGIIKDTWARVYASCEDVGVTILIR-FFVNFPSAK--QYFSQFQDM-EDPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGEC-FT-PEVQTSWSKLMAALYWHITGAYTEVGWVKLSSSAV----------- Zebrafish_HbA -MS-------------------------------LSDTDKAVVKAIWAKISPKADEIGAEALAR-MLTVYPQTK--TYFSHWADL-SP-----GSGPVKKHGKTIMGAVGEAVSKIDDLV---GGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFPAD-FT-PEVHVSVDKFFNNLALALSEKYR----------------------- Zebrafish_HbB MVE-------------------------------WTDAERTAILGLWGKL--NIDEIGPQALSR-CLIVYPWTQ--RYFATFGNL-SSPAAIMGNPKVAAHGRTVMGGLERAIKNMDNVK---NTYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGFN-ADVQEAWQKFLAVVVSALCRQYH----------------------- Zebrafish_Mb -M-----------------------------------ADHDLVLKCWGAVEADYAANGGEVLNR-LFKEYPDTL--KLFPKFSGI-SQGD-LAGSPAVAAHGATVLKKLGELLKAKGDHA---ALLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEKAGLD----AAGQGALRRVMDAVIGDIDGYYKEIGFAG----------------- Zebrafish_NgB -ME------------------------------KLSEKDKGLIRDSWESLGKNKVPHGIVLFTR-LFELDPALL--TLFSYSTNC-GDAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKH-QAVGV-NTQSFALVGESLLYMLQSSLGPA-YT-TSLRQAWLTMYSIVVSAMTRGWAKNGEHKSN--------------- ; end; Alignment 6 of 20 file name: vertebrate_globins.NgB.aa.muscle.nex #NEXUS begin data; dimensions ntax=68 nchar=215; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb MEKVQGEMEI-----------------ERWERNEEMSDAEKKMIQETWNTVYAKCEDVGVSLLIR-FFVNFP---SAKHYFS-QFKHMEDPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLLG-VLLEVLAEEYTNE-FSPPEVQRAWAKMKSLICTHVTAAYKEVGWVQ------YPNSTM----- Anolis_GbY -------------------------------KAGKMTDLDRRHIREIWTAAFENPEENGRLVIIR-FFSDYP---ASKQYF----KTVPTDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLGRT-FT-PEKRVSWEKFFQVIQEEVEAAYDR---------------------- Anolis_HbA ----------------------------------MLTEDDKNHIRAIWGHVSSNPELYGAEALTR-LFAAHH---TTKTYFP-HY-DMSP-----GSAQIKAHGKKVVEAITQAVNNLDDIAGA---LAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNRGP-LK-PEFILALDKCFTSIGRVLIAQYR----------------------- Anolis_HbB --------------------------------MVHWTAEEKQLIANCWSKV--DIGQIGGDALAC-LLCVYP---WTQRFFP-DFGNLSNAAAICANAKVKAHGKKVLTAFGEAVKNLDNIKDT---FAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFGKD-FT-PACHAAYQKLVNSVAHGLSRRYH----------------------- Anolis_Mb ---------------------------------MELSDQEWQKVIDIWGKVEPEIPAYGQMVILR-LFEQHP---ETQEKFD-KFKNLKSLDEMKNSEDLKKHGTIVLTALGKILKQKRQHEAE---LAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSAD-FG-AESQAAMRKALELFRNDMDRKYKELGFQG----------------- Arctic_lamprey_Hb1 -------MPI-----------------VDSGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTP---AAQEFFP-KFKGMTSADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG-----------FEKLMSMICILLRSAY------------------------ Arctic_lamprey_Hb2 -------MPI-----------------VDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNP---AAQEFFP-KFQGLTSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTVLPGDAG-----------LEKLMSMICILLKSSY------------------------ Arctic_lamprey_Hb4 -------MPI-----------------EDSGSKPDFSDDEKKAIKDSWSGVYSEYESTSSEILIK-FFVDNP---SAQDFFP-KFKDLDSEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKNDGS-FS-DSARSAWEKLLTYICISLKVAY------------------------ Chicken_Cygb MEKVQGEMEI-----------------ERWERSEEISDAEKKVIQETWSRVYANCEDVGVSILIR-FFVNFP---SAKQYFS-QFKHMDDTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGND-FT-PEAHGAWTKMRTLIYTHVTAAYKEAGWVS------YPSATL----- Chicken_GbE ---------------------------------MSFSEAEVQSARGAWEKMYVDAEDNGTAVLVR-MFTEHP---DTKSYFT-HFKGMDSAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFGGD------CKASFEKVTNEICTHLTNIYKEAGW------------------- Chicken_HbA ---------------------------------MVLSAADKNNVKGIFTKIAGHAEEYGAETLER-MFTTYP---PTKTYFP-HF-DLSH-----GSAQIKGHGKKVVAALIEAANHIDDIAGT---LSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHPAA-LT-PEVHASLDKFLCAVGTVLTAKYR----------------------- Chicken_HbB --------------------------------MVHWSAEEKQLITSVWSKV--NVEECGAEALAR-LLIVYP---WTQRFFA-SFGNLSSPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNIKNT---YAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFARD-FT-PACQFAWQKLVNVVAHALARKYH----------------------- Chicken_Mb ---------------------------------MGLSDQEWQQVLTIWGKVEADIAGHGHEVLMR-LFHDHP---ETLDRFD-KFKGLKTPDQMKGSEDLKKHGATVLTQLGKILKQKGNHESE---LKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAAD-FG-ADSQAAMKKALELFRNDMASKYKEFGFQG----------------- Finch_Cygb MEKVQGEMEI-----------------ERWERSEEISDAEKKVIQEIWSRVYANCEDVGVSILIR-FFVNFP---SAKQYFS-QFKHMEDPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPND-FT-PEAHGAWTKMKTLIYTHVTAAYKEVGWAQ------YPTATL----- Finch_GbE ---------------------------------MSLSEAEVQSARGAWEKIYVDAEDNGTAVLVR-MFTEHP---DTKSYFP-HFKGMDSAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFGGD------CKASFEKVTNEICTHLNNIYKEEGW------------------- Finch_HbA ---------------------------------MVLSAGDKSNVKAVFGKIGGQADEYGADALER-MFATYP---QTKTYFP-HF-DLGK-----GSAQVKGHGKKVAAALVEAANNVDDLAGA---LSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNPSL-LT-PEVHASLDKFLCAVGTVLTAKYR----------------------- Finch_HbB --------------------------------MVHWSAEEKQLIASVWGRV--SVEECGAEALAR-LLIVYP---WTQRFFS-DFGNLSSPTAIVGNPKVRAHGKKVLTSFGEAIKNLDNLKGT---YSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFTKE-FT-PACQATWQKLVGVVAHALARKYH----------------------- Finch_Mb ---------------------------------MGLSDQEWQQVLTVWGKVESDLAGHGHQILMR-LFQDHP---ETLDRFE-KFKGLKTPDAMKGSEDLKKHGVTVLTQLGKILKAKGNHEAE---LKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAAD-FG-ADAQAAMKKALELFRNDMATKYKEFGFQG----------------- Frog_Cygb MEKVQGENDM-----------------ERWERLEEITESERGVIKETWARVYANCEDVGVSILIR-FFVNFP---SAKQHFS-QFKHMEDPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAKD-FT-PDVQLAWNKLRSHLYSHVLSAYKEAGWTQ------YPSNSV----- Frog_GbY --------------------------------MADLTGADIENINEVWSKIYANPEESGRTVVIS-LFLTYP---QTKIYFK-NLKNISTLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALGSG-FT-PEQSKSWEKLFSITYKYLESCYANTDS------------------- Frog_HbA1 ---------------------------------MHLTADDKKHIKAIWPSVAAHGDKYGGEALHR-MFMCAP---KTKTYFP-DF-DFSE-----HSKHILAHGKKVSDALNEACNHLDNIAGC---LSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFPKQ-FD-PATHKALDKFLVSVSNVLTSKYR----------------------- Frog_HbB --------------------------------MVNLTAKERQLITGTWSKI--CAKTLGKQALGS-MLYTYP---WTQRYFS-SFGNLSSIEAIFHNAAVATHGEKVLTSIGEAIKHMDDIKGY---YAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQED-FT-PELQAAFEKLFAAIADALGKGYH----------------------- Frog_NgB ------------------------------MEKDQLSGPQKELIRESWQTVSQDQLHHGTVLFSSDIFQLKSGLYWSSE-VPRECLIRVVHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKH-RAVGV-KLESFNTVGESLLFALESCLGDA-FT-SDTREAWSLLYANVVQSMSRGWHRDSQEQREGI------------- Hagfish_Hb1 -------MPI-----------------TDQGPLPTLSEGDKKAIRESWPQIYQNFEQTGLVVLLE-FLQKNP---GAQQSFP-KFSATKC--NLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTIRGKAA------------YEKLFSIICTLLRSSYDE---------------------- Hagfish_Hb2 ---------------------------MSAHGIARTTEGERAAVRASWAVLMKDYEHAGVQILDK-FFKANP---AAKPFFT-KMKDLHTLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKRNGG--LS-GEGKSGWHKVMTIICKMLKSKY------------------------ Hagfish_Hb3 -------MPI-----------------TDHGQPPTLSEGDKKAIRESWPQIYKNFEQNSLAVLLE-FLKKFP---KAQDSFP-KFSAKKS--HLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTMGGKAA------------YEKLFSIIATLLRSTYDA---------------------- Hagfish_Hb4 -------MPI-----------------TDQRPLPTLSEGEKKAIKESWPQIYQNFEQTSLDVLIE-FLQKFP---EAQDSFP-KFSAKKC--HLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTIRGKAA------------YEKLFSIICTLLRSSYDE---------------------- Houndshark_HbA ---------------------------------MAFTACEKQTIGKIAQVLAKSPEAYGAECLAR-LFVTHP---GSKSYF--EYKDYSA-----AGAKVQVHGGKVIRAVVKAAEHVDDLHSH---LETLALTHGKKLLV-DPQNFPMLSECIIVTLATHLTE--FS-PDTHCAVDKLLSAICQELSSRYR----------------------- Houndshark_HbB --------------------------------MVHWTQEERDEISKTFQGT--DMKTVVTQALDR-MFKVYP---WTNRYFQ-KRTDFRS----------SIHAGIVVGALQDAVKHMDDVKTL---FKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRKDC-FT-PHIQGIWDKFFEVVIDAISKQYH----------------------- Houndshark_Mb -------------------------------------MVDWEKVNSVWSAVESDLTAIGQNILLR-LFEQYP---ESQNHFP-KFKN-KSLGELKDTADIKAQADTVLSALGNIVKKKGSHSQP---VKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPSE-MN-AQVQAAFSGAFKIICSDIEKEYKAANFQG----------------- Human_Cygb MEKVPGEMEI-----------------ERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVR-FFVNFP---SAKQYFS-QFKHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFASD-FP-PETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATTPPATLPSSGP Human_HbA ---------------------------------MVLSPADKTNVKAAWGKVGAHAGEYGAEALER-MFLSFP---TTKTYFP-HF-DLSH-----GSAQVKGHGKKVADALTNAVAHVDDMPNA---LSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLPAE-FT-PAVHASLDKFLASVSTVLTSKYR----------------------- Human_HbB --------------------------------MVHLTPEEKSAVTALWGKV--NVDEVGGEALGR-LLVVYP---WTQRFFE-SFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGT---FATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFGKE-FT-PPVQAAYQKVVAGVANALAHKYH----------------------- Human_Mb ---------------------------------MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIR-LFKGHP---ETLEKFD-KFKHLKSEDEMKASEDLKKHGATVLTALGGILKKKGHHEAE---IKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPGD-FG-ADAQGAMNKALELFRKDMASNYKELGFQG----------------- Human_NgB -----------------------------------MERPEPELIRQSWRAVSRSPLEHGTVLFAR-LFALEP---DLLPLFQYNCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGV-KLSSFSTVGESLLYMLEKCLGPA-FT-PATRAAWSQLYGAVVQAMSRGWDGE--------------------- Medaka_Cygb_1 MER--KQGEV-----------------DHLERSRPLTDKERVMIQDSWAKVYQNCDDAGVAILVR-LFVNFP---SSKQYFS-QFKHIEDAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQV-MT-AEVASAWTNLLAILCCSIKAVYEELGWPH------LSNSTS----- Medaka_Cygb_2 MSCRESPPPPSPPPQMLGVQRGECE--DRPERAEPLSDAEMEIIQHTWGHVYKNCEDVGVSVLIR-FFVNFP---SAKQYFS-QFQDMQDPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPEF-FT-AEVQLVWTKLMAAVYWHVTGAYTEVGWLQ------VSSSAV----- Medaka_HbA --------------------------------KMSLSAKDKAAVKAFWAKVSGQADAIGSDALSR-MLVVYP---QTKTYFA-HWKDLSP-----GSAPVKKHGKTVMGGIADAVGKIDDISSG---LLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFPQD-FT-PEVHVALDKFLAAVSLALSEKYR----------------------- Medaka_HbB --------------------------------MVEWTEQERSIITNIFGNL--DYEDVGSKALSR-CLIVYP---WTQRYFA-SFGNLYNAEAIKTNPNIAAHGTKVLHGLDRAVKNMDNIKAT---YAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLGSA-FS-PEIQATFQKFLAVVVSALGRQYH----------------------- Medaka_Mb -------------------------------------MADYDMVLKHWGPVEADYNTHGNLVLTR-LFHEYP---ETQKLFP-KFAGIAK-GDMAGNAALSAHGATVLKKLGELLKARGNHGAI---LKPLANSHATKHKI-PINNFRLITEVIGKVMAEKAGLD----AAGQQALRSVMAGIIAEIEADYKELGFAG----------------- Medaka_NgB --------------------------------MEKLSGKDKELIRGSWESLGKNKVPHGVIMFSR-LFELDP---ALLSLFN-YNTNCGSTQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKH-QAVGV-STQSFAVVGESLLYMLQCSLGQA-YT-AALSQAWLNMYSIVVAAMSRGWAKNGEDKAD--------------- Platypus_GbY --------------------------------MVQVTDVEKANIQSIWSKMMENLEKNGIDIFTR-LFREYP---ETKKYF----KNIPLEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLGPC-YT-PEIAESFQKLQSSLYDQVVITYLHSGSD------------------ Platypus_HbA ---------------------------------MGLTDGEKKEVAALWANVSGHEEEFGAEALDR-LFLSFP---PTKTYFP-HF-ELSQ-----GSAQVKAHGKKVADALTTAVAHLDDLDST---LSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLPAE-FT-PSAHAALDKFLSKVATVLTSKYR----------------------- Platypus_HbB --------------------------------MVHLSGGEKSAVTNLWGKV--NINELGGEALGR-LLVVYP---WTQRFFE-AFGDLSSAGAVMGNPKVKAHGAKVLTSFGDALKNLDDLKGT---FAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFSKD-FS-PEVQAAWQKLVSGVAHALGHKYH----------------------- Platypus_HbW --------------------------------MVNWTSEEKHAIVSIWGKV--DIEETGANALSR-LLVVYP---WTQRYFS-AFGNLSSPTAIVGNPRVRAHGKKVLTSFGEAVKDLDHVKSN---FAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLGKD-FT-PEAQAAWQKLVGVVASALSSQYH----------------------- Platypus_Mb ---------------------------------MGLSDGEWQLVLKVWGKVEGDLPGHGQEVLIR-LFKTHP---ETLEKFD-KFKGLKTEDEMKASADLKKHGGTVLTALGNILKKKGQHEAE---LKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSAD-FG-ADAQAAMGKALELFRNDMAAKYKEFGFQG----------------- Platypus_NgB ------------------------------MENGRLSGPEQELIRESWRSVNSNPLEHGMILFTR-LFDLEP---DLLPLFQYNCRQFSSPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKH-KAIGV-KLSSFSTVGESLLFMLEKCLGPA-FS-PATREAWTRLYTAMVHAMSRGWGGE--------------------- Port_Jackson_shark_Mb -------------------------------------MTEWEHVNKVWAVVEPDIPAVGLAILLR-LFKEHK---ETKDLFP-KFKEIPV-QQLGNNEDLRKHGVTVLRALGNILKQKGKHSTN---VKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPSD-MT-GPMQESFSKVFTVICSDLETLYKEANFQG----------------- Sea_lamprey_Hb1a -------MPI-----------------VDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNP---AAQAFFP-KFQGLTSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTVLPGDAG-----------LEKLMSMICILLRSSY------------------------ Sea_lamprey_Hb1b -------MPI-----------------VDSGSVSPLSDAEKNKIRAAWDLVYKDYEKTGVDILVK-FFTGTP---AAQAFFP-KFKGLTTADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTTAPGDAG-----------FEKLMSMICILLSSAY------------------------ Sea_lamprey_Hb2 -------MPI-----------------VDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTP---AAQEFFP-KFKGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG-----------FEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb3 -------MPI-----------------VDSGSVAPLSAAEKTKIRSAWAPVYSNYETTGVDILVK-FFTSTP---AAQEFFP-KFKGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG-----------FEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb5 -------MPI-----------------VDTGSVAPLSAAEKTKIRSAWAPVYSTYETSGVDILVK-FFTSTP---AAQEFFP-KFKGLTTADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG-----------FEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb_PMII -------MPI-----------------VDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTP---AAQEFFP-KFKGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG-----------FEKLMSMICILLRSAY------------------------ Stingray_HbB --------------------------------MVKLSEDQEHYIKGVWKDV--DHKQITAKALER-VFVVYP---WTTRLFS-KLQGLFSANDI----GVQQHADKVQRALGEAIDDLKKVEIN---FQNLSGKH-QEIGV-DTQNFKLLGQTFMVELALHYKKT-FR-PKEHAAAYKFFRLVAEALSSNYH----------------------- Stingray_HbA ---------------------------------MVLSSQNKKAIEELGNLIKANAEAWGADALAR-LFELHP---QTKTYFS-KFSGFEA-----CNEQVKKHGKRVMNALADATHHLDNLHLH---LEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNLQA--FT-PVTHCAVDKFLELVAYELSSCYR----------------------- Tetraodon_Cygb_1 MERMQRDGEV-----------------DHVEQPGPLTEKEKVMIQDSWAKVFQSCDDAGVAILVR-FFVNFP---SSKQFFK-DFKHMEEPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTEI-IT-AEVASAWTKLLANMCCGIAAVYKEAGWTE------LSSSVE----- Tetraodon_Cygb_2 MSHREPPPPQ------LAVQRRDVDGQDGPERAEPLSDTEREMIRDAWGHVYKNCEDVGVSILIR-FFVNFP---SAKQYFS-QFQDMEEPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPEF-FT-ADVQLVWSKLMATVYWHVTGAYTDVGWLQ------VSSSAV----- Tetraodon_HbA --------------------------------MTSLSTKDKETVRAFWAKVASNREEIGASALCR-LLSVYP---QTKTYFS-HWKDQSP-----NSASAKKHGITIMNAVGDAVSKIDDLKTG---LFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYPAD-FT-PEVHVAMDKFLASLALALSEKYR----------------------- Tetraodon_HbB --------------------------------MVVWTDQERAIIDNIFSNL--DYEDVGSKALIR-CLIVYP---WTQRYFS-SFGNLYNAEAIRNNPNVAKHGVTVLHGLDRALKNMDNIKEE-------YKKHSEKLHV-DPDNFKLLSDCLTVVIAGKLGSK-FT-PEYQAALQKFLAVVVSALGRQYH----------------------- Tetraodon_Mb -------------------------------------MGDFDMVLKFWGPVEADYSAHGGMVLTR-LFTENP---ETQQLFP-KFVGIAQ-SELAGNAAVSAHGATVLKKLGELLKAKGNHAAI---LQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEKAGLD----TAGQQALRNIMATIIADIDATYKELGFS------------------ Tetraodon_NgB --------------------------------MEKLSSKDKELIRGSWDSLGKNKVPHGVILFSR-LFELDP---ELLNLFH-YTTNCGSTQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKH-QAVGV-KPQSFAMVGESLLYMLQCSLGQA-YT-ASLRQAWLNMYSVVVASMSRGWAKNGEDKAD--------------- Zebrafish_Cygb_1 ---MEGDGGV-----------------QLTQSPDSLTEEDVCVIQDTWKPVYAERDNAGVAVLVR-FFTNFP---SAKQYFE-HFRELQDPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQC-FSPAEVQSSWSKLMGILYWQMNRVYAEVGWEN---------SKK----- Zebrafish_Cygb_2 MEKEREDEET-----------------EGRERPEPLTDVERGIIKDTWARVYASCEDVGVTILIR-FFVNFP---SAKQYFS-QFQDMEDPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGEC-FT-PEVQTSWSKLMAALYWHITGAYTEVGWVK------LSSSAV----- Zebrafish_HbA ---------------------------------MSLSDTDKAVVKAIWAKISPKADEIGAEALAR-MLTVYP---QTKTYFS-HWADLSP-----GSGPVKKHGKTIMGAVGEAVSKIDDLVGG---LAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFPAD-FT-PEVHVSVDKFFNNLALALSEKYR----------------------- Zebrafish_HbB --------------------------------MVEWTDAERTAILGLWGKL--NIDEIGPQALSR-CLIVYP---WTQRYFA-TFGNLSSPAAIMGNPKVAAHGRTVMGGLERAIKNMDNVKNT---YAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGFN-ADVQEAWQKFLAVVVSALCRQYH----------------------- Zebrafish_Mb -------------------------------------MADHDLVLKCWGAVEADYAANGGEVLNR-LFKEYP---DTLKLFP-KFSGISQ-GDLAGSPAVAAHGATVLKKLGELLKAKGDHAAL---LKPLANTHANIHKV-ALNNFRLITEVLVKVMAEKAGLD----AAGQGALRRVMDAVIGDIDGYYKEIGFAG----------------- Zebrafish_NgB --------------------------------MEKLSEKDKGLIRDSWESLGKNKVPHGIVLFTR-LFELDP---ALLTLFS-YSTNCGDAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKH-QAVGV-NTQSFALVGESLLYMLQSSLGPA-YT-TSLRQAWLTMYSIVVSAMTRGWAKNGEHKSN--------------- ; end; Alignment 7 of 20 file name: vertebrate_globins.NgB.aa.prank.nex #NEXUS begin data; dimensions ntax=68 nchar=280; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb -ME-----------------KV----QGEMEIERWERNEE------------MSDAEKKMIQETWNTVYAKCEDVGVSLLIR-FFVNFPSAKHYFSQFKH-M---ED------------PL---------E--MERSQ-QLRKHARRVMGAINSVVENIYDSEKVAS---VLALVGKAHAVKHKV-EPVYF-QLLGVLLEVLAEEYTN-E--FSPP-EVQRA---------WAKMKSLICT------HVTAAYKEVGW--VQ------YPNSTM------ Anolis_GbY K--------------------A-----------------G---------K--MTDLDRRHIREIWTAAFENPEENGRLVIIR-FFSDYPASKQYFKT----V---PT------------DG---------D--LKAHP-QVAFHGRRIMVAFSQVIENMENWNQACV---LLERLVNNHKNIHQV-PSGMFQLLFQAMLCTF-DDLLGRT--FT-P-EKRVS---------WEKFFQVIQE------EVEAAYDR------------------------- Anolis_HbA ---------------------------------------M------------LTEDDKNHIRAIWGHVSSNPELYGAEALTR-LFAAHHTTKTYFPHY-D-M---SP------------G----------------SA-QIKAHGKKVVEAITQAVNNLDD---IAG---ALAKLADLHAEKLRV-DPVNFPLLGHCLLVTI-AAHNRGP--LK-P-EFILA---------LDKCFTSIGRVLIAQYR-------------------------------- Anolis_HbB ---------------------M-----------------V---------H--WTAEEKQLIANCWSKV--DIGQIGGDALAC-LLCVYPWTQRFFPDFGN-L---SNAAAICANAKV--K----------------------AHGKKVLTAFGEAVKNLDN---IKD---TFAKLSELHCDKLHV-DPVNFNLLGDVLIVCL-AAHFGKD--FT-P-ACHAA---------YQKLVNSVAHGLSRRYH-------------------------------- Anolis_Mb ---------------------MELSD-----------------------------QEWQKVIDIWGKVEPEIPAYGQMVILR-LFEQHPETQEKFDKFKNLK----S------------LD---------E--MKNSE-DLKKHGTIVLTALGKILKQKRQHEA------ELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSA-D--FG-A-ESQAA---------MRKALELFRN------DMDRKYKELGFQG-------------------- Arctic_lamprey_Hb1 ---------------------M-----------------PIVDSGSVAP---LSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQEFFPKFKG-M---TS------------AD---------Q--LKKSA-DVRWHAERIINAVNDAVASMDDTEKMSM---KLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-------------A-AGDAG---------FEKLMSMICI------LLRSAY--------------------------- Arctic_lamprey_Hb2 ---------------------M-----------------PIVDSGSVPA---LTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQEFFPKFQG-L---TS------------AD---------Q--LKKSM-DVRWHAERIINAVNDAVVAMDDTEKMSL---KLKELSSKHAKSFQV-DPQYFKVLAAVIVDTV-------------L-PGDAG---------LEKLMSMICI------LLKSSY--------------------------- Arctic_lamprey_Hb4 ---------------------M-----------------PIEDSGSKPD---FSDDEKKAIKDSWSGVYSEYESTSSEILIK-FFVDNPSAQDFFPKFKD-L---DS------------EE---------K--LKGST-AVRWHAERIINAVNDAIWLLDEPEKNAK---KLKELSEKHAVQLNV-DAKFFKVLAEVILDKV-------------A-EKNDGSFSDSARSAWEKLLTYICI------SLKVAY--------------------------- Chicken_Cygb -ME-----------------KV----QGEMEIERWERSEE------------ISDAEKKVIQETWSRVYANCEDVGVSILIR-FFVNFPSAKQYFSQFKH-M---DD------------TL---------E--MERSL-QLRKHAQRVMGAINTVVENLDDPEKVSS---VLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGN-D--FT-P-EAHGA---------WTKMRTLIYT------HVTAAYKEAGW--VS------YPSATL------ Chicken_GbE ---------------------M-----------------S------------FSEAEVQSARGAWEKMYVDAEDNGTAVLVR-MFTEHPDTKSYFTHFKG-M---DS------------AE---------E--MKQSD-QVRGHGKRVFTAINDMVQHLDNTEAFLG---ILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEK-------FG-G-DCKAS---------FEKVTNEICT------HLTNIYKEAGW---------------------- Chicken_HbA ---------------------M-----------------V------------LSAADKNNVKGIFTKIAGHAEEYGAETLER-MFTTYPPTKTYFPHF-D-L---SH------------G----------------SA-QIKGHGKKVVAALIEAANHIDD---IAG---TLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVV-AIHHPAA--LT-P-EVHAS---------LDKFLCAVGTVLTAKYR-------------------------------- Chicken_HbB ---------------------M-----------------V---------H--WSAEEKQLITSVWSKV--NVEECGAEALAR-LLIVYPWTQRFFASFGN-L---SSPTAIMGNPRV--R----------------------AHGKKVLSSFGEAVKNLDN---IKN---TYAKLSELHCDKLHV-DPENFRLLGDILIIVL-ASHFARD--FT-P-ACQFA---------WQKLVNVVAHALARKYH-------------------------------- Chicken_Mb ---------------------MGLSD-----------------------------QEWQQVLTIWGKVEADIAGHGHEVLMR-LFHDHPETLDRFDKFKGLK----T------------PD---------Q--MKGSE-DLKKHGATVLTQLGKILKQKGNHES------ELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAA-D--FG-A-DSQAA---------MKKALELFRN------DMASKYKEFGFQG-------------------- Finch_Cygb -ME-----------------KV----QGEMEIERWERSEE------------ISDAEKKVIQEIWSRVYANCEDVGVSILIR-FFVNFPSAKQYFSQFKH-M---ED------------PL---------E--MERSL-QLRKHARRVMGAINTVVENLNDSEKVSS---VLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPN-D--FT-P-EAHGA---------WTKMKTLIYT------HVTAAYKEVGW--AQ------YPTATL------ Finch_GbE ---------------------M-----------------S------------LSEAEVQSARGAWEKIYVDAEDNGTAVLVR-MFTEHPDTKSYFPHFKG-M---DS------------AE---------E--MKQSD-QVRGHGKKVFGAINDMVQHLDNSEAFLG---IVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEK-------FG-G-DCKAS---------FEKVTNEICT------HLNNIYKEEGW---------------------- Finch_HbA ---------------------M-----------------V------------LSAGDKSNVKAVFGKIGGQADEYGADALER-MFATYPQTKTYFPHF-D-L---GK------------G----------------SA-QVKGHGKKVAAALVEAANNVDD---LAG---ALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVV-ATRNPSL--LT-P-EVHAS---------LDKFLCAVGTVLTAKYR-------------------------------- Finch_HbB ---------------------M-----------------V---------H--WSAEEKQLIASVWGRV--SVEECGAEALAR-LLIVYPWTQRFFSDFGN-L---SSPTAIVGNPKV--R----------------------AHGKKVLTSFGEAIKNLDN---LKG---TYSKLSELHCDKLHV-DPENFRLLGDILVIVL-AAHFTKE--FT-P-ACQAT---------WQKLVGVVAHALARKYH-------------------------------- Finch_Mb ---------------------MGLSD-----------------------------QEWQQVLTVWGKVESDLAGHGHQILMR-LFQDHPETLDRFEKFKGLK----T------------PD---------A--MKGSE-DLKKHGVTVLTQLGKILKAKGNHEA------ELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAA-D--FG-A-DAQAA---------MKKALELFRN------DMATKYKEFGFQG-------------------- Frog_Cygb -ME-----------------KV----QGENDMERWERLEE------------ITESERGVIKETWARVYANCEDVGVSILIR-FFVNFPSAKQHFSQFKH-M---ED------------PL---------E--MEGSV-QLRKHARRVMGAVNSVVENLGDPEKITT---VLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAK-D--FT-P-DVQLA---------WNKLRSHLYS------HVLSAYKEAGW--TQ------YPSNSV------ Frog_GbY ---------------------M-----------------A---------D--LTGADIENINEVWSKIYANPEESGRTVVIS-LFLTYPQTKIYFKNLKN-I---ST------------LQ---------E--MQDNA-GIRAHGKRVMGALNHVIENLKDWDAVCS---ALSHLAKRHQDVHKV-EVNNFELLFLVIISVF-KEALGSG--FT-P-EQSKS---------WEKLFSITYK------YLESCYANTDS---------------------- Frog_HbA1 ---------------------M-----------------H------------LTADDKKHIKAIWPSVAAHGDKYGGEALHR-MFMCAPKTKTYFPDF-D-F---SE------------H----------------SK-HILAHGKKVSDALNEACNHLDN---IAG---CLSKLSDLHAYDLRV-DPGNFPLLAHQILVVV-AIHFPKQ--FD-P-ATHKA---------LDKFLVSVSNVLTSKYR-------------------------------- Frog_HbB ---------------------M-----------------V---------N--LTAKERQLITGTWSKI--CAKTLGKQALGS-MLYTYPWTQRYFSSFGN-L---SSIEAIFHNAAV--A----------------------THGEKVLTSIGEAIKHMDD---IKG---YYAQLSKYHSETLHV-DPYNFKRFCSCTIISM-AQTLQED--FT-P-ELQAA---------FEKLFAAIADALGKGYH-------------------------------- Frog_NgB ---------------------M-----------------E---------KDQLSGPQKELIRESWQTVSQDQLHHGTVLFSSDIFQLKSGLY------------WSS----------EVPRECLIRVVHQD--CLSSA-EFTEHIRKVMTVIDAAVSSLDC---LSSLDEYLTSLGRKH-RAVGV-KLESFNTVGESLLFAL-ESCLGDA--FT-S-DTREA---------WSLLYANVVQSMSRGWHRDSQEQREGI---------------------- Hagfish_Hb1 ---------------------M-----------------PITDQGPLPT---LSEGDKKAIRESWPQIYQNFEQTGLVVLLE-FLQKNPGAQQSFPKF--------S------------AT---------KCNLEQDN-EVKWQASRIINAVNHTIGLMDKEAAMKQ---YLKELSAKHSSEFQV-DPKLFKELSAIFVSTI-------------R--GKAA---------YEKLFSIICT------LLRSSYDE------------------------- Hagfish_Hb2 ----------------------------------------MSAHGIART----TEGERAAVRASWAVLMKDYEHAGVQILDK-FFKANPAAKPFFTKMKD-L---HT------------LE---------D--LASSA-DARWHVERIIQAVNFAVINIEDREKLSN---KFVKLSQDHIEEFHVTDPQYFMILSQTILDEV-EKRNG-G--LS-G-EGKSG---------WHKVMTIICK------MLKSKY--------------------------- Hagfish_Hb3 ---------------------M-----------------PITDHGQPPT---LSEGDKKAIRESWPQIYKNFEQNSLAVLLE-FLKKFPKAQDSFPKF--------S------------AK---------KSHLEQDP-AVKLQAEVIINAVNHTIGLMDKEAAMKK---YLKDLSTKHSTEFQV-NPDMFKELSAVFVSTM-------------G--GKAA---------YEKLFSIIAT------LLRSTYDA------------------------- Hagfish_Hb4 ---------------------M-----------------PITDQRPLPT---LSEGEKKAIKESWPQIYQNFEQTSLDVLIE-FLQKFPEAQDSFPKF--------S------------AK---------KCHLEQDN-EVKWQASRIINAVNAVVGHLDNEVAMKQ---YLKELSVKHSSEFQV-DPKMFKELSAIFVSTI-------------R--GKAA---------YEKLFSIICT------LLRSSYDE------------------------- Houndshark_HbA ---------------------M-----------------A------------FTACEKQTIGKIAQVLAKSPEAYGAECLAR-LFVTHPGSKSYF-EYKD-Y---SA------------A----------------GA-KVQVHGGKVIRAVVKAAEHVDD---LHS---HLETLALTHGKKLLV-DPQNFPMLSECIIVTL-ATHL-TE--FS-P-DTHCA---------VDKLLSAICQELSSRYR-------------------------------- Houndshark_HbB ---------------------M-----------------V---------H--WTQEERDEISKTFQGT--DMKTVVTQALDR-MFKVYPWTNRYFQKRTD-F---RS------------S----------------------IHAGIVVGALQDAVKHMDD---VKT---LFKDLSKKHADDLHV-DPGSFHLLTDCIIVEL-A-YLRKD-CFT-P-HIQGI---------WDKFFEVVIDAISKQYH-------------------------------- Houndshark_Mb ---------------------M---------------------------------VDWEKVNSVWSAVESDLTAIGQNILLR-LFEQYPESQNHFPKFKN-K----S------------LG---------E--LKDTA-DIKAQADTVLSALGNIVKKKGSHSQ------PVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPS-E--MN-A-QVQAA---------FSGAFKIICS------DIEKEYKAANFQG-------------------- Human_Cygb -ME-----------------KV----PGEMEIERRERSEE------------LSEAERKAVQAMWARLYANCEDVGVAILVR-FFVNFPSAKQYFSQFKH-M---ED------------PL---------E--MERSP-QLRKHACRVMGALNTVVENLHDPDKVSS---VLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFAS-D--FP-P-ETQRA---------WAKLRGLIYS------HVTAAYKEVGW--VQQVPNATTPPATLPSSGP- Human_HbA ---------------------M-----------------V------------LSPADKTNVKAAWGKVGAHAGEYGAEALER-MFLSFPTTKTYFPHF-D-L---SH------------G----------------SA-QVKGHGKKVADALTNAVAHVDD---MPN---ALSALSDLHAHKLRV-DPVNFKLLSHCLLVTL-AAHLPAE--FT-P-AVHAS---------LDKFLASVSTVLTSKYR-------------------------------- Human_HbB ---------------------M-----------------V---------H--LTPEEKSAVTALWGKV--NVDEVGGEALGR-LLVVYPWTQRFFESFGD-L---STPDAVMGNPKV--K----------------------AHGKKVLGAFSDGLAHLDN---LKG---TFATLSELHCDKLHV-DPENFRLLGNVLVCVL-AHHFGKE--FT-P-PVQAA---------YQKVVAGVANALAHKYH-------------------------------- Human_Mb ---------------------MGLSD-----------------------------GEWQLVLNVWGKVEADIPGHGQEVLIR-LFKGHPETLEKFDKFKHLK----S------------ED---------E--MKASE-DLKKHGATVLTALGGILKKKGHHEA------EIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPG-D--FG-A-DAQGA---------MNKALELFRK------DMASNYKELGFQG-------------------- Human_NgB ---------------------M-----------------E---------R-----PEPELIRQSWRAVSRSPLEHGTVLFAR-LFALEPDLLPLFQY--N-CRQFSS------------PE---------D--CLSSP-EFLDHIRKVMLVIDAAVTNVED---LSSLEEYLASLGRKH-RAVGV-KLSSFSTVGESLLYML-EKCLGPA--FT-P-ATRAA---------WSQLYGAVVQAMSRGW--------DGE---------------------- Medaka_Cygb_1 -ME-----------------RK----Q--GEVDHLERSRP------------LTDKERVMIQDSWAKVYQNCDDAGVAILVR-LFVNFPSSKQYFSQFKH-I---ED------------AE---------E--LEKSS-QLRKHARRVMNAINTLVESLDNSDKVSS---VLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQ-V--MT-A-EVASA---------WTNLLAILCC------SIKAVYEELGW--PH------LSNSTS------ Medaka_Cygb_2 -MSCRESPPPPSPPPQMLGVQR----GECE--DRPERAEP------------LSDAEMEIIQHTWGHVYKNCEDVGVSVLIR-FFVNFPSAKQYFSQFQD-M---QD------------PE---------E--MEKSS-QLRQHARRVMNAIN-VVENLQDPEKVSS---VLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPE-F--FT-A-EVQLV---------WTKLMAAVYW------HVTGAYTEVGW--LQ------VSSSAV------ Medaka_HbA K--------------------M-----------------S------------LSAKDKAAVKAFWAKVSGQADAIGSDALSR-MLVVYPQTKTYFAHWKD-L---SP------------G----------------SA-PVKKHGKTVMGGIADAVGKIDD---ISS---GLLNLSELHAFTLRV-DPTNFKILSHNILVVM-AIMFPQD--FT-P-EVHVA---------LDKFLAAVSLALSEKYR-------------------------------- Medaka_HbB ---------------------M-----------------V---------E--WTEQERSIITNIFGNL--DYEDVGSKALSR-CLIVYPWTQRYFASFGN-L---YNAEAIKTNPNI--A----------------------AHGTKVLHGLDRAVKNMDN---IKA---TYAELSVLHSEKLHV-DPDNFKLLADCLTIVI-AAKLGSA--FS-P-EIQAT---------FQKFLAVVVSALGRQYH-------------------------------- Medaka_Mb ---------------------M---------------------------------ADYDMVLKHWGPVEADYNTHGNLVLTR-LFHEYPETQKLFPKFAG-I----A------------KG---------D--MAGNA-ALSAHGATVLKKLGELLKARGNHGA------ILKPLANSHATKHKI-PINNFRLITEVIGKVMAEK--A-G--LD-A-AGQQA---------LRSVMAGIIA------EIEADYKELGFAG-------------------- Medaka_NgB ---------------------M-----------------E---------K--LSGKDKELIRGSWESLGKNKVPHGVIMFSR-LFELDPALLSLFNYNTN-C---GS------------TQ---------D--CLSSP-EFLDHVTKVMLVIDAAVNHLDD---LHSLEDFLLNLGRKH-QAVGV-STQSFAVVGESLLYML-QCSLGQA--YT-A-ALSQA---------WLNMYSIVVAAMSRGWAKNGEDKAD------------------------ Platypus_GbY ---------------------M-----------------V---------Q--VTDVEKANIQSIWSKMMENLEKNGIDIFTR-LFREYPETKKYFKN----I---PL------------EG---------N--LQEDP-LLRSHGRRVMVALNRIIQNLDNWKQVCK---ILNPLAEKHKIIHSV-DVENFQFMLKCVGDVC-QDYLGPC--YT-P-EIAES---------FQKLQSSLYD------QVVITYLHSGS---------------------D Platypus_HbA ---------------------M-----------------G------------LTDGEKKEVAALWANVSGHEEEFGAEALDR-LFLSFPPTKTYFPHF-E-L---SQ------------G----------------SA-QVKAHGKKVADALTTAVAHLDD---LDS---TLSALSDLHAHKLRV-DPINFKLLAHCILVVV-ARHLPAE--FT-P-SAHAA---------LDKFLSKVATVLTSKYR-------------------------------- Platypus_HbB ---------------------M-----------------V---------H--LSGGEKSAVTNLWGKV--NINELGGEALGR-LLVVYPWTQRFFEAFGD-L---SSAGAVMGNPKV--K----------------------AHGAKVLTSFGDALKNLDD---LKG---TFAKLSELHCDKLHV-DPENFNRLGNVLIVVL-ARHFSKD--FS-P-EVQAA---------WQKLVSGVAHALGHKYH-------------------------------- Platypus_HbW ---------------------M-----------------V---------N--WTSEEKHAIVSIWGKV--DIEETGANALSR-LLVVYPWTQRYFSAFGN-L---SSPTAIVGNPRV--R----------------------AHGKKVLTSFGEAVKDLDH---VKS---NFAKLSQLHSEKLHV-DPENFRLLGDNLIIVL-AATLGKD--FT-P-EAQAA---------WQKLVGVVASALSSQYH-------------------------------- Platypus_Mb ---------------------MGLSD-----------------------------GEWQLVLKVWGKVEGDLPGHGQEVLIR-LFKTHPETLEKFDKFKGLK----T------------ED---------E--MKASA-DLKKHGGTVLTALGNILKKKGQHEA------ELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSA-D--FG-A-DAQAA---------MGKALELFRN------DMAAKYKEFGFQG-------------------- Platypus_NgB ---------------------M-----------------E---------NGRLSGPEQELIRESWRSVNSNPLEHGMILFTR-LFDLEPDLLPLFQY--N-CRQFSS------------PR---------D--CLASP-EFLDHIRKVMLVIDAAVIHLDD---LSSLEEYLTNLGRKH-KAIGV-KLSSFSTVGESLLFML-EKCLGPA--FS-P-ATREA---------WTRLYTAMVHAMSRGW--------GGE---------------------- Port_Jackson_shark_Mb ---------------------M---------------------------------TEWEHVNKVWAVVEPDIPAVGLAILLR-LFKEHKETKDLFPKFKE-I----P------------VQ---------Q--LGNNE-DLRKHGVTVLRALGNILKQKGKHST------NVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPS-D--MT-G-PMQES---------FSKVFTVICS------DLETLYKEANFQG-------------------- Sea_lamprey_Hb1a ---------------------M-----------------PIVDSGSVPA---LTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQAFFPKFQG-L---TS------------AD---------Q--LKKSM-DVRWHAERIINAVNDAVVAMDDTEKMSL---KLRELSGKHAKSFQV-DPQYFKVLAAVIVDTV-------------L-PGDAG---------LEKLMSMICI------LLRSSY--------------------------- Sea_lamprey_Hb1b ---------------------M-----------------PIVDSGSVSP---LSDAEKNKIRAAWDLVYKDYEKTGVDILVK-FFTGTPAAQAFFPKFKG-L---TT------------AD---------D--LKQSS-DVRWHAERIINAVNDAVKSMDDTEKMSM---KLKELSIKHAQSFYV-DRQYFKVLAGIIADTT-------------A-PGDAG---------FEKLMSMICI------LLSSAY--------------------------- Sea_lamprey_Hb2 ---------------------M-----------------PIVDTGSVAP---LSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQEFFPKFKG-L---TT------------AD---------Q--LKKSA-DVRWHAERIINAVNDAVVSMDDTEKMSM---KLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-------------A-AGDAG---------FEKLMSMICI------LLRSAY--------------------------- Sea_lamprey_Hb3 ---------------------M-----------------PIVDSGSVAP---LSAAEKTKIRSAWAPVYSNYETTGVDILVK-FFTSTPAAQEFFPKFKG-L---TT------------AD---------Q--LKKSA-DVRWHAERIINAVNDAVVSMDDTEKMSM---KLGDLSGKHAKSFQV-DPQYFKVLAAVIADTV-------------A-AGDAG---------FEKLMSMICI------LLRSAY--------------------------- Sea_lamprey_Hb5 ---------------------M-----------------PIVDTGSVAP---LSAAEKTKIRSAWAPVYSTYETSGVDILVK-FFTSTPAAQEFFPKFKG-L---TT------------AD---------Q--LKKSA-DVRWHAERIINAVNDAVASMDDTEKMSM---KLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-------------A-AGDAG---------FEKLMSMICI------LLRSAY--------------------------- Sea_lamprey_Hb_PMII ---------------------M-----------------PIVDTGSVAP---LSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQEFFPKFKG-L---TT------------AD---------Q--LKKSA-DVRWHAERIINAVNDAVVSMDDTEKMSM---KLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-------------A-AGDAG---------FEKLMSMICI------LLRSAY--------------------------- Stingray_HbB ---------------------M-----------------V---------K--LSEDQEHYIKGVWKDV--DHKQITAKALER-VFVVYPWTTRLFSKLQG-L---FS------------A----------------NDIGVQQHADKVQRALGEAIDDLKK---VEI---NFQNLSGKHQE-IGV-DTQNFKLLGQTFMVEL-ALHYKKT--FR-P-KEHAA---------AYKFFRLVAEALSSNYH-------------------------------- Stingray_HbA ---------------------M-----------------V------------LSSQNKKAIEELGNLIKANAEAWGADALAR-LFELHPQTKTYFSKFSG-F---EA------------C----------------NE-QVKKHGKRVMNALADATHHLDN---LHL---HLEDLARKHGENLLV-DPHNFHLFADCIVVTL-AVNL-QA--FT-P-VTHCA---------VDKFLELVAYELSSCYR-------------------------------- Tetraodon_Cygb_1 -ME-----------------RM----QRDGEVDHVEQPGP------------LTEKEKVMIQDSWAKVFQSCDDAGVAILVR-FFVNFPSSKQFFKDFKH-M---EE------------PE---------E--MQQSV-QLRKHAHRVMTALNTLVESLDNADRVAS---VLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTE-I--IT-A-EVASA---------WTKLLANMCC------GIAAVYKEAGW--TE------LSSSVE------ Tetraodon_Cygb_2 -MSHREPPPP------QLAVQR----RDVDGQDGPERAEP------------LSDTEREMIRDAWGHVYKNCEDVGVSILIR-FFVNFPSAKQYFSQFQD-M---EE------------PE---------E--MERSS-QLRHHACRVMNALNTVVENLHDPEKVSS---VLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPE-F--FT-A-DVQLV---------WSKLMATVYW------HVTGAYTDVGW--LQ------VSSSAV------ Tetraodon_HbA M--------------------T-----------------S------------LSTKDKETVRAFWAKVASNREEIGASALCR-LLSVYPQTKTYFSHWKD-Q---SP------------N----------------SA-SAKKHGITIMNAVGDAVSKIDD---LKT---GLFNLSELHAFTLRV-DPANFKLLAQCMMVVI-AIMYPAD--FT-P-EVHVA---------MDKFLASLALALSEKYR-------------------------------- Tetraodon_HbB ---------------------M-----------------V---------V--WTDQERAIIDNIFSNL--DYEDVGSKALIR-CLIVYPWTQRYFSSFGN-L---YNAEAIRNNPNV--A----------------------KHGVTVLHGLDRALKNMDN---IKE---EYKK----HSEKLHV-DPDNFKLLSDCLTVVI-AGKLGSK--FT-P-EYQAA---------LQKFLAVVVSALGRQYH-------------------------------- Tetraodon_Mb ---------------------M---------------------------------GDFDMVLKFWGPVEADYSAHGGMVLTR-LFTENPETQQLFPKFVG-I----A------------QS---------E--LAGNA-AVSAHGATVLKKLGELLKAKGNHAA------ILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEK--A-G--LD-T-AGQQA---------LRNIMATIIA------DIDATYKELGFS--------------------- Tetraodon_NgB ---------------------M-----------------E---------K--LSSKDKELIRGSWDSLGKNKVPHGVILFSR-LFELDPELLNLFHYTTN-C---GS------------TQ---------D--CLSSP-EFLEHVTKVMLVIDAAVSHLDD---LHSLEDFLLNLGRKH-QAVGV-KPQSFAMVGESLLYML-QCSLGQA--YT-A-SLRQA---------WLNMYSVVVASMSRGWAKNGEDKAD------------------------ Zebrafish_Cygb_1 ---------------------M----EGDGGVQLTQSPDS------------LTEEDVCVIQDTWKPVYAERDNAGVAVLVR-FFTNFPSAKQYFEHFRE-L---QD------------PA---------E--MQQNA-QLKKHGQRVLNALNTLVENLRDADKLNT---IFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQ-C--FS-PAEVQSS---------WSKLMGILYW------QMNRVYAEVGW-----------ENSKK------ Zebrafish_Cygb_2 -ME-----------------KE----REDEETEGRERPEP------------LTDVERGIIKDTWARVYASCEDVGVTILIR-FFVNFPSAKQYFSQFQD-M---ED------------PE---------E--MEKSS-QLRKHARRVMNAINTVVENLHDPEKVSS---VLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGE-C--FT-P-EVQTS---------WSKLMAALYW------HITGAYTEVGW--VK------LSSSAV------ Zebrafish_HbA ---------------------M-----------------S------------LSDTDKAVVKAIWAKISPKADEIGAEALAR-MLTVYPQTKTYFSHWAD-L---SP------------G----------------SG-PVKKHGKTIMGAVGEAVSKIDD---LVG---GLAALSELHAFKLRV-DPANFKILSHNVIVVI-AMLFPAD--FT-P-EVHVS---------VDKFFNNLALALSEKYR-------------------------------- Zebrafish_HbB ---------------------M-----------------V---------E--WTDAERTAILGLWGKL--NIDEIGPQALSR-CLIVYPWTQRYFATFGN-L---SSPAAIMGNPKV--A----------------------AHGRTVMGGLERAIKNMDN---VKN---TYAALSVMHSEKLHV-DPDNFRLLADCITVCA-AMKFGQAG-FN-A-DVQEA---------WQKFLAVVVSALCRQYH-------------------------------- Zebrafish_Mb ---------------------M---------------------------------ADHDLVLKCWGAVEADYAANGGEVLNR-LFKEYPDTLKLFPKFSG-I----S------------QG---------D--LAGSP-AVAAHGATVLKKLGELLKAKGDHAA------LLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEK--A-G--LD-A-AGQGA---------LRRVMDAVIG------DIDGYYKEIGFAG-------------------- Zebrafish_NgB ---------------------M-----------------E---------K--LSEKDKGLIRDSWESLGKNKVPHGIVLFTR-LFELDPALLTLFSYSTN-C---GD------------AP---------E--CLSSP-EFLEHVTKVMLVIDAAVSHLDD---LHTLEDFLLNLGRKH-QAVGV-NTQSFALVGESLLYML-QSSLGPA--YT-T-SLRQA---------WLTMYSIVVSAMTRGWAKNGEHKSN------------------------ ; end; Alignment 8 of 20 file name: vertebrate_globins.NgB.aa.probalign.nex #NEXUS begin data; dimensions ntax=68 nchar=219; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb ---------------MEKVQGEMEIERWERNEEMSDAEKKMIQETWNTVYAKCEDVGVSLLIR-FFVNFPSAKHYFSQ-F------KHMEDPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLLG-VLLEVLAEEYT-NEFSPP-EVQRAWAKMKSLICTHVTAAYKE--VGWVQ-----------YPNSTM Anolis_GbY -----------------------------KAGKMTDLDRRHIREIWTAAFENPEENGRLVIIR-FFSDYPASKQYFKT-V---------PTDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLG-RTFT-P-EKRVSWEKFFQVIQEEVEAAYDR------------------------ Anolis_HbA --------------------------------MLTEDDKNHIRAIWGHVSSNPELYGAEALTR-LFAAHHTTKTYFPH-Y------DM-S-----PGSAQIKAHGKKVVEAITQAVNNLDDIA---GALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNR-GPLK-P-EFILALDKCFTSIGRVLIAQYR------------------------- Anolis_HbB ------------------------------MVHWTAEEKQLIANCWSKVD--IGQIGGDALAC-LLCVYPWTQRFFPD-F------GNLSNAAAICANAKVKAHGKKVLTAFGEAVKNLDNIK---DTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFG-KDFT-P-ACHAAYQKLVNSVAHGLSRRYH------------------------- Anolis_Mb -------------------------------MELSDQEWQKVIDIWGKVEPEIPAYGQMVILR-LFEQHPETQEKFDK-F------KNLKSLDEMKNSEDLKKHGTIVLTALGKILKQKRQHE---AELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRS-ADFG-A-ESQAAMRKALELFRNDMDRKYKE--LGFQG----------------- Arctic_lamprey_Hb1 ----------------------MPIVDSGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQEFFPK-F------KGMTSADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY-------------------------- Arctic_lamprey_Hb2 ----------------------MPIVDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQEFFPK-F------QGLTSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTVL------------PGDAGLEKLMSMICILLKSSY-------------------------- Arctic_lamprey_Hb4 ----------------------MPIEDSGSKPDFSDDEKKAIKDSWSGVYSEYESTSSEILIK-FFVDNPSAQDFFPK-F------KDLDSEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKND-GSFS-D-SARSAWEKLLTYICISLKVAY-------------------------- Chicken_Cygb ---------------MEKVQGEMEIERWERSEEISDAEKKVIQETWSRVYANCEDVGVSILIR-FFVNFPSAKQYFSQ-F------KHMDDTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYG-NDFT-P-EAHGAWTKMRTLIYTHVTAAYKE--AGWVS-----------YPSATL Chicken_GbE -------------------------------MSFSEAEVQSARGAWEKMYVDAEDNGTAVLVR-MFTEHPDTKSYFTH-F------KGMDSAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFG------G-DCKASFEKVTNEICTHLTNIYKE--AGW------------------- Chicken_HbA -------------------------------MVLSAADKNNVKGIFTKIAGHAEEYGAETLER-MFTTYPPTKTYFPH-F------DL-S-----HGSAQIKGHGKKVVAALIEAANHIDDIA---GTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHP-AALT-P-EVHASLDKFLCAVGTVLTAKYR------------------------- Chicken_HbB ------------------------------MVHWSAEEKQLITSVWSKVN--VEECGAEALAR-LLIVYPWTQRFFAS-F------GNLSSPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNIK---NTYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFA-RDFT-P-ACQFAWQKLVNVVAHALARKYH------------------------- Chicken_Mb -------------------------------MGLSDQEWQQVLTIWGKVEADIAGHGHEVLMR-LFHDHPETLDRFDK-F------KGLKTPDQMKGSEDLKKHGATVLTQLGKILKQKGNHE---SELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHA-ADFG-A-DSQAAMKKALELFRNDMASKYKE--FGFQG----------------- Finch_Cygb ---------------MEKVQGEMEIERWERSEEISDAEKKVIQEIWSRVYANCEDVGVSILIR-FFVNFPSAKQYFSQ-F------KHMEDPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYP-NDFT-P-EAHGAWTKMKTLIYTHVTAAYKE--VGWAQ-----------YPTATL Finch_GbE -------------------------------MSLSEAEVQSARGAWEKIYVDAEDNGTAVLVR-MFTEHPDTKSYFPH-F------KGMDSAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFG------G-DCKASFEKVTNEICTHLNNIYKE--EGW------------------- Finch_HbA -------------------------------MVLSAGDKSNVKAVFGKIGGQADEYGADALER-MFATYPQTKTYFPH-F------DL-G-----KGSAQVKGHGKKVAAALVEAANNVDDLA---GALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNP-SLLT-P-EVHASLDKFLCAVGTVLTAKYR------------------------- Finch_HbB ------------------------------MVHWSAEEKQLIASVWGRVS--VEECGAEALAR-LLIVYPWTQRFFSD-F------GNLSSPTAIVGNPKVRAHGKKVLTSFGEAIKNLDNLK---GTYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFT-KEFT-P-ACQATWQKLVGVVAHALARKYH------------------------- Finch_Mb -------------------------------MGLSDQEWQQVLTVWGKVESDLAGHGHQILMR-LFQDHPETLDRFEK-F------KGLKTPDAMKGSEDLKKHGVTVLTQLGKILKAKGNHE---AELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHA-ADFG-A-DAQAAMKKALELFRNDMATKYKE--FGFQG----------------- Frog_Cygb ---------------MEKVQGENDMERWERLEEITESERGVIKETWARVYANCEDVGVSILIR-FFVNFPSAKQHFSQ-F------KHMEDPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYA-KDFT-P-DVQLAWNKLRSHLYSHVLSAYKE--AGWTQ-----------YPSNSV Frog_GbY ------------------------------MADLTGADIENINEVWSKIYANPEESGRTVVIS-LFLTYPQTKIYFKN-L------KNISTLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALG-SGFT-P-EQSKSWEKLFSITYKYLESCYAN--TDS------------------- Frog_HbA1 -------------------------------MHLTADDKKHIKAIWPSVAAHGDKYGGEALHR-MFMCAPKTKTYFPD-F------DF-S-----EHSKHILAHGKKVSDALNEACNHLDNIA---GCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFP-KQFD-P-ATHKALDKFLVSVSNVLTSKYR------------------------- Frog_HbB ------------------------------MVNLTAKERQLITGTWSKIC--AKTLGKQALGS-MLYTYPWTQRYFSS-F------GNLSSIEAIFHNAAVATHGEKVLTSIGEAIKHMDDIK---GYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQ-EDFT-P-ELQAAFEKLFAAIADALGKGYH------------------------- Frog_NgB -------------------------M---EKDQLSGPQKELIRESWQTVSQDQLHHGTVLFSSDIFQLKSG-L-YWSS-EVPRECLIRV-VHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKHR-AVGV-KLESFNTVGESLLFALESCLG-DAFT-S-DTREAWSLLYANVVQSMSRGWHRDSQE---------------QREGI Hagfish_Hb1 ----------------------MPITDQGPLPTLSEGDKKAIRESWPQIYQNFEQTGLVVLLE-FLQKNPGAQQSFPK-F------SATK--CNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTIR-------------GKAAYEKLFSIICTLLRSSYDE------------------------ Hagfish_Hb2 -------------------------MSAHGIARTTEGERAAVRASWAVLMKDYEHAGVQILDK-FFKANPAAKPFFTK-M------KDLHTLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKR-N-GGLS-G-EGKSGWHKVMTIICKMLKSKY-------------------------- Hagfish_Hb3 ----------------------MPITDHGQPPTLSEGDKKAIRESWPQIYKNFEQNSLAVLLE-FLKKFPKAQDSFPK-F------SAKK--SHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTMG-------------GKAAYEKLFSIIATLLRSTYDA------------------------ Hagfish_Hb4 ----------------------MPITDQRPLPTLSEGEKKAIKESWPQIYQNFEQTSLDVLIE-FLQKFPEAQDSFPK-F------SAKK--CHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTIR-------------GKAAYEKLFSIICTLLRSSYDE------------------------ Houndshark_HbA -------------------------------MAFTACEKQTIGKIAQVLAKSPEAYGAECLAR-LFVTHPGSKSYFEY--------KDYS-----AAGAKVQVHGGKVIRAVVKAAEHVDDLH---SHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHL--TEFS-P-DTHCAVDKLLSAICQELSSRYR------------------------- Houndshark_HbB ------------------------------MVHWTQEERDEISKTFQGTD--MKTVVTQALDR-MFKVYPWTNRYFQK-R------TDFR----------SSIHAGIVVGALQDAVKHMDDVK---TLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRK-DCFT-P-HIQGIWDKFFEVVIDAISKQYH------------------------- Houndshark_Mb -----------------------------------MVDWEKVNSVWSAVESDLTAIGQNILLR-LFEQYPESQNHFPK-F------KNKS-LGELKDTADIKAQADTVLSALGNIVKKKGSHS---QPVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYP-SEMN-A-QVQAAFSGAFKIICSDIEKEYKA--ANFQG----------------- Human_Cygb ---------------MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVR-FFVNFPSAKQYFSQ-F------KHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFA-SDFP-P-ETQRAWAKLRGLIYSHVTAAYKE--VGWVQQVPNATTPPATLPSSGP Human_HbA -------------------------------MVLSPADKTNVKAAWGKVGAHAGEYGAEALER-MFLSFPTTKTYFPH-F------DL-S-----HGSAQVKGHGKKVADALTNAVAHVDDMP---NALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLP-AEFT-P-AVHASLDKFLASVSTVLTSKYR------------------------- Human_HbB ------------------------------MVHLTPEEKSAVTALWGKVN--VDEVGGEALGR-LLVVYPWTQRFFES-F------GDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLK---GTFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFG-KEFT-P-PVQAAYQKVVAGVANALAHKYH------------------------- Human_Mb -------------------------------MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIR-LFKGHPETLEKFDK-F------KHLKSEDEMKASEDLKKHGATVLTALGGILKKKGHHE---AEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHP-GDFG-A-DAQGAMNKALELFRKDMASNYKE--LGFQG----------------- Human_NgB ---------------------------------MERPEPELIRQSWRAVSRSPLEHGTVLFAR-LFALEPDLLPLFQYNC------RQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHR-AVGV-KLSSFSTVGESLLYMLEKCLG-PAFT-P-ATRAAWSQLYGAVVQAMSRGWDG-----------------------E Medaka_Cygb_1 -----------------MERKQGEVDHLERSRPLTDKERVMIQDSWAKVYQNCDDAGVAILVR-LFVNFPSSKQYFSQ-F------KHIEDAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYP-QVMT-A-EVASAWTNLLAILCCSIKAVYEE--LGWPH-----------LSNSTS Medaka_Cygb_2 MSCRESPPPPSPPPQMLGVQRGECEDRPERAEPLSDAEMEIIQHTWGHVYKNCEDVGVSVLIR-FFVNFPSAKQYFSQ-F------QDMQDPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFP-EFFT-A-EVQLVWTKLMAAVYWHVTGAYTE--VGWLQ-----------VSSSAV Medaka_HbA ------------------------------KMSLSAKDKAAVKAFWAKVSGQADAIGSDALSR-MLVVYPQTKTYFAH-W------KDLS-----PGSAPVKKHGKTVMGGIADAVGKIDDIS---SGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFP-QDFT-P-EVHVALDKFLAAVSLALSEKYR------------------------- Medaka_HbB ------------------------------MVEWTEQERSIITNIFGNLD--YEDVGSKALSR-CLIVYPWTQRYFAS-F------GNLYNAEAIKTNPNIAAHGTKVLHGLDRAVKNMDNIK---ATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLG-SAFS-P-EIQATFQKFLAVVVSALGRQYH------------------------- Medaka_Mb -----------------------------------MADYDMVLKHWGPVEADYNTHGNLVLTR-LFHEYPETQKLFPK-F------AGIAK-GDMAGNAALSAHGATVLKKLGELLKARGNHG---AILKPLANSHATKHKI-PINNFRLITEVIGKVMAEKAG---LD-A-AGQQALRSVMAGIIAEIEADYKE--LGFAG----------------- Medaka_NgB ------------------------------MEKLSGKDKELIRGSWESLGKNKVPHGVIMFSR-LFELDPALLSLFNY-N------TNCGSTQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKHQ-AVGV-STQSFAVVGESLLYMLQCSLG-QAYT-A-ALSQAWLNMYSIVVAAMSRGWAK--NG---------------EDKAD Platypus_GbY ------------------------------MVQVTDVEKANIQSIWSKMMENLEKNGIDIFTR-LFREYPETKKYFKN-I---------PLEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLG-PCYT-P-EIAESFQKLQSSLYDQVVITYLH--SGSD------------------ Platypus_HbA -------------------------------MGLTDGEKKEVAALWANVSGHEEEFGAEALDR-LFLSFPPTKTYFPH-F------EL-S-----QGSAQVKAHGKKVADALTTAVAHLDDLD---STLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLP-AEFT-P-SAHAALDKFLSKVATVLTSKYR------------------------- Platypus_HbB ------------------------------MVHLSGGEKSAVTNLWGKVN--INELGGEALGR-LLVVYPWTQRFFEA-F------GDLSSAGAVMGNPKVKAHGAKVLTSFGDALKNLDDLK---GTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFS-KDFS-P-EVQAAWQKLVSGVAHALGHKYH------------------------- Platypus_HbW ------------------------------MVNWTSEEKHAIVSIWGKVD--IEETGANALSR-LLVVYPWTQRYFSA-F------GNLSSPTAIVGNPRVRAHGKKVLTSFGEAVKDLDHVK---SNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLG-KDFT-P-EAQAAWQKLVGVVASALSSQYH------------------------- Platypus_Mb -------------------------------MGLSDGEWQLVLKVWGKVEGDLPGHGQEVLIR-LFKTHPETLEKFDK-F------KGLKTEDEMKASADLKKHGGTVLTALGNILKKKGQHE---AELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHS-ADFG-A-DAQAAMGKALELFRNDMAAKYKE--FGFQG----------------- Platypus_NgB -------------------------M---ENGRLSGPEQELIRESWRSVNSNPLEHGMILFTR-LFDLEPDLLPLFQYNC------RQFSSPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKHK-AIGV-KLSSFSTVGESLLFMLEKCLG-PAFS-P-ATREAWTRLYTAMVHAMSRGWGG-----------------------E Port_Jackson_shark_Mb -----------------------------------MTEWEHVNKVWAVVEPDIPAVGLAILLR-LFKEHKETKDLFPK-F------KEIP-VQQLGNNEDLRKHGVTVLRALGNILKQKGKHS---TNVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYP-SDMT-G-PMQESFSKVFTVICSDLETLYKE--ANFQG----------------- Sea_lamprey_Hb1a ----------------------MPIVDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQAFFPK-F------QGLTSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTVL------------PGDAGLEKLMSMICILLRSSY-------------------------- Sea_lamprey_Hb1b ----------------------MPIVDSGSVSPLSDAEKNKIRAAWDLVYKDYEKTGVDILVK-FFTGTPAAQAFFPK-F------KGLTTADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTTA------------PGDAGFEKLMSMICILLSSAY-------------------------- Sea_lamprey_Hb2 ----------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQEFFPK-F------KGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb3 ----------------------MPIVDSGSVAPLSAAEKTKIRSAWAPVYSNYETTGVDILVK-FFTSTPAAQEFFPK-F------KGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb5 ----------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYSTYETSGVDILVK-FFTSTPAAQEFFPK-F------KGLTTADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb_PMII ----------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQEFFPK-F------KGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY-------------------------- Stingray_HbA -------------------------------MVLSSQNKKAIEELGNLIKANAEAWGADALAR-LFELHPQTKTYFSK-F------SGFE-----ACNEQVKKHGKRVMNALADATHHLDNLH---LHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNL--QAFT-P-VTHCAVDKFLELVAYELSSCYR------------------------- Stingray_HbB ------------------------------MVKLSEDQEHYIKGVWKDVD--HKQITAKALER-VFVVYPWTTRLFSK-L------QGLFSAND----IGVQQHADKVQRALGEAIDDLKKVE---INFQNLSGKHQ-EIGV-DTQNFKLLGQTFMVELALHYK-KTFR-P-KEHAAAYKFFRLVAEALSSNYH------------------------- Tetraodon_Cygb_1 ---------------MERMQRDGEVDHVEQPGPLTEKEKVMIQDSWAKVFQSCDDAGVAILVR-FFVNFPSSKQFFKD-F------KHMEEPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFT-EIIT-A-EVASAWTKLLANMCCGIAAVYKE--AGWTE-----------LSSSVE Tetraodon_Cygb_2 ----MSHREPPPPQLAVQRRDVDGQDGPERAEPLSDTEREMIRDAWGHVYKNCEDVGVSILIR-FFVNFPSAKQYFSQ-F------QDMEEPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFP-EFFT-A-DVQLVWSKLMATVYWHVTGAYTD--VGWLQ-----------VSSSAV Tetraodon_HbA ------------------------------MTSLSTKDKETVRAFWAKVASNREEIGASALCR-LLSVYPQTKTYFSH-W------KDQS-----PNSASAKKHGITIMNAVGDAVSKIDDLK---TGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYP-ADFT-P-EVHVAMDKFLASLALALSEKYR------------------------- Tetraodon_HbB ------------------------------MVVWTDQERAIIDNIFSNLD--YEDVGSKALIR-CLIVYPWTQRYFSS-F------GNLYNAEAIRNNPNVAKHGVTVLHGLDRALKNMDNIK---EE----YKKHSEKLHV-DPDNFKLLSDCLTVVIAGKLG-SKFT-P-EYQAALQKFLAVVVSALGRQYH------------------------- Tetraodon_Mb -----------------------------------MGDFDMVLKFWGPVEADYSAHGGMVLTR-LFTENPETQQLFPK-F------VGIAQ-SELAGNAAVSAHGATVLKKLGELLKAKGNHA---AILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEKAG---LD-T-AGQQALRNIMATIIADIDATYKE--LGFS------------------ Tetraodon_NgB ------------------------------MEKLSSKDKELIRGSWDSLGKNKVPHGVILFSR-LFELDPELLNLFHY-T------TNCGSTQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKHQ-AVGV-KPQSFAMVGESLLYMLQCSLG-QAYT-A-SLRQAWLNMYSVVVASMSRGWAK--NG---------------EDKAD Zebrafish_Cygb_1 ------------------MEGDGGVQLTQSPDSLTEEDVCVIQDTWKPVYAERDNAGVAVLVR-FFTNFPSAKQYFEH-F------RELQDPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFP-QCFS-PAEVQSSWSKLMGILYWQMNRVYAE--VGWEN--------------SKK Zebrafish_Cygb_2 ---------------MEKEREDEETEGRERPEPLTDVERGIIKDTWARVYASCEDVGVTILIR-FFVNFPSAKQYFSQ-F------QDMEDPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFG-ECFT-P-EVQTSWSKLMAALYWHITGAYTE--VGWVK-----------LSSSAV Zebrafish_HbA -------------------------------MSLSDTDKAVVKAIWAKISPKADEIGAEALAR-MLTVYPQTKTYFSH-W------ADLS-----PGSGPVKKHGKTIMGAVGEAVSKIDDLV---GGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFP-ADFT-P-EVHVSVDKFFNNLALALSEKYR------------------------- Zebrafish_HbB ------------------------------MVEWTDAERTAILGLWGKLN--IDEIGPQALSR-CLIVYPWTQRYFAT-F------GNLSSPAAIMGNPKVAAHGRTVMGGLERAIKNMDNVK---NTYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGFN-A-DVQEAWQKFLAVVVSALCRQYH------------------------- Zebrafish_Mb -----------------------------------MADHDLVLKCWGAVEADYAANGGEVLNR-LFKEYPDTLKLFPK-F------SGISQ-GDLAGSPAVAAHGATVLKKLGELLKAKGDHA---ALLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEKAG---LD-A-AGQGALRRVMDAVIGDIDGYYKE--IGFAG----------------- Zebrafish_NgB ------------------------------MEKLSEKDKGLIRDSWESLGKNKVPHGIVLFTR-LFELDPALLTLFSY-S------TNCGDAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKHQ-AVGV-NTQSFALVGESLLYMLQSSLG-PAYT-T-SLRQAWLTMYSIVVSAMTRGWAK--NG---------------EHKSN ; end; Alignment 9 of 20 file name: vertebrate_globins.NgB.aa.probcons.nex #NEXUS begin data; dimensions ntax=68 nchar=225; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb MEKVQGEMEIE---------------R-------WERNEEMSDAEKKMIQETWNTVYAKCEDVGVSLLIRFF-VNFPSAKHYFSQ-F-----KHMEDPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLLG-VLLEVLAEEYTN-EFSPP-EVQRAWAKMKSLICTHVTAAYKE--VGWV-----------QYPNSTM Anolis_GbY KA------------------------------------GKMTDLDRRHIREIWTAAFENPEENGRLVIIRFF-SDYPASKQYFKT-V--------PTDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLGR-TFT-P-EKRVSWEKFFQVIQEEVEAAY------------------------DR Anolis_HbA M---------------------------------------LTEDDKNHIRAIWGHVSSNPELYGAEALTRLF-AAHHTTKTYFPH-Y-----D-M-----SPGSAQIKAHGKKVVEAITQAVNNLDDI---AGALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNRG-PLK-P-EFILALDKCFTSIGRVLIAQYR------------------------- Anolis_HbB MV-------------------------------------HWTAEEKQLIANCWSKVD--IGQIGGDALACLL-CVYPWTQRFFPD-F-----GNLSNAAAICANAKVKAHGKKVLTAFGEAVKNLDNIKD---TFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFGK-DFT-P-ACHAAYQKLVNSVAHGLSRRY-------------------------H Anolis_Mb M--------------------------------------ELSDQEWQKVIDIWGKVEPEIPAYGQMVILRLF-EQHPETQEKFDK-F-----KNLKSLDEMKNSEDLKKHGTIVLTALGKILKQKRQH---EAELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSA-DFG-A-ESQAAMRKALELFRNDMDRKYKE--LGF-----------------QG Arctic_lamprey_Hb1 MPI-------V---------------D-------SGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVKFF-TSTPAAQEFFPK-F-----KGMTSADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY-------------------------- Arctic_lamprey_Hb2 MPI-------V---------------D-------SGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIKFF-TSNPAAQEFFPK-F-----QGLTSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTVL------------PGDAGLEKLMSMICILLKSSY-------------------------- Arctic_lamprey_Hb4 MP-------IE---------------D-------SGSKPDFSDDEKKAIKDSWSGVYSEYESTSSEILIKFF-VDNPSAQDFFPK-F-----KDLDSEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKNDG-SFS-D-SARSAWEKLLTYICISLKVAY-------------------------- Chicken_Cygb MEK-------V---------------QGEMEIERWERSEEISDAEKKVIQETWSRVYANCEDVGVSILIRFF-VNFPSAKQYFSQ-F-----KHMDDTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGN-DFT-P-EAHGAWTKMRTLIYTHVTAAYKE--AGWV-----------SYPSATL Chicken_GbE M--------------------------------------SFSEAEVQSARGAWEKMYVDAEDNGTAVLVRMF-TEHPDTKSYFTH-F-----KGMDSAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFGG-D------CKASFEKVTNEICTHLTNIYKE--AGW------------------- Chicken_HbA M--------------------------------------VLSAADKNNVKGIFTKIAGHAEEYGAETLERMF-TTYPPTKTYFPH-F-----D-L-----SHGSAQIKGHGKKVVAALIEAANHIDDI---AGTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHPA-ALT-P-EVHASLDKFLCAVGTVLTAKYR------------------------- Chicken_HbB MV-------------------------------------HWSAEEKQLITSVWSKVN--VEECGAEALARLL-IVYPWTQRFFAS-F-----GNLSSPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNIKN---TYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFAR-DFT-P-ACQFAWQKLVNVVAHALARKY-------------------------H Chicken_Mb M--------------------------------------GLSDQEWQQVLTIWGKVEADIAGHGHEVLMRLF-HDHPETLDRFDK-F-----KGLKTPDQMKGSEDLKKHGATVLTQLGKILKQKGNH---ESELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAA-DFG-A-DSQAAMKKALELFRNDMASKYKE--FGF-----------------QG Finch_Cygb MEK-------V---------------QGEMEIERWERSEEISDAEKKVIQEIWSRVYANCEDVGVSILIRFF-VNFPSAKQYFSQ-F-----KHMEDPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPN-DFT-P-EAHGAWTKMKTLIYTHVTAAYKE--VGWA-----------QYPTATL Finch_GbE M--------------------------------------SLSEAEVQSARGAWEKIYVDAEDNGTAVLVRMF-TEHPDTKSYFPH-F-----KGMDSAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFGG-D------CKASFEKVTNEICTHLNNIYKE--EGW------------------- Finch_HbA M--------------------------------------VLSAGDKSNVKAVFGKIGGQADEYGADALERMF-ATYPQTKTYFPH-F-----D-L-----GKGSAQVKGHGKKVAAALVEAANNVDDL---AGALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNPS-LLT-P-EVHASLDKFLCAVGTVLTAKYR------------------------- Finch_HbB MV-------------------------------------HWSAEEKQLIASVWGRVS--VEECGAEALARLL-IVYPWTQRFFSD-F-----GNLSSPTAIVGNPKVRAHGKKVLTSFGEAIKNLDNLKG---TYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFTK-EFT-P-ACQATWQKLVGVVAHALARKY-------------------------H Finch_Mb M--------------------------------------GLSDQEWQQVLTVWGKVESDLAGHGHQILMRLF-QDHPETLDRFEK-F-----KGLKTPDAMKGSEDLKKHGVTVLTQLGKILKAKGNH---EAELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAA-DFG-A-DAQAAMKKALELFRNDMATKYKE--FGF-----------------QG Frog_Cygb MEK-------V---------------QGENDMERWERLEEITESERGVIKETWARVYANCEDVGVSILIRFF-VNFPSAKQHFSQ-F-----KHMEDPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAK-DFT-P-DVQLAWNKLRSHLYSHVLSAYKE--AGWT-----------QYPSNSV Frog_GbY MA-------------------------------------DLTGADIENINEVWSKIYANPEESGRTVVISLF-LTYPQTKIYFKN-L-----KNISTLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALGS-GFT-P-EQSKSWEKLFSITYKYLESCYA---------------------NTDS Frog_HbA1 M--------------------------------------HLTADDKKHIKAIWPSVAAHGDKYGGEALHRMF-MCAPKTKTYFPD-F-----D-F-----SEHSKHILAHGKKVSDALNEACNHLDNI---AGCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFPK-QFD-P-ATHKALDKFLVSVSNVLTSKYR------------------------- Frog_HbB MV-------------------------------------NLTAKERQLITGTWSKIC--AKTLGKQALGSML-YTYPWTQRYFSS-F-----GNLSSIEAIFHNAAVATHGEKVLTSIGEAIKHMDDIKG---YYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQE-DFT-P-ELQAAFEKLFAAIADALGKGY-------------------------H Frog_NgB MEK-----------------------------------DQLSGPQKELIRESWQTVSQDQLHHGTVLFSSDIFQLKSGL--YWSS-EVPRECLIRVVHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKHR-AVGV-KLESFNTVGESLLFALESCLGD-AFT-S-DTREAWSLLYANVVQSMSRGWHRDSQE---------------QREGI Hagfish_Hb1 MPI-------T---------------D-------QGPLPTLSEGDKKAIRESWPQIYQNFEQTGLVVLLEFL-QKNPGAQQSFPK-F-----SATK--CNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTIR-------------GKAAYEKLFSIICTLLRSSYD------------------------E Hagfish_Hb2 MSA-------H-------------------------GIARTTEGERAAVRASWAVLMKDYEHAGVQILDKFF-KANPAAKPFFTK-M-----KDLHTLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKR-NG-GLS-G-EGKSGWHKVMTIICKMLKSKY-------------------------- Hagfish_Hb3 MPI-------T---------------D-------HGQPPTLSEGDKKAIRESWPQIYKNFEQNSLAVLLEFL-KKFPKAQDSFPK-F-----SAKK--SHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTMG-------------GKAAYEKLFSIIATLLRSTYD------------------------A Hagfish_Hb4 MPI-------T---------------D-------QRPLPTLSEGEKKAIKESWPQIYQNFEQTSLDVLIEFL-QKFPEAQDSFPK-F-----SAKK--CHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTIR-------------GKAAYEKLFSIICTLLRSSYD------------------------E Houndshark_HbA M--------------------------------------AFTACEKQTIGKIAQVLAKSPEAYGAECLARLF-VTHPGSKSYFEY-------KDY-----SAAGAKVQVHGGKVIRAVVKAAEHVDDL---HSHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHL-T-EFS-P-DTHCAVDKLLSAICQELSSRYR------------------------- Houndshark_HbB MV-------------------------------------HWTQEERDEISKTFQGTD--MKTVVTQALDRMF-KVYPWTNRYFQK-R-----TDFR----------SSIHAGIVVGALQDAVKHMDDVKT---LFKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRKD-CFT-P-HIQGIWDKFFEVVIDAISKQY-------------------------H Houndshark_Mb M------------------------------------------VDWEKVNSVWSAVESDLTAIGQNILLRLF-EQYPESQNHFPK-F-----KNKS-LGELKDTADIKAQADTVLSALGNIVKKKGSH---SQPVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPS-EMN-A-QVQAAFSGAFKIICSDIEKEYKA--ANF-----------------QG Human_Cygb MEKVPGEMEIE---------------R-------RERSEELSEAERKAVQAMWARLYANCEDVGVAILVRFF-VNFPSAKQYFSQ-F-----KHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFAS-DFP-P-ETQRAWAKLRGLIYSHVTAAYKE--VGWVQQVPNATTPPATLPSSGP Human_HbA M--------------------------------------VLSPADKTNVKAAWGKVGAHAGEYGAEALERMF-LSFPTTKTYFPH-F-----D-L-----SHGSAQVKGHGKKVADALTNAVAHVDDM---PNALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLPA-EFT-P-AVHASLDKFLASVSTVLTSKYR------------------------- Human_HbB MV-------------------------------------HLTPEEKSAVTALWGKVN--VDEVGGEALGRLL-VVYPWTQRFFES-F-----GDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKG---TFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFGK-EFT-P-PVQAAYQKVVAGVANALAHKY-------------------------H Human_Mb M--------------------------------------GLSDGEWQLVLNVWGKVEADIPGHGQEVLIRLF-KGHPETLEKFDK-F-----KHLKSEDEMKASEDLKKHGATVLTALGGILKKKGHH---EAEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPG-DFG-A-DAQGAMNKALELFRKDMASNYKE--LGF-----------------QG Human_NgB M----------------------------------------ERPEPELIRQSWRAVSRSPLEHGTVLFARLF-ALEPDLLPLFQYNC-----RQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHR-AVGV-KLSSFSTVGESLLYMLEKCLGP-AFT-P-ATRAAWSQLYGAVVQAMSRGW-----------------------DGE Medaka_Cygb_1 MER-------K---------------QG--EVDHLERSRPLTDKERVMIQDSWAKVYQNCDDAGVAILVRLF-VNFPSSKQYFSQ-F-----KHIEDAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQ-VMT-A-EVASAWTNLLAILCCSIKAVYEE--LGWP-----------HLSNSTS Medaka_Cygb_2 MSC-------RESPPPPSPPPQMLGVQRGECEDRPERAEPLSDAEMEIIQHTWGHVYKNCEDVGVSVLIRFF-VNFPSAKQYFSQ-F-----QDMQDPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPE-FFT-A-EVQLVWTKLMAAVYWHVTGAYTE--VGWL-----------QVSSSAV Medaka_HbA K-------------------------------------MSLSAKDKAAVKAFWAKVSGQADAIGSDALSRML-VVYPQTKTYFAH-W-----KDL-----SPGSAPVKKHGKTVMGGIADAVGKIDDI---SSGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFPQ-DFT-P-EVHVALDKFLAAVSLALSEKYR------------------------- Medaka_HbB MV-------------------------------------EWTEQERSIITNIFGNLD--YEDVGSKALSRCL-IVYPWTQRYFAS-F-----GNLYNAEAIKTNPNIAAHGTKVLHGLDRAVKNMDNIKA---TYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLGS-AFS-P-EIQATFQKFLAVVVSALGRQY-------------------------H Medaka_Mb M------------------------------------------ADYDMVLKHWGPVEADYNTHGNLVLTRLF-HEYPETQKLFPK-F-----AGIAK-GDMAGNAALSAHGATVLKKLGELLKARGNH---GAILKPLANSHATKHKI-PINNFRLITEVIGKVMAEKAGL---D-A-AGQQALRSVMAGIIAEIEADYKE--LGF-----------------AG Medaka_NgB ME-------------------------------------KLSGKDKELIRGSWESLGKNKVPHGVIMFSRLF-ELDPALLSLFNY-N-----TNCGSTQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKHQ-AVGV-STQSFAVVGESLLYMLQCSLGQ-AYT-A-ALSQAWLNMYSIVVAAMSRGWAK--NG---------------EDKAD Platypus_GbY M-------------------------------------VQVTDVEKANIQSIWSKMMENLEKNGIDIFTRLF-REYPETKKYFKN-I--------PLEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLGP-CYT-P-EIAESFQKLQSSLYDQVVITYLH--------------------SGSD Platypus_HbA M--------------------------------------GLTDGEKKEVAALWANVSGHEEEFGAEALDRLF-LSFPPTKTYFPH-F-----E-L-----SQGSAQVKAHGKKVADALTTAVAHLDDL---DSTLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLPA-EFT-P-SAHAALDKFLSKVATVLTSKYR------------------------- Platypus_HbB MV-------------------------------------HLSGGEKSAVTNLWGKVN--INELGGEALGRLL-VVYPWTQRFFEA-F-----GDLSSAGAVMGNPKVKAHGAKVLTSFGDALKNLDDLKG---TFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFSK-DFS-P-EVQAAWQKLVSGVAHALGHKY-------------------------H Platypus_HbW MV-------------------------------------NWTSEEKHAIVSIWGKVD--IEETGANALSRLL-VVYPWTQRYFSA-F-----GNLSSPTAIVGNPRVRAHGKKVLTSFGEAVKDLDHVKS---NFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLGK-DFT-P-EAQAAWQKLVGVVASALSSQY-------------------------H Platypus_Mb M--------------------------------------GLSDGEWQLVLKVWGKVEGDLPGHGQEVLIRLF-KTHPETLEKFDK-F-----KGLKTEDEMKASADLKKHGGTVLTALGNILKKKGQH---EAELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSA-DFG-A-DAQAAMGKALELFRNDMAAKYKE--FGF-----------------QG Platypus_NgB MEN-----------------------------------GRLSGPEQELIRESWRSVNSNPLEHGMILFTRLF-DLEPDLLPLFQYNC-----RQFSSPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKHK-AIGV-KLSSFSTVGESLLFMLEKCLGP-AFS-P-ATREAWTRLYTAMVHAMSRGW-----------------------GGE Port_Jackson_shark_Mb M------------------------------------------TEWEHVNKVWAVVEPDIPAVGLAILLRLF-KEHKETKDLFPK-F-----KEIP-VQQLGNNEDLRKHGVTVLRALGNILKQKGKH---STNVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPS-DMT-G-PMQESFSKVFTVICSDLETLYKE--ANF-----------------QG Sea_lamprey_Hb1a MPI-------V---------------D-------SGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIKFF-TSNPAAQAFFPK-F-----QGLTSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTVL------------PGDAGLEKLMSMICILLRSSY-------------------------- Sea_lamprey_Hb1b MPI-------V---------------D-------SGSVSPLSDAEKNKIRAAWDLVYKDYEKTGVDILVKFF-TGTPAAQAFFPK-F-----KGLTTADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTTA------------PGDAGFEKLMSMICILLSSAY-------------------------- Sea_lamprey_Hb2 MPI-------V---------------D-------TGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVKFF-TSTPAAQEFFPK-F-----KGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb3 MPI-------V---------------D-------SGSVAPLSAAEKTKIRSAWAPVYSNYETTGVDILVKFF-TSTPAAQEFFPK-F-----KGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb5 MPI-------V---------------D-------TGSVAPLSAAEKTKIRSAWAPVYSTYETSGVDILVKFF-TSTPAAQEFFPK-F-----KGLTTADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb_PMII MPI-------V---------------D-------TGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVKFF-TSTPAAQEFFPK-F-----KGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY-------------------------- Stingray_HbA M--------------------------------------VLSSQNKKAIEELGNLIKANAEAWGADALARLF-ELHPQTKTYFSK-F-----SGF-----EACNEQVKKHGKRVMNALADATHHLDNL---HLHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNL-Q-AFT-P-VTHCAVDKFLELVAYELSSCYR------------------------- Stingray_HbB MV-------------------------------------KLSEDQEHYIKGVWKDVD--HKQITAKALERVF-VVYPWTTRLFSK-L-----QGLFSAN----DIGVQQHADKVQRALGEAIDDLKKVEI---NFQNLSGKHQ-EIGV-DTQNFKLLGQTFMVELALHYKK-TFR-P-KEHAAAYKFFRLVAEALSSNY-------------------------H Tetraodon_Cygb_1 MER-------M---------------QRDGEVDHVEQPGPLTEKEKVMIQDSWAKVFQSCDDAGVAILVRFF-VNFPSSKQFFKD-F-----KHMEEPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTE-IIT-A-EVASAWTKLLANMCCGIAAVYKE--AGWT-----------ELSSSVE Tetraodon_Cygb_2 MSH-------R----EPPPPQLAVQRRDVDGQDGPERAEPLSDTEREMIRDAWGHVYKNCEDVGVSILIRFF-VNFPSAKQYFSQ-F-----QDMEEPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPE-FFT-A-DVQLVWSKLMATVYWHVTGAYTD--VGWL-----------QVSSSAV Tetraodon_HbA M-------------------------------------TSLSTKDKETVRAFWAKVASNREEIGASALCRLL-SVYPQTKTYFSH-W-----KDQ-----SPNSASAKKHGITIMNAVGDAVSKIDDL---KTGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYPA-DFT-P-EVHVAMDKFLASLALALSEKYR------------------------- Tetraodon_HbB MV-------------------------------------VWTDQERAIIDNIFSNLD--YEDVGSKALIRCL-IVYPWTQRYFSS-F-----GNLYNAEAIRNNPNVAKHGVTVLHGLDRALKNMDNIKE-------EYKKHSEKLHV-DPDNFKLLSDCLTVVIAGKLGS-KFT-P-EYQAALQKFLAVVVSALGRQY-------------------------H Tetraodon_Mb M------------------------------------------GDFDMVLKFWGPVEADYSAHGGMVLTRLF-TENPETQQLFPK-F-----VGIAQ-SELAGNAAVSAHGATVLKKLGELLKAKGNH---AAILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEKAGL---D-T-AGQQALRNIMATIIADIDATYKE--LGF------------------S Tetraodon_NgB ME-------------------------------------KLSSKDKELIRGSWDSLGKNKVPHGVILFSRLF-ELDPELLNLFHY-T-----TNCGSTQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKHQ-AVGV-KPQSFAMVGESLLYMLQCSLGQ-AYT-A-SLRQAWLNMYSVVVASMSRGWAK--NG---------------EDKAD Zebrafish_Cygb_1 MEG-------------------------DGGVQLTQSPDSLTEEDVCVIQDTWKPVYAERDNAGVAVLVRFF-TNFPSAKQYFEH-F-----RELQDPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQ-CFS-PAEVQSSWSKLMGILYWQMNRVYAE--VGW--------------ENSKK Zebrafish_Cygb_2 MEK-------E---------------REDEETEGRERPEPLTDVERGIIKDTWARVYASCEDVGVTILIRFF-VNFPSAKQYFSQ-F-----QDMEDPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGE-CFT-P-EVQTSWSKLMAALYWHITGAYTE--VGWV-----------KLSSSAV Zebrafish_HbA M--------------------------------------SLSDTDKAVVKAIWAKISPKADEIGAEALARML-TVYPQTKTYFSH-W-----ADL-----SPGSGPVKKHGKTIMGAVGEAVSKIDDL---VGGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFPA-DFT-P-EVHVSVDKFFNNLALALSEKYR------------------------- Zebrafish_HbB MV-------------------------------------EWTDAERTAILGLWGKLN--IDEIGPQALSRCL-IVYPWTQRYFAT-F-----GNLSSPAAIMGNPKVAAHGRTVMGGLERAIKNMDNVKN---TYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGFN-A-DVQEAWQKFLAVVVSALCRQY-------------------------H Zebrafish_Mb M------------------------------------------ADHDLVLKCWGAVEADYAANGGEVLNRLF-KEYPDTLKLFPK-F-----SGISQ-GDLAGSPAVAAHGATVLKKLGELLKAKGDH---AALLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEKAGL---D-A-AGQGALRRVMDAVIGDIDGYYKE--IGF-----------------AG Zebrafish_NgB ME-------------------------------------KLSEKDKGLIRDSWESLGKNKVPHGIVLFTRLF-ELDPALLTLFSY-S-----TNCGDAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKHQ-AVGV-NTQSFALVGESLLYMLQSSLGP-AYT-T-SLRQAWLTMYSIVVSAMTRGWAK--NG---------------EHKSN ; end; Alignment 10 of 20 file name: vertebrate_globins.NgB.aa.promal_wPDB.nex #NEXUS begin data; dimensions ntax=68 nchar=212; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb ---------------MEKVQGEMEIERWERNEEMSDAEKKMIQETWNTVYAKCEDVGVSLLIR-FFVNFPSAKH---YFSQ-FKHMEDPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHK-VEPVYFQLL-GVLLEVLAEEYTNEFSPPEVQRAWAKMKSLICTHVTAAYKEVGWVQYPNSTM----------- Anolis_GbY -----------------------------KAGKMTDLDRRHIREIWTAAFENPEENGRLVIIR-FFSDYPASKQ---YFKT-VPT---DGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQ-VPSGMFQLLFQAMLCTFDDLLGRTF-TPEKRVSWEKFFQVIQEEVEAAYDR---------------------- Anolis_HbA --------------------------------MLTEDDKNHIRAIWGHVSSNPELYGAEALTR-LFAAHHTTKT---YFPH--YDM-----SPGSAQIKAHGKKVVEAITQAVNNLDD---IAGALAKLADLHAEKLR-VDPVNFPLLGHCLLVTIAAHNRGPL-KPEFILALDKCFTSIGRVLIAQYR----------------------- Anolis_HbB ------------------------------MVHWTAEEKQLIANCWSKV--DIGQIGGDALAC-LLCVYPWTQR---FFPD-FGNLSNAAAICANAKVKAHGKKVLTAFGEAVKNLDN---IKDTFAKLSELHCDKLH-VDPVNFNLLGDVLIVCLAAHFGKDF-TPACHAAYQKLVNSVAHGLSRRYH----------------------- Anolis_Mb -------------------------------MELSDQEWQKVIDIWGKVEPEIPAYGQMVILR-LFEQHPETQE---KFDK-FKNLKSLDEMKNSEDLKKHGTIVLTALGKILKQKRQ---HEAELAPLAQSHATKHK-IPVKYLEFISEVIVGVIAEKRSADF-GAESQAAMRKALELFRNDMDRKYKELGFQG----------------- Arctic_lamprey_Hb1 ----------------------MPIVDSGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQE---FFPK-FKGMTSADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQ-VDPQYFKVLAAVIADTVA----------AGDAGFEKLMSMICILLRSAY------------------------ Arctic_lamprey_Hb2 ----------------------MPIVDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQE---FFPK-FQGLTSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQ-VDPQYFKVLAAVIVDTVL----------PGDAGLEKLMSMICILLKSSY------------------------ Arctic_lamprey_Hb4 ----------------------MPIEDSGSKPDFSDDEKKAIKDSWSGVYSEYESTSSEILIK-FFVDNPSAQD---FFPK-FKDLDSEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLN-VDAKFFKVLAEVILDKVAEKNDGSF-SDSARSAWEKLLTYICISLKVAY------------------------ Chicken_Cygb ---------------MEKVQGEMEIERWERSEEISDAEKKVIQETWSRVYANCEDVGVSILIR-FFVNFPSAKQ---YFSQ-FKHMDDTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHK-VEPVYFKKLTGVMLEVIAEAYGNDF-TPEAHGAWTKMRTLIYTHVTAAYKEAGWVSYPSATL----------- Chicken_GbE -------------------------------MSFSEAEVQSARGAWEKMYVDAEDNGTAVLVR-MFTEHPDTKS---YFTH-FKGMDSAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLK-IDPKNFRIICDIILQLMEEKFG-----GDCKASFEKVTNEICTHLTNIYKEAGW------------------- Chicken_HbA -------------------------------MVLSAADKNNVKGIFTKIAGHAEEYGAETLER-MFTTYPPTKT---YFPH-FDL------SHGSAQIKGHGKKVVAALIEAANHIDD---IAGTLSKLSDLHAHKLR-VDPVNFKLLGQCFLVVVAIHHPAAL-TPEVHASLDKFLCAVGTVLTAKYR----------------------- Chicken_HbB ------------------------------MVHWSAEEKQLITSVWSKV--NVEECGAEALAR-LLIVYPWTQR---FFAS-FGNLSSPTAIMGNPRVRAHGKKVLSSFGEAVKNLDN---IKNTYAKLSELHCDKLH-VDPENFRLLGDILIIVLASHFARDF-TPACQFAWQKLVNVVAHALARKYH----------------------- Chicken_Mb -------------------------------MGLSDQEWQQVLTIWGKVEADIAGHGHEVLMR-LFHDHPETLD---RFDK-FKGLKTPDQMKGSEDLKKHGATVLTQLGKILKQKGN---HESELKPLAQTHATKHK-IPVKYLEFISEVIIKVIAEKHAADF-GADSQAAMKKALELFRNDMASKYKEFGFQG----------------- Finch_Cygb ---------------MEKVQGEMEIERWERSEEISDAEKKVIQEIWSRVYANCEDVGVSILIR-FFVNFPSAKQ---YFSQ-FKHMEDPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHK-VEPIYFKKLTGVMLEVIAEEYPNDF-TPEAHGAWTKMKTLIYTHVTAAYKEVGWAQYPTATL----------- Finch_GbE -------------------------------MSLSEAEVQSARGAWEKIYVDAEDNGTAVLVR-MFTEHPDTKS---YFPH-FKGMDSAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLK-IDPKNFRIICDIILQLMEEKFG-----GDCKASFEKVTNEICTHLNNIYKEEGW------------------- Finch_HbA -------------------------------MVLSAGDKSNVKAVFGKIGGQADEYGADALER-MFATYPQTKT---YFPH-FDL------GKGSAQVKGHGKKVAAALVEAANNVDD---LAGALSKLSDLHAQKLR-VDPVNFKLLGQCFLVVVATRNPSLL-TPEVHASLDKFLCAVGTVLTAKYR----------------------- Finch_HbB ------------------------------MVHWSAEEKQLIASVWGRV--SVEECGAEALAR-LLIVYPWTQR---FFSD-FGNLSSPTAIVGNPKVRAHGKKVLTSFGEAIKNLDN---LKGTYSKLSELHCDKLH-VDPENFRLLGDILVIVLAAHFTKEF-TPACQATWQKLVGVVAHALARKYH----------------------- Finch_Mb -------------------------------MGLSDQEWQQVLTVWGKVESDLAGHGHQILMR-LFQDHPETLD---RFEK-FKGLKTPDAMKGSEDLKKHGVTVLTQLGKILKAKGN---HEAELKPLAQTHATKHK-IPVKYLEFISEVIIKVLAEKHAADF-GADAQAAMKKALELFRNDMATKYKEFGFQG----------------- Frog_Cygb ---------------MEKVQGENDMERWERLEEITESERGVIKETWARVYANCEDVGVSILIR-FFVNFPSAKQ---HFSQ-FKHMEDPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHK-VDPVYFKILTGVMLEVIAEEYAKDF-TPDVQLAWNKLRSHLYSHVLSAYKEAGWTQYPSNSV----------- Frog_GbY ------------------------------MADLTGADIENINEVWSKIYANPEESGRTVVIS-LFLTYPQTKI---YFKN-LKNISTLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHK-VEVNNFELLFLVIISVFKEALGSGF-TPEQSKSWEKLFSITYKYLESCYANTDS------------------- Frog_HbA1 -------------------------------MHLTADDKKHIKAIWPSVAAHGDKYGGEALHR-MFMCAPKTKT---YFPD-FDF------SEHSKHILAHGKKVSDALNEACNHLDN---IAGCLSKLSDLHAYDLR-VDPGNFPLLAHQILVVVAIHFPKQF-DPATHKALDKFLVSVSNVLTSKYR----------------------- Frog_HbB ------------------------------MVNLTAKERQLITGTWSKI--CAKTLGKQALGS-MLYTYPWTQR---YFSS-FGNLSSIEAIFHNAAVATHGEKVLTSIGEAIKHMDD---IKGYYAQLSKYHSETLH-VDPYNFKRFCSCTIISMAQTLQEDF-TPELQAAFEKLFAAIADALGKGYH----------------------- Frog_NgB ----------------------------MEKDQLSGPQKELIRESWQTVSQDQLHHGTVLFSSDIFQLKSGLYWSSEVPRE-CLIRVVHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKHR-AVG-VKLESFNTVGESLLFALESCLGDAF-TSDTREAWSLLYANVVQSMSRGWHRDSQEQREGI------------- Hagfish_Hb1 ----------------------MPITDQGPLPTLSEGDKKAIRESWPQIYQNFEQTGLVVLLE-FLQKNPGAQQ---SFPK-FSAT--KCNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQ-VDPKLFKELSAIFVSTI-----------RGKAAYEKLFSIICTLLRSSYDE---------------------- Hagfish_Hb2 ------------------------MSAH-GIARTTEGERAAVRASWAVLMKDYEHAGVQILDK-FFKANPAAKP---FFTK-MKDLHTLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKRNGGL--SGEGKSGWHKVMTIICKMLKSKY------------------------ Hagfish_Hb3 ----------------------MPITDHGQPPTLSEGDKKAIRESWPQIYKNFEQNSLAVLLE-FLKKFPKAQD---SFPK-FSAK--KSHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQ-VNPDMFKELSAVFVSTM-----------GGKAAYEKLFSIIATLLRSTYDA---------------------- Hagfish_Hb4 ----------------------MPITDQRPLPTLSEGEKKAIKESWPQIYQNFEQTSLDVLIE-FLQKFPEAQD---SFPK-FSAK--KCHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQ-VDPKMFKELSAIFVSTI-----------RGKAAYEKLFSIICTLLRSSYDE---------------------- Houndshark_HbA -------------------------------MAFTACEKQTIGKIAQVLAKSPEAYGAECLAR-LFVTHPGSKS---YFEY-KDY------SAAGAKVQVHGGKVIRAVVKAAEHVDD---LHSHLETLALTHGKKLL-VDPQNFPMLSECIIVTLATHLTEF--SPDTHCAVDKLLSAICQELSSRYR----------------------- Houndshark_HbB ------------------------------MVHWTQEERDEISKTFQGT--DMKTVVTQALDR-MFKVYPWTNR---YFQK-RTD----------FRSSIHAGIVVGALQDAVKHMDD---VKTLFKDLSKKHADDLH-VDPGSFHLLTDCIIVELAYLRKDCF-TPHIQGIWDKFFEVVIDAISKQYH----------------------- Houndshark_Mb -----------------------------------MVDWEKVNSVWSAVESDLTAIGQNILLR-LFEQYPESQN---HFPK-FKNKS-LGELKDTADIKAQADTVLSALGNIVKKKGS---HSQPVKALAATHITTHK-IPPHYFTKITTIAVDVLSEMYPSEM-NAQVQAAFSGAFKIICSDIEKEYKAANFQG----------------- Human_Cygb ---------------MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVR-FFVNFPSAKQ---YFSQ-FKHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHK-VEPVYFKILSGVILEVVAEEFASDF-PPETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATTPPATLPSSGP Human_HbA -------------------------------MVLSPADKTNVKAAWGKVGAHAGEYGAEALER-MFLSFPTTKT---YFPH-FDL------SHGSAQVKGHGKKVADALTNAVAHVDD---MPNALSALSDLHAHKLR-VDPVNFKLLSHCLLVTLAAHLPAEF-TPAVHASLDKFLASVSTVLTSKYR----------------------- Human_HbB ------------------------------MVHLTPEEKSAVTALWGKV--NVDEVGGEALGR-LLVVYPWTQR---FFES-FGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDN---LKGTFATLSELHCDKLH-VDPENFRLLGNVLVCVLAHHFGKEF-TPPVQAAYQKVVAGVANALAHKYH----------------------- Human_Mb -------------------------------MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIR-LFKGHPETLE---KFDK-FKHLKSEDEMKASEDLKKHGATVLTALGGILKKKGH---HEAEIKPLAQSHATKHK-IPVKYLEFISECIIQVLQSKHPGDF-GADAQGAMNKALELFRKDMASNYKELGFQG----------------- Human_NgB ---------------------------------MERPEPELIRQSWRAVSRSPLEHGTVLFAR-LFALEPDLLP---LFQYNCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHR-AVG-VKLSSFSTVGESLLYMLEKCLGPAF-TPATRAAWSQLYGAVVQAMSRGWDGE--------------------- Medaka_Cygb_1 -----------------MERKQGEVDHLERSRPLTDKERVMIQDSWAKVYQNCDDAGVAILVR-LFVNFPSSKQ---YFSQ-FKHIEDAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHK-VDPVYFKILSGVILEVLGEAYPQVM-TAEVASAWTNLLAILCCSIKAVYEELGWPHLSNSTS----------- Medaka_Cygb_2 MSCRESPPPPSPPPQMLGVQRGECEDRPERAEPLSDAEMEIIQHTWGHVYKNCEDVGVSVLIR-FFVNFPSAKQ---YFSQ-FQDMQDPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHK-VEPIYFKILSGVMLSVLSEDFPEFF-TAEVQLVWTKLMAAVYWHVTGAYTEVGWLQVSSSAV----------- Medaka_HbA ------------------------------KMSLSAKDKAAVKAFWAKVSGQADAIGSDALSR-MLVVYPQTKT---YFAH-WKDL-----SPGSAPVKKHGKTVMGGIADAVGKIDD---ISSGLLNLSELHAFTLR-VDPTNFKILSHNILVVMAIMFPQDF-TPEVHVALDKFLAAVSLALSEKYR----------------------- Medaka_HbB ------------------------------MVEWTEQERSIITNIFGNL--DYEDVGSKALSR-CLIVYPWTQR---YFAS-FGNLYNAEAIKTNPNIAAHGTKVLHGLDRAVKNMDN---IKATYAELSVLHSEKLH-VDPDNFKLLADCLTIVIAAKLGSAF-SPEIQATFQKFLAVVVSALGRQYH----------------------- Medaka_Mb -----------------------------------MADYDMVLKHWGPVEADYNTHGNLVLTR-LFHEYPETQK---LFPK-FAGIA-KGDMAGNAALSAHGATVLKKLGELLKARGN---HGAILKPLANSHATKHK-IPINNFRLITEVIGKVMAEKAGL---DAAGQQALRSVMAGIIAEIEADYKELGFAG----------------- Medaka_NgB ------------------------------MEKLSGKDKELIRGSWESLGKNKVPHGVIMFSR-LFELDPALLS---LFNY-NTNCGSTQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKHQ-AVG-VSTQSFAVVGESLLYMLQCSLGQAY-TAALSQAWLNMYSIVVAAMSRGWAKNGEDKAD--------------- Platypus_GbY ------------------------------MVQVTDVEKANIQSIWSKMMENLEKNGIDIFTR-LFREYPETKK---YFKN-IPL---EGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHS-VDVENFQFMLKCVGDVCQDYLGPCY-TPEIAESFQKLQSSLYDQVVITYLHSGSD------------------ Platypus_HbA -------------------------------MGLTDGEKKEVAALWANVSGHEEEFGAEALDR-LFLSFPPTKT---YFPH-FEL------SQGSAQVKAHGKKVADALTTAVAHLDD---LDSTLSALSDLHAHKLR-VDPINFKLLAHCILVVVARHLPAEF-TPSAHAALDKFLSKVATVLTSKYR----------------------- Platypus_HbB ------------------------------MVHLSGGEKSAVTNLWGKV--NINELGGEALGR-LLVVYPWTQR---FFEA-FGDLSSAGAVMGNPKVKAHGAKVLTSFGDALKNLDD---LKGTFAKLSELHCDKLH-VDPENFNRLGNVLIVVLARHFSKDF-SPEVQAAWQKLVSGVAHALGHKYH----------------------- Platypus_HbW ------------------------------MVNWTSEEKHAIVSIWGKV--DIEETGANALSR-LLVVYPWTQR---YFSA-FGNLSSPTAIVGNPRVRAHGKKVLTSFGEAVKDLDH---VKSNFAKLSQLHSEKLH-VDPENFRLLGDNLIIVLAATLGKDF-TPEAQAAWQKLVGVVASALSSQYH----------------------- Platypus_Mb -------------------------------MGLSDGEWQLVLKVWGKVEGDLPGHGQEVLIR-LFKTHPETLE---KFDK-FKGLKTEDEMKASADLKKHGGTVLTALGNILKKKGQ---HEAELKPLAQSHATKHK-ISIKFLEYISEAIIHVLQSKHSADF-GADAQAAMGKALELFRNDMAAKYKEFGFQG----------------- Platypus_NgB ----------------------------MENGRLSGPEQELIRESWRSVNSNPLEHGMILFTR-LFDLEPDLLP---LFQYNCRQFSSPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKHK-AIG-VKLSSFSTVGESLLFMLEKCLGPAF-SPATREAWTRLYTAMVHAMSRGWGGE--------------------- Port_Jackson_shark_Mb -----------------------------------MTEWEHVNKVWAVVEPDIPAVGLAILLR-LFKEHKETKD---LFPK-FKEIP-VQQLGNNEDLRKHGVTVLRALGNILKQKGK---HSTNVKELADTHINKHK-IPPKNFVLITNIAVKVLTEMYPSDM-TGPMQESFSKVFTVICSDLETLYKEANFQG----------------- Sea_lamprey_Hb1a ----------------------MPIVDSGSVPALTAAEKATIRTAWAPVYAKYQSTGVDILIK-FFTSNPAAQA---FFPK-FQGLTSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQ-VDPQYFKVLAAVIVDTVL----------PGDAGLEKLMSMICILLRSSY------------------------ Sea_lamprey_Hb1b ----------------------MPIVDSGSVSPLSDAEKNKIRAAWDLVYKDYEKTGVDILVK-FFTGTPAAQA---FFPK-FKGLTTADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFY-VDRQYFKVLAGIIADTTA----------PGDAGFEKLMSMICILLSSAY------------------------ Sea_lamprey_Hb2 ----------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQE---FFPK-FKGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQ-VDPQYFKVLAAVIADTVA----------AGDAGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb3 ----------------------MPIVDSGSVAPLSAAEKTKIRSAWAPVYSNYETTGVDILVK-FFTSTPAAQE---FFPK-FKGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQ-VDPQYFKVLAAVIADTVA----------AGDAGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb5 ----------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYSTYETSGVDILVK-FFTSTPAAQE---FFPK-FKGLTTADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQ-VDPQYFKVLAAVIADTVA----------AGDAGFEKLMSMICILLRSAY------------------------ Sea_lamprey_Hb_PMII ----------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYSNYETSGVDILVK-FFTSTPAAQE---FFPK-FKGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQ-VDPQYFKVLAAVIADTVA----------AGDAGFEKLMSMICILLRSAY------------------------ Stingray_HbB ------------------------------MVKLSEDQEHYIKGVWKDV--DHKQITAKALER-VFVVYPWTTR---LFSK-LQGLF----SANDIGVQQHADKVQRALGEAIDDLKK---VEINFQNLSGKHQ-EIG-VDTQNFKLLGQTFMVELALHYKKTF-RPKEHAAAYKFFRLVAEALSSNYH----------------------- Stingray_HbA -------------------------------MVLSSQNKKAIEELGNLIKANAEAWGADALAR-LFELHPQTKT---YFSK-FSGF-----EACNEQVKKHGKRVMNALADATHHLDN---LHLHLEDLARKHGENLL-VDPHNFHLFADCIVVTLAVNLQAF--TPVTHCAVDKFLELVAYELSSCYR----------------------- Tetraodon_Cygb_1 ---------------MERMQRDGEVDHVEQPGPLTEKEKVMIQDSWAKVFQSCDDAGVAILVR-FFVNFPSSKQ---FFKD-FKHMEEPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHN-VDPKYFKILSGVILEVLGEAFTEII-TAEVASAWTKLLANMCCGIAAVYKEAGWTELSSSVE----------- Tetraodon_Cygb_2 ----MSHREPPPPQLAVQRRDVDGQDGPERAEPLSDTEREMIRDAWGHVYKNCEDVGVSILIR-FFVNFPSAKQ---YFSQ-FQDMEEPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHK-VEPMYFKILSGVILEVLCEDFPEFF-TADVQLVWSKLMATVYWHVTGAYTDVGWLQVSSSAV----------- Tetraodon_HbA ------------------------------MTSLSTKDKETVRAFWAKVASNREEIGASALCR-LLSVYPQTKT---YFSH-WKDQ-----SPNSASAKKHGITIMNAVGDAVSKIDD---LKTGLFNLSELHAFTLR-VDPANFKLLAQCMMVVIAIMYPADF-TPEVHVAMDKFLASLALALSEKYR----------------------- Tetraodon_HbB ------------------------------MVVWTDQERAIIDNIFSNL--DYEDVGSKALIR-CLIVYPWTQR---YFSS-FGNLYNAEAIRNNPNVAKHGVTVLHGLDRALKNMDN---IKEEYKK----HSEKLH-VDPDNFKLLSDCLTVVIAGKLGSKF-TPEYQAALQKFLAVVVSALGRQYH----------------------- Tetraodon_Mb -----------------------------------MGDFDMVLKFWGPVEADYSAHGGMVLTR-LFTENPETQQ---LFPK-FVGIA-QSELAGNAAVSAHGATVLKKLGELLKAKGN---HAAILQPLANSHATKHK-IPIKNFKLIAEVIGKVMAEKAGL---DTAGQQALRNIMATIIADIDATYKELGFS------------------ Tetraodon_NgB ------------------------------MEKLSSKDKELIRGSWDSLGKNKVPHGVILFSR-LFELDPELLN---LFHY-TTNCGSTQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKHQ-AVG-VKPQSFAMVGESLLYMLQCSLGQAY-TASLRQAWLNMYSVVVASMSRGWAKNGEDKAD--------------- Zebrafish_Cygb_1 ------------------MEGDGGVQLTQSPDSLTEEDVCVIQDTWKPVYAERDNAGVAVLVR-FFTNFPSAKQ---YFEH-FRELQDPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHK-VDPVYFKILAGVILEVLVEAFPQCFSPAEVQSSWSKLMGILYWQMNRVYAEVGWENSKK-------------- Zebrafish_Cygb_2 ---------------MEKEREDEETEGRERPEPLTDVERGIIKDTWARVYASCEDVGVTILIR-FFVNFPSAKQ---YFSQ-FQDMEDPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYK-VEPVYFKILSGVILEILAEEFGECF-TPEVQTSWSKLMAALYWHITGAYTEVGWVKLSSSAV----------- Zebrafish_HbA -------------------------------MSLSDTDKAVVKAIWAKISPKADEIGAEALAR-MLTVYPQTKT---YFSH-WADL-----SPGSGPVKKHGKTIMGAVGEAVSKIDD---LVGGLAALSELHAFKLR-VDPANFKILSHNVIVVIAMLFPADF-TPEVHVSVDKFFNNLALALSEKYR----------------------- Zebrafish_HbB ------------------------------MVEWTDAERTAILGLWGKL--NIDEIGPQALSR-CLIVYPWTQR---YFAT-FGNLSSPAAIMGNPKVAAHGRTVMGGLERAIKNMDN---VKNTYAALSVMHSEKLH-VDPDNFRLLADCITVCAAMKFGQAGFNADVQEAWQKFLAVVVSALCRQYH----------------------- Zebrafish_Mb -----------------------------------MADHDLVLKCWGAVEADYAANGGEVLNR-LFKEYPDTLK---LFPK-FSGIS-QGDLAGSPAVAAHGATVLKKLGELLKAKGD---HAALLKPLANTHANIHK-VALNNFRLITEVLVKVMAEKAGL---DAAGQGALRRVMDAVIGDIDGYYKEIGFAG----------------- Zebrafish_NgB ------------------------------MEKLSEKDKGLIRDSWESLGKNKVPHGIVLFTR-LFELDPALLT---LFSY-STNCGDAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKHQ-AVG-VNTQSFALVGESLLYMLQSSLGPAY-TTSLRQAWLTMYSIVVSAMTRGWAKNGEHKSN--------------- ; end; Alignment 11 of 20 file name: vertebrate_globins.NgB_GbX_Ciona.aa.dialign.nex #NEXUS begin data; dimensions ntax=76 nchar=336; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb --------------------------------------------------------------------------------------------MEK---------------------------VQGEMEIERWE-----RNEE-----MSDAEKKMIQETWNTVYA-KCEDVGVSLLIRFFVNFPSAKHYFSQF-K----HMEDPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLLGVLLEVLAE-EYTNEF-SPP-EVQRAWAKMKSLICTHVTAAYKEVGWVQY-PNSTM----------------- Anolis_GbY ------------------------------------------------------------------------------------------------------------------------------------------KAGK-----MTDLDRRHIREIWTAAFE-NPEENGRLVIIRFFSDYPASKQYFKTV-PTD-------GDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFD-DLLGRT-FTP-EKRVSWEKFFQVIQEEVEAAYDR----------------------------- Anolis_HbA ---------------------------------------------------------------------------------------------------------------------------------------------M-----LTEDDKNHIRAIWGHVSS-NPELYGAEALTRLFAAHHTTKTYFPHY------DMSP-----GSAQIKAHGKKVVEAITQAVNNLDD---IAGALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIA-AHNRGP-LKP-EFILALDKCFTSIGRVLIAQYR------------------------------ Anolis_HbB -------------------------------------------------------------------------------------------------------------------------------------------MVH-----WTAEEKQLI--ANCWSKV-DIGQIGGDALACLLCVYPWTQRFFPDF-G----NLSNAAAICANAKVKAHGKKVLTAFGEAVKNLDN---IKDTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLA-AHFGKD-FTP-ACHAAYQKLVNSVAHGLSRRYH------------------------------ Anolis_Mb --------------------------------------------------------------------------------------------------------------------------------------------ME-----LSDQEWQKVIDIWGKVEP-EIPAYGQMVILRLFEQHPETQEKFDKF-K----NLKSLDEMKNSEDLKKHGTIVLTALGKILKQKRQ---HEAELAPLAQSHATKHKI-PVKYLEFISEVIVGVIA-EKRSAD-FGA-ESQAAMRKALELFRNDMDRKYKELGFQG------------------------ Arctic_lamprey_Hb1 ------------------------------------------------------------------------------------------------------------------------------MPIVDSG-----SVAP-----LSAAEKTKIRSAWAPVYS-NYETSGVDILVKFFTSTPAAQEFFPKF-K----GMTSADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGD------------AGFEKLMSMICILLRSAY------------------------------- Arctic_lamprey_Hb2 ------------------------------------------------------------------------------------------------------------------------------MPIVDSG-----SVPA-----LTAAEKATIRTAWAPVYA-KYQSTGVDILIKFFTSNPAAQEFFPKF-Q----GLTSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTVLPGD------------AGLEKLMSMICILLKSSY------------------------------- Arctic_lamprey_Hb4 ------------------------------------------------------------------------------------------------------------------------------MPIEDSG-----SKPD-----FSDDEKKAIKDSWSGVYS-EYESTSSEILIKFFVDNPSAQDFFPKF-K----DLDSEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVA-EKNDGS-FSD-SARSAWEKLLTYICISLKVAY------------------------------- Chicken_Cygb --------------------------------------------------------------------------------------------MEK---------------------------VQGEMEIERWE-----RSEE-----ISDAEKKVIQETWSRVYA-NCEDVGVSILIRFFVNFPSAKQYFSQF-K----HMDDTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIA-EAYGND-FTP-EAHGAWTKMRTLIYTHVTAAYKEAGWVSY-PSATL----------------- Chicken_GbE --------------------------------------------------------------------------------------------------------------------------------------------MS-----FSEAEVQSARGAWEKMYV-DAEDNGTAVLVRMFTEHPDTKSYFTHF-K----GMDSAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLME-EKFGGD-C-----KASFEKVTNEICTHLTNIYKEAGW-------------------------- Chicken_HbA --------------------------------------------------------------------------------------------------------------------------------------------MV-----LSAADKNNVKGIFTKIAG-HAEEYGAETLERMFTTYPPTKTYFPHF------DLSH-----GSAQIKGHGKKVVAALIEAANHIDD---IAGTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVA-IHHPAA-LTP-EVHASLDKFLCAVGTVLTAKYR------------------------------ Chicken_HbB -------------------------------------------------------------------------------------------------------------------------------------------MVH-----WSAEEKQLI--TSVWSKV-NVEECGAEALARLLIVYPWTQRFFASF-G----NLSSPTAIMGNPRVRAHGKKVLSSFGEAVKNLDN---IKNTYAKLSELHCDKLHV-DPENFRLLGDILIIVLA-SHFARD-FTP-ACQFAWQKLVNVVAHALARKYH------------------------------ Chicken_Mb --------------------------------------------------------------------------------------------------------------------------------------------MG-----LSDQEWQQVLTIWGKVEA-DIAGHGHEVLMRLFHDHPETLDRFDKF-K----GLKTPDQMKGSEDLKKHGATVLTQLGKILKQKGN---HESELKPLAQTHATKHKI-PVKYLEFISEVIIKVIA-EKHAAD-FGA-DSQAAMKKALELFRNDMASKYKEFGFQG------------------------ Finch_Cygb --------------------------------------------------------------------------------------------MEK---------------------------VQGEMEIERWE-----RSEE-----ISDAEKKVIQEIWSRVYA-NCEDVGVSILIRFFVNFPSAKQYFSQF-K----HMEDPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIA-EEYPND-FTP-EAHGAWTKMKTLIYTHVTAAYKEVGWAQY-PTATL----------------- Finch_GbE --------------------------------------------------------------------------------------------------------------------------------------------MS-----LSEAEVQSARGAWEKIYV-DAEDNGTAVLVRMFTEHPDTKSYFPHF-K----GMDSAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLME-EKFGGD-C-----KASFEKVTNEICTHLNNIYKEEGW-------------------------- Finch_HbA --------------------------------------------------------------------------------------------------------------------------------------------MV-----LSAGDKSNVKAVFGKIGG-QADEYGADALERMFATYPQTKTYFPHF------DLGK-----GSAQVKGHGKKVAAALVEAANNVDD---LAGALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVA-TRNPSL-LTP-EVHASLDKFLCAVGTVLTAKYR------------------------------ Finch_HbB -------------------------------------------------------------------------------------------------------------------------------------------MVH-----WSAEEKQLI--ASVWGRV-SVEECGAEALARLLIVYPWTQRFFSDF-G----NLSSPTAIVGNPKVRAHGKKVLTSFGEAIKNLDN---LKGTYSKLSELHCDKLHV-DPENFRLLGDILVIVLA-AHFTKE-FTP-ACQATWQKLVGVVAHALARKYH------------------------------ Finch_Mb --------------------------------------------------------------------------------------------------------------------------------------------MG-----LSDQEWQQVLTVWGKVES-DLAGHGHQILMRLFQDHPETLDRFEKF-K----GLKTPDAMKGSEDLKKHGVTVLTQLGKILKAKGN---HEAELKPLAQTHATKHKI-PVKYLEFISEVIIKVLA-EKHAAD-FGA-DAQAAMKKALELFRNDMATKYKEFGFQG------------------------ Frog_Cygb --------------------------------------------------------------------------------------------MEK---------------------------VQGENDMERWE-----RLEE-----ITESERGVIKETWARVYA-NCEDVGVSILIRFFVNFPSAKQHFSQF-K----HMEDPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIA-EEYAKD-FTP-DVQLAWNKLRSHLYSHVLSAYKEAGWTQY-PSNSV----------------- Frog_GbX M----------------------------------------------------------------GCILSSLGwqwrds-------------------------------------------------LDHTEtspllPTLN-----LSEQQQQLLVESWRLIQH-DIAKVGVILFVRLFETHPECKDVFFLF-R----DVDDLQALRANKDLRAHGLRVLSFVEKSVARIADCARLEELALELGRSXYRY-NA-PPRYYQYVGTEFISAVC-PMLHDK-WTA-EVEEAWKGLFAYICTVMERGYQEEERRHS-DGrslidglqgnkgli------ Frog_GbY -------------------------------------------------------------------------------------------------------------------------------------------MAD-----LTGADIENINEVWSKIYA-NPEESGRTVVISLFLTYPQTKIYFKNL-K----NISTLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFK-EALGSG-FTP-EQSKSWEKLFSITYKYLESCYANTDS-------------------------- Frog_HbA1 --------------------------------------------------------------------------------------------------------------------------------------------MH-----LTADDKKHIKAIWPSVAA-HGDKYGGEALHRMFMCAPKTKTYFPDF------DFSE-----HSKHILAHGKKVSDALNEACNHLDN---IAGCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVA-IHFPKQ-FDP-ATHKALDKFLVSVSNVLTSKYR------------------------------ Frog_HbB -------------------------------------------------------------------------------------------------------------------------------------------MVN-----LTAKERQLI--TGTWSKI-CAKTLGKQALGSMLYTYPWTQRYFSSF-G----NLSSIEAIFHNAAVATHGEKVLTSIGEAIKHMDD---IKGYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMA-QTLQED-FTP-ELQAAFEKLFAAIADALGKGYH------------------------------ Frog_NgB ------------------------------------------------------------------------------------------------------------------------------------M-----EKDQ-----LSGPQKELIRESWQTVSQ-DQLHHGTVLFSSDIFQLKSGLYWSSEV-PREclirvVHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKH-RAVGV-KLESFNTVGESLLFALE-SCLGDA-FTS-DTREAWSLLYANVVQSMSRGWHRDSQEQR-EGi------------------- Hagfish_Hb1 ------------------------------------------------------------------------------------------------------------------------------MPITDQG-----PLPT-----LSEGDKKAIRESWPQIYQ-NFEQTGLVVLLEFLQKNPGAQQSFPKF-S----ATKC--NLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTIR-GK------------AAYEKLFSIICTLLRSSYDE----------------------------- Hagfish_Hb2 msah--------------------------------------------------------------------------------------------------------------------------------------GIAR-----TTEGERAAVRASWAVLMK-DYEHAGVQILDKFFKANPAAKPFFTKM-K----DLHTLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVtDPQYFMILSQTILDEV--EKRNGG-LSG-EGKSGWHKVMTIICKMLKSKY------------------------------- Hagfish_Hb3 ------------------------------------------------------------------------------------------------------------------------------MPITDHG-----QPPT-----LSEGDKKAIRESWPQIYK-NFEQNSLAVLLEFLKKFPKAQDSFPKF-S----AKKS--HLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTMG-GK------------AAYEKLFSIIATLLRSTYDA----------------------------- Hagfish_Hb4 ------------------------------------------------------------------------------------------------------------------------------MPITDQR-----PLPT-----LSEGEKKAIKESWPQIYQ-NFEQTSLDVLIEFLQKFPEAQDSFPKF-S----AKKC--HLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTIR-GK------------AAYEKLFSIICTLLRSSYDE----------------------------- Houndshark_HbA --------------------------------------------------------------------------------------------------------------------------------------------MA-----FTACEKQTIGKIAQVLAK-SPEAYGAECLARLFVTHPGSKSYFEYK------DYSA-----AGAKVQVHGGKVIRAVVKAAEHVDD---LHSHLETLALTHGKKLLV-DPQNFPMLSECIIVTLA-THLTE--FSP-DTHCAVDKLLSAICQELSSRYR------------------------------ Houndshark_HbB -------------------------------------------------------------------------------------------------------------------------------------------MVH-----WTQEERDEI--SKTFQGT-DMKTVVTQALDRMFKVYPWTNRYFQKR-T----DFRSS----------IHAGIVVGALQDAVKHMDD---VKTLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELA-YLRKDC-FTP-HIQGIWDKFFEVVIDAISKQYH------------------------------ Houndshark_Mb M-----------------------------------------------------------------------------------------------------------------------------------------------------VDWEKVNSVWSAVES-DLTAIGQNILLRLFEQYPESQNHFPKF-K----NKSLGE-LKDTADIKAQADTVLSALGNIVKKKGS---HSQPVKALAATHITTHKI-PPHYFTKITTIAVDVLS-EMYPSE-MNA-QVQAAFSGAFKIICSDIEKEYKAANFQG------------------------ Human_Cygb --------------------------------------------------------------------------------------------MEK---------------------------VPGEMEIERRE-----RSEE-----LSEAERKAVQAMWARLYA-NCEDVGVAILVRFFVNFPSAKQYFSQF-K----HMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVA-EEFASD-FPP-ETQRAWAKLRGLIYSHVTAAYKEVGWVQqvPNATtppatlPSSGP------- Human_HbA --------------------------------------------------------------------------------------------------------------------------------------------MV-----LSPADKTNVKAAWGKVGA-HAGEYGAEALERMFLSFPTTKTYFPHF------DLSH-----GSAQVKGHGKKVADALTNAVAHVDD---MPNALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLA-AHLPAE-FTP-AVHASLDKFLASVSTVLTSKYR------------------------------ Human_HbB -------------------------------------------------------------------------------------------------------------------------------------------MVH-----LTPEEKSAV--TALWGKV-NVDEVGGEALGRLLVVYPWTQRFFESF-G----DLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDN---LKGTFATLSELHCDKLHV-DPENFRLLGNVLVCVLA-HHFGKE-FTP-PVQAAYQKVVAGVANALAHKYH------------------------------ Human_Mb --------------------------------------------------------------------------------------------------------------------------------------------MG-----LSDGEWQLVLNVWGKVEA-DIPGHGQEVLIRLFKGHPETLEKFDKF-K----HLKSEDEMKASEDLKKHGATVLTALGGILKKKGH---HEAEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQ-SKHPGD-FGA-DAQGAMNKALELFRKDMASNYKELGFQG------------------------ Human_NgB ---------------------------------------------------------------------------------------------------------------------------------------------------MERPEPELIRQSWRAVSR-SPLEHGTVLFARLFALEPDLLPLFQYNCR----QFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGV-KLSSFSTVGESLLYMLE-KCLGPA-FTP-ATRAAWSQLYGAVVQAMSRGWDGE---------------------------- Medaka_Cygb_1 m-------------------------------------------------------------------------------------------------------------------------ERKQGEVDHLE-----RSRP-----LTDKERVMIQDSWAKVYQ-NCDDAGVAILVRLFVNFPSSKQYFSQF-K----HIEDAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLG-EAYPQV-MTA-EVASAWTNLLAILCCSIKAVYEELGWPHL-SNSTs----------------- Medaka_Cygb_2 MS--------------------------------CR------------------------------------------ESPPPPSPPPQMLGVQRGECE------------------------------DRPE-----RAEP-----LSDAEMEIIQHTWGHVYK-NCEDVGVSVLIRFFVNFPSAKQYFSQF-Q----DMQDPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLS-EDFPEF-FTA-EVQLVWTKLMAAVYWHVTGAYTEVGWLQV-SSSAV----------------- Medaka_GbX M----------------------------------------------------------------GCAISGLAAKTD-------------------------------------------LAERSREDAa---------VEH-----PNEEQIQMIKDSWKVIRD-DIAKVGIIMFVRLFETHPECKDVFFLF-R----DVEDLERLRTNRELRAHGLRVMSFIEKSVARLDQPERLEALAVELGKSHYHY-NA-PPKYYNYVGAEFICAVQ-PILKEQ-WTT-ELEKAWQTLFQFVTALMKQGYQEESARQR-QLATS-----PKDRLDKRNTAL Medaka_HbA -------------------------------------------------------------------------------------------------------------------------------------------KMS-----LSAKDKAAVKAFWAKVSG-QADAIGSDALSRMLVVYPQTKTYFAHW-K----DLSP-----GSAPVKKHGKTVMGGIADAVGKIDD---ISSGLLNLSELHAFTLRV-DPTNFKILSHNILVVMA-IMFPQD-FTP-EVHVALDKFLAAVSLALSEKYR------------------------------ Medaka_HbB -------------------------------------------------------------------------------------------------------------------------------------------MVE-----WTEQERSII--TNIFGNL-DYEDVGSKALSRCLIVYPWTQRYFASF-G----NLYNAEAIKTNPNIAAHGTKVLHGLDRAVKNMDN---IKATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIA-AKLGSA-FSP-EIQATFQKFLAVVVSALGRQYH------------------------------ Medaka_Mb M-----------------------------------------------------------------------------------------------------------------------------------------------------ADYDMVLKHWGPVEA-DYNTHGNLVLTRLFHEYPETQKLFPKF-A----GIAKGD-MAGNAALSAHGATVLKKLGELLKARGN---HGAILKPLANSHATKHKI-PINNFRLITEVIGKVMA-EKAGLD-AAG---QQALRSVMAGIIAEIEADYKELGFAG------------------------ Medaka_NgB -------------------------------------------------------------------------------------------------------------------------------------------MEK-----LSGKDKELIRGSWESLGK-NKVPHGVIMFSRLFELDPALLSLFNYN-T----NCGSTQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKH-QAVGV-STQSFAVVGESLLYMLQ-CSLGQA-YTA-ALSQAWLNMYSIVVAAMSRGWAKNGEDKA-D--------------------- Platypus_GbY -------------------------------------------------------------------------------------------------------------------------------------------MVQ-----VTDVEKANIQSIWSKMME-NLEKNGIDIFTRLFREYPETKKYFKNI-PLE-------GNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQ-DYLGPC-YTP-EIAESFQKLQSSLYDQVVITYLHSGSD------------------------- Platypus_HbA --------------------------------------------------------------------------------------------------------------------------------------------MG-----LTDGEKKEVAALWANVSG-HEEEFGAEALDRLFLSFPPTKTYFPHF------ELSQ-----GSAQVKAHGKKVADALTTAVAHLDD---LDSTLSALSDLHAHKLRV-DPINFKLLAHCILVVVA-RHLPAE-FTP-SAHAALDKFLSKVATVLTSKYR------------------------------ Platypus_HbB -------------------------------------------------------------------------------------------------------------------------------------------MVH-----LSGGEKSAV--TNLWGKV-NINELGGEALGRLLVVYPWTQRFFEAF-G----DLSSAGAVMGNPKVKAHGAKVLTSFGDALKNLDD---LKGTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLA-RHFSKD-FSP-EVQAAWQKLVSGVAHALGHKYH------------------------------ Platypus_HbW -------------------------------------------------------------------------------------------------------------------------------------------MVN-----WTSEEKHAI--VSIWGKV-DIEETGANALSRLLVVYPWTQRYFSAF-G----NLSSPTAIVGNPRVRAHGKKVLTSFGEAVKDLDH---VKSNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLA-ATLGKD-FTP-EAQAAWQKLVGVVASALSSQYH------------------------------ Platypus_Mb --------------------------------------------------------------------------------------------------------------------------------------------MG-----LSDGEWQLVLKVWGKVEG-DLPGHGQEVLIRLFKTHPETLEKFDKF-K----GLKTEDEMKASADLKKHGGTVLTALGNILKKKGQ---HEAELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQ-SKHSAD-FGA-DAQAAMGKALELFRNDMAAKYKEFGFQG------------------------ Platypus_NgB ------------------------------------------------------------------------------------------------------------------------------------M-----ENGR-----LSGPEQELIRESWRSVNS-NPLEHGMILFTRLFDLEPDLLPLFQYNCR----QFSSPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKH-KAIGV-KLSSFSTVGESLLFMLE-KCLGPA-FSP-ATREAWTRLYTAMVHAMSRGWGGE---------------------------- Port_Jackson_shark_Mb M-----------------------------------------------------------------------------------------------------------------------------------------------------TEWEHVNKVWAVVEP-DIPAVGLAILLRLFKEHKETKDLFPKF-K----EIPVQQ-LGNNEDLRKHGVTVLRALGNILKQKGK---HSTNVKELADTHINKHKI-PPKNFVLITNIAVKVLT-EMYPSD-MTG-PMQESFSKVFTVICSDLETLYKEANFQG------------------------ Sea_lamprey_Hb1a ------------------------------------------------------------------------------------------------------------------------------MPIVDSG-----SVPA-----LTAAEKATIRTAWAPVYA-KYQSTGVDILIKFFTSNPAAQAFFPKF-Q----GLTSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTVLPGD------------AGLEKLMSMICILLRSSY------------------------------- Sea_lamprey_Hb1b ------------------------------------------------------------------------------------------------------------------------------MPIVDSG-----SVSP-----LSDAEKNKIRAAWDLVYK-DYEKTGVDILVKFFTGTPAAQAFFPKF-K----GLTTADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTTAPGD------------AGFEKLMSMICILLSSAY------------------------------- Sea_lamprey_Hb2 ------------------------------------------------------------------------------------------------------------------------------MPIVDTG-----SVAP-----LSAAEKTKIRSAWAPVYS-NYETSGVDILVKFFTSTPAAQEFFPKF-K----GLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGD------------AGFEKLMSMICILLRSAY------------------------------- Sea_lamprey_Hb3 ------------------------------------------------------------------------------------------------------------------------------MPIVDSG-----SVAP-----LSAAEKTKIRSAWAPVYS-NYETTGVDILVKFFTSTPAAQEFFPKF-K----GLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGD------------AGFEKLMSMICILLRSAY------------------------------- Sea_lamprey_Hb5 ------------------------------------------------------------------------------------------------------------------------------MPIVDTG-----SVAP-----LSAAEKTKIRSAWAPVYS-TYETSGVDILVKFFTSTPAAQEFFPKF-K----GLTTADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGD------------AGFEKLMSMICILLRSAY------------------------------- Sea_lamprey_Hb_PMII ------------------------------------------------------------------------------------------------------------------------------MPIVDTG-----SVAP-----LSAAEKTKIRSAWAPVYS-NYETSGVDILVKFFTSTPAAQEFFPKF-K----GLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGD------------AGFEKLMSMICILLRSAY------------------------------- Sea_squirt_Glb1 --------------------------------------------------------------------------------------------------------------------------------------------MP-----FTDEELKLLRDSWDEVKKLGMKEVGLHIFTGLLNAAPSLRTLFYTI-DLPDEEELTIDVMRENKKVVAHATRIANAISKFIKFLDQPDELEKLLTSLGESHARR-QV-DPESFEYVAPVILSVIG-GHLKLP-SNS-PTLQAWVKAYGVLRNGIVSAMEA----------------------------- Sea_squirt_Glb2 --------------------------------------------------------------------------------------------------------------------------------------------MG-----LTTEEIGLLRSSWNEMKTIGMKELGLLIFHRLFSDVPRIRKMFYNL-ELPDDETLTMEAMRSNQKMSRHATRIATSISTYLKLADQPEELKTFLNGLGELHAGH-NV-EPEDFEYLAPVMLAVIG-GQLNLN-SNS-SILQAWVKAYGVLRNGIVRGMYAyqg-------------------------- Sea_squirt_Glb3 --------------------------------------------------------------------------------------------------------------------------------------------MS-----LTSEQVVLLRSSWQTIGKLGMSNVGLAVLHRLFNDVPETLPFFHSV--LSPTQQTEIEVLKSNAKVVRHASRVGLSIDKIINLLDNGEELVKYLLFLGQVHVKR-SI-PRKYFSAMGPVLLSVIS-AVLEKD-LDA-PVMQAWATAYGVIEQGIIDGM------------------------------- Sea_squirt_Glb4 mkiicglilfstfaiifvsglncwtcnvlggnnvCRrsgglrtcfnnqvcynevrrrgntinirkGCKNSGVcenhimQSMSTPNPNNQCVNGPNYFCScccgnsvcnsnwltcvtagsvAPTVSTTV---PP-----ADEG-----LKRSDIINIQDSWNTLKGFGYETVGMLVLHRLFNDAPQTRYLFSQL-SLSSNESFTLEQMRNNSRVVYHANRVARAVGRLVDLIELPTNFTDHLVWLGQRHAYH-GV-APVNFDYMGPVLLETIK-VNLELP-SDS-PTLSAWAKAYGVIKNGIKDAIIAtyaeg------------------------ Stingray_HbA --------------------------------------------------------------------------------------------------------------------------------------------MV-----LSSQNKKAIEELGNLIKA-NAEAWGADALARLFELHPQTKTYFSKF-S----GFEA-----CNEQVKKHGKRVMNALADATHHLDN---LHLHLEDLARKHGENLLV-DPHNFHLFADCIVVTLA-VNLQA--FTP-VTHCAVDKFLELVAYELSSCYR------------------------------ Stingray_HbB -------------------------------------------------------------------------------------------------------------------------------------------MVK-----LSEDQEHYI--KGVWKDV-DHKQITAKALERVFVVYPWTTRLFSKL-Q----GLFSANDIG----VQQHADKVQRALG---EAIDDLKKVEINFQNLSGKH-QEIGV-DTQNFKLLGQTFMVELA-LHYKKT-FRP-KEHAAAYKFFRLVAEALSSNYH------------------------------ Tetraodon_Cygb_1 --------------------------------------------------------------------------------------------MER---------------------------MQRDGEVDHVE-----QPGP-----LTEKEKVMIQDSWAKVFQ-SCDDAGVAILVRFFVNFPSSKQFFKDF-K----HMEEPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLG-EAFTEI-ITA-EVASAWTKLLANMCCGIAAVYKEAGWTEL-SSSve----------------- Tetraodon_Cygb_2 MS--------------------------------HR------------------------------------------E------PPPPQLAVQR---------------------------RDVDGQ-DGPE-----RAEP-----LSDTEREMIRDAWGHVYK-NCEDVGVSILIRFFVNFPSAKQYFSQF-Q----DMEEPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLC-EDFPEF-FTA-DVQLVWSKLMATVYWHVTGAYTDVGWLQV-SSSAV----------------- Tetraodon_GbX M----------------------------------------------------------------GCAISSLGAKAE-------------------------------------------FGDRSAEE---ED-----AAAAaavvyPREDQIQMIKDSWKVIRD-DIAKVGIIMFVRLFETHPECKDVFFLF-R----DVEDLERLRSSRELRAHGLRVMSFIEKSVARLDQQDRLEALAVELGKSHYHY-NA-PPKYYSYVGAEFICAVQ-PILKER-FTS-ELEEAWKTLFQYVTGLMRKGHQEEGSRQR-HLALP-----PKDGPEKRTSAL Tetraodon_HbA -------------------------------------------------------------------------------------------------------------------------------------------MTS-----LSTKDKETVRAFWAKVAS-NREEIGASALCRLLSVYPQTKTYFSHW-K----DQSP-----NSASAKKHGITIMNAVGDAVSKIDD---LKTGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIA-IMYPAD-FTP-EVHVAMDKFLASLALALSEKYR------------------------------ Tetraodon_HbB -------------------------------------------------------------------------------------------------------------------------------------------MVV-----WTDQERAII--DNIFSNL-DYEDVGSKALIRCLIVYPWTQRYFSSF-G----NLYNAEAIRNNPNVAKHGVTVLHGLDRALKNMDN---IKEEY----KKHSEKLHV-DPDNFKLLSDCLTVVIA-GKLGSK-FTP-EYQAALQKFLAVVVSALGRQYH------------------------------ Tetraodon_Mb M-----------------------------------------------------------------------------------------------------------------------------------------------------GDFDMVLKFWGPVEA-DYSAHGGMVLTRLFTENPETQQLFPKF-V----GIAQSE-LAGNAAVSAHGATVLKKLGELLKAKGN---HAAILQPLANSHATKHKI-PIKNFKLIAEVIGKVMA-EKAGLD-TAG---QQALRNIMATIIADIDATYKELGFS------------------------- Tetraodon_NgB -------------------------------------------------------------------------------------------------------------------------------------------MEK-----LSSKDKELIRGSWDSLGK-NKVPHGVILFSRLFELDPELLNLFHYT-T----NCGSTQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKH-QAVGV-KPQSFAMVGESLLYMLQ-CSLGQA-YTA-SLRQAWLNMYSVVVASMSRGWAKNGEDKA-D--------------------- Zebrafish_Cygb_1 --------------------------------------------------------------------------------------------------------------------------MEGDGGVQLTQ-----SPDS-----LTEEDVCVIQDTWKPVYA-ERDNAGVAVLVRFFTNFPSAKQYFEHF-R----ELQDPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLV-EAFPQC-FSPaEVQSSWSKLMGILYWQMNRVYAEVGWENS-Kk-------------------- Zebrafish_Cygb_2 --------------------------------------------------------------------------------------------MEK---------------------------EREDEETEGRE-----RPEP-----LTDVERGIIKDTWARVYA-SCEDVGVTILIRFFVNFPSAKQYFSQF-Q----DMEDPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILA-EEFGEC-FTP-EVQTSWSKLMAALYWHITGAYTEVGWVKL-SSSAV----------------- Zebrafish_GbX M----------------------------------------------------------------GCAISGSGLTAG-------------------------------------------APEIRPGE---EE-----TPAG-----LTTNHIRLIKESWRLIQE-DIAKVGIIMFVRLFETHPECKDVFFLF-R----DVEDLERLRTSRELRAHGLRVMSFIEKSVARLDQLERLETLALELGKSHYRY-NA-PPKYYGYVGAEFICAVR-PILKDR-WTP-ELEEAWKTLFQYVTSIMREGFLEEERNKRsntqTS-----SRERPDKRSTAI Zebrafish_HbA --------------------------------------------------------------------------------------------------------------------------------------------MS-----LSDTDKAVVKAIWAKISP-KADEIGAEALARMLTVYPQTKTYFSHW-A----DLSP-----GSGPVKKHGKTIMGAVGEAVSKIDD---LVGGLAALSELHAFKLRV-DPANFKILSHNVIVVIA-MLFPAD-FTP-EVHVSVDKFFNNLALALSEKYR------------------------------ Zebrafish_HbB -------------------------------------------------------------------------------------------------------------------------------------------MVE-----WTDAERTAI--LGLWGKL-NIDEIGPQALSRCLIVYPWTQRYFATF-G----NLSSPAAIMGNPKVAAHGRTVMGGLERAIKNMDN---VKNTYAALSVMHSEKLHV-DPDNFRLLADCITVCAA-MKFGQAgFNA-DVQEAWQKFLAVVVSALCRQYH------------------------------ Zebrafish_Mb M-----------------------------------------------------------------------------------------------------------------------------------------------------ADHDLVLKCWGAVEA-DYAANGGEVLNRLFKEYPDTLKLFPKF-S----GISQGD-LAGSPAVAAHGATVLKKLGELLKAKGD---HAALLKPLANTHANIHKV-ALNNFRLITEVLVKVMA-EKAGLD-AAG---QGALRRVMDAVIGDIDGYYKEIGFAG------------------------ Zebrafish_NgB -------------------------------------------------------------------------------------------------------------------------------------------MEK-----LSEKDKGLIRDSWESLGK-NKVPHGIVLFTRLFELDPALLTLFSYS-T----NCGDAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKH-QAVGV-NTQSFALVGESLLYMLQ-SSLGPA-YTT-SLRQAWLTMYSIVVSAMTRGWAKNGEHKS-N--------------------- ; end; Alignment 12 of 20 file name: vertebrate_globins.NgB_GbX_Ciona.aa.kalign.nex #NEXUS begin data; dimensions ntax=76 nchar=389; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb ------------------------------------------------------------------------------------------------------------------------------------------------------------MEKVQGEME-IERWERNEE--MSDAEKKMIQETWNTVYA-KCEDVGVSLLIR-FFVNFPSAK--HYFSQF----KHM---EDPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLL-GVLLEVLAEEYTN--E-FSPP-EVQRA-WAKMKSLICTHVTAAY-KEVGWVQY------PNSTM-------------------------- Anolis_GbY ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAGK--MTDLDRRHIREIWTAAFE-NPEENGRLVIIR-FFSDYPASK--QY---F----KTV---PTDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLGR--T-F-TP-EKRVS-WEKFFQVIQEEVEAAY-DR------------------------------------------- Anolis_HbA ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--LTEDDKNHIRAIWGHVSS-NPELYGAEALTR-LFAAHHTTK--TYFPHY-----DM---S-----PGSAQIKAHGKKVVEAITQAVNNLDD---IAGALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNRG--P-L-KP-EFILA-LDKCFTSIGRVLIAQY-R-------------------------------------------- Anolis_HbB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVH--WTAEEKQLIANCWSKV---DIGQIGGDALAC-LLCVYPWTQ--RFFPDF----GNL---SNAAAICANAKVKAHGKKVLTAFGEAVKNLDN---IKDTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFGK--D-F-TP-ACHAA-YQKLVNSVAHGLSRRY-H-------------------------------------------- Anolis_Mb -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------ME--LSDQEWQKVIDIWGKVEP-EIPAYGQMVILR-LFEQHPETQ--EKFDKF----KNL---KSLDEMKNSEDLKKHGTIVLTALGKILKQKRQ---HEAELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSA--D-F-GA-ESQAA-MRKALELFRNDMDRKY-KELGFQG-------------------------------------- Arctic_lamprey_Hb1 ------------------------------------------------------------------------------------------------------------------------------------------------------------MPIVDSGSV--------AP--LSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQ--EFFPKF----KGM---TSADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG---------------FEKLMSMICILLRSAY---------------------------------------------- Arctic_lamprey_Hb2 ------------------------------------------------------------------------------------------------------------------------------------------------------------MPIVDSGSV--------PA--LTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNPAAQ--EFFPKF----QGL---TSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTVLPGDAG---------------LEKLMSMICILLKSSY---------------------------------------------- Arctic_lamprey_Hb4 ------------------------------------------------------------------------------------------------------------------------------------------------------------MPIEDSGSK--------PD--FSDDEKKAIKDSWSGVYS-EYESTSSEILIK-FFVDNPSAQ--DFFPKF----KDL---DSEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKNDGSFS------DSARSAWEKLLTYICISLKVAY---------------------------------------------- Chicken_Cygb ------------------------------------------------------------------------------------------------------------------------------------------------------------MEKVQGEME-IERWERSEE--ISDAEKKVIQETWSRVYA-NCEDVGVSILIR-FFVNFPSAK--QYFSQF----KHM---DDTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGN--D-F-TP-EAHGA-WTKMRTLIYTHVTAAY-KEAGWVSY------PSATL-------------------------- Chicken_GbE -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS--FSEAEVQSARGAWEKMYV-DAEDNGTAVLVR-MFTEHPDTK--SYFTHF----KGM---DSAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFGG---------DCKAS-FEKVTNEICTHLTNIY-KEAGW---------------------------------------- Chicken_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV--LSAADKNNVKGIFTKIAG-HAEEYGAETLER-MFTTYPPTK--TYFPHF-----DL---S-----HGSAQIKGHGKKVVAALIEAANHIDD---IAGTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHPA--A-L-TP-EVHAS-LDKFLCAVGTVLTAKY-R-------------------------------------------- Chicken_HbB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVH--WSAEEKQLITSVWSKV---NVEECGAEALAR-LLIVYPWTQ--RFFASF----GNL---SSPTAIMGNPRVRAHGKKVLSSFGEAVKNLDN---IKNTYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFAR--D-F-TP-ACQFA-WQKLVNVVAHALARKY-H-------------------------------------------- Chicken_Mb -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG--LSDQEWQQVLTIWGKVEA-DIAGHGHEVLMR-LFHDHPETL--DRFDKF----KGL---KTPDQMKGSEDLKKHGATVLTQLGKILKQKGN---HESELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAA--D-F-GA-DSQAA-MKKALELFRNDMASKY-KEFGFQG-------------------------------------- Finch_Cygb ------------------------------------------------------------------------------------------------------------------------------------------------------------MEKVQGEME-IERWERSEE--ISDAEKKVIQEIWSRVYA-NCEDVGVSILIR-FFVNFPSAK--QYFSQF----KHM---EDPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPN--D-F-TP-EAHGA-WTKMKTLIYTHVTAAY-KEVGWAQY------PTATL-------------------------- Finch_GbE -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS--LSEAEVQSARGAWEKIYV-DAEDNGTAVLVR-MFTEHPDTK--SYFPHF----KGM---DSAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFGG---------DCKAS-FEKVTNEICTHLNNIY-KEEGW---------------------------------------- Finch_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV--LSAGDKSNVKAVFGKIGG-QADEYGADALER-MFATYPQTK--TYFPHF-----DL---G-----KGSAQVKGHGKKVAAALVEAANNVDD---LAGALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNPS--L-L-TP-EVHAS-LDKFLCAVGTVLTAKY-R-------------------------------------------- Finch_HbB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVH--WSAEEKQLIASVWGRV---SVEECGAEALAR-LLIVYPWTQ--RFFSDF----GNL---SSPTAIVGNPKVRAHGKKVLTSFGEAIKNLDN---LKGTYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFTK--E-F-TP-ACQAT-WQKLVGVVAHALARKY-H-------------------------------------------- Finch_Mb -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG--LSDQEWQQVLTVWGKVES-DLAGHGHQILMR-LFQDHPETL--DRFEKF----KGL---KTPDAMKGSEDLKKHGVTVLTQLGKILKAKGN---HEAELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAA--D-F-GA-DAQAA-MKKALELFRNDMATKY-KEFGFQG-------------------------------------- Frog_Cygb ------------------------------------------------------------------------------------------------------------------------------------------------------------MEKVQGEND-MERWERLEE--ITESERGVIKETWARVYA-NCEDVGVSILIR-FFVNFPSAK--QHFSQF----KHM---EDPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAK--D-F-TP-DVQLA-WNKLRSHLYSHVLSAY-KEAGWTQY------PSNSV-------------------------- Frog_GbX ---------------------------------------------------------------------------------------------------------------MGCILSSLGWQWRDSL-DHTET---SPLLP-T------------------------------LN--LSEQQQQLLVESWRLIQH-DIAKVGVILFVR-LFETHPECK--DVFFLF----RDV---DDLQALRANKDLRAHGLRVLSFVEKSVARIADCARLEELALELGRSX-YRYNA-PPRYYQYVGTEFISAVCPMLHD--K-W-TA-EVEEA-WKGLFAYICTVMERGY----------------------QEEERRHSDGRSLIDGLQGNKGLI Frog_GbY ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAD--LTGADIENINEVWSKIYA-NPEESGRTVVIS-LFLTYPQTK--IYFKNL----KNI---STLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALGS--G-F-TP-EQSKS-WEKLFSITYKYLESCY---------------ANTDS-------------------------- Frog_HbA1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MH--LTADDKKHIKAIWPSVAA-HGDKYGGEALHR-MFMCAPKTK--TYFPDF-----DF---S-----EHSKHILAHGKKVSDALNEACNHLDN---IAGCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFPK--Q-F-DP-ATHKA-LDKFLVSVSNVLTSKY-R-------------------------------------------- Frog_HbB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVN--LTAKERQLITGTWSKI---CAKTLGKQALGS-MLYTYPWTQ--RYFSSF----GNL---SSIEAIFHNAAVATHGEKVLTSIGEAIKHMDD---IKGYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQE--D-F-TP-ELQAA-FEKLFAAIADALGKGY-H-------------------------------------------- Frog_NgB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEKDQLSGPQKELIRESWQTVSQ-DQLHHGTVLFSSDIFQLKSGLYWSSEVPR------ECLIRVVHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKH-RAVGV-KLESFNTVGESLLFALESCLGD--A-F-TS-DTREA-WSLLYANVVQSMSRGW---------------HRDSQ--------------------EQREGI Hagfish_Hb1 ------------------------------------------------------------------------------------------------------------------------------------------------------------MPITDQGPL-PT---------LSEGDKKAIRESWPQIYQ-NFEQTGLVVLLE-FLQKNPGAQ--QSFPKF--------S-ATKCNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTI---------------RGKAA-YEKLFSIICTLLRSSY-----------DE--------------------------------- Hagfish_Hb2 ---------------------------------------------------------------------------------------------------------------------------------------------------------------MSAHGI--------AR--TTEGERAAVRASWAVLMK-DYEHAGVQILDK-FFKANPAAK--PFFTKM----KDL---HTLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKRNGG-LS------GEGKSGWHKVMTIICKMLKSKY---------------------------------------------- Hagfish_Hb3 ------------------------------------------------------------------------------------------------------------------------------------------------------------MPITDHGQP-PT---------LSEGDKKAIRESWPQIYK-NFEQNSLAVLLE-FLKKFPKAQ--DSFPKF--------S-AKKSHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTM---------------GGKAA-YEKLFSIIATLLRSTY-----------DA--------------------------------- Hagfish_Hb4 ------------------------------------------------------------------------------------------------------------------------------------------------------------MPITDQRPL-PT---------LSEGEKKAIKESWPQIYQ-NFEQTSLDVLIE-FLQKFPEAQ--DSFPKF--------S-AKKCHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTI---------------RGKAA-YEKLFSIICTLLRSSY-----------DE--------------------------------- Houndshark_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA--FTACEKQTIGKIAQVLAK-SPEAYGAECLAR-LFVTHPGSK--SYF-------------EYKDYSAAGAKVQVHGGKVIRAVVKAAEHVDD---LHSHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHLTE----F-SP-DTHCA-VDKLLSAICQELSSRY-R-------------------------------------------- Houndshark_HbB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVH--WTQEERDEISKTFQGT---DMKTVVTQALDR-MFKVYPWTN--RYFQKR----TDF-------------RSSIHAGIVVGALQDAVKHMDD---VKTLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRKD--C-F-TP-HIQGI-WDKFFEVVIDAISKQY-H-------------------------------------------- Houndshark_Mb -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------VDWEKVNSVWSAVES-DLTAIGQNILLR-LFEQYPESQ--NHFPKF----KN----KSLGELKDTADIKAQADTVLSALGNIVKKKGS---HSQPVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPS--E-M-NA-QVQAA-FSGAFKIICSDIEKEY-KAANFQG-------------------------------------- Human_Cygb ------------------------------------------------------------------------------------------------------------------------------------------------------------MEKVPGEME-IERRERSEE--LSEAERKAVQAMWARLYA-NCEDVGVAILVR-FFVNFPSAK--QYFSQF----KHM---EDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFAS--D-F-PP-ETQRA-WAKLRGLIYSHVTAAY-KEVGWVQQVPNATTPPATLPSSGP--------------------- Human_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV--LSPADKTNVKAAWGKVGA-HAGEYGAEALER-MFLSFPTTK--TYFPHF-----DL---S-----HGSAQVKGHGKKVADALTNAVAHVDD---MPNALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLPA--E-F-TP-AVHAS-LDKFLASVSTVLTSKY-R-------------------------------------------- Human_HbB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVH--LTPEEKSAVTALWGKV---NVDEVGGEALGR-LLVVYPWTQ--RFFESF----GDL---STPDAVMGNPKVKAHGKKVLGAFSDGLAHLDN---LKGTFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFGK--E-F-TP-PVQAA-YQKVVAGVANALAHKY-H-------------------------------------------- Human_Mb -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG--LSDGEWQLVLNVWGKVEA-DIPGHGQEVLIR-LFKGHPETL--EKFDKF----KHL---KSEDEMKASEDLKKHGATVLTALGGILKKKGH---HEAEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPG--D-F-GA-DAQGA-MNKALELFRKDMASNY-KELGFQG-------------------------------------- Human_NgB ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERPEPELIRQSWRAVSR-SPLEHGTVLFAR-LFALEPDLL--PLFQY------NCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGV-KLSSFSTVGESLLYMLEKCLGP--A-F-TP-ATRAA-WSQLYGAVVQAMSRGW---------------DGE---------------------------- Medaka_Cygb_1 ------------------------------------------------------------------------------------------------------------------------------------------------------------MER--KQGE-VDHLERSRP--LTDKERVMIQDSWAKVYQ-NCDDAGVAILVR-LFVNFPSSK--QYFSQF----KHI---EDAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQ--V-M-TA-EVASA-WTNLLAILCCSIKAVY-EELGWPHL------SNSTS-------------------------- Medaka_Cygb_2 --------------------------------------------------------------------------------------------------------------------------------------------MSCRESPPPPSPPPQMLGVQRGECE--DRPERAEP--LSDAEMEIIQHTWGHVYK-NCEDVGVSVLIR-FFVNFPSAK--QYFSQF----QDM---QDPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPE--F-F-TA-EVQLV-WTKLMAAVYWHVTGAY-TEVGWLQV------SSSAV-------------------------- Medaka_GbX ---------------------------------------------------------------------------------------------------------------MGCAISGLAAKTDLAE-RSRED------AA-V------------------------------EH--PNEEQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHPECK--DVFFLF----RDV---EDLERLRTNRELRAHGLRVMSFIEKSVARLDQPERLEALAVELGKSH-YHYNA-PPKYYNYVGAEFICAVQPILKE--Q-W-TT-ELEKA-WQTLFQFVTALMKQGY-Q--------------------EESARQRQLATSPKDRLDKRNTAL Medaka_HbA ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMS--LSAKDKAAVKAFWAKVSG-QADAIGSDALSR-MLVVYPQTK--TYFAHW----KDL---S-----PGSAPVKKHGKTVMGGIADAVGKIDD---ISSGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFPQ--D-F-TP-EVHVA-LDKFLAAVSLALSEKY-R-------------------------------------------- Medaka_HbB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVE--WTEQERSIITNIFGNL---DYEDVGSKALSR-CLIVYPWTQ--RYFASF----GNL---YNAEAIKTNPNIAAHGTKVLHGLDRAVKNMDN---IKATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLGS--A-F-SP-EIQAT-FQKFLAVVVSALGRQY-H-------------------------------------------- Medaka_Mb -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------ADYDMVLKHWGPVEA-DYNTHGNLVLTR-LFHEYPETQ--KLFPKF----AG----IAKGDMAGNAALSAHGATVLKKLGELLKARGN---HGAILKPLANSHATKHKI-PINNFRLITEVIGKVMAEK--A--G-L-DA-AGQQA-LRSVMAGIIAEIEADY-KELGFAG-------------------------------------- Medaka_NgB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEK--LSGKDKELIRGSWESLGK-NKVPHGVIMFSR-LFELDPALL--SLFNYN----TNC---GSTQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKH-QAVGV-STQSFAVVGESLLYMLQCSLGQ--A-Y-TA-ALSQA-WLNMYSIVVAAMSRGW---------------AKNGE--------------------DKAD-- Platypus_GbY ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVQ--VTDVEKANIQSIWSKMME-NLEKNGIDIFTR-LFREYPETK--KYFKNI----------PLEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLGP--C-Y-TP-EIAES-FQKLQSSLYDQVVITY------------LH-SGSD--------------------------- Platypus_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG--LTDGEKKEVAALWANVSG-HEEEFGAEALDR-LFLSFPPTK--TYFPHF-----EL---S-----QGSAQVKAHGKKVADALTTAVAHLDD---LDSTLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLPA--E-F-TP-SAHAA-LDKFLSKVATVLTSKY-R-------------------------------------------- Platypus_HbB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVH--LSGGEKSAVTNLWGKV---NINELGGEALGR-LLVVYPWTQ--RFFEAF----GDL---SSAGAVMGNPKVKAHGAKVLTSFGDALKNLDD---LKGTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFSK--D-F-SP-EVQAA-WQKLVSGVAHALGHKY-H-------------------------------------------- Platypus_HbW ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVN--WTSEEKHAIVSIWGKV---DIEETGANALSR-LLVVYPWTQ--RYFSAF----GNL---SSPTAIVGNPRVRAHGKKVLTSFGEAVKDLDH---VKSNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLGK--D-F-TP-EAQAA-WQKLVGVVASALSSQY-H-------------------------------------------- Platypus_Mb -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG--LSDGEWQLVLKVWGKVEG-DLPGHGQEVLIR-LFKTHPETL--EKFDKF----KGL---KTEDEMKASADLKKHGGTVLTALGNILKKKGQ---HEAELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSA--D-F-GA-DAQAA-MGKALELFRNDMAAKY-KEFGFQG-------------------------------------- Platypus_NgB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENGRLSGPEQELIRESWRSVNS-NPLEHGMILFTR-LFDLEPDLL--PLFQY------NCRQFSSPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKH-KAIGV-KLSSFSTVGESLLFMLEKCLGP--A-F-SP-ATREA-WTRLYTAMVHAMSRGW---------------GGE---------------------------- Port_Jackson_shark_Mb -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------TEWEHVNKVWAVVEP-DIPAVGLAILLR-LFKEHKETK--DLFPKF----KE----IPVQQLGNNEDLRKHGVTVLRALGNILKQKGK---HSTNVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPS--D-M-TG-PMQES-FSKVFTVICSDLETLY-KEANFQG-------------------------------------- Sea_lamprey_Hb1a ------------------------------------------------------------------------------------------------------------------------------------------------------------MPIVDSGSV--------PA--LTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNPAAQ--AFFPKF----QGL---TSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTVLPGDAG---------------LEKLMSMICILLRSSY---------------------------------------------- Sea_lamprey_Hb1b ------------------------------------------------------------------------------------------------------------------------------------------------------------MPIVDSGSV--------SP--LSDAEKNKIRAAWDLVYK-DYEKTGVDILVK-FFTGTPAAQ--AFFPKF----KGL---TTADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTTAPGDAG---------------FEKLMSMICILLSSAY---------------------------------------------- Sea_lamprey_Hb2 ------------------------------------------------------------------------------------------------------------------------------------------------------------MPIVDTGSV--------AP--LSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQ--EFFPKF----KGL---TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG---------------FEKLMSMICILLRSAY---------------------------------------------- Sea_lamprey_Hb3 ------------------------------------------------------------------------------------------------------------------------------------------------------------MPIVDSGSV--------AP--LSAAEKTKIRSAWAPVYS-NYETTGVDILVK-FFTSTPAAQ--EFFPKF----KGL---TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG---------------FEKLMSMICILLRSAY---------------------------------------------- Sea_lamprey_Hb5 ------------------------------------------------------------------------------------------------------------------------------------------------------------MPIVDTGSV--------AP--LSAAEKTKIRSAWAPVYS-TYETSGVDILVK-FFTSTPAAQ--EFFPKF----KGL---TTADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG---------------FEKLMSMICILLRSAY---------------------------------------------- Sea_lamprey_Hb_PMII ------------------------------------------------------------------------------------------------------------------------------------------------------------MPIVDTGSV--------AP--LSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQ--EFFPKF----KGL---TTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG---------------FEKLMSMICILLRSAY---------------------------------------------- Sea_squirt_Glb1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MP--FTDEELKLLRDSWDEVKKLGMKEVGLHIFTG-LLNAAPSLR--TLFYTIDLPDEEE---LTIDVMRENKKVVAHATRIANAISKFIKFLDQPDELEKLLTSLGESH-ARRQV-DPESFEYVAPVILSVIGGHLKL--P-S-NS-PTLQA-WVKAYGVLRNGIVSAM---------------EA----------------------------- Sea_squirt_Glb2 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG--LTTEEIGLLRSSWNEMKTIGMKELGLLIFHR-LFSDVPRIR--KMFYNLELPDDET---LTMEAMRSNQKMSRHATRIATSISTYLKLADQPEELKTFLNGLGELH-AGHNV-EPEDFEYLAPVMLAVIGGQLNL--N-S-NS-SILQA-WVKAYGVLRNGIVRGM---------------YAYQG-------------------------- Sea_squirt_Glb3 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS--LTSEQVVLLRSSWQTIGKLGMSNVGLAVLHR-LFNDVPETL--PFFHSV-LS-PTQ-Q-TEIEVLKSNAKVVRHASRVGLSIDKIINLLDNGEELVKYLLFLGQVH-VKRSI-PRKYFSAMGPVLLSVISAVLEK--D-L-DA-PVMQA-WATAYGVIEQGIIDGM---------------------------------------------- Sea_squirt_Glb4 MKIICGLILFSTFAIIFVSGLNCWTCNVLGGNNVCRRSGGLRTCFNNQVCYNEVRRRGNTINIRKGCKNSGVCENHIMQSMSTPNPNNQCVNGPNYFCSCCCGNSVCNSNWLTCVTAGSVAPTVSTT-----------------------------VPPADEG--------------LKRSDIINIQDSWNTLKGFGYETVGMLVLHR-LFNDAPQTR--YLFSQLSLS-SNE-S-FTLEQMRNNSRVVYHANRVARAVGRLVDLIELPTNFTDHLVWLGQRH-AYHGV-APVNFDYMGPVLLETIKVNLEL--P-S-DS-PTLSA-WAKAYGVIKNGIKDAI------------I--ATYAE--G----------------------- Stingray_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV--LSSQNKKAIEELGNLIKA-NAEAWGADALAR-LFELHPQTK--TYFSKF----SGF-E-------ACNEQVKKHGKRVMNALADATHHLDN---LHLHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNLQA----F-TP-VTHCA-VDKFLELVAYELSSCY-R-------------------------------------------- Stingray_HbB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVK--LSEDQEHYIKGVWKDV---DHKQITAKALER-VFVVYPWTT--RLFSKL----QGL-F------SANDIGVQQHADKVQRALGEAIDDLKK---VEINFQNLSGKH-QEIGV-DTQNFKLLGQTFMVELALHYKK--T-F-RP-KEHAA-AYKFFRLVAEALSSNY-H-------------------------------------------- Tetraodon_Cygb_1 ------------------------------------------------------------------------------------------------------------------------------------------------------------MERMQRDGE-VDHVEQPGP--LTEKEKVMIQDSWAKVFQ-SCDDAGVAILVR-FFVNFPSSK--QFFKDF----KHM---EEPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTE--I-I-TA-EVASA-WTKLLANMCCGIAAVY-KEAGWTEL------SSSVE-------------------------- Tetraodon_Cygb_2 --------------------------------------------------------------------------------------------------------------------------------------------MSHREPPPPQ------LAVQRRDVDGQDGPERAEP--LSDTEREMIRDAWGHVYK-NCEDVGVSILIR-FFVNFPSAK--QYFSQF----QDM---EEPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPE--F-F-TA-DVQLV-WSKLMATVYWHVTGAY-TDVGWLQV------SSSAV-------------------------- Tetraodon_GbX ---------------------------------------------------------------------------------------------------------------MGCAISSLGAKAEFGD-RSAEEEDAAAAAA-V------------------------------VY--PREDQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHPECK--DVFFLF----RDV---EDLERLRSSRELRAHGLRVMSFIEKSVARLDQQDRLEALAVELGKSH-YHYNA-PPKYYSYVGAEFICAVQPILKE--R-F-TS-ELEEA-WKTLFQYVTGLMRKGH-Q--------------------EEGSRQRHLALPPKDGPEKRTSAL Tetraodon_HbA ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTS--LSTKDKETVRAFWAKVAS-NREEIGASALCR-LLSVYPQTK--TYFSHW----KDQ---S-----PNSASAKKHGITIMNAVGDAVSKIDD---LKTGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYPA--D-F-TP-EVHVA-MDKFLASLALALSEKY-R-------------------------------------------- Tetraodon_HbB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVV--WTDQERAIIDNIFSNL---DYEDVGSKALIR-CLIVYPWTQ--RYFSSF----GNL---YNAEAIRNNPNVAKHGVTVLHGLDRALKNMDN---IKEEYKK----HSEKLHV-DPDNFKLLSDCLTVVIAGKLGS--K-F-TP-EYQAA-LQKFLAVVVSALGRQY-H-------------------------------------------- Tetraodon_Mb -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------GDFDMVLKFWGPVEA-DYSAHGGMVLTR-LFTENPETQ--QLFPKF----VG----IAQSELAGNAAVSAHGATVLKKLGELLKAKGN---HAAILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEK--A--G-L-DT-AGQQA-LRNIMATIIADIDATY-KELGFS--------------------------------------- Tetraodon_NgB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEK--LSSKDKELIRGSWDSLGK-NKVPHGVILFSR-LFELDPELL--NLFHYT----TNC---GSTQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKH-QAVGV-KPQSFAMVGESLLYMLQCSLGQ--A-Y-TA-SLRQA-WLNMYSVVVASMSRGW---------------AKNGE--------------------DKAD-- Zebrafish_Cygb_1 ---------------------------------------------------------------------------------------------------------------------------------------------------------------MEGDGG-VQLTQSPDS--LTEEDVCVIQDTWKPVYA-ERDNAGVAVLVR-FFTNFPSAK--QYFEHF----REL---QDPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQ--C-F-SPAEVQSS-WSKLMGILYWQMNRVY-AEVGW---------ENSKK-------------------------- Zebrafish_Cygb_2 ------------------------------------------------------------------------------------------------------------------------------------------------------------MEKEREDEE-TEGRERPEP--LTDVERGIIKDTWARVYA-SCEDVGVTILIR-FFVNFPSAK--QYFSQF----QDM---EDPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGE--C-F-TP-EVQTS-WSKLMAALYWHITGAY-TEVGWVKL------SSSAV-------------------------- Zebrafish_GbX ---------------------------------------------------------------------------------------------------------------MGCAISGSGLTAGAPEIRPGEE------ET-P------------------------------AG--LTTNHIRLIKESWRLIQE-DIAKVGIIMFVR-LFETHPECK--DVFFLF----RDV---EDLERLRTSRELRAHGLRVMSFIEKSVARLDQLERLETLALELGKSH-YRYNA-PPKYYGYVGAEFICAVRPILKD--R-W-TP-ELEEA-WKTLFQYVTSIMREGFLE--------------------EERNKRSNTQTSSRERPDKRSTAI Zebrafish_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS--LSDTDKAVVKAIWAKISP-KADEIGAEALAR-MLTVYPQTK--TYFSHW----ADL---S-----PGSGPVKKHGKTIMGAVGEAVSKIDD---LVGGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFPA--D-F-TP-EVHVS-VDKFFNNLALALSEKY-R-------------------------------------------- Zebrafish_HbB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVE--WTDAERTAILGLWGKL---NIDEIGPQALSR-CLIVYPWTQ--RYFATF----GNL---SSPAAIMGNPKVAAHGRTVMGGLERAIKNMDN---VKNTYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQ--AGF-NA-DVQEA-WQKFLAVVVSALCRQY-H-------------------------------------------- Zebrafish_Mb -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------ADHDLVLKCWGAVEA-DYAANGGEVLNR-LFKEYPDTL--KLFPKF----SG----ISQGDLAGSPAVAAHGATVLKKLGELLKAKGD---HAALLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEK--A--G-L-DA-AGQGA-LRRVMDAVIGDIDGYY-KEIGFAG-------------------------------------- Zebrafish_NgB ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEK--LSEKDKGLIRDSWESLGK-NKVPHGIVLFTR-LFELDPALL--TLFSYS----TNC---GDAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKH-QAVGV-NTQSFALVGESLLYMLQSSLGP--A-Y-TT-SLRQA-WLTMYSIVVSAMTRGW---------------AKNGE--------------------HKSN-- ; end; Alignment 13 of 20 file name: vertebrate_globins.NgB_GbX_Ciona.aa.mafft_einsi.nex #NEXUS begin data; dimensions ntax=76 nchar=320; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb ME--------------------------------------------------------------------------------------------------------------------KVQGEMEIERWERNEEMSDAEKKMIQETWNTVYA-KCEDVGVSLLIR-FFVNFPSAK--HYF-SQFKHME----DPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLL-GVLLEVLAEEYTNE-FSPPEVQRAWAKMKSLICTHVTAAYKEVGWVQYPNSTM------------- Anolis_GbY KA----------------------------------------------------------------------------------------------------------------------------------GKMTDLDRRHIREIWTAAFE-NPEENGRLVIIR-FFSDYPASK--QYF----KTVP----TDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLGRT-FT-PEKRVSWEKFFQVIQEEVEAAYDR------------------------ Anolis_HbA M-------------------------------------------------------------------------------------------------------------------------------------LTEDDKNHIRAIWGHVSS-NPELYGAEALTR-LFAAHHTTK--TYF-PHY-DMS----P-----GSAQIKAHGKKVVEAITQAVNNLDDIA---GALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNRGP-LK-PEFILALDKCFTSIGRVLIAQYR------------------------- Anolis_HbB MV-----------------------------------------------------------------------------------------------------------------------------------HWTAEEKQLIANCWSKV---DIGQIGGDALAC-LLCVYPWTQ--RFF-PDFGNLS----NAAAICANAKVKAHGKKVLTAFGEAVKNLDNIK---DTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFGKD-FT-PACHAAYQKLVNSVAHGLSRRYH------------------------- Anolis_Mb ME------------------------------------------------------------------------------------------------------------------------------------LSDQEWQKVIDIWGKVEP-EIPAYGQMVILR-LFEQHPETQ--EKF-DKFKNLK----SLDEMKNSEDLKKHGTIVLTALGKILKQKRQHE---AELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSAD-FG-AESQAAMRKALELFRNDMDRKYKELGFQG------------------- Arctic_lamprey_Hb1 MP---------------------------------------------------------------------------------------------------------------------------IVDSGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQ--EFF-PKFKGMT----SADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Arctic_lamprey_Hb2 MP---------------------------------------------------------------------------------------------------------------------------IVDSGSVPALTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNPAAQ--EFF-PKFQGLT----SADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTV-----------LPGDAGLEKLMSMICILLKSSY-------------------------- Arctic_lamprey_Hb4 MP---------------------------------------------------------------------------------------------------------------------------IEDSGSKPDFSDDEKKAIKDSWSGVYS-EYESTSSEILIK-FFVDNPSAQ--DFF-PKFKDLD----SEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKNDGS-FS-DSARSAWEKLLTYICISLKVAY-------------------------- Chicken_Cygb ME--------------------------------------------------------------------------------------------------------------------KVQGEMEIERWERSEEISDAEKKVIQETWSRVYA-NCEDVGVSILIR-FFVNFPSAK--QYF-SQFKHMD----DTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGND-FT-PEAHGAWTKMRTLIYTHVTAAYKEAGWVSYPSATL------------- Chicken_GbE MS------------------------------------------------------------------------------------------------------------------------------------FSEAEVQSARGAWEKMYV-DAEDNGTAVLVR-MFTEHPDTK--SYF-THFKGMD----SAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFG------GDCKASFEKVTNEICTHLTNIYKEAGW--------------------- Chicken_HbA MV------------------------------------------------------------------------------------------------------------------------------------LSAADKNNVKGIFTKIAG-HAEEYGAETLER-MFTTYPPTK--TYF-PHF-DLS----H-----GSAQIKGHGKKVVAALIEAANHIDDIA---GTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHPAA-LT-PEVHASLDKFLCAVGTVLTAKYR------------------------- Chicken_HbB MV-----------------------------------------------------------------------------------------------------------------------------------HWSAEEKQLITSVWSKV---NVEECGAEALAR-LLIVYPWTQ--RFF-ASFGNLS----SPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNIK---NTYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFARD-FT-PACQFAWQKLVNVVAHALARKYH------------------------- Chicken_Mb MG------------------------------------------------------------------------------------------------------------------------------------LSDQEWQQVLTIWGKVEA-DIAGHGHEVLMR-LFHDHPETL--DRF-DKFKGLK----TPDQMKGSEDLKKHGATVLTQLGKILKQKGNHE---SELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAAD-FG-ADSQAAMKKALELFRNDMASKYKEFGFQG------------------- Finch_Cygb ME--------------------------------------------------------------------------------------------------------------------KVQGEMEIERWERSEEISDAEKKVIQEIWSRVYA-NCEDVGVSILIR-FFVNFPSAK--QYF-SQFKHME----DPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPND-FT-PEAHGAWTKMKTLIYTHVTAAYKEVGWAQYPTATL------------- Finch_GbE MS------------------------------------------------------------------------------------------------------------------------------------LSEAEVQSARGAWEKIYV-DAEDNGTAVLVR-MFTEHPDTK--SYF-PHFKGMD----SAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFG------GDCKASFEKVTNEICTHLNNIYKEEGW--------------------- Finch_HbA MV------------------------------------------------------------------------------------------------------------------------------------LSAGDKSNVKAVFGKIGG-QADEYGADALER-MFATYPQTK--TYF-PHF-DLG----K-----GSAQVKGHGKKVAAALVEAANNVDDLA---GALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNPSL-LT-PEVHASLDKFLCAVGTVLTAKYR------------------------- Finch_HbB MV-----------------------------------------------------------------------------------------------------------------------------------HWSAEEKQLIASVWGRV---SVEECGAEALAR-LLIVYPWTQ--RFF-SDFGNLS----SPTAIVGNPKVRAHGKKVLTSFGEAIKNLDNLK---GTYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFTKE-FT-PACQATWQKLVGVVAHALARKYH------------------------- Finch_Mb MG------------------------------------------------------------------------------------------------------------------------------------LSDQEWQQVLTVWGKVES-DLAGHGHQILMR-LFQDHPETL--DRF-EKFKGLK----TPDAMKGSEDLKKHGVTVLTQLGKILKAKGNHE---AELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAAD-FG-ADAQAAMKKALELFRNDMATKYKEFGFQG------------------- Frog_Cygb ME--------------------------------------------------------------------------------------------------------------------KVQGENDMERWERLEEITESERGVIKETWARVYA-NCEDVGVSILIR-FFVNFPSAK--QHF-SQFKHME----DPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAKD-FT-PDVQLAWNKLRSHLYSHVLSAYKEAGWTQYPSNSV------------- Frog_GbX MG--C---------------------------------------------------------------------------------------------------ILSSLGWQWR----DSLDHTETSPLLPTLNLSEQQQQLLVESWRLIQH-DIAKVGVILFVR-LFETHPECK--DVF-FLFRDVD----DLQALRANKDLRAHGLRVLSFVEKSVARIADCARLEELALELGRSXY-RYNA-PPRYYQYVGTEFISAVCPMLHDK-WT-AEVEEAWKGLFAYICTVMERGYQEEERRHS--DGRSLIDGLQGNKGLI Frog_GbY MA-----------------------------------------------------------------------------------------------------------------------------------DLTGADIENINEVWSKIYA-NPEESGRTVVIS-LFLTYPQTK--IYF-KNLKNIS----TLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALGSG-FT-PEQSKSWEKLFSITYKYLESCYANTDS--------------------- Frog_HbA1 M------------------------------------------------------------------------------------------------------------------------------------HLTADDKKHIKAIWPSVAA-HGDKYGGEALHR-MFMCAPKTK--TYF-PDF-DFS----E-----HSKHILAHGKKVSDALNEACNHLDNIA---GCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFPKQ-FD-PATHKALDKFLVSVSNVLTSKYR------------------------- Frog_HbB MV-----------------------------------------------------------------------------------------------------------------------------------NLTAKERQLITGTWSKI---CAKTLGKQALGS-MLYTYPWTQ--RYF-SSFGNLS----SIEAIFHNAAVATHGEKVLTSIGEAIKHMDDIK---GYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQED-FT-PELQAAFEKLFAAIADALGKGYH------------------------- Frog_NgB ME---------------------------------------------------------------------------------------------------------------------------------KDQLSGPQKELIRESWQTVSQ-DQLHHGTVLFSSDIFQLKSGLYWSSEVPRECLIRV----VHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKHR-AVGV-KLESFNTVGESLLFALESCLGDA-FT-SDTREAWSLLYANVVQSMSRGWHRDSQEQREGI--------------- Hagfish_Hb1 MP---------------------------------------------------------------------------------------------------------------------------ITDQGPLPTLSEGDKKAIRESWPQIYQ-NFEQTGLVVLLE-FLQKNPGAQ--QSF-PKFSA------TKCNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTI------------RGKAAYEKLFSIICTLLRSSYDE------------------------ Hagfish_Hb2 MS------------------------------------------------------------------------------------------------------------------------------AHGIARTTEGERAAVRASWAVLMK-DYEHAGVQILDK-FFKANPAAK--PFF-TKMKDLH----TLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKRNGG--LS-GEGKSGWHKVMTIICKMLKSKY-------------------------- Hagfish_Hb3 MP---------------------------------------------------------------------------------------------------------------------------ITDHGQPPTLSEGDKKAIRESWPQIYK-NFEQNSLAVLLE-FLKKFPKAQ--DSF-PKFSA------KKSHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTM------------GGKAAYEKLFSIIATLLRSTYDA------------------------ Hagfish_Hb4 MP---------------------------------------------------------------------------------------------------------------------------ITDQRPLPTLSEGEKKAIKESWPQIYQ-NFEQTSLDVLIE-FLQKFPEAQ--DSF-PKFSA------KKCHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTI------------RGKAAYEKLFSIICTLLRSSYDE------------------------ Houndshark_HbA MA------------------------------------------------------------------------------------------------------------------------------------FTACEKQTIGKIAQVLAK-SPEAYGAECLAR-LFVTHPGSK--SYF--EYKDYS----A-----AGAKVQVHGGKVIRAVVKAAEHVDDLH---SHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHLTE--FS-PDTHCAVDKLLSAICQELSSRYR------------------------- Houndshark_HbB MV-----------------------------------------------------------------------------------------------------------------------------------HWTQEERDEISKTFQGT---DMKTVVTQALDR-MFKVYPWTN--RYF-QKRTDFR----S----------SIHAGIVVGALQDAVKHMDDVK---TLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRKDC-FT-PHIQGIWDKFFEVVIDAISKQYH------------------------- Houndshark_Mb M----------------------------------------------------------------------------------------------------------------------------------------VDWEKVNSVWSAVES-DLTAIGQNILLR-LFEQYPESQ--NHF-PKFKNKS----LGE-LKDTADIKAQADTVLSALGNIVKKKGSHS---QPVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPSE-MN-AQVQAAFSGAFKIICSDIEKEYKAANFQG------------------- Human_Cygb ME--------------------------------------------------------------------------------------------------------------------KVPGEMEIERRERSEELSEAERKAVQAMWARLYA-NCEDVGVAILVR-FFVNFPSAK--QYF-SQFKHME----DPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFASD-FP-PETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATTPPATLPSSGP-- Human_HbA MV------------------------------------------------------------------------------------------------------------------------------------LSPADKTNVKAAWGKVGA-HAGEYGAEALER-MFLSFPTTK--TYF-PHF-DLS----H-----GSAQVKGHGKKVADALTNAVAHVDDMP---NALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLPAE-FT-PAVHASLDKFLASVSTVLTSKYR------------------------- Human_HbB MV-----------------------------------------------------------------------------------------------------------------------------------HLTPEEKSAVTALWGKV---NVDEVGGEALGR-LLVVYPWTQ--RFF-ESFGDLS----TPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLK---GTFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFGKE-FT-PPVQAAYQKVVAGVANALAHKYH------------------------- Human_Mb MG------------------------------------------------------------------------------------------------------------------------------------LSDGEWQLVLNVWGKVEA-DIPGHGQEVLIR-LFKGHPETL--EKF-DKFKHLK----SEDEMKASEDLKKHGATVLTALGGILKKKGHHE---AEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPGD-FG-ADAQGAMNKALELFRKDMASNYKELGFQG------------------- Human_NgB --------------------------------------------------------------------------------------------------------------------------------------MERPEPELIRQSWRAVSR-SPLEHGTVLFAR-LFALEPDLL--PLFQYNCRQFS----SPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHR-AVGV-KLSSFSTVGESLLYMLEKCLGPA-FT-PATRAAWSQLYGAVVQAMSRGWDGE----------------------- Medaka_Cygb_1 ME----------------------------------------------------------------------------------------------------------------------RKQGEVDHLERSRPLTDKERVMIQDSWAKVYQ-NCDDAGVAILVR-LFVNFPSSK--QYF-SQFKHIE----DAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQV-MT-AEVASAWTNLLAILCCSIKAVYEELGWPHLSNSTS------------- Medaka_Cygb_2 MSCRE---------------------------------------------------------------------------------------------------SPPPPSPPPQML--GVQRGECEDRPERAEPLSDAEMEIIQHTWGHVYK-NCEDVGVSVLIR-FFVNFPSAK--QYF-SQFQDMQ----DPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPEF-FT-AEVQLVWTKLMAAVYWHVTGAYTEVGWLQVSSSAV------------- Medaka_GbX MG--C---------------------------------------------------------------------------------------------------AISGLAAKTDLAE-RSRED------AAVEHPNEEQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHPECK--DVF-FLFRDVE----DLERLRTNRELRAHGLRVMSFIEKSVARLDQPERLEALAVELGKSHY-HYNA-PPKYYNYVGAEFICAVQPILKEQ-WT-TELEKAWQTLFQFVTALMKQGYQEESARQRQ-LATSPKDRLDKRNTAL Medaka_HbA KM-----------------------------------------------------------------------------------------------------------------------------------SLSAKDKAAVKAFWAKVSG-QADAIGSDALSR-MLVVYPQTK--TYF-AHWKDLS----P-----GSAPVKKHGKTVMGGIADAVGKIDDIS---SGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFPQD-FT-PEVHVALDKFLAAVSLALSEKYR------------------------- Medaka_HbB MV-----------------------------------------------------------------------------------------------------------------------------------EWTEQERSIITNIFGNL---DYEDVGSKALSR-CLIVYPWTQ--RYF-ASFGNLY----NAEAIKTNPNIAAHGTKVLHGLDRAVKNMDNIK---ATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLGSA-FS-PEIQATFQKFLAVVVSALGRQYH------------------------- Medaka_Mb M----------------------------------------------------------------------------------------------------------------------------------------ADYDMVLKHWGPVEA-DYNTHGNLVLTR-LFHEYPETQ--KLF-PKFAGIA----KGD-MAGNAALSAHGATVLKKLGELLKARGNHG---AILKPLANSHATKHKI-PINNFRLITEVIGKVMAEKAGLD----AAGQQALRSVMAGIIAEIEADYKELGFAG------------------- Medaka_NgB ME-----------------------------------------------------------------------------------------------------------------------------------KLSGKDKELIRGSWESLGK-NKVPHGVIMFSR-LFELDPALL--SLF-NYNTNCG----STQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKHQ-AVGV-STQSFAVVGESLLYMLQCSLGQA-YT-AALSQAWLNMYSIVVAAMSRGWAKNGEDKAD----------------- Platypus_GbY MV-----------------------------------------------------------------------------------------------------------------------------------QVTDVEKANIQSIWSKMME-NLEKNGIDIFTR-LFREYPETK--KYF----KNIP----LEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLGPC-YT-PEIAESFQKLQSSLYDQVVITYLHSGSD-------------------- Platypus_HbA MG------------------------------------------------------------------------------------------------------------------------------------LTDGEKKEVAALWANVSG-HEEEFGAEALDR-LFLSFPPTK--TYF-PHF-ELS----Q-----GSAQVKAHGKKVADALTTAVAHLDDLD---STLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLPAE-FT-PSAHAALDKFLSKVATVLTSKYR------------------------- Platypus_HbB MV-----------------------------------------------------------------------------------------------------------------------------------HLSGGEKSAVTNLWGKV---NINELGGEALGR-LLVVYPWTQ--RFF-EAFGDLS----SAGAVMGNPKVKAHGAKVLTSFGDALKNLDDLK---GTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFSKD-FS-PEVQAAWQKLVSGVAHALGHKYH------------------------- Platypus_HbW MV-----------------------------------------------------------------------------------------------------------------------------------NWTSEEKHAIVSIWGKV---DIEETGANALSR-LLVVYPWTQ--RYF-SAFGNLS----SPTAIVGNPRVRAHGKKVLTSFGEAVKDLDHVK---SNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLGKD-FT-PEAQAAWQKLVGVVASALSSQYH------------------------- Platypus_Mb MG------------------------------------------------------------------------------------------------------------------------------------LSDGEWQLVLKVWGKVEG-DLPGHGQEVLIR-LFKTHPETL--EKF-DKFKGLK----TEDEMKASADLKKHGGTVLTALGNILKKKGQHE---AELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSAD-FG-ADAQAAMGKALELFRNDMAAKYKEFGFQG------------------- Platypus_NgB ME---------------------------------------------------------------------------------------------------------------------------------NGRLSGPEQELIRESWRSVNS-NPLEHGMILFTR-LFDLEPDLL--PLFQYNCRQFS----SPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKHK-AIGV-KLSSFSTVGESLLFMLEKCLGPA-FS-PATREAWTRLYTAMVHAMSRGWGGE----------------------- Port_Jackson_shark_Mb M----------------------------------------------------------------------------------------------------------------------------------------TEWEHVNKVWAVVEP-DIPAVGLAILLR-LFKEHKETK--DLF-PKFKEIP----VQQ-LGNNEDLRKHGVTVLRALGNILKQKGKHS---TNVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPSD-MT-GPMQESFSKVFTVICSDLETLYKEANFQG------------------- Sea_lamprey_Hb1a MP---------------------------------------------------------------------------------------------------------------------------IVDSGSVPALTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNPAAQ--AFF-PKFQGLT----SADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTV-----------LPGDAGLEKLMSMICILLRSSY-------------------------- Sea_lamprey_Hb1b MP---------------------------------------------------------------------------------------------------------------------------IVDSGSVSPLSDAEKNKIRAAWDLVYK-DYEKTGVDILVK-FFTGTPAAQ--AFF-PKFKGLT----TADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTT-----------APGDAGFEKLMSMICILLSSAY-------------------------- Sea_lamprey_Hb2 MP---------------------------------------------------------------------------------------------------------------------------IVDTGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQ--EFF-PKFKGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb3 MP---------------------------------------------------------------------------------------------------------------------------IVDSGSVAPLSAAEKTKIRSAWAPVYS-NYETTGVDILVK-FFTSTPAAQ--EFF-PKFKGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb5 MP---------------------------------------------------------------------------------------------------------------------------IVDTGSVAPLSAAEKTKIRSAWAPVYS-TYETSGVDILVK-FFTSTPAAQ--EFF-PKFKGLT----TADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb_PMII MP---------------------------------------------------------------------------------------------------------------------------IVDTGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQ--EFF-PKFKGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Sea_squirt_Glb1 MP------------------------------------------------------------------------------------------------------------------------------------FTDEELKLLRDSWDEVKKLGMKEVGLHIFTG-LLNAAPSLR--TLF-YTIDLPDEEELTIDVMRENKKVVAHATRIANAISKFIKFLDQPDELEKLLTSLGESHA-RRQV-DPESFEYVAPVILSVIGGHLKLP-SN-SPTLQAWVKAYGVLRNGIVSAMEA------------------------ Sea_squirt_Glb2 MG------------------------------------------------------------------------------------------------------------------------------------LTTEEIGLLRSSWNEMKTIGMKELGLLIFHR-LFSDVPRIR--KMF-YNLELPDDETLTMEAMRSNQKMSRHATRIATSISTYLKLADQPEELKTFLNGLGELHA-GHNV-EPEDFEYLAPVMLAVIGGQLNLN-SN-SSILQAWVKAYGVLRNGIVRGMYAYQG--------------------- Sea_squirt_Glb3 MS------------------------------------------------------------------------------------------------------------------------------------LTSEQVVLLRSSWQTIGKLGMSNVGLAVLHR-LFNDVPETL--PFF-HSVLSPT-QQTEIEVLKSNAKVVRHASRVGLSIDKIINLLDNGEELVKYLLFLGQVHV-KRSI-PRKYFSAMGPVLLSVISAVLEKD-LD-APVMQAWATAYGVIEQGIIDGM-------------------------- Sea_squirt_Glb4 MKIICGLILFSTFAIIFVSGLNCWTCNVLGGNNVCRRSGGLRTCFNNQVCYNEVRRRGNTINIRKGCKNSGVCENHIMQSMSTPNPNNQCVNGPNYFCSCCCGNSVCNSNWLTCVTAGSVAPTVSTTVPPADEGLKRSDIINIQDSWNTLKGFGYETVGMLVLHR-LFNDAPQTR--YLF-SQLSLSSNESFTLEQMRNNSRVVYHANRVARAVGRLVDLIELPTNFTDHLVWLGQRHA-YHGV-APVNFDYMGPVLLETIKVNLELP-SD-SPTLSAWAKAYGVIKNGIKDAIIATYAEG------------------- Stingray_HbA MV------------------------------------------------------------------------------------------------------------------------------------LSSQNKKAIEELGNLIKA-NAEAWGADALAR-LFELHPQTK--TYF-SKFSGFE----A-----CNEQVKKHGKRVMNALADATHHLDNLH---LHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNLQA--FT-PVTHCAVDKFLELVAYELSSCYR------------------------- Stingray_HbB MV-----------------------------------------------------------------------------------------------------------------------------------KLSEDQEHYIKGVWKDV---DHKQITAKALER-VFVVYPWTT--RLF-SKLQGLF----SA----NDIGVQQHADKVQRALGEAIDDLKKVE---INFQNLSGKHQ-EIGV-DTQNFKLLGQTFMVELALHYKKT-FR-PKEHAAAYKFFRLVAEALSSNYH------------------------- Tetraodon_Cygb_1 ME--------------------------------------------------------------------------------------------------------------------RMQRDGEVDHVEQPGPLTEKEKVMIQDSWAKVFQ-SCDDAGVAILVR-FFVNFPSSK--QFF-KDFKHME----EPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTEI-IT-AEVASAWTKLLANMCCGIAAVYKEAGWTELSSSVE------------- Tetraodon_Cygb_2 MSHRE---------------------------------------------------------------------------------------------------PPPP------QLAVQRRDVDGQDGPERAEPLSDTEREMIRDAWGHVYK-NCEDVGVSILIR-FFVNFPSAK--QYF-SQFQDME----EPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPEF-FT-ADVQLVWSKLMATVYWHVTGAYTDVGWLQVSSSAV------------- Tetraodon_GbX MG--C---------------------------------------------------------------------------------------------------AISSLGAKAEFGD-RSAEEEDAAAAAAVVYPREDQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHPECK--DVF-FLFRDVE----DLERLRSSRELRAHGLRVMSFIEKSVARLDQQDRLEALAVELGKSHY-HYNA-PPKYYSYVGAEFICAVQPILKER-FT-SELEEAWKTLFQYVTGLMRKGHQEEGSRQRH-LALPPKDGPEKRTSAL Tetraodon_HbA MT-----------------------------------------------------------------------------------------------------------------------------------SLSTKDKETVRAFWAKVAS-NREEIGASALCR-LLSVYPQTK--TYF-SHWKDQS----P-----NSASAKKHGITIMNAVGDAVSKIDDLK---TGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYPAD-FT-PEVHVAMDKFLASLALALSEKYR------------------------- Tetraodon_HbB MV-----------------------------------------------------------------------------------------------------------------------------------VWTDQERAIIDNIFSNL---DYEDVGSKALIR-CLIVYPWTQ--RYF-SSFGNLY----NAEAIRNNPNVAKHGVTVLHGLDRALKNMDNIK---EEYKK----HSEKLHV-DPDNFKLLSDCLTVVIAGKLGSK-FT-PEYQAALQKFLAVVVSALGRQYH------------------------- Tetraodon_Mb M----------------------------------------------------------------------------------------------------------------------------------------GDFDMVLKFWGPVEA-DYSAHGGMVLTR-LFTENPETQ--QLF-PKFVGIA----QSE-LAGNAAVSAHGATVLKKLGELLKAKGNHA---AILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEKAGLD----TAGQQALRNIMATIIADIDATYKELGFS-------------------- Tetraodon_NgB ME-----------------------------------------------------------------------------------------------------------------------------------KLSSKDKELIRGSWDSLGK-NKVPHGVILFSR-LFELDPELL--NLF-HYTTNCG----STQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKHQ-AVGV-KPQSFAMVGESLLYMLQCSLGQA-YT-ASLRQAWLNMYSVVVASMSRGWAKNGEDKAD----------------- Zebrafish_Cygb_1 ME-----------------------------------------------------------------------------------------------------------------------GDGGVQLTQSPDSLTEEDVCVIQDTWKPVYA-ERDNAGVAVLVR-FFTNFPSAK--QYF-EHFRELQ----DPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQC-FSPAEVQSSWSKLMGILYWQMNRVYAEVGWENSKK---------------- Zebrafish_Cygb_2 ME--------------------------------------------------------------------------------------------------------------------KEREDEETEGRERPEPLTDVERGIIKDTWARVYA-SCEDVGVTILIR-FFVNFPSAK--QYF-SQFQDME----DPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGEC-FT-PEVQTSWSKLMAALYWHITGAYTEVGWVKLSSSAV------------- Zebrafish_GbX MG--C---------------------------------------------------------------------------------------------------AISGSGLTAGAPEIRPGEE------ETPAGLTTNHIRLIKESWRLIQE-DIAKVGIIMFVR-LFETHPECK--DVF-FLFRDVE----DLERLRTSRELRAHGLRVMSFIEKSVARLDQLERLETLALELGKSHY-RYNA-PPKYYGYVGAEFICAVRPILKDR-WT-PELEEAWKTLFQYVTSIMREGFLEEERNKRSNTQTSSRERPDKRSTAI Zebrafish_HbA M------------------------------------------------------------------------------------------------------------------------------------SLSDTDKAVVKAIWAKISP-KADEIGAEALAR-MLTVYPQTK--TYF-SHWADLS----P-----GSGPVKKHGKTIMGAVGEAVSKIDDLV---GGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFPAD-FT-PEVHVSVDKFFNNLALALSEKYR------------------------- Zebrafish_HbB MV-----------------------------------------------------------------------------------------------------------------------------------EWTDAERTAILGLWGKL---NIDEIGPQALSR-CLIVYPWTQ--RYF-ATFGNLS----SPAAIMGNPKVAAHGRTVMGGLERAIKNMDNVK---NTYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGFN-ADVQEAWQKFLAVVVSALCRQYH------------------------- Zebrafish_Mb M----------------------------------------------------------------------------------------------------------------------------------------ADHDLVLKCWGAVEA-DYAANGGEVLNR-LFKEYPDTL--KLF-PKFSGIS----QGD-LAGSPAVAAHGATVLKKLGELLKAKGDHA---ALLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEKAGLD----AAGQGALRRVMDAVIGDIDGYYKEIGFAG------------------- Zebrafish_NgB ME-----------------------------------------------------------------------------------------------------------------------------------KLSEKDKGLIRDSWESLGK-NKVPHGIVLFTR-LFELDPALL--TLF-SYSTNCG----DAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKHQ-AVGV-NTQSFALVGESLLYMLQSSLGPA-YT-TSLRQAWLTMYSIVVSAMTRGWAKNGEHKSN----------------- ; end; Alignment 14 of 20 file name: vertebrate_globins.NgB_GbX_Ciona.aa.mafft_ginsi.nex #NEXUS begin data; dimensions ntax=76 nchar=320; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb ME--------------------------------------------------------------------------------------------------------------------KVQGEMEIERWERNEEMSDAEKKMIQETWNTVYA-KCEDVGVSLLIR-FFVNFPSAK--HYF-SQFKHME----DPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLL-GVLLEVLAEEYTNE-FSPPEVQRAWAKMKSLICTHVTAAYKEVGWVQ-------------YPNSTM Anolis_GbY KA----------------------------------------------------------------------------------------------------------------------------------GKMTDLDRRHIREIWTAAFE-NPEENGRLVIIR-FFSDYPASK--QYF----KTVP----TDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLGRT-FT-PEKRVSWEKFFQVIQEEVEAAYDR------------------------ Anolis_HbA M-------------------------------------------------------------------------------------------------------------------------------------LTEDDKNHIRAIWGHVSS-NPELYGAEALTR-LFAAHHTTK--TYF-PHY-DMS----P-----GSAQIKAHGKKVVEAITQAVNNLDDIA---GALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNRGP-LK-PEFILALDKCFTSIGRVLIAQYR------------------------- Anolis_HbB MV-----------------------------------------------------------------------------------------------------------------------------------HWTAEEKQLIANCWSKV---DIGQIGGDALAC-LLCVYPWTQ--RFF-PDFGNLS----NAAAICANAKVKAHGKKVLTAFGEAVKNLDNIK---DTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFGKD-FT-PACHAAYQKLVNSVAHGLSRRYH------------------------- Anolis_Mb M------------------------------------------------------------------------------------------------------------------------------------ELSDQEWQKVIDIWGKVEP-EIPAYGQMVILR-LFEQHPETQ--EKF-DKFKNLK----SLDEMKNSEDLKKHGTIVLTALGKILKQKRQHE---AELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSAD-FG-AESQAAMRKALELFRNDMDRKYKELGFQG------------------- Arctic_lamprey_Hb1 MP---------------------------------------------------------------------------------------------------------------------------IVDSGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQ--EFF-PKFKGMT----SADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Arctic_lamprey_Hb2 MP---------------------------------------------------------------------------------------------------------------------------IVDSGSVPALTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNPAAQ--EFF-PKFQGLT----SADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTV-----------LPGDAGLEKLMSMICILLKSSY-------------------------- Arctic_lamprey_Hb4 MP---------------------------------------------------------------------------------------------------------------------------IEDSGSKPDFSDDEKKAIKDSWSGVYS-EYESTSSEILIK-FFVDNPSAQ--DFF-PKFKDLD----SEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKNDGS-FS-DSARSAWEKLLTYICISLKVAY-------------------------- Chicken_Cygb ME--------------------------------------------------------------------------------------------------------------------KVQGEMEIERWERSEEISDAEKKVIQETWSRVYA-NCEDVGVSILIR-FFVNFPSAK--QYF-SQFKHMD----DTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGND-FT-PEAHGAWTKMRTLIYTHVTAAYKEAGWVS-------------YPSATL Chicken_GbE M------------------------------------------------------------------------------------------------------------------------------------SFSEAEVQSARGAWEKMYV-DAEDNGTAVLVR-MFTEHPDTK--SYF-THFKGMD----SAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFG------GDCKASFEKVTNEICTHLTNIYKEAGW--------------------- Chicken_HbA M------------------------------------------------------------------------------------------------------------------------------------VLSAADKNNVKGIFTKIAG-HAEEYGAETLER-MFTTYPPTK--TYF-PHF-DLS----H-----GSAQIKGHGKKVVAALIEAANHIDDIA---GTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHPAA-LT-PEVHASLDKFLCAVGTVLTAKYR------------------------- Chicken_HbB MV-----------------------------------------------------------------------------------------------------------------------------------HWSAEEKQLITSVWSKV---NVEECGAEALAR-LLIVYPWTQ--RFF-ASFGNLS----SPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNIK---NTYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFARD-FT-PACQFAWQKLVNVVAHALARKYH------------------------- Chicken_Mb M------------------------------------------------------------------------------------------------------------------------------------GLSDQEWQQVLTIWGKVEA-DIAGHGHEVLMR-LFHDHPETL--DRF-DKFKGLK----TPDQMKGSEDLKKHGATVLTQLGKILKQKGNHE---SELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAAD-FG-ADSQAAMKKALELFRNDMASKYKEFGFQG------------------- Finch_Cygb ME--------------------------------------------------------------------------------------------------------------------KVQGEMEIERWERSEEISDAEKKVIQEIWSRVYA-NCEDVGVSILIR-FFVNFPSAK--QYF-SQFKHME----DPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPND-FT-PEAHGAWTKMKTLIYTHVTAAYKEVGWAQ-------------YPTATL Finch_GbE M------------------------------------------------------------------------------------------------------------------------------------SLSEAEVQSARGAWEKIYV-DAEDNGTAVLVR-MFTEHPDTK--SYF-PHFKGMD----SAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFG------GDCKASFEKVTNEICTHLNNIYKEEGW--------------------- Finch_HbA M------------------------------------------------------------------------------------------------------------------------------------VLSAGDKSNVKAVFGKIGG-QADEYGADALER-MFATYPQTK--TYF-PHF-DLG----K-----GSAQVKGHGKKVAAALVEAANNVDDLA---GALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNPSL-LT-PEVHASLDKFLCAVGTVLTAKYR------------------------- Finch_HbB MV-----------------------------------------------------------------------------------------------------------------------------------HWSAEEKQLIASVWGRV---SVEECGAEALAR-LLIVYPWTQ--RFF-SDFGNLS----SPTAIVGNPKVRAHGKKVLTSFGEAIKNLDNLK---GTYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFTKE-FT-PACQATWQKLVGVVAHALARKYH------------------------- Finch_Mb M------------------------------------------------------------------------------------------------------------------------------------GLSDQEWQQVLTVWGKVES-DLAGHGHQILMR-LFQDHPETL--DRF-EKFKGLK----TPDAMKGSEDLKKHGVTVLTQLGKILKAKGNHE---AELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAAD-FG-ADAQAAMKKALELFRNDMATKYKEFGFQG------------------- Frog_Cygb ME--------------------------------------------------------------------------------------------------------------------KVQGENDMERWERLEEITESERGVIKETWARVYA-NCEDVGVSILIR-FFVNFPSAK--QHF-SQFKHME----DPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAKD-FT-PDVQLAWNKLRSHLYSHVLSAYKEAGWTQ-------------YPSNSV Frog_GbX MG-----------------------------------------------------------------------------------------------------CILSSLGWQWR----DSLDHTETSPLLPTLNLSEQQQQLLVESWRLIQH-DIAKVGVILFVR-LFETHPECK--DVF-FLFRDVD----DLQALRANKDLRAHGLRVLSFVEKSVARIADCARLEELALELGRSXY-RYNA-PPRYYQYVGTEFISAVCPMLHDK-WT-AEVEEAWKGLFAYICTVMERGYQEEERRHS--DGRSLIDGLQGNKGLI Frog_GbY MA-----------------------------------------------------------------------------------------------------------------------------------DLTGADIENINEVWSKIYA-NPEESGRTVVIS-LFLTYPQTK--IYF-KNLKNIS----TLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALGSG-FT-PEQSKSWEKLFSITYKYLESCYANTDS--------------------- Frog_HbA1 M------------------------------------------------------------------------------------------------------------------------------------HLTADDKKHIKAIWPSVAA-HGDKYGGEALHR-MFMCAPKTK--TYF-PDF-DFS----E-----HSKHILAHGKKVSDALNEACNHLDNIA---GCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFPKQ-FD-PATHKALDKFLVSVSNVLTSKYR------------------------- Frog_HbB MV-----------------------------------------------------------------------------------------------------------------------------------NLTAKERQLITGTWSKI---CAKTLGKQALGS-MLYTYPWTQ--RYF-SSFGNLS----SIEAIFHNAAVATHGEKVLTSIGEAIKHMDDIK---GYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQED-FT-PELQAAFEKLFAAIADALGKGYH------------------------- Frog_NgB ME---------------------------------------------------------------------------------------------------------------------------------KDQLSGPQKELIRESWQTVSQ-DQLHHGTVLFSSDIFQLKSGLYWSSEVPRECLIRV----VHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKHR-AVGV-KLESFNTVGESLLFALESCLGDA-FT-SDTREAWSLLYANVVQSMSRGWHRDSQEQREGI--------------- Hagfish_Hb1 MP---------------------------------------------------------------------------------------------------------------------------ITDQGPLPTLSEGDKKAIRESWPQIYQ-NFEQTGLVVLLE-FLQKNPGAQ--QSF-PKFSA------TKCNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTI------------RGKAAYEKLFSIICTLLRSSYDE------------------------ Hagfish_Hb2 MS------------------------------------------------------------------------------------------------------------------------------AHGIARTTEGERAAVRASWAVLMK-DYEHAGVQILDK-FFKANPAAK--PFF-TKMKDLH----TLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKRNGG--LS-GEGKSGWHKVMTIICKMLKSKY-------------------------- Hagfish_Hb3 MP---------------------------------------------------------------------------------------------------------------------------ITDHGQPPTLSEGDKKAIRESWPQIYK-NFEQNSLAVLLE-FLKKFPKAQ--DSF-PKFSA------KKSHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTM------------GGKAAYEKLFSIIATLLRSTYDA------------------------ Hagfish_Hb4 MP---------------------------------------------------------------------------------------------------------------------------ITDQRPLPTLSEGEKKAIKESWPQIYQ-NFEQTSLDVLIE-FLQKFPEAQ--DSF-PKFSA------KKCHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTI------------RGKAAYEKLFSIICTLLRSSYDE------------------------ Houndshark_HbA M------------------------------------------------------------------------------------------------------------------------------------AFTACEKQTIGKIAQVLAK-SPEAYGAECLAR-LFVTHPGSK--SYF--EYKDYS----A-----AGAKVQVHGGKVIRAVVKAAEHVDDLH---SHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHLTE--FS-PDTHCAVDKLLSAICQELSSRYR------------------------- Houndshark_HbB MV-----------------------------------------------------------------------------------------------------------------------------------HWTQEERDEISKTFQGT---DMKTVVTQALDR-MFKVYPWTN--RYF-QKRTDFR----S----------SIHAGIVVGALQDAVKHMDDVK---TLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRKDC-FT-PHIQGIWDKFFEVVIDAISKQYH------------------------- Houndshark_Mb M----------------------------------------------------------------------------------------------------------------------------------------VDWEKVNSVWSAVES-DLTAIGQNILLR-LFEQYPESQ--NHF-PKFKNK-----SLGELKDTADIKAQADTVLSALGNIVKKKGSHS---QPVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPSE-MN-AQVQAAFSGAFKIICSDIEKEYKAANFQG------------------- Human_Cygb ME--------------------------------------------------------------------------------------------------------------------KVPGEMEIERRERSEELSEAERKAVQAMWARLYA-NCEDVGVAILVR-FFVNFPSAK--QYF-SQFKHME----DPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFASD-FP-PETQRAWAKLRGLIYSHVTAAYKEVGWVQQ--VPNATTPPATLPSSGP Human_HbA M------------------------------------------------------------------------------------------------------------------------------------VLSPADKTNVKAAWGKVGA-HAGEYGAEALER-MFLSFPTTK--TYF-PHF-DLS----H-----GSAQVKGHGKKVADALTNAVAHVDDMP---NALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLPAE-FT-PAVHASLDKFLASVSTVLTSKYR------------------------- Human_HbB MV-----------------------------------------------------------------------------------------------------------------------------------HLTPEEKSAVTALWGKV---NVDEVGGEALGR-LLVVYPWTQ--RFF-ESFGDLS----TPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLK---GTFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFGKE-FT-PPVQAAYQKVVAGVANALAHKYH------------------------- Human_Mb M------------------------------------------------------------------------------------------------------------------------------------GLSDGEWQLVLNVWGKVEA-DIPGHGQEVLIR-LFKGHPETL--EKF-DKFKHLK----SEDEMKASEDLKKHGATVLTALGGILKKKGHHE---AEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPGD-FG-ADAQGAMNKALELFRKDMASNYKELGFQG------------------- Human_NgB ME--------------------------------------------------------------------------------------------------------------------------------------RPEPELIRQSWRAVSR-SPLEHGTVLFAR-LFALEPDLL--PLFQYNCRQFS----SPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHR-AVGV-KLSSFSTVGESLLYMLEKCLGPA-FT-PATRAAWSQLYGAVVQAMSRGWDGE----------------------- Medaka_Cygb_1 ME--------------------------------------------------------------------------------------------------------------------RKQ--GEVDHLERSRPLTDKERVMIQDSWAKVYQ-NCDDAGVAILVR-LFVNFPSSK--QYF-SQFKHIE----DAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQV-MT-AEVASAWTNLLAILCCSIKAVYEELGWPH-------------LSNSTS Medaka_Cygb_2 MS---------------------------------------------------------------------------------------------------CRESPPPPSPPPQML--GVQRGECEDRPERAEPLSDAEMEIIQHTWGHVYK-NCEDVGVSVLIR-FFVNFPSAK--QYF-SQFQDMQ----DPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPEF-FT-AEVQLVWTKLMAAVYWHVTGAYTEVGWLQ-------------VSSSAV Medaka_GbX MG-----------------------------------------------------------------------------------------------------CAISGLAAKTDLAE-RSRED------AAVEHPNEEQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHPECK--DVF-FLFRDVE----DLERLRTNRELRAHGLRVMSFIEKSVARLDQPERLEALAVELGKSHY-HYNA-PPKYYNYVGAEFICAVQPILKEQ-WT-TELEKAWQTLFQFVTALMKQGYQEESARQR-QLATSPKDRLDKRNTAL Medaka_HbA KM-----------------------------------------------------------------------------------------------------------------------------------SLSAKDKAAVKAFWAKVSG-QADAIGSDALSR-MLVVYPQTK--TYF-AHWKDLS----P-----GSAPVKKHGKTVMGGIADAVGKIDDIS---SGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFPQD-FT-PEVHVALDKFLAAVSLALSEKYR------------------------- Medaka_HbB MV-----------------------------------------------------------------------------------------------------------------------------------EWTEQERSIITNIFGNL---DYEDVGSKALSR-CLIVYPWTQ--RYF-ASFGNLY----NAEAIKTNPNIAAHGTKVLHGLDRAVKNMDNIK---ATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLGSA-FS-PEIQATFQKFLAVVVSALGRQYH------------------------- Medaka_Mb M----------------------------------------------------------------------------------------------------------------------------------------ADYDMVLKHWGPVEA-DYNTHGNLVLTR-LFHEYPETQ--KLF-PKFAGI-----AKGDMAGNAALSAHGATVLKKLGELLKARGNHG---AILKPLANSHATKHKI-PINNFRLITEVIGKVMAEKAGLD----AAGQQALRSVMAGIIAEIEADYKELGFAG------------------- Medaka_NgB ME-----------------------------------------------------------------------------------------------------------------------------------KLSGKDKELIRGSWESLGK-NKVPHGVIMFSR-LFELDPALL--SLF-NYNTNCG----STQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKHQ-AVGV-STQSFAVVGESLLYMLQCSLGQA-YT-AALSQAWLNMYSIVVAAMSRGWAKNGEDKAD----------------- Platypus_GbY MV-----------------------------------------------------------------------------------------------------------------------------------QVTDVEKANIQSIWSKMME-NLEKNGIDIFTR-LFREYPETK--KYF----KNIP----LEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLGPC-YT-PEIAESFQKLQSSLYDQVVITYLHSGSD-------------------- Platypus_HbA M------------------------------------------------------------------------------------------------------------------------------------GLTDGEKKEVAALWANVSG-HEEEFGAEALDR-LFLSFPPTK--TYF-PHF-ELS----Q-----GSAQVKAHGKKVADALTTAVAHLDDLD---STLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLPAE-FT-PSAHAALDKFLSKVATVLTSKYR------------------------- Platypus_HbB MV-----------------------------------------------------------------------------------------------------------------------------------HLSGGEKSAVTNLWGKV---NINELGGEALGR-LLVVYPWTQ--RFF-EAFGDLS----SAGAVMGNPKVKAHGAKVLTSFGDALKNLDDLK---GTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFSKD-FS-PEVQAAWQKLVSGVAHALGHKYH------------------------- Platypus_HbW MV-----------------------------------------------------------------------------------------------------------------------------------NWTSEEKHAIVSIWGKV---DIEETGANALSR-LLVVYPWTQ--RYF-SAFGNLS----SPTAIVGNPRVRAHGKKVLTSFGEAVKDLDHVK---SNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLGKD-FT-PEAQAAWQKLVGVVASALSSQYH------------------------- Platypus_Mb M------------------------------------------------------------------------------------------------------------------------------------GLSDGEWQLVLKVWGKVEG-DLPGHGQEVLIR-LFKTHPETL--EKF-DKFKGLK----TEDEMKASADLKKHGGTVLTALGNILKKKGQHE---AELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSAD-FG-ADAQAAMGKALELFRNDMAAKYKEFGFQG------------------- Platypus_NgB ME---------------------------------------------------------------------------------------------------------------------------------NGRLSGPEQELIRESWRSVNS-NPLEHGMILFTR-LFDLEPDLL--PLFQYNCRQFS----SPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKHK-AIGV-KLSSFSTVGESLLFMLEKCLGPA-FS-PATREAWTRLYTAMVHAMSRGWGGE----------------------- Port_Jackson_shark_Mb M----------------------------------------------------------------------------------------------------------------------------------------TEWEHVNKVWAVVEP-DIPAVGLAILLR-LFKEHKETK--DLF-PKFKEI-----PVQQLGNNEDLRKHGVTVLRALGNILKQKGKHS---TNVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPSD-MT-GPMQESFSKVFTVICSDLETLYKEANFQG------------------- Sea_lamprey_Hb1a MP---------------------------------------------------------------------------------------------------------------------------IVDSGSVPALTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNPAAQ--AFF-PKFQGLT----SADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTV-----------LPGDAGLEKLMSMICILLRSSY-------------------------- Sea_lamprey_Hb1b MP---------------------------------------------------------------------------------------------------------------------------IVDSGSVSPLSDAEKNKIRAAWDLVYK-DYEKTGVDILVK-FFTGTPAAQ--AFF-PKFKGLT----TADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTT-----------APGDAGFEKLMSMICILLSSAY-------------------------- Sea_lamprey_Hb2 MP---------------------------------------------------------------------------------------------------------------------------IVDTGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQ--EFF-PKFKGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb3 MP---------------------------------------------------------------------------------------------------------------------------IVDSGSVAPLSAAEKTKIRSAWAPVYS-NYETTGVDILVK-FFTSTPAAQ--EFF-PKFKGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb5 MP---------------------------------------------------------------------------------------------------------------------------IVDTGSVAPLSAAEKTKIRSAWAPVYS-TYETSGVDILVK-FFTSTPAAQ--EFF-PKFKGLT----TADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb_PMII MP---------------------------------------------------------------------------------------------------------------------------IVDTGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQ--EFF-PKFKGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Sea_squirt_Glb1 M------------------------------------------------------------------------------------------------------------------------------------PFTDEELKLLRDSWDEVKKLGMKEVGLHIFTG-LLNAAPSLR--TLF-YTIDLPDEEELTIDVMRENKKVVAHATRIANAISKFIKFLDQPDELEKLLTSLGESHA-RRQV-DPESFEYVAPVILSVIGGHLKLP-SN-SPTLQAWVKAYGVLRNGIVSAMEA------------------------ Sea_squirt_Glb2 M------------------------------------------------------------------------------------------------------------------------------------GLTTEEIGLLRSSWNEMKTIGMKELGLLIFHR-LFSDVPRIR--KMF-YNLELPDDETLTMEAMRSNQKMSRHATRIATSISTYLKLADQPEELKTFLNGLGELHA-GHNV-EPEDFEYLAPVMLAVIGGQLNLN-SN-SSILQAWVKAYGVLRNGIVRGMYAY--QG------------------- Sea_squirt_Glb3 M------------------------------------------------------------------------------------------------------------------------------------SLTSEQVVLLRSSWQTIGKLGMSNVGLAVLHR-LFNDVPETL--PFF-HSVLSPT-QQTEIEVLKSNAKVVRHASRVGLSIDKIINLLDNGEELVKYLLFLGQVHV-KRSI-PRKYFSAMGPVLLSVISAVLEKD-LD-APVMQAWATAYGVIEQGIIDGM-------------------------- Sea_squirt_Glb4 MKIICGLILFSTFAIIFVSGLNCWTCNVLGGNNVCRRSGGLRTCFNNQVCYNEVRRRGNTINIRKGCKNSGVCENHIMQSMSTPNPNNQCVNGPNYFCSCCCGNSVCNSNWLTCVTAGSVAPTVSTTVPPADEGLKRSDIINIQDSWNTLKGFGYETVGMLVLHR-LFNDAPQTR--YLF-SQLSLSSNESFTLEQMRNNSRVVYHANRVARAVGRLVDLIELPTNFTDHLVWLGQRHA-YHGV-APVNFDYMGPVLLETIKVNLELP-SD-SPTLSAWAKAYGVIKNGIKDAIIATYAEG------------------- Stingray_HbA M------------------------------------------------------------------------------------------------------------------------------------VLSSQNKKAIEELGNLIKA-NAEAWGADALAR-LFELHPQTK--TYF-SKFSGFE----A-----CNEQVKKHGKRVMNALADATHHLDNLH---LHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNLQA--FT-PVTHCAVDKFLELVAYELSSCYR------------------------- Stingray_HbB MV-----------------------------------------------------------------------------------------------------------------------------------KLSEDQEHYIKGVWKDV---DHKQITAKALER-VFVVYPWTT--RLF-SKLQGLF----SA----NDIGVQQHADKVQRALGEAIDDLKKVE---INFQNLSGKHQ-EIGV-DTQNFKLLGQTFMVELALHYKKT-FR-PKEHAAAYKFFRLVAEALSSNYH------------------------- Tetraodon_Cygb_1 ME--------------------------------------------------------------------------------------------------------------------RMQRDGEVDHVEQPGPLTEKEKVMIQDSWAKVFQ-SCDDAGVAILVR-FFVNFPSSK--QFF-KDFKHME----EPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTEI-IT-AEVASAWTKLLANMCCGIAAVYKEAGWTE-------------LSSSVE Tetraodon_Cygb_2 MS---------------------------------------------------------------------------------------------------HREPPPP------QLAVQRRDVDGQDGPERAEPLSDTEREMIRDAWGHVYK-NCEDVGVSILIR-FFVNFPSAK--QYF-SQFQDME----EPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPEF-FT-ADVQLVWSKLMATVYWHVTGAYTDVGWLQ-------------VSSSAV Tetraodon_GbX MG-----------------------------------------------------------------------------------------------------CAISSLGAKAEFGD-RSAEEEDAAAAAAVVYPREDQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHPECK--DVF-FLFRDVE----DLERLRSSRELRAHGLRVMSFIEKSVARLDQQDRLEALAVELGKSHY-HYNA-PPKYYSYVGAEFICAVQPILKER-FT-SELEEAWKTLFQYVTGLMRKGHQEEGSRQR-HLALPPKDGPEKRTSAL Tetraodon_HbA MT-----------------------------------------------------------------------------------------------------------------------------------SLSTKDKETVRAFWAKVAS-NREEIGASALCR-LLSVYPQTK--TYF-SHWKDQS----P-----NSASAKKHGITIMNAVGDAVSKIDDLK---TGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYPAD-FT-PEVHVAMDKFLASLALALSEKYR------------------------- Tetraodon_HbB MV-----------------------------------------------------------------------------------------------------------------------------------VWTDQERAIIDNIFSNL---DYEDVGSKALIR-CLIVYPWTQ--RYF-SSFGNLY----NAEAIRNNPNVAKHGVTVLHGLDRALKNMDNIK---EEYKK----HSEKLHV-DPDNFKLLSDCLTVVIAGKLGSK-FT-PEYQAALQKFLAVVVSALGRQYH------------------------- Tetraodon_Mb M----------------------------------------------------------------------------------------------------------------------------------------GDFDMVLKFWGPVEA-DYSAHGGMVLTR-LFTENPETQ--QLF-PKFVGI-----AQSELAGNAAVSAHGATVLKKLGELLKAKGNHA---AILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEKAGLD----TAGQQALRNIMATIIADIDATYKELGFS-------------------- Tetraodon_NgB ME-----------------------------------------------------------------------------------------------------------------------------------KLSSKDKELIRGSWDSLGK-NKVPHGVILFSR-LFELDPELL--NLF-HYTTNCG----STQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKHQ-AVGV-KPQSFAMVGESLLYMLQCSLGQA-YT-ASLRQAWLNMYSVVVASMSRGWAKNGEDKAD----------------- Zebrafish_Cygb_1 ME-----------------------------------------------------------------------------------------------------------------------GDGGVQLTQSPDSLTEEDVCVIQDTWKPVYA-ERDNAGVAVLVR-FFTNFPSAK--QYF-EHFRELQ----DPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQC-FSPAEVQSSWSKLMGILYWQMNRVYAEVGW----------------ENSKK Zebrafish_Cygb_2 ME--------------------------------------------------------------------------------------------------------------------KEREDEETEGRERPEPLTDVERGIIKDTWARVYA-SCEDVGVTILIR-FFVNFPSAK--QYF-SQFQDME----DPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGEC-FT-PEVQTSWSKLMAALYWHITGAYTEVGWVK-------------LSSSAV Zebrafish_GbX MG-----------------------------------------------------------------------------------------------------CAISGSGLTAGAPEIRPGEE------ETPAGLTTNHIRLIKESWRLIQE-DIAKVGIIMFVR-LFETHPECK--DVF-FLFRDVE----DLERLRTSRELRAHGLRVMSFIEKSVARLDQLERLETLALELGKSHY-RYNA-PPKYYGYVGAEFICAVRPILKDR-WT-PELEEAWKTLFQYVTSIMREGFLEEERNKRSNTQTSSRERPDKRSTAI Zebrafish_HbA M------------------------------------------------------------------------------------------------------------------------------------SLSDTDKAVVKAIWAKISP-KADEIGAEALAR-MLTVYPQTK--TYF-SHWADLS----P-----GSGPVKKHGKTIMGAVGEAVSKIDDLV---GGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFPAD-FT-PEVHVSVDKFFNNLALALSEKYR------------------------- Zebrafish_HbB MV-----------------------------------------------------------------------------------------------------------------------------------EWTDAERTAILGLWGKL---NIDEIGPQALSR-CLIVYPWTQ--RYF-ATFGNLS----SPAAIMGNPKVAAHGRTVMGGLERAIKNMDNVK---NTYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGFN-ADVQEAWQKFLAVVVSALCRQYH------------------------- Zebrafish_Mb M----------------------------------------------------------------------------------------------------------------------------------------ADHDLVLKCWGAVEA-DYAANGGEVLNR-LFKEYPDTL--KLF-PKFSGI-----SQGDLAGSPAVAAHGATVLKKLGELLKAKGDHA---ALLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEKAGLD----AAGQGALRRVMDAVIGDIDGYYKEIGFAG------------------- Zebrafish_NgB ME-----------------------------------------------------------------------------------------------------------------------------------KLSEKDKGLIRDSWESLGK-NKVPHGIVLFTR-LFELDPALL--TLF-SYSTNCG----DAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKHQ-AVGV-NTQSFALVGESLLYMLQSSLGPA-YT-TSLRQAWLTMYSIVVSAMTRGWAKNGEHKSN----------------- ; end; Alignment 15 of 20 file name: vertebrate_globins.NgB_GbX_Ciona.aa.mafft_linsi.nex #NEXUS begin data; dimensions ntax=76 nchar=320; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb ME--------------------------------------------------------------------------------------------------------------------KVQGEMEIERWERNEEMSDAEKKMIQETWNTVYA-KCEDVGVSLLIR-FFVNFPSAK--HYF-SQFKHME----DPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLL-GVLLEVLAEEYTNE-FSPPEVQRAWAKMKSLICTHVTAAYKEVGWVQY--PNSTM----------- Anolis_GbY K----------------------------------------------------------------------------------------------------------------------------------AGKMTDLDRRHIREIWTAAFE-NPEENGRLVIIR-FFSDYPASK--QYF----KTVP----TDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLGRT-FT-PEKRVSWEKFFQVIQEEVEAAYDR------------------------ Anolis_HbA M-------------------------------------------------------------------------------------------------------------------------------------LTEDDKNHIRAIWGHVSS-NPELYGAEALTR-LFAAHHTTK--TYF-PHY-DMS----P-----GSAQIKAHGKKVVEAITQAVNNLDDIA---GALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNRGP-LK-PEFILALDKCFTSIGRVLIAQYR------------------------- Anolis_HbB M-----------------------------------------------------------------------------------------------------------------------------------VHWTAEEKQLIANCWSKV---DIGQIGGDALAC-LLCVYPWTQ--RFF-PDFGNLS----NAAAICANAKVKAHGKKVLTAFGEAVKNLDNIK---DTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFGKD-FT-PACHAAYQKLVNSVAHGLSRRYH------------------------- Anolis_Mb M------------------------------------------------------------------------------------------------------------------------------------ELSDQEWQKVIDIWGKVEP-EIPAYGQMVILR-LFEQHPETQ--EKF-DKFKNLK----SLDEMKNSEDLKKHGTIVLTALGKILKQKRQHE---AELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSAD-FG-AESQAAMRKALELFRNDMDRKYKELGFQG------------------- Arctic_lamprey_Hb1 M---------------------------------------------------------------------------------------------------------------------------PIVDSGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQ--EFF-PKFKGMT----SADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Arctic_lamprey_Hb2 M---------------------------------------------------------------------------------------------------------------------------PIVDSGSVPALTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNPAAQ--EFF-PKFQGLT----SADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTV-----------LPGDAGLEKLMSMICILLKSSY-------------------------- Arctic_lamprey_Hb4 M---------------------------------------------------------------------------------------------------------------------------PIEDSGSKPDFSDDEKKAIKDSWSGVYS-EYESTSSEILIK-FFVDNPSAQ--DFF-PKFKDLD----SEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKNDGS-FS-DSARSAWEKLLTYICISLKVAY-------------------------- Chicken_Cygb ME--------------------------------------------------------------------------------------------------------------------KVQGEMEIERWERSEEISDAEKKVIQETWSRVYA-NCEDVGVSILIR-FFVNFPSAK--QYF-SQFKHMD----DTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGND-FT-PEAHGAWTKMRTLIYTHVTAAYKEAGWVSY--PSATL----------- Chicken_GbE M------------------------------------------------------------------------------------------------------------------------------------SFSEAEVQSARGAWEKMYV-DAEDNGTAVLVR-MFTEHPDTK--SYF-THFKGMD----SAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFG------GDCKASFEKVTNEICTHLTNIYKEAGW--------------------- Chicken_HbA M------------------------------------------------------------------------------------------------------------------------------------VLSAADKNNVKGIFTKIAG-HAEEYGAETLER-MFTTYPPTK--TYF-PHF-DLS----H-----GSAQIKGHGKKVVAALIEAANHIDDIA---GTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHPAA-LT-PEVHASLDKFLCAVGTVLTAKYR------------------------- Chicken_HbB M-----------------------------------------------------------------------------------------------------------------------------------VHWSAEEKQLITSVWSKV---NVEECGAEALAR-LLIVYPWTQ--RFF-ASFGNLS----SPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNIK---NTYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFARD-FT-PACQFAWQKLVNVVAHALARKYH------------------------- Chicken_Mb M------------------------------------------------------------------------------------------------------------------------------------GLSDQEWQQVLTIWGKVEA-DIAGHGHEVLMR-LFHDHPETL--DRF-DKFKGLK----TPDQMKGSEDLKKHGATVLTQLGKILKQKGNHE---SELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAAD-FG-ADSQAAMKKALELFRNDMASKYKEFGFQG------------------- Finch_Cygb ME--------------------------------------------------------------------------------------------------------------------KVQGEMEIERWERSEEISDAEKKVIQEIWSRVYA-NCEDVGVSILIR-FFVNFPSAK--QYF-SQFKHME----DPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPND-FT-PEAHGAWTKMKTLIYTHVTAAYKEVGWAQY--PTATL----------- Finch_GbE M------------------------------------------------------------------------------------------------------------------------------------SLSEAEVQSARGAWEKIYV-DAEDNGTAVLVR-MFTEHPDTK--SYF-PHFKGMD----SAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFG------GDCKASFEKVTNEICTHLNNIYKEEGW--------------------- Finch_HbA M------------------------------------------------------------------------------------------------------------------------------------VLSAGDKSNVKAVFGKIGG-QADEYGADALER-MFATYPQTK--TYF-PHF-DLG----K-----GSAQVKGHGKKVAAALVEAANNVDDLA---GALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNPSL-LT-PEVHASLDKFLCAVGTVLTAKYR------------------------- Finch_HbB M-----------------------------------------------------------------------------------------------------------------------------------VHWSAEEKQLIASVWGRV---SVEECGAEALAR-LLIVYPWTQ--RFF-SDFGNLS----SPTAIVGNPKVRAHGKKVLTSFGEAIKNLDNLK---GTYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFTKE-FT-PACQATWQKLVGVVAHALARKYH------------------------- Finch_Mb M------------------------------------------------------------------------------------------------------------------------------------GLSDQEWQQVLTVWGKVES-DLAGHGHQILMR-LFQDHPETL--DRF-EKFKGLK----TPDAMKGSEDLKKHGVTVLTQLGKILKAKGNHE---AELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAAD-FG-ADAQAAMKKALELFRNDMATKYKEFGFQG------------------- Frog_Cygb ME--------------------------------------------------------------------------------------------------------------------KVQGENDMERWERLEEITESERGVIKETWARVYA-NCEDVGVSILIR-FFVNFPSAK--QHF-SQFKHME----DPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAKD-FT-PDVQLAWNKLRSHLYSHVLSAYKEAGWTQY--PSNSV----------- Frog_GbX MG--C---------------------------------------------------------------------------------------------------ILSSLGWQWR----DSLDHTETSPLLPTLNLSEQQQQLLVESWRLIQH-DIAKVGVILFVR-LFETHPECK--DVF-FLFRDVD----DLQALRANKDLRAHGLRVLSFVEKSVARIADCARLEELALELGRSXY-RYNA-PPRYYQYVGTEFISAVCPMLHDK-WT-AEVEEAWKGLFAYICTVMERGYQEEERRHS--DGRSLIDGLQGNKGLI Frog_GbY M-----------------------------------------------------------------------------------------------------------------------------------ADLTGADIENINEVWSKIYA-NPEESGRTVVIS-LFLTYPQTK--IYF-KNLKNIS----TLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALGSG-FT-PEQSKSWEKLFSITYKYLESCYANTDS--------------------- Frog_HbA1 M------------------------------------------------------------------------------------------------------------------------------------HLTADDKKHIKAIWPSVAA-HGDKYGGEALHR-MFMCAPKTK--TYF-PDF-DFS----E-----HSKHILAHGKKVSDALNEACNHLDNIA---GCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFPKQ-FD-PATHKALDKFLVSVSNVLTSKYR------------------------- Frog_HbB M-----------------------------------------------------------------------------------------------------------------------------------VNLTAKERQLITGTWSKI---CAKTLGKQALGS-MLYTYPWTQ--RYF-SSFGNLS----SIEAIFHNAAVATHGEKVLTSIGEAIKHMDDIK---GYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQED-FT-PELQAAFEKLFAAIADALGKGYH------------------------- Frog_NgB M---------------------------------------------------------------------------------------------------------------------------------EKDQLSGPQKELIRESWQTVSQ-DQLHHGTVLFSSDIFQLKSGLYWSSEVPRECLIRV----VHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKHR-AVGV-KLESFNTVGESLLFALESCLGDA-FT-SDTREAWSLLYANVVQSMSRGWHRDSQEQR--EGI------------- Hagfish_Hb1 M---------------------------------------------------------------------------------------------------------------------------PITDQGPLPTLSEGDKKAIRESWPQIYQ-NFEQTGLVVLLE-FLQKNPGAQ--QSF-PKFSA------TKCNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTI------------RGKAAYEKLFSIICTLLRSSYDE------------------------ Hagfish_Hb2 M------------------------------------------------------------------------------------------------------------------------------SAHGIARTTEGERAAVRASWAVLMK-DYEHAGVQILDK-FFKANPAAK--PFF-TKMKDLH----TLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKRNGG--LS-GEGKSGWHKVMTIICKMLKSKY-------------------------- Hagfish_Hb3 M---------------------------------------------------------------------------------------------------------------------------PITDHGQPPTLSEGDKKAIRESWPQIYK-NFEQNSLAVLLE-FLKKFPKAQ--DSF-PKFSA------KKSHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTM------------GGKAAYEKLFSIIATLLRSTYDA------------------------ Hagfish_Hb4 M---------------------------------------------------------------------------------------------------------------------------PITDQRPLPTLSEGEKKAIKESWPQIYQ-NFEQTSLDVLIE-FLQKFPEAQ--DSF-PKFSA------KKCHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTI------------RGKAAYEKLFSIICTLLRSSYDE------------------------ Houndshark_HbA M------------------------------------------------------------------------------------------------------------------------------------AFTACEKQTIGKIAQVLAK-SPEAYGAECLAR-LFVTHPGSK--SYF--EYKDYS----A-----AGAKVQVHGGKVIRAVVKAAEHVDDLH---SHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHLTE--FS-PDTHCAVDKLLSAICQELSSRYR------------------------- Houndshark_HbB M-----------------------------------------------------------------------------------------------------------------------------------VHWTQEERDEISKTFQGT---DMKTVVTQALDR-MFKVYPWTN--RYF-QKRTDFR----S----------SIHAGIVVGALQDAVKHMDDVK---TLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRKDC-FT-PHIQGIWDKFFEVVIDAISKQYH------------------------- Houndshark_Mb M----------------------------------------------------------------------------------------------------------------------------------------VDWEKVNSVWSAVES-DLTAIGQNILLR-LFEQYPESQ--NHF-PKFKNK-----SLGELKDTADIKAQADTVLSALGNIVKKKGSHS---QPVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPSE-MN-AQVQAAFSGAFKIICSDIEKEYKAANFQG------------------- Human_Cygb ME--------------------------------------------------------------------------------------------------------------------KVPGEMEIERRERSEELSEAERKAVQAMWARLYA-NCEDVGVAILVR-FFVNFPSAK--QYF-SQFKHME----DPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFASD-FP-PETQRAWAKLRGLIYSHVTAAYKEVGWVQQ--VPNATTPPATLPSSGP Human_HbA M------------------------------------------------------------------------------------------------------------------------------------VLSPADKTNVKAAWGKVGA-HAGEYGAEALER-MFLSFPTTK--TYF-PHF-DLS----H-----GSAQVKGHGKKVADALTNAVAHVDDMP---NALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLPAE-FT-PAVHASLDKFLASVSTVLTSKYR------------------------- Human_HbB M-----------------------------------------------------------------------------------------------------------------------------------VHLTPEEKSAVTALWGKV---NVDEVGGEALGR-LLVVYPWTQ--RFF-ESFGDLS----TPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLK---GTFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFGKE-FT-PPVQAAYQKVVAGVANALAHKYH------------------------- Human_Mb M------------------------------------------------------------------------------------------------------------------------------------GLSDGEWQLVLNVWGKVEA-DIPGHGQEVLIR-LFKGHPETL--EKF-DKFKHLK----SEDEMKASEDLKKHGATVLTALGGILKKKGHHE---AEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPGD-FG-ADAQGAMNKALELFRKDMASNYKELGFQG------------------- Human_NgB --------------------------------------------------------------------------------------------------------------------------------------MERPEPELIRQSWRAVSR-SPLEHGTVLFAR-LFALEPDLL--PLFQYNCRQFS----SPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHR-AVGV-KLSSFSTVGESLLYMLEKCLGPA-FT-PATRAAWSQLYGAVVQAMSRGWDGE----------------------- Medaka_Cygb_1 ME----------------------------------------------------------------------------------------------------------------------RKQGEVDHLERSRPLTDKERVMIQDSWAKVYQ-NCDDAGVAILVR-LFVNFPSSK--QYF-SQFKHIE----DAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQV-MT-AEVASAWTNLLAILCCSIKAVYEELGWPHL--SNSTS----------- Medaka_Cygb_2 MSCRE---------------------------------------------------------------------------------------------------SPPPPSPPPQML--GVQRGECEDRPERAEPLSDAEMEIIQHTWGHVYK-NCEDVGVSVLIR-FFVNFPSAK--QYF-SQFQDMQ----DPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPEF-FT-AEVQLVWTKLMAAVYWHVTGAYTEVGWLQV--SSSAV----------- Medaka_GbX MG--C---------------------------------------------------------------------------------------------------AISGLAAKTDLAE-RSRED------AAVEHPNEEQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHPECK--DVF-FLFRDVE----DLERLRTNRELRAHGLRVMSFIEKSVARLDQPERLEALAVELGKSHY-HYNA-PPKYYNYVGAEFICAVQPILKEQ-WT-TELEKAWQTLFQFVTALMKQGYQEESARQR-QLATSPKDRLDKRNTAL Medaka_HbA K-----------------------------------------------------------------------------------------------------------------------------------MSLSAKDKAAVKAFWAKVSG-QADAIGSDALSR-MLVVYPQTK--TYF-AHWKDLS----P-----GSAPVKKHGKTVMGGIADAVGKIDDIS---SGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFPQD-FT-PEVHVALDKFLAAVSLALSEKYR------------------------- Medaka_HbB M-----------------------------------------------------------------------------------------------------------------------------------VEWTEQERSIITNIFGNL---DYEDVGSKALSR-CLIVYPWTQ--RYF-ASFGNLY----NAEAIKTNPNIAAHGTKVLHGLDRAVKNMDNIK---ATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLGSA-FS-PEIQATFQKFLAVVVSALGRQYH------------------------- Medaka_Mb M----------------------------------------------------------------------------------------------------------------------------------------ADYDMVLKHWGPVEA-DYNTHGNLVLTR-LFHEYPETQ--KLF-PKFAGI-----AKGDMAGNAALSAHGATVLKKLGELLKARGNHG---AILKPLANSHATKHKI-PINNFRLITEVIGKVMAEKAGLD----AAGQQALRSVMAGIIAEIEADYKELGFAG------------------- Medaka_NgB M-----------------------------------------------------------------------------------------------------------------------------------EKLSGKDKELIRGSWESLGK-NKVPHGVIMFSR-LFELDPALL--SLF-NYNTNCG----STQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKHQ-AVGV-STQSFAVVGESLLYMLQCSLGQA-YT-AALSQAWLNMYSIVVAAMSRGWAKNGEDKA--D--------------- Platypus_GbY M-----------------------------------------------------------------------------------------------------------------------------------VQVTDVEKANIQSIWSKMME-NLEKNGIDIFTR-LFREYPETK--KYF----KNIP----LEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLGPC-YT-PEIAESFQKLQSSLYDQVVITYLHSGSD-------------------- Platypus_HbA M------------------------------------------------------------------------------------------------------------------------------------GLTDGEKKEVAALWANVSG-HEEEFGAEALDR-LFLSFPPTK--TYF-PHF-ELS----Q-----GSAQVKAHGKKVADALTTAVAHLDDLD---STLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLPAE-FT-PSAHAALDKFLSKVATVLTSKYR------------------------- Platypus_HbB M-----------------------------------------------------------------------------------------------------------------------------------VHLSGGEKSAVTNLWGKV---NINELGGEALGR-LLVVYPWTQ--RFF-EAFGDLS----SAGAVMGNPKVKAHGAKVLTSFGDALKNLDDLK---GTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFSKD-FS-PEVQAAWQKLVSGVAHALGHKYH------------------------- Platypus_HbW M-----------------------------------------------------------------------------------------------------------------------------------VNWTSEEKHAIVSIWGKV---DIEETGANALSR-LLVVYPWTQ--RYF-SAFGNLS----SPTAIVGNPRVRAHGKKVLTSFGEAVKDLDHVK---SNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLGKD-FT-PEAQAAWQKLVGVVASALSSQYH------------------------- Platypus_Mb M------------------------------------------------------------------------------------------------------------------------------------GLSDGEWQLVLKVWGKVEG-DLPGHGQEVLIR-LFKTHPETL--EKF-DKFKGLK----TEDEMKASADLKKHGGTVLTALGNILKKKGQHE---AELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSAD-FG-ADAQAAMGKALELFRNDMAAKYKEFGFQG------------------- Platypus_NgB M---------------------------------------------------------------------------------------------------------------------------------ENGRLSGPEQELIRESWRSVNS-NPLEHGMILFTR-LFDLEPDLL--PLFQYNCRQFS----SPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKHK-AIGV-KLSSFSTVGESLLFMLEKCLGPA-FS-PATREAWTRLYTAMVHAMSRGWGGE----------------------- Port_Jackson_shark_Mb M----------------------------------------------------------------------------------------------------------------------------------------TEWEHVNKVWAVVEP-DIPAVGLAILLR-LFKEHKETK--DLF-PKFKEI-----PVQQLGNNEDLRKHGVTVLRALGNILKQKGKHS---TNVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPSD-MT-GPMQESFSKVFTVICSDLETLYKEANFQG------------------- Sea_lamprey_Hb1a M---------------------------------------------------------------------------------------------------------------------------PIVDSGSVPALTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNPAAQ--AFF-PKFQGLT----SADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTV-----------LPGDAGLEKLMSMICILLRSSY-------------------------- Sea_lamprey_Hb1b M---------------------------------------------------------------------------------------------------------------------------PIVDSGSVSPLSDAEKNKIRAAWDLVYK-DYEKTGVDILVK-FFTGTPAAQ--AFF-PKFKGLT----TADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTT-----------APGDAGFEKLMSMICILLSSAY-------------------------- Sea_lamprey_Hb2 M---------------------------------------------------------------------------------------------------------------------------PIVDTGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQ--EFF-PKFKGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb3 M---------------------------------------------------------------------------------------------------------------------------PIVDSGSVAPLSAAEKTKIRSAWAPVYS-NYETTGVDILVK-FFTSTPAAQ--EFF-PKFKGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb5 M---------------------------------------------------------------------------------------------------------------------------PIVDTGSVAPLSAAEKTKIRSAWAPVYS-TYETSGVDILVK-FFTSTPAAQ--EFF-PKFKGLT----TADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb_PMII M---------------------------------------------------------------------------------------------------------------------------PIVDTGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQ--EFF-PKFKGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------AAGDAGFEKLMSMICILLRSAY-------------------------- Sea_squirt_Glb1 M------------------------------------------------------------------------------------------------------------------------------------PFTDEELKLLRDSWDEVKKLGMKEVGLHIFTG-LLNAAPSLR--TLF-YTIDLPDEEELTIDVMRENKKVVAHATRIANAISKFIKFLDQPDELEKLLTSLGESHA-RRQV-DPESFEYVAPVILSVIGGHLKLP-SN-SPTLQAWVKAYGVLRNGIVSAMEA------------------------ Sea_squirt_Glb2 M------------------------------------------------------------------------------------------------------------------------------------GLTTEEIGLLRSSWNEMKTIGMKELGLLIFHR-LFSDVPRIR--KMF-YNLELPDDETLTMEAMRSNQKMSRHATRIATSISTYLKLADQPEELKTFLNGLGELHA-GHNV-EPEDFEYLAPVMLAVIGGQLNLN-SN-SSILQAWVKAYGVLRNGIVRGMYAYQG--------------------- Sea_squirt_Glb3 M------------------------------------------------------------------------------------------------------------------------------------SLTSEQVVLLRSSWQTIGKLGMSNVGLAVLHR-LFNDVPETL--PFF-HSVLSPT-QQTEIEVLKSNAKVVRHASRVGLSIDKIINLLDNGEELVKYLLFLGQVHV-KRSI-PRKYFSAMGPVLLSVISAVLEKD-LD-APVMQAWATAYGVIEQGIIDGM-------------------------- Sea_squirt_Glb4 MKIICGLILFSTFAIIFVSGLNCWTCNVLGGNNVCRRSGGLRTCFNNQVCYNEVRRRGNTINIRKGCKNSGVCENHIMQSMSTPNPNNQCVNGPNYFCSCCCGNSVCNSNWLTCVTAGSVAPTVSTTVPPADEGLKRSDIINIQDSWNTLKGFGYETVGMLVLHR-LFNDAPQTR--YLF-SQLSLSSNESFTLEQMRNNSRVVYHANRVARAVGRLVDLIELPTNFTDHLVWLGQRHA-YHGV-APVNFDYMGPVLLETIKVNLELP-SD-SPTLSAWAKAYGVIKNGIKDAIIATYAEG------------------- Stingray_HbA M------------------------------------------------------------------------------------------------------------------------------------VLSSQNKKAIEELGNLIKA-NAEAWGADALAR-LFELHPQTK--TYF-SKFSGFE----A-----CNEQVKKHGKRVMNALADATHHLDNLH---LHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNLQA--FT-PVTHCAVDKFLELVAYELSSCYR------------------------- Stingray_HbB M-----------------------------------------------------------------------------------------------------------------------------------VKLSEDQEHYIKGVWKDV---DHKQITAKALER-VFVVYPWTT--RLF-SKLQGLF----SA----NDIGVQQHADKVQRALGEAIDDLKKVE---INFQNLSGKHQ-EIGV-DTQNFKLLGQTFMVELALHYKKT-FR-PKEHAAAYKFFRLVAEALSSNYH------------------------- Tetraodon_Cygb_1 ME--------------------------------------------------------------------------------------------------------------------RMQRDGEVDHVEQPGPLTEKEKVMIQDSWAKVFQ-SCDDAGVAILVR-FFVNFPSSK--QFF-KDFKHME----EPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTEI-IT-AEVASAWTKLLANMCCGIAAVYKEAGWTEL--SSSVE----------- Tetraodon_Cygb_2 MSHRE---------------------------------------------------------------------------------------------------PPPP------QLAVQRRDVDGQDGPERAEPLSDTEREMIRDAWGHVYK-NCEDVGVSILIR-FFVNFPSAK--QYF-SQFQDME----EPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPEF-FT-ADVQLVWSKLMATVYWHVTGAYTDVGWLQV--SSSAV----------- Tetraodon_GbX MG--C---------------------------------------------------------------------------------------------------AISSLGAKAEFGD-RSAEEEDAAAAAAVVYPREDQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHPECK--DVF-FLFRDVE----DLERLRSSRELRAHGLRVMSFIEKSVARLDQQDRLEALAVELGKSHY-HYNA-PPKYYSYVGAEFICAVQPILKER-FT-SELEEAWKTLFQYVTGLMRKGHQEEGSRQR-HLALPPKDGPEKRTSAL Tetraodon_HbA M-----------------------------------------------------------------------------------------------------------------------------------TSLSTKDKETVRAFWAKVAS-NREEIGASALCR-LLSVYPQTK--TYF-SHWKDQS----P-----NSASAKKHGITIMNAVGDAVSKIDDLK---TGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYPAD-FT-PEVHVAMDKFLASLALALSEKYR------------------------- Tetraodon_HbB M-----------------------------------------------------------------------------------------------------------------------------------VVWTDQERAIIDNIFSNL---DYEDVGSKALIR-CLIVYPWTQ--RYF-SSFGNLY----NAEAIRNNPNVAKHGVTVLHGLDRALKNMDNIK---EEYKK----HSEKLHV-DPDNFKLLSDCLTVVIAGKLGSK-FT-PEYQAALQKFLAVVVSALGRQYH------------------------- Tetraodon_Mb M----------------------------------------------------------------------------------------------------------------------------------------GDFDMVLKFWGPVEA-DYSAHGGMVLTR-LFTENPETQ--QLF-PKFVGI-----AQSELAGNAAVSAHGATVLKKLGELLKAKGNHA---AILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEKAGLD----TAGQQALRNIMATIIADIDATYKELGFS-------------------- Tetraodon_NgB M-----------------------------------------------------------------------------------------------------------------------------------EKLSSKDKELIRGSWDSLGK-NKVPHGVILFSR-LFELDPELL--NLF-HYTTNCG----STQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKHQ-AVGV-KPQSFAMVGESLLYMLQCSLGQA-YT-ASLRQAWLNMYSVVVASMSRGWAKNGEDKA--D--------------- Zebrafish_Cygb_1 ME-----------------------------------------------------------------------------------------------------------------------GDGGVQLTQSPDSLTEEDVCVIQDTWKPVYA-ERDNAGVAVLVR-FFTNFPSAK--QYF-EHFRELQ----DPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQC-FSPAEVQSSWSKLMGILYWQMNRVYAEVGWENS--KK-------------- Zebrafish_Cygb_2 ME--------------------------------------------------------------------------------------------------------------------KEREDEETEGRERPEPLTDVERGIIKDTWARVYA-SCEDVGVTILIR-FFVNFPSAK--QYF-SQFQDME----DPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGEC-FT-PEVQTSWSKLMAALYWHITGAYTEVGWVKL--SSSAV----------- Zebrafish_GbX MG--C---------------------------------------------------------------------------------------------------AISGSGLTAGAPEIRPGEE------ETPAGLTTNHIRLIKESWRLIQE-DIAKVGIIMFVR-LFETHPECK--DVF-FLFRDVE----DLERLRTSRELRAHGLRVMSFIEKSVARLDQLERLETLALELGKSHY-RYNA-PPKYYGYVGAEFICAVRPILKDR-WT-PELEEAWKTLFQYVTSIMREGFLEEERNKRSNTQTSSRERPDKRSTAI Zebrafish_HbA M------------------------------------------------------------------------------------------------------------------------------------SLSDTDKAVVKAIWAKISP-KADEIGAEALAR-MLTVYPQTK--TYF-SHWADLS----P-----GSGPVKKHGKTIMGAVGEAVSKIDDLV---GGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFPAD-FT-PEVHVSVDKFFNNLALALSEKYR------------------------- Zebrafish_HbB M-----------------------------------------------------------------------------------------------------------------------------------VEWTDAERTAILGLWGKL---NIDEIGPQALSR-CLIVYPWTQ--RYF-ATFGNLS----SPAAIMGNPKVAAHGRTVMGGLERAIKNMDNVK---NTYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGFN-ADVQEAWQKFLAVVVSALCRQYH------------------------- Zebrafish_Mb M----------------------------------------------------------------------------------------------------------------------------------------ADHDLVLKCWGAVEA-DYAANGGEVLNR-LFKEYPDTL--KLF-PKFSGI-----SQGDLAGSPAVAAHGATVLKKLGELLKAKGDHA---ALLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEKAGLD----AAGQGALRRVMDAVIGDIDGYYKEIGFAG------------------- Zebrafish_NgB M-----------------------------------------------------------------------------------------------------------------------------------EKLSEKDKGLIRDSWESLGK-NKVPHGIVLFTR-LFELDPALL--TLF-SYSTNCG----DAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKHQ-AVGV-NTQSFALVGESLLYMLQSSLGPA-YT-TSLRQAWLTMYSIVVSAMTRGWAKNGEHKS--N--------------- ; end; Alignment 16 of 20 file name: vertebrate_globins.NgB_GbX_Ciona.aa.muscle.nex #NEXUS begin data; dimensions ntax=76 nchar=320; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb --------------------------------------------------------------------------------------------------------------------MEKVQGEMEIERWERNEEMSDAEKKMIQETWNTVYA-KCEDVGVSLLIR-FFVNFP---SAKHYFSQF----KHMEDPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLLG-VLLEVLAEEYTNE-FSPPEVQRAWAKMKSLICTHVTAAYKEVGWVQ------YPNSTM------- Anolis_GbY ----------------------------------------------------------------------------------------------------------------------------------KAGKMTDLDRRHIREIWTAAFE-NPEENGRLVIIR-FFSDYP---ASKQYF-------KTVPTDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLGRT-FT-PEKRVSWEKFFQVIQEEVEAAYDR------------------------ Anolis_HbA -------------------------------------------------------------------------------------------------------------------------------------MLTEDDKNHIRAIWGHVSS-NPELYGAEALTR-LFAAHH---TTKTYFPHY----------DMSPGSAQIKAHGKKVVEAITQAVNNLDDIAGA---LAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNRGP-LK-PEFILALDKCFTSIGRVLIAQYR------------------------- Anolis_HbB -----------------------------------------------------------------------------------------------------------------------------------MVHWTAEEKQLIANCWSKV---DIGQIGGDALAC-LLCVYP---WTQRFFPDF----GNLSNAAAICANAKVKAHGKKVLTAFGEAVKNLDNIKDT---FAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFGKD-FT-PACHAAYQKLVNSVAHGLSRRYH------------------------- Anolis_Mb ------------------------------------------------------------------------------------------------------------------------------------MELSDQEWQKVIDIWGKVEP-EIPAYGQMVILR-LFEQHP---ETQEKFDKF----KNLKSLDEMKNSEDLKKHGTIVLTALGKILKQKRQHEAE---LAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSAD-FG-AESQAAMRKALELFRNDMDRKYKELGFQG------------------- Arctic_lamprey_Hb1 ---------------------------------------------------------------------------------------------------------------------------MPIVDSGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTP---AAQEFFPKF----KGMTSADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG-----------FEKLMSMICILLRSAY-------------------------- Arctic_lamprey_Hb2 ---------------------------------------------------------------------------------------------------------------------------MPIVDSGSVPALTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNP---AAQEFFPKF----QGLTSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTVLPGDAG-----------LEKLMSMICILLKSSY-------------------------- Arctic_lamprey_Hb4 ---------------------------------------------------------------------------------------------------------------------------MPIEDSGSKPDFSDDEKKAIKDSWSGVYS-EYESTSSEILIK-FFVDNP---SAQDFFPKF----KDLDSEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKNDGS-FS-DSARSAWEKLLTYICISLKVAY-------------------------- Chicken_Cygb --------------------------------------------------------------------------------------------------------------------MEKVQGEMEIERWERSEEISDAEKKVIQETWSRVYA-NCEDVGVSILIR-FFVNFP---SAKQYFSQF----KHMDDTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGND-FT-PEAHGAWTKMRTLIYTHVTAAYKEAGWVS------YPSATL------- Chicken_GbE ------------------------------------------------------------------------------------------------------------------------------------MSFSEAEVQSARGAWEKMYV-DAEDNGTAVLVR-MFTEHP---DTKSYFTHF----KGMDSAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFGGD------CKASFEKVTNEICTHLTNIYKEAGW--------------------- Chicken_HbA ------------------------------------------------------------------------------------------------------------------------------------MVLSAADKNNVKGIFTKIAG-HAEEYGAETLER-MFTTYP---PTKTYFPHF----------DLSHGSAQIKGHGKKVVAALIEAANHIDDIAGT---LSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHPAA-LT-PEVHASLDKFLCAVGTVLTAKYR------------------------- Chicken_HbB -----------------------------------------------------------------------------------------------------------------------------------MVHWSAEEKQLITSVWSKV---NVEECGAEALAR-LLIVYP---WTQRFFASF----GNLSSPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNIKNT---YAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFARD-FT-PACQFAWQKLVNVVAHALARKYH------------------------- Chicken_Mb ------------------------------------------------------------------------------------------------------------------------------------MGLSDQEWQQVLTIWGKVEA-DIAGHGHEVLMR-LFHDHP---ETLDRFDKF----KGLKTPDQMKGSEDLKKHGATVLTQLGKILKQKGNHESE---LKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAAD-FG-ADSQAAMKKALELFRNDMASKYKEFGFQG------------------- Finch_Cygb --------------------------------------------------------------------------------------------------------------------MEKVQGEMEIERWERSEEISDAEKKVIQEIWSRVYA-NCEDVGVSILIR-FFVNFP---SAKQYFSQF----KHMEDPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPND-FT-PEAHGAWTKMKTLIYTHVTAAYKEVGWAQ------YPTATL------- Finch_GbE ------------------------------------------------------------------------------------------------------------------------------------MSLSEAEVQSARGAWEKIYV-DAEDNGTAVLVR-MFTEHP---DTKSYFPHF----KGMDSAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFGGD------CKASFEKVTNEICTHLNNIYKEEGW--------------------- Finch_HbA ------------------------------------------------------------------------------------------------------------------------------------MVLSAGDKSNVKAVFGKIGG-QADEYGADALER-MFATYP---QTKTYFPHF----------DLGKGSAQVKGHGKKVAAALVEAANNVDDLAGA---LSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNPSL-LT-PEVHASLDKFLCAVGTVLTAKYR------------------------- Finch_HbB -----------------------------------------------------------------------------------------------------------------------------------MVHWSAEEKQLIASVWGRV---SVEECGAEALAR-LLIVYP---WTQRFFSDF----GNLSSPTAIVGNPKVRAHGKKVLTSFGEAIKNLDNLKGT---YSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFTKE-FT-PACQATWQKLVGVVAHALARKYH------------------------- Finch_Mb ------------------------------------------------------------------------------------------------------------------------------------MGLSDQEWQQVLTVWGKVES-DLAGHGHQILMR-LFQDHP---ETLDRFEKF----KGLKTPDAMKGSEDLKKHGVTVLTQLGKILKAKGNHEAE---LKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAAD-FG-ADAQAAMKKALELFRNDMATKYKEFGFQG------------------- Frog_Cygb --------------------------------------------------------------------------------------------------------------------MEKVQGENDMERWERLEEITESERGVIKETWARVYA-NCEDVGVSILIR-FFVNFP---SAKQHFSQF----KHMEDPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAKD-FT-PDVQLAWNKLRSHLYSHVLSAYKEAGWTQ------YPSNSV------- Frog_GbX ------------------------------------------------------------------------------------------------------MGCILSSLGWQ---WRDSLDHTETSPLLPTLNLSEQQQQLLVESWRLIQH-DIAKVGVILFVR-LFETHP---ECKDVFFLF----RDVDDLQALRANKDLRAHGLRVLSFVEKSVARIADCARLEELALELGRSX-YRYNA-PPRYYQYVGTEFISAVCPMLHDK-WT-AEVEEAWKGLFAYICTVMERGYQEEERRHSDGRSLIDGLQGNKGLI-- Frog_GbY -----------------------------------------------------------------------------------------------------------------------------------MADLTGADIENINEVWSKIYA-NPEESGRTVVIS-LFLTYP---QTKIYFKNL----KNISTLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALGSG-FT-PEQSKSWEKLFSITYKYLESCYANTDS--------------------- Frog_HbA1 ------------------------------------------------------------------------------------------------------------------------------------MHLTADDKKHIKAIWPSVAA-HGDKYGGEALHR-MFMCAP---KTKTYFPDF----------DFSEHSKHILAHGKKVSDALNEACNHLDNIAGC---LSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFPKQ-FD-PATHKALDKFLVSVSNVLTSKYR------------------------- Frog_HbB -----------------------------------------------------------------------------------------------------------------------------------MVNLTAKERQLITGTWSKI---CAKTLGKQALGS-MLYTYP---WTQRYFSSF----GNLSSIEAIFHNAAVATHGEKVLTSIGEAIKHMDDIKGY---YAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQED-FT-PELQAAFEKLFAAIADALGKGYH------------------------- Frog_NgB ---------------------------------------------------------------------------------------------------------------------------------MEKDQLSGPQKELIRESWQTVSQ-DQLHHGTVLFSSDIFQLKSGLYWSSEVPREC----LIRVVHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKH-RAVGV-KLESFNTVGESLLFALESCLGDA-FT-SDTREAWSLLYANVVQSMSRGWHRDSQEQREGI--------------- Hagfish_Hb1 ---------------------------------------------------------------------------------------------------------------------------MPITDQGPLPTLSEGDKKAIRESWPQIYQ-NFEQTGLVVLLE-FLQKNP---GAQQSFPKF----SATKC--NLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTIRGKAA------------YEKLFSIICTLLRSSYDE------------------------ Hagfish_Hb2 ------------------------------------------------------------------------------------------------------------------------------MSAHGIARTTEGERAAVRASWAVLMK-DYEHAGVQILDK-FFKANP---AAKPFFTKM----KDLHTLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKRNGG--LS-GEGKSGWHKVMTIICKMLKSKY-------------------------- Hagfish_Hb3 ---------------------------------------------------------------------------------------------------------------------------MPITDHGQPPTLSEGDKKAIRESWPQIYK-NFEQNSLAVLLE-FLKKFP---KAQDSFPKF----SAKKS--HLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTMGGKAA------------YEKLFSIIATLLRSTYDA------------------------ Hagfish_Hb4 ---------------------------------------------------------------------------------------------------------------------------MPITDQRPLPTLSEGEKKAIKESWPQIYQ-NFEQTSLDVLIE-FLQKFP---EAQDSFPKF----SAKKC--HLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTIRGKAA------------YEKLFSIICTLLRSSYDE------------------------ Houndshark_HbA ------------------------------------------------------------------------------------------------------------------------------------MAFTACEKQTIGKIAQVLAK-SPEAYGAECLAR-LFVTHP---GSKSYF-EY----KDYSA-----AGAKVQVHGGKVIRAVVKAAEHVDDLHSH---LETLALTHGKKLLV-DPQNFPMLSECIIVTLATHLTE--FS-PDTHCAVDKLLSAICQELSSRYR------------------------- Houndshark_HbB -----------------------------------------------------------------------------------------------------------------------------------MVHWTQEERDEISKTFQGT---DMKTVVTQALDR-MFKVYP---WTNRYFQKR----TDFRSSI----------HAGIVVGALQDAVKHMDDVKTL---FKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRKDC-FT-PHIQGIWDKFFEVVIDAISKQYH------------------------- Houndshark_Mb ----------------------------------------------------------------------------------------------------------------------------------------MVDWEKVNSVWSAVES-DLTAIGQNILLR-LFEQYP---ESQNHFPKF----KNK-SLGELKDTADIKAQADTVLSALGNIVKKKGSHSQP---VKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPSE-MN-AQVQAAFSGAFKIICSDIEKEYKAANFQG------------------- Human_Cygb --------------------------------------------------------------------------------------------------------------------MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYA-NCEDVGVAILVR-FFVNFP---SAKQYFSQF----KHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFASD-FP-PETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATTPPATLPSSGP-- Human_HbA ------------------------------------------------------------------------------------------------------------------------------------MVLSPADKTNVKAAWGKVGA-HAGEYGAEALER-MFLSFP---TTKTYFPHF----------DLSHGSAQVKGHGKKVADALTNAVAHVDDMPNA---LSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLPAE-FT-PAVHASLDKFLASVSTVLTSKYR------------------------- Human_HbB -----------------------------------------------------------------------------------------------------------------------------------MVHLTPEEKSAVTALWGKV---NVDEVGGEALGR-LLVVYP---WTQRFFESF----GDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGT---FATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFGKE-FT-PPVQAAYQKVVAGVANALAHKYH------------------------- Human_Mb ------------------------------------------------------------------------------------------------------------------------------------MGLSDGEWQLVLNVWGKVEA-DIPGHGQEVLIR-LFKGHP---ETLEKFDKF----KHLKSEDEMKASEDLKKHGATVLTALGGILKKKGHHEAE---IKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPGD-FG-ADAQGAMNKALELFRKDMASNYKELGFQG------------------- Human_NgB --------------------------------------------------------------------------------------------------------------------------------------MERPEPELIRQSWRAVSR-SPLEHGTVLFAR-LFALEP---DLLPLFQYNC---RQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGV-KLSSFSTVGESLLYMLEKCLGPA-FT-PATRAAWSQLYGAVVQAMSRGWDGE----------------------- Medaka_Cygb_1 ----------------------------------------------------------------------------------------------------------------------MERKQGEVDHLERSRPLTDKERVMIQDSWAKVYQ-NCDDAGVAILVR-LFVNFP---SSKQYFSQF----KHIEDAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQV-MT-AEVASAWTNLLAILCCSIKAVYEELGWPH------LSNSTS------- Medaka_Cygb_2 -----------------------------------------------------------------------------------------------------MSCRESPPPPSPPPQMLGVQRGECEDRPERAEPLSDAEMEIIQHTWGHVYK-NCEDVGVSVLIR-FFVNFP---SAKQYFSQF----QDMQDPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPEF-FT-AEVQLVWTKLMAAVYWHVTGAYTEVGWLQ------VSSSAV------- Medaka_GbX ------------------------------------------------------------------------------------------------------------MGCAISGLAAKTDLAERSREDAAVEHPNEEQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHP---ECKDVFFLF----RDVEDLERLRTNRELRAHGLRVMSFIEKSVARLDQPERLEALAVELGKSH-YHYNA-PPKYYNYVGAEFICAVQPILKEQ-WT-TELEKAWQTLFQFVTALMKQGYQEESARQRQLATSPKDRLDKRNTAL- Medaka_HbA -----------------------------------------------------------------------------------------------------------------------------------KMSLSAKDKAAVKAFWAKVSG-QADAIGSDALSR-MLVVYP---QTKTYFAHW----KDLSP-----GSAPVKKHGKTVMGGIADAVGKIDDISSG---LLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFPQD-FT-PEVHVALDKFLAAVSLALSEKYR------------------------- Medaka_HbB -----------------------------------------------------------------------------------------------------------------------------------MVEWTEQERSIITNIFGNL---DYEDVGSKALSR-CLIVYP---WTQRYFASF----GNLYNAEAIKTNPNIAAHGTKVLHGLDRAVKNMDNIKAT---YAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLGSA-FS-PEIQATFQKFLAVVVSALGRQYH------------------------- Medaka_Mb ----------------------------------------------------------------------------------------------------------------------------------------MADYDMVLKHWGPVEA-DYNTHGNLVLTR-LFHEYP---ETQKLFPKF----AGIAK-GDMAGNAALSAHGATVLKKLGELLKARGNHGAI---LKPLANSHATKHKI-PINNFRLITEVIGKVMAEKAGLD----AAGQQALRSVMAGIIAEIEADYKELGFAG------------------- Medaka_NgB -----------------------------------------------------------------------------------------------------------------------------------MEKLSGKDKELIRGSWESLGK-NKVPHGVIMFSR-LFELDP---ALLSLFNYN----TNCGSTQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKH-QAVGV-STQSFAVVGESLLYMLQCSLGQA-YT-AALSQAWLNMYSIVVAAMSRGWAKNGEDKAD----------------- Platypus_GbY -----------------------------------------------------------------------------------------------------------------------------------MVQVTDVEKANIQSIWSKMME-NLEKNGIDIFTR-LFREYP---ETKKYF-------KNIPLEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLGPC-YT-PEIAESFQKLQSSLYDQVVITYLHSGSD-------------------- Platypus_HbA ------------------------------------------------------------------------------------------------------------------------------------MGLTDGEKKEVAALWANVSG-HEEEFGAEALDR-LFLSFP---PTKTYFPHF----------ELSQGSAQVKAHGKKVADALTTAVAHLDDLDST---LSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLPAE-FT-PSAHAALDKFLSKVATVLTSKYR------------------------- Platypus_HbB -----------------------------------------------------------------------------------------------------------------------------------MVHLSGGEKSAVTNLWGKV---NINELGGEALGR-LLVVYP---WTQRFFEAF----GDLSSAGAVMGNPKVKAHGAKVLTSFGDALKNLDDLKGT---FAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFSKD-FS-PEVQAAWQKLVSGVAHALGHKYH------------------------- Platypus_HbW -----------------------------------------------------------------------------------------------------------------------------------MVNWTSEEKHAIVSIWGKV---DIEETGANALSR-LLVVYP---WTQRYFSAF----GNLSSPTAIVGNPRVRAHGKKVLTSFGEAVKDLDHVKSN---FAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLGKD-FT-PEAQAAWQKLVGVVASALSSQYH------------------------- Platypus_Mb ------------------------------------------------------------------------------------------------------------------------------------MGLSDGEWQLVLKVWGKVEG-DLPGHGQEVLIR-LFKTHP---ETLEKFDKF----KGLKTEDEMKASADLKKHGGTVLTALGNILKKKGQHEAE---LKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSAD-FG-ADAQAAMGKALELFRNDMAAKYKEFGFQG------------------- Platypus_NgB ---------------------------------------------------------------------------------------------------------------------------------MENGRLSGPEQELIRESWRSVNS-NPLEHGMILFTR-LFDLEP---DLLPLFQYNC---RQFSSPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKH-KAIGV-KLSSFSTVGESLLFMLEKCLGPA-FS-PATREAWTRLYTAMVHAMSRGWGGE----------------------- Port_Jackson_shark_Mb ----------------------------------------------------------------------------------------------------------------------------------------MTEWEHVNKVWAVVEP-DIPAVGLAILLR-LFKEHK---ETKDLFPKF----KEIPV-QQLGNNEDLRKHGVTVLRALGNILKQKGKHSTN---VKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPSD-MT-GPMQESFSKVFTVICSDLETLYKEANFQG------------------- Sea_lamprey_Hb1a ---------------------------------------------------------------------------------------------------------------------------MPIVDSGSVPALTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNP---AAQAFFPKF----QGLTSADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTVLPGDAG-----------LEKLMSMICILLRSSY-------------------------- Sea_lamprey_Hb1b ---------------------------------------------------------------------------------------------------------------------------MPIVDSGSVSPLSDAEKNKIRAAWDLVYK-DYEKTGVDILVK-FFTGTP---AAQAFFPKF----KGLTTADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTTAPGDAG-----------FEKLMSMICILLSSAY-------------------------- Sea_lamprey_Hb2 ---------------------------------------------------------------------------------------------------------------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTP---AAQEFFPKF----KGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG-----------FEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb3 ---------------------------------------------------------------------------------------------------------------------------MPIVDSGSVAPLSAAEKTKIRSAWAPVYS-NYETTGVDILVK-FFTSTP---AAQEFFPKF----KGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG-----------FEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb5 ---------------------------------------------------------------------------------------------------------------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYS-TYETSGVDILVK-FFTSTP---AAQEFFPKF----KGLTTADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG-----------FEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb_PMII ---------------------------------------------------------------------------------------------------------------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTP---AAQEFFPKF----KGLTTADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVAAGDAG-----------FEKLMSMICILLRSAY-------------------------- Sea_squirt_Glb1 ------------------------------------------------------------------------------------------------------------------------------------MPFTDEELKLLRDSWDEVKKLGMKEVGLHIFTG-LLNAAP---SLRTLFYTIDLPDEEELTIDVMRENKKVVAHATRIANAISKFIKFLDQPDELEKLLTSLGESH-ARRQV-DPESFEYVAPVILSVIGGHLKLP-SN-SPTLQAWVKAYGVLRNGIVSAMEA------------------------ Sea_squirt_Glb2 ------------------------------------------------------------------------------------------------------------------------------------MGLTTEEIGLLRSSWNEMKTIGMKELGLLIFHR-LFSDVP---RIRKMFYNLELPDDETLTMEAMRSNQKMSRHATRIATSISTYLKLADQPEELKTFLNGLGELH-AGHNV-EPEDFEYLAPVMLAVIGGQLNLN-SN-SSILQAWVKAYGVLRNGIVRGMYAYQG--------------------- Sea_squirt_Glb3 ------------------------------------------------------------------------------------------------------------------------------------MSLTSEQVVLLRSSWQTIGKLGMSNVGLAVLHR-LFNDVP---ETLPFFHSV-LSPTQQTEIEVLKSNAKVVRHASRVGLSIDKIINLLDNGEELVKYLLFLGQVH-VKRSI-PRKYFSAMGPVLLSVISAVLEKD-LD-APVMQAWATAYGVIEQGIIDGM-------------------------- Sea_squirt_Glb4 MKIICGLILFSTFAIIFVSGLNCWTCNVLGGNNVCRRSGGLRTCFNNQVCYNEVRRRGNTINIRKGCKNSGVCENHIMQSMSTPNPNNQCVNGPNYFCSCCCGNSVCNSNWLTCVTAGSVAPTVSTTVPPADEGLKRSDIINIQDSWNTLKGFGYETVGMLVLHR-LFNDAP---QTRYLFSQLSLSSNESFTLEQMRNNSRVVYHANRVARAVGRLVDLIELPTNFTDHLVWLGQRH-AYHGV-APVNFDYMGPVLLETIKVNLELP-SD-SPTLSAWAKAYGVIKNGIKDAIIATYAEG------------------- Stingray_HbA ------------------------------------------------------------------------------------------------------------------------------------MVLSSQNKKAIEELGNLIKA-NAEAWGADALAR-LFELHP---QTKTYFSKF----SGFEA-----CNEQVKKHGKRVMNALADATHHLDNLHLH---LEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNLQA--FT-PVTHCAVDKFLELVAYELSSCYR------------------------- Stingray_HbB -----------------------------------------------------------------------------------------------------------------------------------MVKLSEDQEHYIKGVWKDV---DHKQITAKALER-VFVVYP---WTTRLFSKL----QGLFSANDI----GVQQHADKVQRALGEAIDDLKKVEIN---FQNLSGKH-QEIGV-DTQNFKLLGQTFMVELALHYKKT-FR-PKEHAAAYKFFRLVAEALSSNYH------------------------- Tetraodon_Cygb_1 --------------------------------------------------------------------------------------------------------------------MERMQRDGEVDHVEQPGPLTEKEKVMIQDSWAKVFQ-SCDDAGVAILVR-FFVNFP---SSKQFFKDF----KHMEEPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTEI-IT-AEVASAWTKLLANMCCGIAAVYKEAGWTE------LSSSVE------- Tetraodon_Cygb_2 ---------------------------------------------------------------------------------------------------------MSHREPPPPQLAVQRRDVDGQDGPERAEPLSDTEREMIRDAWGHVYK-NCEDVGVSILIR-FFVNFP---SAKQYFSQF----QDMEEPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPEF-FT-ADVQLVWSKLMATVYWHVTGAYTDVGWLQ------VSSSAV------- Tetraodon_GbX ------------------------------------------------------------------------------------------------------MGCAISSLGAKAEFGDRSAEEEDAAAAAAVVYPREDQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHP---ECKDVFFLF----RDVEDLERLRSSRELRAHGLRVMSFIEKSVARLDQQDRLEALAVELGKSH-YHYNA-PPKYYSYVGAEFICAVQPILKER-FT-SELEEAWKTLFQYVTGLMRKGHQEEGSRQRHLALPPKDGPEKRTSAL- Tetraodon_HbA -----------------------------------------------------------------------------------------------------------------------------------MTSLSTKDKETVRAFWAKVAS-NREEIGASALCR-LLSVYP---QTKTYFSHW----KDQSP-----NSASAKKHGITIMNAVGDAVSKIDDLKTG---LFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYPAD-FT-PEVHVAMDKFLASLALALSEKYR------------------------- Tetraodon_HbB -----------------------------------------------------------------------------------------------------------------------------------MVVWTDQERAIIDNIFSNL---DYEDVGSKALIR-CLIVYP---WTQRYFSSF----GNLYNAEAIRNNPNVAKHGVTVLHGLDRALKNMDNIKEE-------YKKHSEKLHV-DPDNFKLLSDCLTVVIAGKLGSK-FT-PEYQAALQKFLAVVVSALGRQYH------------------------- Tetraodon_Mb ----------------------------------------------------------------------------------------------------------------------------------------MGDFDMVLKFWGPVEA-DYSAHGGMVLTR-LFTENP---ETQQLFPKF----VGIAQ-SELAGNAAVSAHGATVLKKLGELLKAKGNHAAI---LQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEKAGLD----TAGQQALRNIMATIIADIDATYKELGFS-------------------- Tetraodon_NgB -----------------------------------------------------------------------------------------------------------------------------------MEKLSSKDKELIRGSWDSLGK-NKVPHGVILFSR-LFELDP---ELLNLFHYT----TNCGSTQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKH-QAVGV-KPQSFAMVGESLLYMLQCSLGQA-YT-ASLRQAWLNMYSVVVASMSRGWAKNGEDKAD----------------- Zebrafish_Cygb_1 -----------------------------------------------------------------------------------------------------------------------MEGDGGVQLTQSPDSLTEEDVCVIQDTWKPVYA-ERDNAGVAVLVR-FFTNFP---SAKQYFEHF----RELQDPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQC-FSPAEVQSSWSKLMGILYWQMNRVYAEVGWENSKK---------------- Zebrafish_Cygb_2 --------------------------------------------------------------------------------------------------------------------MEKEREDEETEGRERPEPLTDVERGIIKDTWARVYA-SCEDVGVTILIR-FFVNFP---SAKQYFSQF----QDMEDPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGEC-FT-PEVQTSWSKLMAALYWHITGAYTEVGWVK------LSSSAV------- Zebrafish_GbX -----------------------------------------------------------------------------------------------------------MGCAISGSGLTAGAPEIRPGEEETPAGLTTNHIRLIKESWRLIQE-DIAKVGIIMFVR-LFETHP---ECKDVFFLF----RDVEDLERLRTSRELRAHGLRVMSFIEKSVARLDQLERLETLALELGKSH-YRYNA-PPKYYGYVGAEFICAVRPILKDR-WT-PELEEAWKTLFQYVTSIMREGFLEEERNKRSNTQTSSRERPDKRSTAI Zebrafish_HbA ------------------------------------------------------------------------------------------------------------------------------------MSLSDTDKAVVKAIWAKISP-KADEIGAEALAR-MLTVYP---QTKTYFSHW----ADLSP-----GSGPVKKHGKTIMGAVGEAVSKIDDLVGG---LAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFPAD-FT-PEVHVSVDKFFNNLALALSEKYR------------------------- Zebrafish_HbB -----------------------------------------------------------------------------------------------------------------------------------MVEWTDAERTAILGLWGKL---NIDEIGPQALSR-CLIVYP---WTQRYFATF----GNLSSPAAIMGNPKVAAHGRTVMGGLERAIKNMDNVKNT---YAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGFN-ADVQEAWQKFLAVVVSALCRQYH------------------------- Zebrafish_Mb ----------------------------------------------------------------------------------------------------------------------------------------MADHDLVLKCWGAVEA-DYAANGGEVLNR-LFKEYP---DTLKLFPKF----SGISQ-GDLAGSPAVAAHGATVLKKLGELLKAKGDHAAL---LKPLANTHANIHKV-ALNNFRLITEVLVKVMAEKAGLD----AAGQGALRRVMDAVIGDIDGYYKEIGFAG------------------- Zebrafish_NgB -----------------------------------------------------------------------------------------------------------------------------------MEKLSEKDKGLIRDSWESLGK-NKVPHGIVLFTR-LFELDP---ALLTLFSYS----TNCGDAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKH-QAVGV-NTQSFALVGESLLYMLQSSLGPA-YT-TSLRQAWLTMYSIVVSAMTRGWAKNGEHKSN----------------- ; end; Alignment 17 of 20 file name: vertebrate_globins.NgB_GbX_Ciona.aa.prank.nex #NEXUS begin data; dimensions ntax=76 nchar=487; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb ME-----------------K---------------------------------------------------------------------------------------------------------------V-----QGEMEIERWERNEE-------------------------------------------------------------------MSDAEKKMIQETWNTVYA-KCEDVGVSLLIR-FFVNFP---SAKHYFSQFKH-ME-------D----------P---LE----ME------------RSQ-QLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYF-QLLGVLLEVLAEEYTNE--FSPP-EVQRA---------WAKMKSL----ICTHVTAAY-KE--VG------------------------------W--VQ-YPNSTM----------- Anolis_GbY ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAGKMTDLDRRHIREIWTAAFE-NPEENGRLVIIR-FFSDYP---ASKQYFK---T-VP-------T----------D---GD----LK------------AHP-QVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLGRT--FTP--EKRVS---------WEKFFQV----IQEEVEAAY-DR--------------------------------------------------------- Anolis_HbA ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-LTEDDKNHIRAIWGHVSS-NPELYGAEALTR-LFAAHH---TTKTYFPHY-D-MS-------P----------------------------------GSA-QIKAHGKKVVEAITQAVNNLDDIA---GALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNRGP--LKP--EFILA---------LDKCFTS----IGRVLIAQY-R---------------------------------------------------------- Anolis_HbB -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVHWTAEEKQLIANCWSKV---DIGQIGGDALAC-LLCVYP---WTQRFFPDFGN-LS-------NAAAICANAKV------------------------K------AHGKKVLTAFGEAVKNLDNIK---DTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFGKD--FTP--ACHAA---------YQKLVNS----VAHGLSRRY-H---------------------------------------------------------- Anolis_Mb -----------------------------------------------------------------------------------------------------------------------------------M-ELSD------------------------------------------------------------------------------------QEWQKVIDIWGKVEP-EIPAYGQMVILR-LFEQHP---ETQEKFDKFKNLK--------S----------L---DE----MK------------NSE-DLKKHGTIVLTALGKILKQKRQHEA---ELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRSAD--FGA--ESQAA---------MRKALEL----FRNDMDRKY-KE--LG------------------------------FQG-------------------- Arctic_lamprey_Hb1 -----------------------------------------------------------------------------------------------------------------------------------M------------------PIVDSGSVAP----------------------------------------------------------LSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTP---AAQEFFPKFKG-MT-------S----------A---DQ----LK------------KSA-DVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------A--AGDAG---------FEKLMSM----ICILLRSAY------------------------------------------------------------ Arctic_lamprey_Hb2 -----------------------------------------------------------------------------------------------------------------------------------M------------------PIVDSGSVPA----------------------------------------------------------LTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNP---AAQEFFPKFQG-LT-------S----------A---DQ----LK------------KSM-DVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTV-----------L--PGDAG---------LEKLMSM----ICILLKSSY------------------------------------------------------------ Arctic_lamprey_Hb4 -----------------------------------------------------------------------------------------------------------------------------------M------------------PIEDSGSKPD----------------------------------------------------------FSDDEKKAIKDSWSGVYS-EYESTSSEILIK-FFVDNP---SAQDFFPKFKD-LD-------S----------E---EK----LK------------GST-AVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKV-----------A--EKNDGSFSDSARSAWEKLLTY----ICISLKVAY------------------------------------------------------------ Chicken_Cygb ME-----------------K---------------------------------------------------------------------------------------------------------------V-----QGEMEIERWERSEE-------------------------------------------------------------------ISDAEKKVIQETWSRVYA-NCEDVGVSILIR-FFVNFP---SAKQYFSQFKH-MD-------D----------T---LE----ME------------RSL-QLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYGND--FTP--EAHGA---------WTKMRTL----IYTHVTAAY-KE--AG------------------------------W--VS-YPSATL----------- Chicken_GbE -----------------------------------------------------------------------------------------------------------------------------------M------------------S-------------------------------------------------------------------FSEAEVQSARGAWEKMYV-DAEDNGTAVLVR-MFTEHP---DTKSYFTHFKG-MD-------S----------A---EE----MK------------QSD-QVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEK------FGG--DCKAS---------FEKVTNE----ICTHLTNIY-KE--AG------------------------------W---------------------- Chicken_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV-LSAADKNNVKGIFTKIAG-HAEEYGAETLER-MFTTYP---PTKTYFPHF-D-LS-------H----------------------------------GSA-QIKGHGKKVVAALIEAANHIDDIA---GTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHPAA--LTP--EVHAS---------LDKFLCA----VGTVLTAKY-R---------------------------------------------------------- Chicken_HbB -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVHWSAEEKQLITSVWSKV---NVEECGAEALAR-LLIVYP---WTQRFFASFGN-LS-------SPTAIMGNPRV------------------------R------AHGKKVLSSFGEAVKNLDNIK---NTYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFARD--FTP--ACQFA---------WQKLVNV----VAHALARKY-H---------------------------------------------------------- Chicken_Mb -----------------------------------------------------------------------------------------------------------------------------------M-GLSD------------------------------------------------------------------------------------QEWQQVLTIWGKVEA-DIAGHGHEVLMR-LFHDHP---ETLDRFDKFKGLK--------T----------P---DQ----MK------------GSE-DLKKHGATVLTQLGKILKQKGNHES---ELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHAAD--FGA--DSQAA---------MKKALEL----FRNDMASKY-KE--FG------------------------------FQG-------------------- Finch_Cygb ME-----------------K---------------------------------------------------------------------------------------------------------------V-----QGEMEIERWERSEE-------------------------------------------------------------------ISDAEKKVIQEIWSRVYA-NCEDVGVSILIR-FFVNFP---SAKQYFSQFKH-ME-------D----------P---LE----ME------------RSL-QLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYPND--FTP--EAHGA---------WTKMKTL----IYTHVTAAY-KE--VG------------------------------W--AQ-YPTATL----------- Finch_GbE -----------------------------------------------------------------------------------------------------------------------------------M------------------S-------------------------------------------------------------------LSEAEVQSARGAWEKIYV-DAEDNGTAVLVR-MFTEHP---DTKSYFPHFKG-MD-------S----------A---EE----MK------------QSD-QVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEK------FGG--DCKAS---------FEKVTNE----ICTHLNNIY-KE--EG------------------------------W---------------------- Finch_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV-LSAGDKSNVKAVFGKIGG-QADEYGADALER-MFATYP---QTKTYFPHF-D-LG-------K----------------------------------GSA-QVKGHGKKVAAALVEAANNVDDLA---GALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNPSL--LTP--EVHAS---------LDKFLCA----VGTVLTAKY-R---------------------------------------------------------- Finch_HbB -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVHWSAEEKQLIASVWGRV---SVEECGAEALAR-LLIVYP---WTQRFFSDFGN-LS-------SPTAIVGNPKV------------------------R------AHGKKVLTSFGEAIKNLDNLK---GTYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFTKE--FTP--ACQAT---------WQKLVGV----VAHALARKY-H---------------------------------------------------------- Finch_Mb -----------------------------------------------------------------------------------------------------------------------------------M-GLSD------------------------------------------------------------------------------------QEWQQVLTVWGKVES-DLAGHGHQILMR-LFQDHP---ETLDRFEKFKGLK--------T----------P---DA----MK------------GSE-DLKKHGVTVLTQLGKILKAKGNHEA---ELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHAAD--FGA--DAQAA---------MKKALEL----FRNDMATKY-KE--FG------------------------------FQG-------------------- Frog_Cygb ME-----------------K---------------------------------------------------------------------------------------------------------------V-----QGENDMERWERLEE-------------------------------------------------------------------ITESERGVIKETWARVYA-NCEDVGVSILIR-FFVNFP---SAKQHFSQFKH-ME-------D----------P---LE----ME------------GSV-QLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYAKD--FTP--DVQLA---------WNKLRSH----LYSHVLSAY-KE--AG------------------------------W--TQ-YPSNSV----------- Frog_GbX --------------------MGCILSSLGWQWRDSLD-HT---ETSPLLPT--------------------------------------------------------------------------------L------------------N-------------------------------------------------------------------LSEQQQQLLVESWRLIQH-DIAKVGVILFVR-LFETHPECKDV---FFLFRD-VD-------D----------L---QA----LR------------ANK-DLRAHGLRVLSFVEKSVARIADCARLEELALELGRSXY-RYNA-PPRYYQYVGTEFISAVCPMLHDK--WTA--EVEEA---------WKGLFAY----ICTVMERGY-QE--EERRHS----------DGRSLIDGLQGNKGLI----------------------- Frog_GbY -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MADLTGADIENINEVWSKIYA-NPEESGRTVVIS-LFLTYP---QTKIYFKNLKN-IS-------T----------L---QE----MQ------------DNA-GIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALGSG--FTP--EQSKS---------WEKLFSI----TYKYLESCY-AN--TD------------------------------S---------------------- Frog_HbA1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MH-LTADDKKHIKAIWPSVAA-HGDKYGGEALHR-MFMCAP---KTKTYFPDF-D-FS-------E----------------------------------HSK-HILAHGKKVSDALNEACNHLDNIA---GCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFPKQ--FDP--ATHKA---------LDKFLVS----VSNVLTSKY-R---------------------------------------------------------- Frog_HbB -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVNLTAKERQLITGTWSKI---CAKTLGKQALGS-MLYTYP---WTQRYFSSFGN-LS-------SIEAIFHNAAV------------------------A------THGEKVLTSIGEAIKHMDDIK---GYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQED--FTP--ELQAA---------FEKLFAA----IADALGKGY-H---------------------------------------------------------- Frog_NgB -----------------------------------------------------------------------------------------------------------------------------------ME-----------------K-------------------------------------------------------------DQ----LSGPQKELIRESWQTVSQ-DQLHHGTVLFSSDIFQLKS---GL---Y-----------------------------WSS--EVPRECLIRVVHQDCLSSA-EFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKHR-AVGV-KLESFNTVGESLLFALESCLGDA--FTS--DTREA---------WSLLYAN----VVQSMSRGW-HR--DSQEQR----------EG-------------I----------------------- Hagfish_Hb1 -----------------------------------------------------------------------------------------------------------------------------------M------------------PITDQGPLPT----------------------------------------------------------LSEGDKKAIRESWPQIYQ-NFEQTGLVVLLE-FLQKNP---GAQQSFPKF------------S----------A---TKCN--LE------------QDN-EVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTI-----------R---GKAA---------YEKLFSI----ICTLLRSSY-DE--------------------------------------------------------- Hagfish_Hb2 -------------------------------------------------------------------------------------------------------------------------------------------------------MSAHGIART-----------------------------------------------------------TEGERAAVRASWAVLMK-DYEHAGVQILDK-FFKANP---AAKPFFTKMKD-LH-------T----------L---ED----LA------------SSA-DARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEV-EKRNGG--LSG--EGKSG---------WHKVMTI----ICKMLKSKY------------------------------------------------------------ Hagfish_Hb3 -----------------------------------------------------------------------------------------------------------------------------------M------------------PITDHGQPPT----------------------------------------------------------LSEGDKKAIRESWPQIYK-NFEQNSLAVLLE-FLKKFP---KAQDSFPKF------------S----------A---KKSH--LE------------QDP-AVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTM-----------G---GKAA---------YEKLFSI----IATLLRSTY-DA--------------------------------------------------------- Hagfish_Hb4 -----------------------------------------------------------------------------------------------------------------------------------M------------------PITDQRPLPT----------------------------------------------------------LSEGEKKAIKESWPQIYQ-NFEQTSLDVLIE-FLQKFP---EAQDSFPKF------------S----------A---KKCH--LE------------QDN-EVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTI-----------R---GKAA---------YEKLFSI----ICTLLRSSY-DE--------------------------------------------------------- Houndshark_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA-FTACEKQTIGKIAQVLAK-SPEAYGAECLAR-LFVTHP---GSKSYF-EYKD-YS-------A----------------------------------AGA-KVQVHGGKVIRAVVKAAEHVDDLH---SHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHL-TE--FSP--DTHCA---------VDKLLSA----ICQELSSRY-R---------------------------------------------------------- Houndshark_HbB -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVHWTQEERDEISKTFQGT---DMKTVVTQALDR-MFKVYP---WTNRYFQKRTD-FR-------S----------------------------------S------IHAGIVVGALQDAVKHMDDVK---TLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELA-YLRKD-CFTP--HIQGI---------WDKFFEV----VIDAISKQY-H---------------------------------------------------------- Houndshark_Mb -----------------------------------------------------------------------------------------------------------------------------------M-----------------------------------------------------------------------------------------VDWEKVNSVWSAVES-DLTAIGQNILLR-LFEQYP---ESQNHFPKFKN-K--------S----------L---GE----LK------------DTA-DIKAQADTVLSALGNIVKKKGSHSQ---PVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYPSE--MNA--QVQAA---------FSGAFKI----ICSDIEKEY-KA--AN------------------------------FQG-------------------- Human_Cygb ME-----------------K---------------------------------------------------------------------------------------------------------------V-----PGEMEIERRERSEE-------------------------------------------------------------------LSEAERKAVQAMWARLYA-NCEDVGVAILVR-FFVNFP---SAKQYFSQFKH-ME-------D----------P---LE----ME------------RSP-QLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFASD--FPP--ETQRA---------WAKLRGL----IYSHVTAAY-KE--VG------------------------------W--VQQVPNATTPPATLPSSGP- Human_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV-LSPADKTNVKAAWGKVGA-HAGEYGAEALER-MFLSFP---TTKTYFPHF-D-LS-------H----------------------------------GSA-QVKGHGKKVADALTNAVAHVDDMP---NALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLPAE--FTP--AVHAS---------LDKFLAS----VSTVLTSKY-R---------------------------------------------------------- Human_HbB -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVHLTPEEKSAVTALWGKV---NVDEVGGEALGR-LLVVYP---WTQRFFESFGD-LS-------TPDAVMGNPKV------------------------K------AHGKKVLGAFSDGLAHLDNLK---GTFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFGKE--FTP--PVQAA---------YQKVVAG----VANALAHKY-H---------------------------------------------------------- Human_Mb -----------------------------------------------------------------------------------------------------------------------------------M-GLSD------------------------------------------------------------------------------------GEWQLVLNVWGKVEA-DIPGHGQEVLIR-LFKGHP---ETLEKFDKFKHLK--------S----------E---DE----MK------------ASE-DLKKHGATVLTALGGILKKKGHHEA---EIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHPGD--FGA--DAQGA---------MNKALEL----FRKDMASNY-KE--LG------------------------------FQG-------------------- Human_NgB -----------------------------------------------------------------------------------------------------------------------------------ME-----------------R----------------------------------------------------------------------PEPELIRQSWRAVSR-SPLEHGTVLFAR-LFALEP---DL---LPLFQY----------N----------CRQFSS----PE---------DCLSSP-EFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHR-AVGV-KLSSFSTVGESLLYMLEKCLGPA--FTP--ATRAA---------WSQLYGA----VVQAMSRGW---------------------DG-------------E----------------------- Medaka_Cygb_1 ME-----------------R---------------------------------------------------------------------------------------------------------------K-----Q--GEVDHLERSRP-------------------------------------------------------------------LTDKERVMIQDSWAKVYQ-NCDDAGVAILVR-LFVNFP---SSKQYFSQFKH-IE-------D----------A---EE----LE------------KSS-QLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYPQV--MTA--EVASA---------WTNLLAI----LCCSIKAVY-EE--LG------------------------------W--PH-LSNSTS----------- Medaka_Cygb_2 MSCRESPPPPSPPPQMLGVQ---------------------------------------------------------------------------------------------------------------R-----GECE--DRPERAEP-------------------------------------------------------------------LSDAEMEIIQHTWGHVYK-NCEDVGVSVLIR-FFVNFP---SAKQYFSQFQD-MQ-------D----------P---EE----ME------------KSS-QLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFPEF--FTA--EVQLV---------WTKLMAA----VYWHVTGAY-TE--VG------------------------------W--LQ-VSSSAV----------- Medaka_GbX --------------------MGCAISGLAAK-TDLAE-RSRED------AA--------------------------------------------------------------------------------VE-----------------H-------------------------------------------------------------------PNEEQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHPECKDV---FFLFRD-VE-------D----------L---ER----LR------------TNR-ELRAHGLRVMSFIEKSVARLDQPERLEALAVELGKSHY-HYNA-PPKYYNYVGAEFICAVQPILKEQ--WTT--ELEKA---------WQTLFQF----VTALMKQGY-QE--ESARQRQLATSPKDRLDKRNT---------AL----------------------- Medaka_HbA ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMS-LSAKDKAAVKAFWAKVSG-QADAIGSDALSR-MLVVYP---QTKTYFAHWKD-LS-------P----------------------------------GSA-PVKKHGKTVMGGIADAVGKIDDIS---SGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFPQD--FTP--EVHVA---------LDKFLAA----VSLALSEKY-R---------------------------------------------------------- Medaka_HbB -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVEWTEQERSIITNIFGNL---DYEDVGSKALSR-CLIVYP---WTQRYFASFGN-LY-------NAEAIKTNPNI------------------------A------AHGTKVLHGLDRAVKNMDNIK---ATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLGSA--FSP--EIQAT---------FQKFLAV----VVSALGRQY-H---------------------------------------------------------- Medaka_Mb -----------------------------------------------------------------------------------------------------------------------------------M-----------------------------------------------------------------------------------------ADYDMVLKHWGPVEA-DYNTHGNLVLTR-LFHEYP---ETQKLFPKFAG-I--------A----------K---GD----MA------------GNA-ALSAHGATVLKKLGELLKARGNHGA---ILKPLANSHATKHKI-PINNFRLITEVIGKVMAEK--AG--LDA--AGQQA---------LRSVMAG----IIAEIEADY-KE--LG------------------------------FAG-------------------- Medaka_NgB -----------------------------------------------------------------------------------------------------------------------------------ME-----------------K-------------------------------------------------------------------LSGKDKELIRGSWESLGK-NKVPHGVIMFSR-LFELDP---AL---LSLFNY-NT-------N----------C---GS----TQ---------DCLSSP-EFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKHQ-AVGV-STQSFAVVGESLLYMLQCSLGQA--YTA--ALSQA---------WLNMYSI----VVAAMSRGW-AK--NGEDKA----------D-------------------------------------- Platypus_GbY -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVQVTDVEKANIQSIWSKMME-NLEKNGIDIFTR-LFREYP---ETKKYFK---N-IP-------L----------E---GN----LQ------------EDP-LLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLGPC--YTP--EIAES---------FQKLQSS----LYDQVVITY-LH--SG------------------------------S---------------------D Platypus_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG-LTDGEKKEVAALWANVSG-HEEEFGAEALDR-LFLSFP---PTKTYFPHF-E-LS-------Q----------------------------------GSA-QVKAHGKKVADALTTAVAHLDDLD---STLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLPAE--FTP--SAHAA---------LDKFLSK----VATVLTSKY-R---------------------------------------------------------- Platypus_HbB -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVHLSGGEKSAVTNLWGKV---NINELGGEALGR-LLVVYP---WTQRFFEAFGD-LS-------SAGAVMGNPKV------------------------K------AHGAKVLTSFGDALKNLDDLK---GTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFSKD--FSP--EVQAA---------WQKLVSG----VAHALGHKY-H---------------------------------------------------------- Platypus_HbW -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVNWTSEEKHAIVSIWGKV---DIEETGANALSR-LLVVYP---WTQRYFSAFGN-LS-------SPTAIVGNPRV------------------------R------AHGKKVLTSFGEAVKDLDHVK---SNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLGKD--FTP--EAQAA---------WQKLVGV----VASALSSQY-H---------------------------------------------------------- Platypus_Mb -----------------------------------------------------------------------------------------------------------------------------------M-GLSD------------------------------------------------------------------------------------GEWQLVLKVWGKVEG-DLPGHGQEVLIR-LFKTHP---ETLEKFDKFKGLK--------T----------E---DE----MK------------ASA-DLKKHGGTVLTALGNILKKKGQHEA---ELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHSAD--FGA--DAQAA---------MGKALEL----FRNDMAAKY-KE--FG------------------------------FQG-------------------- Platypus_NgB -----------------------------------------------------------------------------------------------------------------------------------ME-----------------N-------------------------------------------------------------GR----LSGPEQELIRESWRSVNS-NPLEHGMILFTR-LFDLEP---DL---LPLFQY----------N----------CRQFSS----PR---------DCLASP-EFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKHK-AIGV-KLSSFSTVGESLLFMLEKCLGPA--FSP--ATREA---------WTRLYTA----MVHAMSRGW---------------------GG-------------E----------------------- Port_Jackson_shark_Mb -----------------------------------------------------------------------------------------------------------------------------------M-----------------------------------------------------------------------------------------TEWEHVNKVWAVVEP-DIPAVGLAILLR-LFKEHK---ETKDLFPKFKE-I--------P----------V---QQ----LG------------NNE-DLRKHGVTVLRALGNILKQKGKHST---NVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYPSD--MTG--PMQES---------FSKVFTV----ICSDLETLY-KE--AN------------------------------FQG-------------------- Sea_lamprey_Hb1a -----------------------------------------------------------------------------------------------------------------------------------M------------------PIVDSGSVPA----------------------------------------------------------LTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNP---AAQAFFPKFQG-LT-------S----------A---DQ----LK------------KSM-DVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTV-----------L--PGDAG---------LEKLMSM----ICILLRSSY------------------------------------------------------------ Sea_lamprey_Hb1b -----------------------------------------------------------------------------------------------------------------------------------M------------------PIVDSGSVSP----------------------------------------------------------LSDAEKNKIRAAWDLVYK-DYEKTGVDILVK-FFTGTP---AAQAFFPKFKG-LT-------T----------A---DD----LK------------QSS-DVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTT-----------A--PGDAG---------FEKLMSM----ICILLSSAY------------------------------------------------------------ Sea_lamprey_Hb2 -----------------------------------------------------------------------------------------------------------------------------------M------------------PIVDTGSVAP----------------------------------------------------------LSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTP---AAQEFFPKFKG-LT-------T----------A---DQ----LK------------KSA-DVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------A--AGDAG---------FEKLMSM----ICILLRSAY------------------------------------------------------------ Sea_lamprey_Hb3 -----------------------------------------------------------------------------------------------------------------------------------M------------------PIVDSGSVAP----------------------------------------------------------LSAAEKTKIRSAWAPVYS-NYETTGVDILVK-FFTSTP---AAQEFFPKFKG-LT-------T----------A---DQ----LK------------KSA-DVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------A--AGDAG---------FEKLMSM----ICILLRSAY------------------------------------------------------------ Sea_lamprey_Hb5 -----------------------------------------------------------------------------------------------------------------------------------M------------------PIVDTGSVAP----------------------------------------------------------LSAAEKTKIRSAWAPVYS-TYETSGVDILVK-FFTSTP---AAQEFFPKFKG-LT-------T----------A---DQ----LK------------KSA-DVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------A--AGDAG---------FEKLMSM----ICILLRSAY------------------------------------------------------------ Sea_lamprey_Hb_PMII -----------------------------------------------------------------------------------------------------------------------------------M------------------PIVDTGSVAP----------------------------------------------------------LSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTP---AAQEFFPKFKG-LT-------T----------A---DQ----LK------------KSA-DVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTV-----------A--AGDAG---------FEKLMSM----ICILLRSAY------------------------------------------------------------ Sea_squirt_Glb1 -----------------------------------------------------------------------------------------------------------------------------------M------------------P-------------------------------------------------------------------FTDEELKLLRDSWDEVKKLGMKEVGLHIFTG-LLNAAP---SL---RTLFYT-IDLPDEEELT----------I---DV----MR------------ENK-KVVAHATRIANAISKFIKFLDQPDELEKLLTSLGESHA-RRQV-DPESFEYVAPVILSVIGGHLKLP--SNS--PTLQA---------WVKAYGVLRNGIVSAM---E-A---------------------------------------------------------- Sea_squirt_Glb2 -----------------------------------------------------------------------------------------------------------------------------------M------------------G-------------------------------------------------------------------LTTEEIGLLRSSWNEMKTIGMKELGLLIFHR-LFSDVP---RI---RKMFYN-LELPDDETLT----------M---EA----MR------------SNQ-KMSRHATRIATSISTYLKLADQPEELKTFLNGLGELHA-GHNV-EPEDFEYLAPVMLAVIGGQLNLN--SNS--SILQA---------WVKAYGVLRNGIVRGM---Y-AY--QG----------------------------------------------------- Sea_squirt_Glb3 -----------------------------------------------------------------------------------------------------------------------------------M------------------S-------------------------------------------------------------------LTSEQVVLLRSSWQTIGKLGMSNVGLAVLHR-LFNDVP---ET---LPFFHS-VLSPTQQT-E----------I---EV----LK------------SNA-KVVRHASRVGLSIDKIINLLDNGEELVKYLLFLGQVHV-KRSI-PRKYFSAMGPVLLSVISAVLEKD--LDA--PVMQA---------WATAYGVIEQGIIDGM---------------------------------------------------------------- Sea_squirt_Glb4 ---------------------------------------------------MKIICGLILFSTFAIIFVSGLNCWTCNVLGGNNVCRRSGGLRTCFNNQVCYNEVRRRGNTINIRKGCKNSGVCENHIMQSM------------------S---------TPNPNNQCVNGPNYFCSCCCGNSVCNSNWLTCVTAGSVAPTVSTTVPPADEG------LKRSDIINIQDSWNTLKGFGYETVGMLVLHR-LFNDAP---QT---RYLFSQ-LSLSSNESFT----------L---EQ----MR------------NNS-RVVYHANRVARAVGRLVDLIELPTNFTDHLVWLGQRHA-YHGV-APVNFDYMGPVLLETIKVNLELP--SDS--PTLSA---------WAKAYGVIKNGIKDAI---I-ATYAEG----------------------------------------------------- Stingray_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV-LSSQNKKAIEELGNLIKA-NAEAWGADALAR-LFELHP---QTKTYFSKFSG-FE-------A----------------------------------CNE-QVKKHGKRVMNALADATHHLDNLH---LHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNL-QA--FTP--VTHCA---------VDKFLEL----VAYELSSCY-R---------------------------------------------------------- Stingray_HbB -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVKLSEDQEHYIKGVWKDV---DHKQITAKALER-VFVVYP---WTTRLFSKLQG-LF-------S----------------------------------ANDIGVQQHADKVQRALGEAIDDLKKVE---INFQNLSGKHQE-IGV-DTQNFKLLGQTFMVELALHYKKT--FRP--KEHAA---------AYKFFRL----VAEALSSNY-H---------------------------------------------------------- Tetraodon_Cygb_1 ME-----------------R---------------------------------------------------------------------------------------------------------------M-----QRDGEVDHVEQPGP-------------------------------------------------------------------LTEKEKVMIQDSWAKVFQ-SCDDAGVAILVR-FFVNFP---SSKQFFKDFKH-ME-------E----------P---EE----MQ------------QSV-QLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFTEI--ITA--EVASA---------WTKLLAN----MCCGIAAVY-KE--AG------------------------------W--TE-LSSSVE----------- Tetraodon_Cygb_2 MSHREPPPP------QLAVQ---------------------------------------------------------------------------------------------------------------R-----RDVDGQDGPERAEP-------------------------------------------------------------------LSDTEREMIRDAWGHVYK-NCEDVGVSILIR-FFVNFP---SAKQYFSQFQD-ME-------E----------P---EE----ME------------RSS-QLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFPEF--FTA--DVQLV---------WSKLMAT----VYWHVTGAY-TD--VG------------------------------W--LQ-VSSSAV----------- Tetraodon_GbX --------------------MGCAISSLGAK-AEFGD-RSAEEEDAAAAAA--------------------------------------------------------------------------------VV-----------------Y-------------------------------------------------------------------PREDQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHPECKDV---FFLFRD-VE-------D----------L---ER----LR------------SSR-ELRAHGLRVMSFIEKSVARLDQQDRLEALAVELGKSHY-HYNA-PPKYYSYVGAEFICAVQPILKER--FTS--ELEEA---------WKTLFQY----VTGLMRKGH-QE--EGSRQRHLALPPKDGPEKRTS---------AL----------------------- Tetraodon_HbA ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTS-LSTKDKETVRAFWAKVAS-NREEIGASALCR-LLSVYP---QTKTYFSHWKD-QS-------P----------------------------------NSA-SAKKHGITIMNAVGDAVSKIDDLK---TGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYPAD--FTP--EVHVA---------MDKFLAS----LALALSEKY-R---------------------------------------------------------- Tetraodon_HbB -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVVWTDQERAIIDNIFSNL---DYEDVGSKALIR-CLIVYP---WTQRYFSSFGN-LY-------NAEAIRNNPNV------------------------A------KHGVTVLHGLDRALKNMDNIK---EEYKK----HSEKLHV-DPDNFKLLSDCLTVVIAGKLGSK--FTP--EYQAA---------LQKFLAV----VVSALGRQY-H---------------------------------------------------------- Tetraodon_Mb -----------------------------------------------------------------------------------------------------------------------------------M-----------------------------------------------------------------------------------------GDFDMVLKFWGPVEA-DYSAHGGMVLTR-LFTENP---ETQQLFPKFVG-I--------A----------Q---SE----LA------------GNA-AVSAHGATVLKKLGELLKAKGNHAA---ILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEK--AG--LDT--AGQQA---------LRNIMAT----IIADIDATY-KE--LG------------------------------FS--------------------- Tetraodon_NgB -----------------------------------------------------------------------------------------------------------------------------------ME-----------------K-------------------------------------------------------------------LSSKDKELIRGSWDSLGK-NKVPHGVILFSR-LFELDP---EL---LNLFHY-TT-------N----------C---GS----TQ---------DCLSSP-EFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKHQ-AVGV-KPQSFAMVGESLLYMLQCSLGQA--YTA--SLRQA---------WLNMYSV----VVASMSRGW-AK--NGEDKA----------D-------------------------------------- Zebrafish_Cygb_1 -----------------------------------------------------------------------------------------------------------------------------------M-----EGDGGVQLTQSPDS-------------------------------------------------------------------LTEEDVCVIQDTWKPVYA-ERDNAGVAVLVR-FFTNFP---SAKQYFEHFRE-LQ-------D----------P---AE----MQ------------QNA-QLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFPQC--FSP-AEVQSS---------WSKLMGI----LYWQMNRVY-AE--VG------------------------------W------ENSKK----------- Zebrafish_Cygb_2 ME-----------------K---------------------------------------------------------------------------------------------------------------E-----REDEETEGRERPEP-------------------------------------------------------------------LTDVERGIIKDTWARVYA-SCEDVGVTILIR-FFVNFP---SAKQYFSQFQD-ME-------D----------P---EE----ME------------KSS-QLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFGEC--FTP--EVQTS---------WSKLMAA----LYWHITGAY-TE--VG------------------------------W--VK-LSSSAV----------- Zebrafish_GbX --------------------MGCAISGSGLT-AGAPEIRPGEEETPAGLTT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------NHIRLIKESWRLIQE-DIAKVGIIMFVR-LFETHPECKDV---FFLFRD-VE-------D----------L---ER----LR------------TSR-ELRAHGLRVMSFIEKSVARLDQLERLETLALELGKSHY-RYNA-PPKYYGYVGAEFICAVRPILKDR--WTP--ELEEA---------WKTLFQY----VTSIMREGFLEE--ERNKRSNTQTSSRERPDKRST---------AI----------------------- Zebrafish_HbA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS-LSDTDKAVVKAIWAKISP-KADEIGAEALAR-MLTVYP---QTKTYFSHWAD-LS-------P----------------------------------GSG-PVKKHGKTIMGAVGEAVSKIDDLV---GGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFPAD--FTP--EVHVS---------VDKFFNN----LALALSEKY-R---------------------------------------------------------- Zebrafish_HbB -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVEWTDAERTAILGLWGKL---NIDEIGPQALSR-CLIVYP---WTQRYFATFGN-LS-------SPAAIMGNPKV------------------------A------AHGRTVMGGLERAIKNMDNVK---NTYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAG-FNA--DVQEA---------WQKFLAV----VVSALCRQY-H---------------------------------------------------------- Zebrafish_Mb -----------------------------------------------------------------------------------------------------------------------------------M-----------------------------------------------------------------------------------------ADHDLVLKCWGAVEA-DYAANGGEVLNR-LFKEYP---DTLKLFPKFSG-I--------S----------Q---GD----LA------------GSP-AVAAHGATVLKKLGELLKAKGDHAA---LLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEK--AG--LDA--AGQGA---------LRRVMDA----VIGDIDGYY-KE--IG------------------------------FAG-------------------- Zebrafish_NgB -----------------------------------------------------------------------------------------------------------------------------------ME-----------------K-------------------------------------------------------------------LSEKDKGLIRDSWESLGK-NKVPHGIVLFTR-LFELDP---AL---LTLFSY-ST-------N----------C---GD----AP---------ECLSSP-EFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKHQ-AVGV-NTQSFALVGESLLYMLQSSLGPA--YTT--SLRQA---------WLTMYSI----VVSAMTRGW-AK--NGEHKS----------N-------------------------------------- ; end; Alignment 18 of 20 file name: vertebrate_globins.NgB_GbX_Ciona.aa.probalign.nex #NEXUS begin data; dimensions ntax=76 nchar=345; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb --------------------------------------------------------------------------------------------------------------------MEKVQGEMEIERWERNEEMSDAEKKMIQETWNTVYA-KCEDVGVSLLIR-FFVNFPSAKHYFSQ-F------KHME----DPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVA---SVLALVGKAHAVKHKV-EPVYFQLLG-VLLEVLAEEYT-NEFSPP-EVQRAWAKMKSLICTHVTAAYK----E--V-GW------------VQ-----------YPNSTM Anolis_GbY ----------------------------------------------------------------------------------------------------------------------------------KAGKMTDLDRRHIREIWTAAFE-NPEENGRLVIIR-FFSDYPASKQYFKT-V---------P----TDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQAC---VLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLG-RTFT-P-EKRVSWEKFFQVIQEEVEAAYD----R------------------------------------- Anolis_HbA -------------------------------------------------------------------------------------------------------------------------------------MLTEDDKNHIRAIWGHVSS-NPELYGAEALTR-LFAAHHTTKTYFPH-Y------DM-S---------PGSAQIKAHGKKVVEAITQAVNNLDDI---A---GALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNR-GPLK-P-EFILALDKCFTSIGRVLIAQYR------------------------------------------ Anolis_HbB -----------------------------------------------------------------------------------------------------------------------------------MVHWTAEEKQLIANCWSKVD---IGQIGGDALAC-LLCVYPWTQRFFPD-F------GNLS----NAAAICANAKVKAHGKKVLTAFGEAVKNLDNI---K---DTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFG-KDFT-P-ACHAAYQKLVNSVAHGLSRRYH------------------------------------------ Anolis_Mb ------------------------------------------------------------------------------------------------------------------------------------MELSDQEWQKVIDIWGKVEP-EIPAYGQMVILR-LFEQHPETQEKFDK-F------KNLK----SLDEMKNSEDLKKHGTIVLTALGKILKQKRQH---E---AELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRS-ADFG-A-ESQAAMRKALELFRNDMDRKYK----E--L-GF------------QG----------------- Arctic_lamprey_Hb1 ---------------------------------------------------------------------------------------------------------------------------MPIVDSGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQEFFPK-F------KGMT----SADQLKKSADVRWHAERIINAVNDAVASMDDTEKMS---MKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY------------------------------------------- Arctic_lamprey_Hb2 ---------------------------------------------------------------------------------------------------------------------------MPIVDSGSVPALTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNPAAQEFFPK-F------QGLT----SADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMS---LKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTVL------------PGDAGLEKLMSMICILLKSSY------------------------------------------- Arctic_lamprey_Hb4 ---------------------------------------------------------------------------------------------------------------------------MPIEDSGSKPDFSDDEKKAIKDSWSGVYS-EYESTSSEILIK-FFVDNPSAQDFFPK-F------KDLD----SEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNA---KKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKND-GSFS-D-SARSAWEKLLTYICISLKVAY------------------------------------------- Chicken_Cygb --------------------------------------------------------------------------------------------------------------------MEKVQGEMEIERWERSEEISDAEKKVIQETWSRVYA-NCEDVGVSILIR-FFVNFPSAKQYFSQ-F------KHMD----DTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVS---SVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYG-NDFT-P-EAHGAWTKMRTLIYTHVTAAYK----E--A-GW------------VS-----------YPSATL Chicken_GbE ------------------------------------------------------------------------------------------------------------------------------------MSFSEAEVQSARGAWEKMYV-DAEDNGTAVLVR-MFTEHPDTKSYFTH-F------KGMD----SAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFL---GILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFG------G-DCKASFEKVTNEICTHLTNIYK----E--A-GW------------------------------- Chicken_HbA ------------------------------------------------------------------------------------------------------------------------------------MVLSAADKNNVKGIFTKIAG-HAEEYGAETLER-MFTTYPPTKTYFPH-F------DL-S---------HGSAQIKGHGKKVVAALIEAANHIDDI---A---GTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHP-AALT-P-EVHASLDKFLCAVGTVLTAKYR------------------------------------------ Chicken_HbB -----------------------------------------------------------------------------------------------------------------------------------MVHWSAEEKQLITSVWSKVN---VEECGAEALAR-LLIVYPWTQRFFAS-F------GNLS----SPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNI---K---NTYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFA-RDFT-P-ACQFAWQKLVNVVAHALARKYH------------------------------------------ Chicken_Mb ------------------------------------------------------------------------------------------------------------------------------------MGLSDQEWQQVLTIWGKVEA-DIAGHGHEVLMR-LFHDHPETLDRFDK-F------KGLK----TPDQMKGSEDLKKHGATVLTQLGKILKQKGNH---E---SELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHA-ADFG-A-DSQAAMKKALELFRNDMASKYK----E--F-GF------------QG----------------- Finch_Cygb --------------------------------------------------------------------------------------------------------------------MEKVQGEMEIERWERSEEISDAEKKVIQEIWSRVYA-NCEDVGVSILIR-FFVNFPSAKQYFSQ-F------KHME----DPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVS---SVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYP-NDFT-P-EAHGAWTKMKTLIYTHVTAAYK----E--V-GW------------AQ-----------YPTATL Finch_GbE ------------------------------------------------------------------------------------------------------------------------------------MSLSEAEVQSARGAWEKIYV-DAEDNGTAVLVR-MFTEHPDTKSYFPH-F------KGMD----SAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFL---GIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFG------G-DCKASFEKVTNEICTHLNNIYK----E--E-GW------------------------------- Finch_HbA ------------------------------------------------------------------------------------------------------------------------------------MVLSAGDKSNVKAVFGKIGG-QADEYGADALER-MFATYPQTKTYFPH-F------DL-G---------KGSAQVKGHGKKVAAALVEAANNVDDL---A---GALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNP-SLLT-P-EVHASLDKFLCAVGTVLTAKYR------------------------------------------ Finch_HbB -----------------------------------------------------------------------------------------------------------------------------------MVHWSAEEKQLIASVWGRVS---VEECGAEALAR-LLIVYPWTQRFFSD-F------GNLS----SPTAIVGNPKVRAHGKKVLTSFGEAIKNLDNL---K---GTYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFT-KEFT-P-ACQATWQKLVGVVAHALARKYH------------------------------------------ Finch_Mb ------------------------------------------------------------------------------------------------------------------------------------MGLSDQEWQQVLTVWGKVES-DLAGHGHQILMR-LFQDHPETLDRFEK-F------KGLK----TPDAMKGSEDLKKHGVTVLTQLGKILKAKGNH---E---AELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHA-ADFG-A-DAQAAMKKALELFRNDMATKYK----E--F-GF------------QG----------------- Frog_Cygb --------------------------------------------------------------------------------------------------------------------MEKVQGENDMERWERLEEITESERGVIKETWARVYA-NCEDVGVSILIR-FFVNFPSAKQHFSQ-F------KHME----DPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKIT---TVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYA-KDFT-P-DVQLAWNKLRSHLYSHVLSAYK----E--A-GW------------TQ-----------YPSNSV Frog_GbX ---------------------------------------------------------------------------------------------------------MGCILSSLGWQWRDSLDHTETSPLLPTLNLSEQQQQLLVESWRLIQH-DIAKVGVILFVR-LFETHPECKDVFFL-F------RDVD----DLQALRANKDLRAHGLRVLSFVEKSVARIADC---ARLEELALELGRSX-YRYNA-PPRYYQYVGTEFISAVCPMLH-DKWT-A-EVEEAWKGLFAYICTVMERGYQ----E--E-E-RRHSDGRSLIDGLQ-----------GNKGLI Frog_GbY -----------------------------------------------------------------------------------------------------------------------------------MADLTGADIENINEVWSKIYA-NPEESGRTVVIS-LFLTYPQTKIYFKN-L------KNIS----TLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVC---SALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALG-SGFT-P-EQSKSWEKLFSITYKYLESCYA----N--T-DS------------------------------- Frog_HbA1 ------------------------------------------------------------------------------------------------------------------------------------MHLTADDKKHIKAIWPSVAA-HGDKYGGEALHR-MFMCAPKTKTYFPD-F------DF-S---------EHSKHILAHGKKVSDALNEACNHLDNI---A---GCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFP-KQFD-P-ATHKALDKFLVSVSNVLTSKYR------------------------------------------ Frog_HbB -----------------------------------------------------------------------------------------------------------------------------------MVNLTAKERQLITGTWSKIC---AKTLGKQALGS-MLYTYPWTQRYFSS-F------GNLS----SIEAIFHNAAVATHGEKVLTSIGEAIKHMDDI---K---GYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQ-EDFT-P-ELQAAFEKLFAAIADALGKGYH------------------------------------------ Frog_NgB ---------------------------------------------------------------------------------------------------------------------------------MEKDQLSGPQKELIRESWQTVSQ-DQLHHGTVLFSSDIFQLKSG-L-YWSS-EVPRECLIRV-----VHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLD---EYLTSLGRKHR-AVGV-KLESFNTVGESLLFALESCLG-DAFT-S-DTREAWSLLYANVVQSMSRGWH----RDSQ-E---------------------------QREGI Hagfish_Hb1 ---------------------------------------------------------------------------------------------------------------------------MPITDQGPLPTLSEGDKKAIRESWPQIYQ-NFEQTGLVVLLE-FLQKNPGAQQSFPK-F------SATK------CNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMK---QYLKELSAKHSSEFQV-DPKLFKELSAIFVSTIR-------------GKAAYEKLFSIICTLLRSSYD----E------------------------------------- Hagfish_Hb2 ------------------------------------------------------------------------------------------------------------------------------MSAHGIARTTEGERAAVRASWAVLMK-DYEHAGVQILDK-FFKANPAAKPFFTK-M------KDLH----TLEDLASSADARWHVERIIQAVNFAVINIEDREKLS---NKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKR-N-GGLS-G-EGKSGWHKVMTIICKMLKSKY------------------------------------------- Hagfish_Hb3 ---------------------------------------------------------------------------------------------------------------------------MPITDHGQPPTLSEGDKKAIRESWPQIYK-NFEQNSLAVLLE-FLKKFPKAQDSFPK-F------SAKK------SHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMK---KYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTMG-------------GKAAYEKLFSIIATLLRSTYD----A------------------------------------- Hagfish_Hb4 ---------------------------------------------------------------------------------------------------------------------------MPITDQRPLPTLSEGEKKAIKESWPQIYQ-NFEQTSLDVLIE-FLQKFPEAQDSFPK-F------SAKK------CHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMK---QYLKELSVKHSSEFQV-DPKMFKELSAIFVSTIR-------------GKAAYEKLFSIICTLLRSSYD----E------------------------------------- Houndshark_HbA ------------------------------------------------------------------------------------------------------------------------------------MAFTACEKQTIGKIAQVLAK-SPEAYGAECLAR-LFVTHPGSKSYFEY--------KDYS---------AAGAKVQVHGGKVIRAVVKAAEHVDDL---H---SHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHL--TEFS-P-DTHCAVDKLLSAICQELSSRYR------------------------------------------ Houndshark_HbB -----------------------------------------------------------------------------------------------------------------------------------MVHWTQEERDEISKTFQGTD---MKTVVTQALDR-MFKVYPWTNRYFQK-R------TDFR--------------SSIHAGIVVGALQDAVKHMDDV---K---TLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRK-DCFT-P-HIQGIWDKFFEVVIDAISKQYH------------------------------------------ Houndshark_Mb ----------------------------------------------------------------------------------------------------------------------------------------MVDWEKVNSVWSAVES-DLTAIGQNILLR-LFEQYPESQNHFPK-F------KNKS-----LGELKDTADIKAQADTVLSALGNIVKKKGSH---S---QPVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYP-SEMN-A-QVQAAFSGAFKIICSDIEKEYK----A--A-NF------------QG----------------- Human_Cygb --------------------------------------------------------------------------------------------------------------------MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYA-NCEDVGVAILVR-FFVNFPSAKQYFSQ-F------KHME----DPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVS---SVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFA-SDFP-P-ETQRAWAKLRGLIYSHVTAAYK----E--V-GW------------VQQVPNATTPPATLPSSGP Human_HbA ------------------------------------------------------------------------------------------------------------------------------------MVLSPADKTNVKAAWGKVGA-HAGEYGAEALER-MFLSFPTTKTYFPH-F------DL-S---------HGSAQVKGHGKKVADALTNAVAHVDDM---P---NALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLP-AEFT-P-AVHASLDKFLASVSTVLTSKYR------------------------------------------ Human_HbB -----------------------------------------------------------------------------------------------------------------------------------MVHLTPEEKSAVTALWGKVN---VDEVGGEALGR-LLVVYPWTQRFFES-F------GDLS----TPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNL---K---GTFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFG-KEFT-P-PVQAAYQKVVAGVANALAHKYH------------------------------------------ Human_Mb ------------------------------------------------------------------------------------------------------------------------------------MGLSDGEWQLVLNVWGKVEA-DIPGHGQEVLIR-LFKGHPETLEKFDK-F------KHLK----SEDEMKASEDLKKHGATVLTALGGILKKKGHH---E---AEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHP-GDFG-A-DAQGAMNKALELFRKDMASNYK----E--L-GF------------QG----------------- Human_NgB --------------------------------------------------------------------------------------------------------------------------------------MERPEPELIRQSWRAVSR-SPLEHGTVLFAR-LFALEPDLLPLFQYNC------RQFS----SPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLE---EYLASLGRKHR-AVGV-KLSSFSTVGESLLYMLEKCLG-PAFT-P-ATRAAWSQLYGAVVQAMSRGWD----G------------------------------------E Medaka_Cygb_1 ----------------------------------------------------------------------------------------------------------------------MERKQGEVDHLERSRPLTDKERVMIQDSWAKVYQ-NCDDAGVAILVR-LFVNFPSSKQYFSQ-F------KHIE----DAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVS---SVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYP-QVMT-A-EVASAWTNLLAILCCSIKAVYE----E--L-GW------------PH-----------LSNSTS Medaka_Cygb_2 -----------------------------------------------------------------------------------------------------MSCRESPPPPSPPPQMLGVQRGECEDRPERAEPLSDAEMEIIQHTWGHVYK-NCEDVGVSVLIR-FFVNFPSAKQYFSQ-F------QDMQ----DPEEMEKSSQLRQHARRVMNAINV-VENLQDPEKVS---SVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFP-EFFT-A-EVQLVWTKLMAAVYWHVTGAYT----E--V-GW------------LQ-----------VSSSAV Medaka_GbX ------------------------------------------------------------------------------------------------------------MGCAISGLAAKTDLAERSREDAAVEHPNEEQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHPECKDVFFL-F------RDVE----DLERLRTNRELRAHGLRVMSFIEKSVARLDQP---ERLEALAVELGKSH-YHYNA-PPKYYNYVGAEFICAVQPILK-EQWT-T-ELEKAWQTLFQFVTALMKQGYQ----E--E-SARQRQLATSPKDRLD-----------KRNTAL Medaka_HbA -----------------------------------------------------------------------------------------------------------------------------------KMSLSAKDKAAVKAFWAKVSG-QADAIGSDALSR-MLVVYPQTKTYFAH-W------KDLS---------PGSAPVKKHGKTVMGGIADAVGKIDDI---S---SGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFP-QDFT-P-EVHVALDKFLAAVSLALSEKYR------------------------------------------ Medaka_HbB -----------------------------------------------------------------------------------------------------------------------------------MVEWTEQERSIITNIFGNLD---YEDVGSKALSR-CLIVYPWTQRYFAS-F------GNLY----NAEAIKTNPNIAAHGTKVLHGLDRAVKNMDNI---K---ATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLG-SAFS-P-EIQATFQKFLAVVVSALGRQYH------------------------------------------ Medaka_Mb ----------------------------------------------------------------------------------------------------------------------------------------MADYDMVLKHWGPVEA-DYNTHGNLVLTR-LFHEYPETQKLFPK-F------AGIA----K-GDMAGNAALSAHGATVLKKLGELLKARGNH---G---AILKPLANSHATKHKI-PINNFRLITEVIGKVMAEKAG---LD-A-AGQQALRSVMAGIIAEIEADYK----E--L-GF------------AG----------------- Medaka_NgB -----------------------------------------------------------------------------------------------------------------------------------MEKLSGKDKELIRGSWESLGK-NKVPHGVIMFSR-LFELDPALLSLFNY-N------TNCG----STQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLE---DFLLNLGRKHQ-AVGV-STQSFAVVGESLLYMLQCSLG-QAYT-A-ALSQAWLNMYSIVVAAMSRGWA----K--N-G---------------------------EDKAD Platypus_GbY -----------------------------------------------------------------------------------------------------------------------------------MVQVTDVEKANIQSIWSKMME-NLEKNGIDIFTR-LFREYPETKKYFKN-I---------P----LEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVC---KILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLG-PCYT-P-EIAESFQKLQSSLYDQVVITYL----H--S-GS------------D------------------ Platypus_HbA ------------------------------------------------------------------------------------------------------------------------------------MGLTDGEKKEVAALWANVSG-HEEEFGAEALDR-LFLSFPPTKTYFPH-F------EL-S---------QGSAQVKAHGKKVADALTTAVAHLDDL---D---STLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLP-AEFT-P-SAHAALDKFLSKVATVLTSKYR------------------------------------------ Platypus_HbB -----------------------------------------------------------------------------------------------------------------------------------MVHLSGGEKSAVTNLWGKVN---INELGGEALGR-LLVVYPWTQRFFEA-F------GDLS----SAGAVMGNPKVKAHGAKVLTSFGDALKNLDDL---K---GTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFS-KDFS-P-EVQAAWQKLVSGVAHALGHKYH------------------------------------------ Platypus_HbW -----------------------------------------------------------------------------------------------------------------------------------MVNWTSEEKHAIVSIWGKVD---IEETGANALSR-LLVVYPWTQRYFSA-F------GNLS----SPTAIVGNPRVRAHGKKVLTSFGEAVKDLDHV---K---SNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLG-KDFT-P-EAQAAWQKLVGVVASALSSQYH------------------------------------------ Platypus_Mb ------------------------------------------------------------------------------------------------------------------------------------MGLSDGEWQLVLKVWGKVEG-DLPGHGQEVLIR-LFKTHPETLEKFDK-F------KGLK----TEDEMKASADLKKHGGTVLTALGNILKKKGQH---E---AELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHS-ADFG-A-DAQAAMGKALELFRNDMAAKYK----E--F-GF------------QG----------------- Platypus_NgB ---------------------------------------------------------------------------------------------------------------------------------MENGRLSGPEQELIRESWRSVNS-NPLEHGMILFTR-LFDLEPDLLPLFQYNC------RQFS----SPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLE---EYLTNLGRKHK-AIGV-KLSSFSTVGESLLFMLEKCLG-PAFS-P-ATREAWTRLYTAMVHAMSRGWG----G------------------------------------E Port_Jackson_shark_Mb ----------------------------------------------------------------------------------------------------------------------------------------MTEWEHVNKVWAVVEP-DIPAVGLAILLR-LFKEHKETKDLFPK-F------KEIP-----VQQLGNNEDLRKHGVTVLRALGNILKQKGKH---S---TNVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYP-SDMT-G-PMQESFSKVFTVICSDLETLYK----E--A-NF------------QG----------------- Sea_lamprey_Hb1a ---------------------------------------------------------------------------------------------------------------------------MPIVDSGSVPALTAAEKATIRTAWAPVYA-KYQSTGVDILIK-FFTSNPAAQAFFPK-F------QGLT----SADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMS---LKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTVL------------PGDAGLEKLMSMICILLRSSY------------------------------------------- Sea_lamprey_Hb1b ---------------------------------------------------------------------------------------------------------------------------MPIVDSGSVSPLSDAEKNKIRAAWDLVYK-DYEKTGVDILVK-FFTGTPAAQAFFPK-F------KGLT----TADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMS---MKLKELSIKHAQSFYV-DRQYFKVLAGIIADTTA------------PGDAGFEKLMSMICILLSSAY------------------------------------------- Sea_lamprey_Hb2 ---------------------------------------------------------------------------------------------------------------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQEFFPK-F------KGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMS---MKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY------------------------------------------- Sea_lamprey_Hb3 ---------------------------------------------------------------------------------------------------------------------------MPIVDSGSVAPLSAAEKTKIRSAWAPVYS-NYETTGVDILVK-FFTSTPAAQEFFPK-F------KGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMS---MKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY------------------------------------------- Sea_lamprey_Hb5 ---------------------------------------------------------------------------------------------------------------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYS-TYETSGVDILVK-FFTSTPAAQEFFPK-F------KGLT----TADQLKKSADVRWHAERIINAVNDAVASMDDTEKMS---MKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY------------------------------------------- Sea_lamprey_Hb_PMII ---------------------------------------------------------------------------------------------------------------------------MPIVDTGSVAPLSAAEKTKIRSAWAPVYS-NYETSGVDILVK-FFTSTPAAQEFFPK-F------KGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMS---MKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSAY------------------------------------------- Sea_squirt_Glb1 ------------------------------------------------------------------------------------------------------------------------------------MPFTDEELKLLRDSWDEVKKLGMKEVGLHIFTG-LLNAAPSLRTLFYT-I------DLPDEEELTIDVMRENKKVVAHATRIANAISKFIKFLDQPDELE---KLLTSLGESHA-RRQV-DPESFEYVAPVILSVIGGHLK-LPSN-S-PTLQAWVKAYGVLRNGIVSAMEA----------------------------------------- Sea_squirt_Glb2 ------------------------------------------------------------------------------------------------------------------------------------MGLTTEEIGLLRSSWNEMKTIGMKELGLLIFHR-LFSDVPRIRKMFYN-L------ELPDDETLTMEAMRSNQKMSRHATRIATSISTYLKLADQPEELK---TFLNGLGELHA-GHNV-EPEDFEYLAPVMLAVIGGQLN-LNSN-S-SILQAWVKAYGVLRNGIVRGMY-AYQ-------------------------------------G Sea_squirt_Glb3 ------------------------------------------------------------------------------------------------------------------------------------MSLTSEQVVLLRSSWQTIGKLGMSNVGLAVLHR-LFNDVPETLPFFHS-V------LSPTQ-QTEIEVLKSNAKVVRHASRVGLSIDKIINLLDNGEELV---KYLLFLGQVHV-KRSI-PRKYFSAMGPVLLSVISAVLE-KDLD-A-PVMQAWATAYGVIEQGIIDGM------------------------------------------- Sea_squirt_Glb4 MKIICGLILFSTFAIIFVSGLNCWTCNVLGGNNVCRRSGGLRTCFNNQVCYNEVRRRGNTINIRKGCKNSGVCENHIMQSMSTPNPNNQCVNGPNYFCSCCCGNSVCNSNWLTCVTAGSVAPTVSTTVPPADEGLKRSDIINIQDSWNTLKGFGYETVGMLVLHR-LFNDAPQTRYLFSQ-L------SLSSNESFTLEQMRNNSRVVYHANRVARAVGRLVDLIELPTNFT---DHLVWLGQRHA-YHGV-APVNFDYMGPVLLETIKVNLE-LPSD-S-PTLSAWAKAYGVIKNGIKDAIIATYAE------------------------------------G Stingray_HbA ------------------------------------------------------------------------------------------------------------------------------------MVLSSQNKKAIEELGNLIKA-NAEAWGADALAR-LFELHPQTKTYFSK-F------SGFE---------ACNEQVKKHGKRVMNALADATHHLDNL---H---LHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNL--QAFT-P-VTHCAVDKFLELVAYELSSCYR------------------------------------------ Stingray_HbB -----------------------------------------------------------------------------------------------------------------------------------MVKLSEDQEHYIKGVWKDVD---HKQITAKALER-VFVVYPWTTRLFSK-L------QGLF----SAN----DIGVQQHADKVQRALGEAIDDLKKV---E---INFQNLSGKHQ-EIGV-DTQNFKLLGQTFMVELALHYK-KTFR-P-KEHAAAYKFFRLVAEALSSNYH------------------------------------------ Tetraodon_Cygb_1 --------------------------------------------------------------------------------------------------------------------MERMQRDGEVDHVEQPGPLTEKEKVMIQDSWAKVFQ-SCDDAGVAILVR-FFVNFPSSKQFFKD-F------KHME----EPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVA---SVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFT-EIIT-A-EVASAWTKLLANMCCGIAAVYK----E--A-GW------------TE-----------LSSSVE Tetraodon_Cygb_2 ---------------------------------------------------------------------------------------------------------MSHREPPPPQLAVQRRDVDGQDGPERAEPLSDTEREMIRDAWGHVYK-NCEDVGVSILIR-FFVNFPSAKQYFSQ-F------QDME----EPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVS---SVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFP-EFFT-A-DVQLVWSKLMATVYWHVTGAYT----D--V-GW------------LQ-----------VSSSAV Tetraodon_GbX ------------------------------------------------------------------------------------------------------MGCAISSLGAKAEFGDRSAEEEDAAAAAAVVYPREDQIQMIKDSWKVIRD-DIAKVGIIMFVR-LFETHPECKDVFFL-F------RDVE----DLERLRSSRELRAHGLRVMSFIEKSVARLDQQ---DRLEALAVELGKSH-YHYNA-PPKYYSYVGAEFICAVQPILK-ERFT-S-ELEEAWKTLFQYVTGLMRKGHQ----E--E-GSRQRHLALPPKDGPE-----------KRTSAL Tetraodon_HbA -----------------------------------------------------------------------------------------------------------------------------------MTSLSTKDKETVRAFWAKVAS-NREEIGASALCR-LLSVYPQTKTYFSH-W------KDQS---------PNSASAKKHGITIMNAVGDAVSKIDDL---K---TGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYP-ADFT-P-EVHVAMDKFLASLALALSEKYR------------------------------------------ Tetraodon_HbB -----------------------------------------------------------------------------------------------------------------------------------MVVWTDQERAIIDNIFSNLD---YEDVGSKALIR-CLIVYPWTQRYFSS-F------GNLY----NAEAIRNNPNVAKHGVTVLHGLDRALKNMDNI---K---EE----YKKHSEKLHV-DPDNFKLLSDCLTVVIAGKLG-SKFT-P-EYQAALQKFLAVVVSALGRQYH------------------------------------------ Tetraodon_Mb ----------------------------------------------------------------------------------------------------------------------------------------MGDFDMVLKFWGPVEA-DYSAHGGMVLTR-LFTENPETQQLFPK-F------VGIA----Q-SELAGNAAVSAHGATVLKKLGELLKAKGNH---A---AILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEKAG---LD-T-AGQQALRNIMATIIADIDATYK----E--L-GF------------S------------------ Tetraodon_NgB -----------------------------------------------------------------------------------------------------------------------------------MEKLSSKDKELIRGSWDSLGK-NKVPHGVILFSR-LFELDPELLNLFHY-T------TNCG----STQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLE---DFLLNLGRKHQ-AVGV-KPQSFAMVGESLLYMLQCSLG-QAYT-A-SLRQAWLNMYSVVVASMSRGWA----K--N-G---------------------------EDKAD Zebrafish_Cygb_1 -----------------------------------------------------------------------------------------------------------------------MEGDGGVQLTQSPDSLTEEDVCVIQDTWKPVYA-ERDNAGVAVLVR-FFTNFPSAKQYFEH-F------RELQ----DPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLN---TIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFP-QCFS-PAEVQSSWSKLMGILYWQMNRVYA----E--V-GW------------EN--------------SKK Zebrafish_Cygb_2 --------------------------------------------------------------------------------------------------------------------MEKEREDEETEGRERPEPLTDVERGIIKDTWARVYA-SCEDVGVTILIR-FFVNFPSAKQYFSQ-F------QDME----DPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVS---SVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFG-ECFT-P-EVQTSWSKLMAALYWHITGAYT----E--V-GW------------VK-----------LSSSAV Zebrafish_GbX -----------------------------------------------------------------------------------------------------------MGCAISGSGLTAGAPEIRPGEEETPAGLTTNHIRLIKESWRLIQE-DIAKVGIIMFVR-LFETHPECKDVFFL-F------RDVE----DLERLRTSRELRAHGLRVMSFIEKSVARLDQL---ERLETLALELGKSH-YRYNA-PPKYYGYVGAEFICAVRPILK-DRWT-P-ELEEAWKTLFQYVTSIMREGFL----E--EERNKRSNTQTSSRERPD-----------KRSTAI Zebrafish_HbA ------------------------------------------------------------------------------------------------------------------------------------MSLSDTDKAVVKAIWAKISP-KADEIGAEALAR-MLTVYPQTKTYFSH-W------ADLS---------PGSGPVKKHGKTIMGAVGEAVSKIDDL---V---GGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFP-ADFT-P-EVHVSVDKFFNNLALALSEKYR------------------------------------------ Zebrafish_HbB -----------------------------------------------------------------------------------------------------------------------------------MVEWTDAERTAILGLWGKLN---IDEIGPQALSR-CLIVYPWTQRYFAT-F------GNLS----SPAAIMGNPKVAAHGRTVMGGLERAIKNMDNV---K---NTYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGFN-A-DVQEAWQKFLAVVVSALCRQYH------------------------------------------ Zebrafish_Mb ----------------------------------------------------------------------------------------------------------------------------------------MADHDLVLKCWGAVEA-DYAANGGEVLNR-LFKEYPDTLKLFPK-F------SGIS----Q-GDLAGSPAVAAHGATVLKKLGELLKAKGDH---A---ALLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEKAG---LD-A-AGQGALRRVMDAVIGDIDGYYK----E--I-GF------------AG----------------- Zebrafish_NgB -----------------------------------------------------------------------------------------------------------------------------------MEKLSEKDKGLIRDSWESLGK-NKVPHGIVLFTR-LFELDPALLTLFSY-S------TNCG----DAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLE---DFLLNLGRKHQ-AVGV-NTQSFALVGESLLYMLQSSLG-PAYT-T-SLRQAWLTMYSIVVSAMTRGWA----K--N-G---------------------------EHKSN ; end; Alignment 19 of 20 file name: vertebrate_globins.NgB_GbX_Ciona.aa.probcons.nex #NEXUS begin data; dimensions ntax=76 nchar=395; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb -M-EKVQGEMEIERW----------------------E---------------RNEEM------------------------------------------------------------------------------------------------------------------------------------SDAEKKMIQETWNTVYA-KCEDVGVSLLIRFFVNFPSAKHYFSQ----FKHME----DPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHKV-EPVYFQLLG-VLLEVLAEEYT-NEFSPP-EVQRAWAKMKSLICTHVTAA--------YKEV-G-----------W-V-----------QYPNSTM Anolis_GbY -KAG----------------------------------------------------KM------------------------------------------------------------------------------------------------------------------------------------TDLDRRHIREIWTAAFE-NPEENGRLVIIRFFSDYPASKQYFKT----V---P----TDGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQV-PSGMFQLLFQAMLCTFDDLLG-RTFT-P-EKRVSWEKFFQVIQEEVEAAY-------D------------------------------------R Anolis_HbA -M-------------------------------------------------------L------------------------------------------------------------------------------------------------------------------------------------TEDDKNHIRAIWGHVSS-NPELYGAEALTRLFAAHHTTKTYFPH----YD-M---------SPGSAQIKAHGKKVVEAITQAVNNLDDIA---GALAKLADLHAEKLRV-DPVNFPLLGHCLLVTIAAHNR-GPLK-P-EFILALDKCFTSIGRVLIAQ--------Y------------------------------------R Anolis_HbB -M-V----------------------------------------------------HW------------------------------------------------------------------------------------------------------------------------------------TAEEKQLIANCWSKV---DIGQIGGDALACLLCVYPWTQRFFPD----FGNLS----NAAAICANAKVKAHGKKVLTAFGEAVKNLDNIK---DTFAKLSELHCDKLHV-DPVNFNLLGDVLIVCLAAHFG-KDFT-P-ACHAAYQKLVNSVAHGLSRR--------Y------------------------------------H Anolis_Mb -M-E-----------------------------------------------------L------------------------------------------------------------------------------------------------------------------------------------SDQEWQKVIDIWGKVEP-EIPAYGQMVILRLFEQHPETQEKFDK----FKNLK----SLDEMKNSEDLKKHGTIVLTALGKILKQKRQ---HEAELAPLAQSHATKHKI-PVKYLEFISEVIVGVIAEKRS-ADFG-A-ESQAAMRKALELFRNDMDRK--------YKEL-G-----------------------------FQG Arctic_lamprey_Hb1 -M-PIVD-------S----------------------G---------------SVAPL------------------------------------------------------------------------------------------------------------------------------------SAAEKTKIRSAWAPVYS-NYETSGVDILVKFFTSTPAAQEFFPK----FKGMT----SADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSA---------------------------------------------Y Arctic_lamprey_Hb2 -M-PIVD-------S----------------------G---------------SVPAL------------------------------------------------------------------------------------------------------------------------------------TAAEKATIRTAWAPVYA-KYQSTGVDILIKFFTSNPAAQEFFPK----FQGLT----SADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQV-DPQYFKVLAAVIVDTVL------------PGDAGLEKLMSMICILLKSS---------------------------------------------Y Arctic_lamprey_Hb4 -M-PIED-------S----------------------G---------------SKPDF------------------------------------------------------------------------------------------------------------------------------------SDDEKKAIKDSWSGVYS-EYESTSSEILIKFFVDNPSAQDFFPK----FKDLD----SEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLNV-DAKFFKVLAEVILDKVAEKND-GSFS-D-SARSAWEKLLTYICISLKVA---------------------------------------------Y Chicken_Cygb -M-EKVQGEMEIERW----------------------E---------------RSEEI------------------------------------------------------------------------------------------------------------------------------------SDAEKKVIQETWSRVYA-NCEDVGVSILIRFFVNFPSAKQYFSQ----FKHMD----DTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKV-EPVYFKKLTGVMLEVIAEAYG-NDFT-P-EAHGAWTKMRTLIYTHVTAA--------YKEA-G-----------W-V-----------SYPSATL Chicken_GbE -M------------------------------------------------------SF------------------------------------------------------------------------------------------------------------------------------------SEAEVQSARGAWEKMYV-DAEDNGTAVLVRMFTEHPDTKSYFTH----FKGMD----SAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKI-DPKNFRIICDIILQLMEEKFG-G------DCKASFEKVTNEICTHLTNI--------YKEA-G-------------------------------W Chicken_HbA -M------------------------------------------------------VL------------------------------------------------------------------------------------------------------------------------------------SAADKNNVKGIFTKIAG-HAEEYGAETLERMFTTYPPTKTYFPH----FD-L---------SHGSAQIKGHGKKVVAALIEAANHIDDIA---GTLSKLSDLHAHKLRV-DPVNFKLLGQCFLVVVAIHHP-AALT-P-EVHASLDKFLCAVGTVLTAK--------Y------------------------------------R Chicken_HbB -M-V----------------------------------------------------HW------------------------------------------------------------------------------------------------------------------------------------SAEEKQLITSVWSKV---NVEECGAEALARLLIVYPWTQRFFAS----FGNLS----SPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNIK---NTYAKLSELHCDKLHV-DPENFRLLGDILIIVLASHFA-RDFT-P-ACQFAWQKLVNVVAHALARK--------Y------------------------------------H Chicken_Mb -M-G-----------------------------------------------------L------------------------------------------------------------------------------------------------------------------------------------SDQEWQQVLTIWGKVEA-DIAGHGHEVLMRLFHDHPETLDRFDK----FKGLK----TPDQMKGSEDLKKHGATVLTQLGKILKQKGN---HESELKPLAQTHATKHKI-PVKYLEFISEVIIKVIAEKHA-ADFG-A-DSQAAMKKALELFRNDMASK--------YKEF-G-----------------------------FQG Finch_Cygb -M-EKVQGEMEIERW----------------------E---------------RSEEI------------------------------------------------------------------------------------------------------------------------------------SDAEKKVIQEIWSRVYA-NCEDVGVSILIRFFVNFPSAKQYFSQ----FKHME----DPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHKV-EPIYFKKLTGVMLEVIAEEYP-NDFT-P-EAHGAWTKMKTLIYTHVTAA--------YKEV-G-----------W-A-----------QYPTATL Finch_GbE -M------------------------------------------------------SL------------------------------------------------------------------------------------------------------------------------------------SEAEVQSARGAWEKIYV-DAEDNGTAVLVRMFTEHPDTKSYFPH----FKGMD----SAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLKI-DPKNFRIICDIILQLMEEKFG-G------DCKASFEKVTNEICTHLNNI--------YKEE-G-------------------------------W Finch_HbA -M------------------------------------------------------VL------------------------------------------------------------------------------------------------------------------------------------SAGDKSNVKAVFGKIGG-QADEYGADALERMFATYPQTKTYFPH----FD-L---------GKGSAQVKGHGKKVAAALVEAANNVDDLA---GALSKLSDLHAQKLRV-DPVNFKLLGQCFLVVVATRNP-SLLT-P-EVHASLDKFLCAVGTVLTAK--------Y------------------------------------R Finch_HbB -M-V----------------------------------------------------HW------------------------------------------------------------------------------------------------------------------------------------SAEEKQLIASVWGRV---SVEECGAEALARLLIVYPWTQRFFSD----FGNLS----SPTAIVGNPKVRAHGKKVLTSFGEAIKNLDNLK---GTYSKLSELHCDKLHV-DPENFRLLGDILVIVLAAHFT-KEFT-P-ACQATWQKLVGVVAHALARK--------Y------------------------------------H Finch_Mb -M-G-----------------------------------------------------L------------------------------------------------------------------------------------------------------------------------------------SDQEWQQVLTVWGKVES-DLAGHGHQILMRLFQDHPETLDRFEK----FKGLK----TPDAMKGSEDLKKHGVTVLTQLGKILKAKGN---HEAELKPLAQTHATKHKI-PVKYLEFISEVIIKVLAEKHA-ADFG-A-DAQAAMKKALELFRNDMATK--------YKEF-G-----------------------------FQG Frog_Cygb -M-EKVQGENDMERW----------------------E---------------RLEEI------------------------------------------------------------------------------------------------------------------------------------TESERGVIKETWARVYA-NCEDVGVSILIRFFVNFPSAKQHFSQ----FKHME----DPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKV-DPVYFKILTGVMLEVIAEEYA-KDFT-P-DVQLAWNKLRSHLYSHVLSA--------YKEA-G-----------W-T-----------QYPSNSV Frog_GbX -M-GCI-----------LSSLGWQWRDSLDHTETSPLL---------------PTLNL------------------------------------------------------------------------------------------------------------------------------------SEQQQQLLVESWRLIQH-DIAKVGVILFVRLFETHPECKDVFFL----FRDVD----DLQALRANKDLRAHGLRVLSFVEKSVARIADCARLEELALELGRS-XYRYNA-PPRYYQYVGTEFISAVCPMLH-DKWT-A-EVEEAWKGLFAYICTVMERG--------YQEE-ERRHSDGRSLIDG-L-----------QGNKGLI Frog_GbY -M-A----------------------------------------------------DL------------------------------------------------------------------------------------------------------------------------------------TGADIENINEVWSKIYA-NPEESGRTVVISLFLTYPQTKIYFKN----LKNIS----TLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHKV-EVNNFELLFLVIISVFKEALG-SGFT-P-EQSKSWEKLFSITYKYLESCYA----NTD------------------------------------S Frog_HbA1 -M------------------------------------------------------HL------------------------------------------------------------------------------------------------------------------------------------TADDKKHIKAIWPSVAA-HGDKYGGEALHRMFMCAPKTKTYFPD----FD-F---------SEHSKHILAHGKKVSDALNEACNHLDNIA---GCLSKLSDLHAYDLRV-DPGNFPLLAHQILVVVAIHFP-KQFD-P-ATHKALDKFLVSVSNVLTSK--------Y------------------------------------R Frog_HbB -M-V----------------------------------------------------NL------------------------------------------------------------------------------------------------------------------------------------TAKERQLITGTWSKI---CAKTLGKQALGSMLYTYPWTQRYFSS----FGNLS----SIEAIFHNAAVATHGEKVLTSIGEAIKHMDDIK---GYYAQLSKYHSETLHV-DPYNFKRFCSCTIISMAQTLQ-EDFT-P-ELQAAFEKLFAAIADALGKG--------Y------------------------------------H Frog_NgB -M-EK--------------------------------------------------DQL------------------------------------------------------------------------------------------------------------------------------------SGPQKELIRESWQTVSQ-DQLHHGTVLFSSDIFQLKSGLYWSSEVPRECLIRV----VHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKHR-AVGV-KLESFNTVGESLLFALESCLG-DAFT-S-DTREAWSLLYANVVQSMSRG--------WHR--------------------------DSQEQREGI Hagfish_Hb1 -M-PITD-------Q----------------------G---------------PLPTL------------------------------------------------------------------------------------------------------------------------------------SEGDKKAIRESWPQIYQ-NFEQTGLVVLLEFLQKNPGAQQSFPK----FSATK------CNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQV-DPKLFKELSAIFVSTIR-------------GKAAYEKLFSIICTLLRSS--------YD-----------------------------------E Hagfish_Hb2 -M-SA--------------------------------H---------------GIART------------------------------------------------------------------------------------------------------------------------------------TEGERAAVRASWAVLMK-DYEHAGVQILDKFFKANPAAKPFFTK----MKDLH----TLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKR-N-GGLS-G-EGKSGWHKVMTIICKMLKSK--------Y------------------------------------- Hagfish_Hb3 -M-PITD-------H----------------------G---------------QPPTL------------------------------------------------------------------------------------------------------------------------------------SEGDKKAIRESWPQIYK-NFEQNSLAVLLEFLKKFPKAQDSFPK----FSAKK------SHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQV-NPDMFKELSAVFVSTMG-------------GKAAYEKLFSIIATLLRST--------YD-----------------------------------A Hagfish_Hb4 -M-PITD-------Q----------------------R---------------PLPTL------------------------------------------------------------------------------------------------------------------------------------SEGEKKAIKESWPQIYQ-NFEQTSLDVLIEFLQKFPEAQDSFPK----FSAKK------CHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQV-DPKMFKELSAIFVSTIR-------------GKAAYEKLFSIICTLLRSS--------YD-----------------------------------E Houndshark_HbA -M------------------------------------------------------AF------------------------------------------------------------------------------------------------------------------------------------TACEKQTIGKIAQVLAK-SPEAYGAECLARLFVTHPGSKSYFEY----K-DY---------SAAGAKVQVHGGKVIRAVVKAAEHVDDLH---SHLETLALTHGKKLLV-DPQNFPMLSECIIVTLATHL--TEFS-P-DTHCAVDKLLSAICQELSSR--------Y------------------------------------R Houndshark_HbB -M-V----------------------------------------------------HW------------------------------------------------------------------------------------------------------------------------------------TQEERDEISKTFQGT---DMKTVVTQALDRMFKVYPWTNRYFQK----RTDF--------------RSSIHAGIVVGALQDAVKHMDDVK---TLFKDLSKKHADDLHV-DPGSFHLLTDCIIVELAYLRK-DCFT-P-HIQGIWDKFFEVVIDAISKQ--------Y------------------------------------H Houndshark_Mb -M----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VDWEKVNSVWSAVES-DLTAIGQNILLRLFEQYPESQNHFPK----FKNKS-----LGELKDTADIKAQADTVLSALGNIVKKKGS---HSQPVKALAATHITTHKI-PPHYFTKITTIAVDVLSEMYP-SEMN-A-QVQAAFSGAFKIICSDIEKE--------YKAA-N-----------------------------FQG Human_Cygb -M-EKVPGEMEIERR----------------------E---------------RSEEL------------------------------------------------------------------------------------------------------------------------------------SEAERKAVQAMWARLYA-NCEDVGVAILVRFFVNFPSAKQYFSQ----FKHME----DPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKV-EPVYFKILSGVILEVVAEEFA-SDFP-P-ETQRAWAKLRGLIYSHVTAA--------YKEV-G-----------W-VQQVPNATTPPATLPSSGP Human_HbA -M------------------------------------------------------VL------------------------------------------------------------------------------------------------------------------------------------SPADKTNVKAAWGKVGA-HAGEYGAEALERMFLSFPTTKTYFPH----FD-L---------SHGSAQVKGHGKKVADALTNAVAHVDDMP---NALSALSDLHAHKLRV-DPVNFKLLSHCLLVTLAAHLP-AEFT-P-AVHASLDKFLASVSTVLTSK--------Y------------------------------------R Human_HbB -M-V----------------------------------------------------HL------------------------------------------------------------------------------------------------------------------------------------TPEEKSAVTALWGKV---NVDEVGGEALGRLLVVYPWTQRFFES----FGDLS----TPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLK---GTFATLSELHCDKLHV-DPENFRLLGNVLVCVLAHHFG-KEFT-P-PVQAAYQKVVAGVANALAHK--------Y------------------------------------H Human_Mb -M-G-----------------------------------------------------L------------------------------------------------------------------------------------------------------------------------------------SDGEWQLVLNVWGKVEA-DIPGHGQEVLIRLFKGHPETLEKFDK----FKHLK----SEDEMKASEDLKKHGATVLTALGGILKKKGH---HEAEIKPLAQSHATKHKI-PVKYLEFISECIIQVLQSKHP-GDFG-A-DAQGAMNKALELFRKDMASN--------YKEL-G-----------------------------FQG Human_NgB -M--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERPEPELIRQSWRAVSR-SPLEHGTVLFARLFALEPDLLPLFQYN---CRQFS----SPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHR-AVGV-KLSSFSTVGESLLYMLEKCLG-PAFT-P-ATRAAWSQLYGAVVQAMSRG--------W----------------------------------DGE Medaka_Cygb_1 -M-ERK------------------------QGEVDHLE---------------RSRPL------------------------------------------------------------------------------------------------------------------------------------TDKERVMIQDSWAKVYQ-NCDDAGVAILVRLFVNFPSSKQYFSQ----FKHIE----DAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHKV-DPVYFKILSGVILEVLGEAYP-QVMT-A-EVASAWTNLLAILCCSIKAV--------YEEL-G-----------W-P-----------HLSNSTS Medaka_Cygb_2 -M-SCRE-------SPPPPSPPPQMLGVQRGECEDRPE---------------RAEPL------------------------------------------------------------------------------------------------------------------------------------SDAEMEIIQHTWGHVYK-NCEDVGVSVLIRFFVNFPSAKQYFSQ----FQDMQ----DPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHKV-EPIYFKILSGVMLSVLSEDFP-EFFT-A-EVQLVWTKLMAAVYWHVTGA--------YTEV-G-----------W-L-----------QVSSSAV Medaka_GbX -M-GCAI-------S----------------------GLAAKTDLAERSREDAAVEHP------------------------------------------------------------------------------------------------------------------------------------NEEQIQMIKDSWKVIRD-DIAKVGIIMFVRLFETHPECKDVFFL----FRDVE----DLERLRTNRELRAHGLRVMSFIEKSVARLDQPERLEALAVELGKSHY-HYNA-PPKYYNYVGAEFICAVQPILK-EQWT-T-ELEKAWQTLFQFVTALMKQG--------YQEE-S-----------ARQRQLATSPKDRLDKRNTAL Medaka_HbA KM------------------------------------------------------SL------------------------------------------------------------------------------------------------------------------------------------SAKDKAAVKAFWAKVSG-QADAIGSDALSRMLVVYPQTKTYFAH----WKDL---------SPGSAPVKKHGKTVMGGIADAVGKIDDIS---SGLLNLSELHAFTLRV-DPTNFKILSHNILVVMAIMFP-QDFT-P-EVHVALDKFLAAVSLALSEK--------Y------------------------------------R Medaka_HbB -M-V----------------------------------------------------EW------------------------------------------------------------------------------------------------------------------------------------TEQERSIITNIFGNL---DYEDVGSKALSRCLIVYPWTQRYFAS----FGNLY----NAEAIKTNPNIAAHGTKVLHGLDRAVKNMDNIK---ATYAELSVLHSEKLHV-DPDNFKLLADCLTIVIAAKLG-SAFS-P-EIQATFQKFLAVVVSALGRQ--------Y------------------------------------H Medaka_Mb -M----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADYDMVLKHWGPVEA-DYNTHGNLVLTRLFHEYPETQKLFPK----FAGIA----K-GDMAGNAALSAHGATVLKKLGELLKARGN---HGAILKPLANSHATKHKI-PINNFRLITEVIGKVMAEKAG-L--D-A-AGQQALRSVMAGIIAEIEAD--------YKEL-G-----------------------------FAG Medaka_NgB -M-E----------------------------------------------------KL------------------------------------------------------------------------------------------------------------------------------------SGKDKELIRGSWESLGK-NKVPHGVIMFSRLFELDPALLSLFNY----NTNCG----STQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKHQ-AVGV-STQSFAVVGESLLYMLQCSLG-QAYT-A-ALSQAWLNMYSIVVAAMSRGWAKNGEDKA------------------------------------D Platypus_GbY -M-V----------------------------------------------------QV------------------------------------------------------------------------------------------------------------------------------------TDVEKANIQSIWSKMME-NLEKNGIDIFTRLFREYPETKKYFKN----I---P----LEGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHSV-DVENFQFMLKCVGDVCQDYLG-PCYT-P-EIAESFQKLQSSLYDQVVITYL---HSGS------------------------------------D Platypus_HbA -M------------------------------------------------------GL------------------------------------------------------------------------------------------------------------------------------------TDGEKKEVAALWANVSG-HEEEFGAEALDRLFLSFPPTKTYFPH----FE-L---------SQGSAQVKAHGKKVADALTTAVAHLDDLD---STLSALSDLHAHKLRV-DPINFKLLAHCILVVVARHLP-AEFT-P-SAHAALDKFLSKVATVLTSK--------Y------------------------------------R Platypus_HbB -M-V----------------------------------------------------HL------------------------------------------------------------------------------------------------------------------------------------SGGEKSAVTNLWGKV---NINELGGEALGRLLVVYPWTQRFFEA----FGDLS----SAGAVMGNPKVKAHGAKVLTSFGDALKNLDDLK---GTFAKLSELHCDKLHV-DPENFNRLGNVLIVVLARHFS-KDFS-P-EVQAAWQKLVSGVAHALGHK--------Y------------------------------------H Platypus_HbW -M-V----------------------------------------------------NW------------------------------------------------------------------------------------------------------------------------------------TSEEKHAIVSIWGKV---DIEETGANALSRLLVVYPWTQRYFSA----FGNLS----SPTAIVGNPRVRAHGKKVLTSFGEAVKDLDHVK---SNFAKLSQLHSEKLHV-DPENFRLLGDNLIIVLAATLG-KDFT-P-EAQAAWQKLVGVVASALSSQ--------Y------------------------------------H Platypus_Mb -M-G-----------------------------------------------------L------------------------------------------------------------------------------------------------------------------------------------SDGEWQLVLKVWGKVEG-DLPGHGQEVLIRLFKTHPETLEKFDK----FKGLK----TEDEMKASADLKKHGGTVLTALGNILKKKGQ---HEAELKPLAQSHATKHKI-SIKFLEYISEAIIHVLQSKHS-ADFG-A-DAQAAMGKALELFRNDMAAK--------YKEF-G-----------------------------FQG Platypus_NgB -M-EN--------------------------------------------------GRL------------------------------------------------------------------------------------------------------------------------------------SGPEQELIRESWRSVNS-NPLEHGMILFTRLFDLEPDLLPLFQYN---CRQFS----SPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKHK-AIGV-KLSSFSTVGESLLFMLEKCLG-PAFS-P-ATREAWTRLYTAMVHAMSRG--------W----------------------------------GGE Port_Jackson_shark_Mb -M----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEWEHVNKVWAVVEP-DIPAVGLAILLRLFKEHKETKDLFPK----FKEIP-----VQQLGNNEDLRKHGVTVLRALGNILKQKGK---HSTNVKELADTHINKHKI-PPKNFVLITNIAVKVLTEMYP-SDMT-G-PMQESFSKVFTVICSDLETL--------YKEA-N-----------------------------FQG Sea_lamprey_Hb1a -M-PIVD-------S----------------------G---------------SVPAL------------------------------------------------------------------------------------------------------------------------------------TAAEKATIRTAWAPVYA-KYQSTGVDILIKFFTSNPAAQAFFPK----FQGLT----SADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQV-DPQYFKVLAAVIVDTVL------------PGDAGLEKLMSMICILLRSS---------------------------------------------Y Sea_lamprey_Hb1b -M-PIVD-------S----------------------G---------------SVSPL------------------------------------------------------------------------------------------------------------------------------------SDAEKNKIRAAWDLVYK-DYEKTGVDILVKFFTGTPAAQAFFPK----FKGLT----TADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYV-DRQYFKVLAGIIADTTA------------PGDAGFEKLMSMICILLSSA---------------------------------------------Y Sea_lamprey_Hb2 -M-PIVD-------T----------------------G---------------SVAPL------------------------------------------------------------------------------------------------------------------------------------SAAEKTKIRSAWAPVYS-NYETSGVDILVKFFTSTPAAQEFFPK----FKGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSA---------------------------------------------Y Sea_lamprey_Hb3 -M-PIVD-------S----------------------G---------------SVAPL------------------------------------------------------------------------------------------------------------------------------------SAAEKTKIRSAWAPVYS-NYETTGVDILVKFFTSTPAAQEFFPK----FKGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSA---------------------------------------------Y Sea_lamprey_Hb5 -M-PIVD-------T----------------------G---------------SVAPL------------------------------------------------------------------------------------------------------------------------------------SAAEKTKIRSAWAPVYS-TYETSGVDILVKFFTSTPAAQEFFPK----FKGLT----TADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSA---------------------------------------------Y Sea_lamprey_Hb_PMII -M-PIVD-------T----------------------G---------------SVAPL------------------------------------------------------------------------------------------------------------------------------------SAAEKTKIRSAWAPVYS-NYETSGVDILVKFFTSTPAAQEFFPK----FKGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQV-DPQYFKVLAAVIADTVA------------AGDAGFEKLMSMICILLRSA---------------------------------------------Y Sea_squirt_Glb1 -M-P-----------------------------------------------------F------------------------------------------------------------------------------------------------------------------------------------TDEELKLLRDSWDEVKKLGMKEVGLHIFTGLLNAAPSLRTLFYT----IDLPDEEELTIDVMRENKKVVAHATRIANAISKFIKFLDQPDELEKLLTSLGESHA-RRQV-DPESFEYVAPVILSVIGGHLK-LPSN-S-PTLQAWVKAYGVLRNGIVS-------AME------------------------------------A Sea_squirt_Glb2 -M-G-----------------------------------------------------L------------------------------------------------------------------------------------------------------------------------------------TTEEIGLLRSSWNEMKTIGMKELGLLIFHRLFSDVPRIRKMFYN----LELPDDETLTMEAMRSNQKMSRHATRIATSISTYLKLADQPEELKTFLNGLGELHA-GHNV-EPEDFEYLAPVMLAVIGGQLN-LNSN-S-SILQAWVKAYGVLRNGIVRGMY----AYQ------------------------------------G Sea_squirt_Glb3 -M-S-----------------------------------------------------L------------------------------------------------------------------------------------------------------------------------------------TSEQVVLLRSSWQTIGKLGMSNVGLAVLHRLFNDVPETLPFFHS----VLSPTQQ-TEIEVLKSNAKVVRHASRVGLSIDKIINLLDNGEELVKYLLFLGQVHV-KRSI-PRKYFSAMGPVLLSVISAVLE-KDLD-A-PVMQAWATAYGVIEQGIID---------G------------------------------------M Sea_squirt_Glb4 -M-K-----------------------------------------------------IICGLILFSTFAIIFVSGLNCWTCNVLGGNNVCRRSGGLRTCFNNQVCYNEVRRRGNTINIRKGCKNSGVCENHIMQSMSTPNPNNQCVNGPNYFCSCCCGNSVCNSNWLTCVTAGSVAPTVSTTVPPADEGLKRSDIINIQDSWNTLKGFGYETVGMLVLHRLFNDAPQTRYLFSQ----LSLSSNESFTLEQMRNNSRVVYHANRVARAVGRLVDLIELPTNFTDHLVWLGQRHA-YHGV-APVNFDYMGPVLLETIKVNLE-LPSD-S-PTLSAWAKAYGVIKNGIKDAIIA--TYAE------------------------------------G Stingray_HbA -M------------------------------------------------------VL------------------------------------------------------------------------------------------------------------------------------------SSQNKKAIEELGNLIKA-NAEAWGADALARLFELHPQTKTYFSK----FSGF---------EACNEQVKKHGKRVMNALADATHHLDNLH---LHLEDLARKHGENLLV-DPHNFHLFADCIVVTLAVNL--QAFT-P-VTHCAVDKFLELVAYELSSC--------Y------------------------------------R Stingray_HbB -M-V----------------------------------------------------KL------------------------------------------------------------------------------------------------------------------------------------SEDQEHYIKGVWKDV---DHKQITAKALERVFVVYPWTTRLFSK----LQGLF----SAN----DIGVQQHADKVQRALGEAIDDLKKVE---INFQNLSGKHQ-EIGV-DTQNFKLLGQTFMVELALHYK-KTFR-P-KEHAAAYKFFRLVAEALSSN--------Y------------------------------------H Tetraodon_Cygb_1 -M-ERMQRDGEVDHV----------------------E---------------QPGPL------------------------------------------------------------------------------------------------------------------------------------TEKEKVMIQDSWAKVFQ-SCDDAGVAILVRFFVNFPSSKQFFKD----FKHME----EPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHNV-DPKYFKILSGVILEVLGEAFT-EIIT-A-EVASAWTKLLANMCCGIAAV--------YKEA-G-----------W-T-----------ELSSSVE Tetraodon_Cygb_2 -M-SHR-----------EPPPPQLAVQRRDVDGQDGPE---------------RAEPL------------------------------------------------------------------------------------------------------------------------------------SDTEREMIRDAWGHVYK-NCEDVGVSILIRFFVNFPSAKQYFSQ----FQDME----EPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHKV-EPMYFKILSGVILEVLCEDFP-EFFT-A-DVQLVWSKLMATVYWHVTGA--------YTDV-G-----------W-L-----------QVSSSAV Tetraodon_GbX -M-GCAI-SSLGAKA----------------------EFGDRSAEEEDAAAAAAVVYP------------------------------------------------------------------------------------------------------------------------------------REDQIQMIKDSWKVIRD-DIAKVGIIMFVRLFETHPECKDVFFL----FRDVE----DLERLRSSRELRAHGLRVMSFIEKSVARLDQQDRLEALAVELGKSHY-HYNA-PPKYYSYVGAEFICAVQPILK-ERFT-S-ELEEAWKTLFQYVTGLMRKG--------HQEE-G-----------SRQRHLALPPKDGPEKRTSAL Tetraodon_HbA MT------------------------------------------------------SL------------------------------------------------------------------------------------------------------------------------------------STKDKETVRAFWAKVAS-NREEIGASALCRLLSVYPQTKTYFSH----WKDQ---------SPNSASAKKHGITIMNAVGDAVSKIDDLK---TGLFNLSELHAFTLRV-DPANFKLLAQCMMVVIAIMYP-ADFT-P-EVHVAMDKFLASLALALSEK--------Y------------------------------------R Tetraodon_HbB -M-V----------------------------------------------------VW------------------------------------------------------------------------------------------------------------------------------------TDQERAIIDNIFSNL---DYEDVGSKALIRCLIVYPWTQRYFSS----FGNLY----NAEAIRNNPNVAKHGVTVLHGLDRALKNMDNIK---EE----YKKHSEKLHV-DPDNFKLLSDCLTVVIAGKLG-SKFT-P-EYQAALQKFLAVVVSALGRQ--------Y------------------------------------H Tetraodon_Mb -M----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDFDMVLKFWGPVEA-DYSAHGGMVLTRLFTENPETQQLFPK----FVGIA----Q-SELAGNAAVSAHGATVLKKLGELLKAKGN---HAAILQPLANSHATKHKI-PIKNFKLIAEVIGKVMAEKAG-L--D-T-AGQQALRNIMATIIADIDAT--------YKEL-G------------------------------FS Tetraodon_NgB -M-E----------------------------------------------------KL------------------------------------------------------------------------------------------------------------------------------------SSKDKELIRGSWDSLGK-NKVPHGVILFSRLFELDPELLNLFHY----TTNCG----STQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKHQ-AVGV-KPQSFAMVGESLLYMLQCSLG-QAYT-A-SLRQAWLNMYSVVVASMSRGWAKNGEDKA------------------------------------D Zebrafish_Cygb_1 -M-EG---DGGVQLT----------------------Q---------------SPDSL------------------------------------------------------------------------------------------------------------------------------------TEEDVCVIQDTWKPVYA-ERDNAGVAVLVRFFTNFPSAKQYFEH----FRELQ----DPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKV-DPVYFKILAGVILEVLVEAFP-QCFS-PAEVQSSWSKLMGILYWQMNRV--------YAEV-G-----------W---------------ENSKK Zebrafish_Cygb_2 -M-EKEREDEETEGR----------------------E---------------RPEPL------------------------------------------------------------------------------------------------------------------------------------TDVERGIIKDTWARVYA-SCEDVGVTILIRFFVNFPSAKQYFSQ----FQDME----DPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYKV-EPVYFKILSGVILEILAEEFG-ECFT-P-EVQTSWSKLMAALYWHITGA--------YTEV-G-----------W-V-----------KLSSSAV Zebrafish_GbX -M-GCAI-------S---------------------GSGLTAGAPEIRPGEEETPAGL------------------------------------------------------------------------------------------------------------------------------------TTNHIRLIKESWRLIQE-DIAKVGIIMFVRLFETHPECKDVFFL----FRDVE----DLERLRTSRELRAHGLRVMSFIEKSVARLDQLERLETLALELGKSHY-RYNA-PPKYYGYVGAEFICAVRPILK-DRWT-P-ELEEAWKTLFQYVTSIMREG--------FLEEER-----------NKRSNTQTSSRERPDKRSTAI Zebrafish_HbA -M------------------------------------------------------SL------------------------------------------------------------------------------------------------------------------------------------SDTDKAVVKAIWAKISP-KADEIGAEALARMLTVYPQTKTYFSH----WADL---------SPGSGPVKKHGKTIMGAVGEAVSKIDDLV---GGLAALSELHAFKLRV-DPANFKILSHNVIVVIAMLFP-ADFT-P-EVHVSVDKFFNNLALALSEK--------Y------------------------------------R Zebrafish_HbB -M-V----------------------------------------------------EW------------------------------------------------------------------------------------------------------------------------------------TDAERTAILGLWGKL---NIDEIGPQALSRCLIVYPWTQRYFAT----FGNLS----SPAAIMGNPKVAAHGRTVMGGLERAIKNMDNVK---NTYAALSVMHSEKLHV-DPDNFRLLADCITVCAAMKFGQAGFN-A-DVQEAWQKFLAVVVSALCRQ--------Y------------------------------------H Zebrafish_Mb -M----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADHDLVLKCWGAVEA-DYAANGGEVLNRLFKEYPDTLKLFPK----FSGIS----Q-GDLAGSPAVAAHGATVLKKLGELLKAKGD---HAALLKPLANTHANIHKV-ALNNFRLITEVLVKVMAEKAG-L--D-A-AGQGALRRVMDAVIGDIDGY--------YKEI-G-----------------------------FAG Zebrafish_NgB -M-E----------------------------------------------------KL------------------------------------------------------------------------------------------------------------------------------------SEKDKGLIRDSWESLGK-NKVPHGIVLFTRLFELDPALLTLFSY----STNCG----DAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKHQ-AVGV-NTQSFALVGESLLYMLQSSLG-PAYT-T-SLRQAWLTMYSIVVSAMTRGWAKNGEHKS------------------------------------N ; end; Alignment 20 of 20 file name: vertebrate_globins.NgB_GbX_Ciona.aa.promal_wPDB.nex #NEXUS begin data; dimensions ntax=76 nchar=326; format missing=? gap=- matchchar=. datatype=protein; matrix Anolis_Cygb MEKVQG--------------------------------------------------------------------------------------------------------EMEIERWE------------RNEEM-------SDAEKKMIQETWNTVYAK-CEDVGVSLLIR-FFVNFPSAKHYFSQF---KHME----DPLEMERSQQLRKHARRVMGAINSVVENIYDSEKVASVLALVGKAHAVKHK-VEPVYFQLL-GVLLEVLAEEYTNEFSPPEVQRAWAKMKSLICTHVTAAYKEVGWVQYPNSTM------------- Anolis_GbY ----------------------------------------------------------------------------------------------------------------------------------KAGKM-------TDLDRRHIREIWTAAFEN-PEENGRLVIIR-FFSDYPASKQYFKTV---PT-------DGDLKAHPQVAFHGRRIMVAFSQVIENMENWNQACVLLERLVNNHKNIHQ-VPSGMFQLLFQAMLCTFDDLLGRTF-TPEKRVSWEKFFQVIQEEVEAAYDR------------------------ Anolis_HbA -------------------------------------------------------------------------------------------------------------------------------------ML-------TEDDKNHIRAIWGHVSSN-PELYGAEALTR-LFAAHHTTKTYFPHY-------------DMSPGSAQIKAHGKKVVEAITQAVNNLDD---IAGALAKLADLHAEKLR-VDPVNFPLLGHCLLVTIAAHNRGPL-KPEFILALDKCFTSIGRVLIAQYR------------------------- Anolis_HbB M-----------------------------------------------------------------------------------------------------------------------------------VHW-------TAEEKQLIANCWSKVD---IGQIGGDALAC-LLCVYPWTQRFFPDF---GNLS----NAAAICANAKVKAHGKKVLTAFGEAVKNLDN---IKDTFAKLSELHCDKLH-VDPVNFNLLGDVLIVCLAAHFGKDF-TPACHAAYQKLVNSVAHGLSRRYH------------------------- Anolis_Mb ------------------------------------------------------------------------------------------------------------------------------------MEL-------SDQEWQKVIDIWGKVEPE-IPAYGQMVILR-LFEQHPETQEKFDKF---KNLK----SLDEMKNSEDLKKHGTIVLTALGKILKQKRQ---HEAELAPLAQSHATKHK-IPVKYLEFISEVIVGVIAEKRSADF-GAESQAAMRKALELFRNDMDRKYKELGFQG------------------- Arctic_lamprey_Hb1 MPI---------------------------------------------------------------------------------------------------------------VDSG------------SVAPL-------SAAEKTKIRSAWAPVYSN-YETSGVDILVK-FFTSTPAAQEFFPKF---KGMT----SADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQ-VDPQYFKVLAAVIADTVA----------AGDAGFEKLMSMICILLRSAY-------------------------- Arctic_lamprey_Hb2 MPI---------------------------------------------------------------------------------------------------------------VDSG------------SVPAL-------TAAEKATIRTAWAPVYAK-YQSTGVDILIK-FFTSNPAAQEFFPKF---QGLT----SADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLKELSSKHAKSFQ-VDPQYFKVLAAVIVDTVL----------PGDAGLEKLMSMICILLKSSY-------------------------- Arctic_lamprey_Hb4 MPI---------------------------------------------------------------------------------------------------------------EDSG------------SKPDF-------SDDEKKAIKDSWSGVYSE-YESTSSEILIK-FFVDNPSAQDFFPKF---KDLD----SEEKLKGSTAVRWHAERIINAVNDAIWLLDEPEKNAKKLKELSEKHAVQLN-VDAKFFKVLAEVILDKVAEKNDGSF-SDSARSAWEKLLTYICISLKVAY-------------------------- Chicken_Cygb MEKVQG--------------------------------------------------------------------------------------------------------EMEIERWE------------RSEEI-------SDAEKKVIQETWSRVYAN-CEDVGVSILIR-FFVNFPSAKQYFSQF---KHMD----DTLEMERSLQLRKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHK-VEPVYFKKLTGVMLEVIAEAYGNDF-TPEAHGAWTKMRTLIYTHVTAAYKEAGWVSYPSATL------------- Chicken_GbE ------------------------------------------------------------------------------------------------------------------------------------MSF-------SEAEVQSARGAWEKMYVD-AEDNGTAVLVR-MFTEHPDTKSYFTHF---KGMD----SAEEMKQSDQVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLK-IDPKNFRIICDIILQLMEEKFG-----GDCKASFEKVTNEICTHLTNIYKEAGW--------------------- Chicken_HbA ------------------------------------------------------------------------------------------------------------------------------------MVL-------SAADKNNVKGIFTKIAGH-AEEYGAETLER-MFTTYPPTKTYFPHF-------------DLSHGSAQIKGHGKKVVAALIEAANHIDD---IAGTLSKLSDLHAHKLR-VDPVNFKLLGQCFLVVVAIHHPAAL-TPEVHASLDKFLCAVGTVLTAKYR------------------------- Chicken_HbB M-----------------------------------------------------------------------------------------------------------------------------------VHW-------SAEEKQLITSVWSKVN---VEECGAEALAR-LLIVYPWTQRFFASF---GNLS----SPTAIMGNPRVRAHGKKVLSSFGEAVKNLDN---IKNTYAKLSELHCDKLH-VDPENFRLLGDILIIVLASHFARDF-TPACQFAWQKLVNVVAHALARKYH------------------------- Chicken_Mb ------------------------------------------------------------------------------------------------------------------------------------MGL-------SDQEWQQVLTIWGKVEAD-IAGHGHEVLMR-LFHDHPETLDRFDKF---KGLK----TPDQMKGSEDLKKHGATVLTQLGKILKQKGN---HESELKPLAQTHATKHK-IPVKYLEFISEVIIKVIAEKHAADF-GADSQAAMKKALELFRNDMASKYKEFGFQG------------------- Finch_Cygb MEKVQG--------------------------------------------------------------------------------------------------------EMEIERWE------------RSEEI-------SDAEKKVIQEIWSRVYAN-CEDVGVSILIR-FFVNFPSAKQYFSQF---KHME----DPLEMERSLQLRKHARRVMGAINTVVENLNDSEKVSSVLALVGKAHALKHK-VEPIYFKKLTGVMLEVIAEEYPNDF-TPEAHGAWTKMKTLIYTHVTAAYKEVGWAQYPTATL------------- Finch_GbE ------------------------------------------------------------------------------------------------------------------------------------MSL-------SEAEVQSARGAWEKIYVD-AEDNGTAVLVR-MFTEHPDTKSYFPHF---KGMD----SAEEMKQSDQVRGHGKKVFGAINDMVQHLDNSEAFLGIVTPLGKKHATQLK-IDPKNFRIICDIILQLMEEKFG-----GDCKASFEKVTNEICTHLNNIYKEEGW--------------------- Finch_HbA ------------------------------------------------------------------------------------------------------------------------------------MVL-------SAGDKSNVKAVFGKIGGQ-ADEYGADALER-MFATYPQTKTYFPHF-------------DLGKGSAQVKGHGKKVAAALVEAANNVDD---LAGALSKLSDLHAQKLR-VDPVNFKLLGQCFLVVVATRNPSLL-TPEVHASLDKFLCAVGTVLTAKYR------------------------- Finch_HbB M-----------------------------------------------------------------------------------------------------------------------------------VHW-------SAEEKQLIASVWGRVS---VEECGAEALAR-LLIVYPWTQRFFSDF---GNLS----SPTAIVGNPKVRAHGKKVLTSFGEAIKNLDN---LKGTYSKLSELHCDKLH-VDPENFRLLGDILVIVLAAHFTKEF-TPACQATWQKLVGVVAHALARKYH------------------------- Finch_Mb ------------------------------------------------------------------------------------------------------------------------------------MGL-------SDQEWQQVLTVWGKVESD-LAGHGHQILMR-LFQDHPETLDRFEKF---KGLK----TPDAMKGSEDLKKHGVTVLTQLGKILKAKGN---HEAELKPLAQTHATKHK-IPVKYLEFISEVIIKVLAEKHAADF-GADAQAAMKKALELFRNDMATKYKEFGFQG------------------- Frog_Cygb MEKVQG--------------------------------------------------------------------------------------------------------ENDMERWE------------RLEEI-------TESERGVIKETWARVYAN-CEDVGVSILIR-FFVNFPSAKQHFSQF---KHME----DPLEMEGSVQLRKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHK-VDPVYFKILTGVMLEVIAEEYAKDF-TPDVQLAWNKLRSHLYSHVLSAYKEAGWTQYPSNSV------------- Frog_GbX MGCILS--------------------------------------------------------------------------------------------------------SLGWQWRDSL--------DHTETSPLLPTLNLSEQQQQLLVESWRLIQHD-IAKVGVILFVR-LFETHPECKDVFFLF---RDVD----DLQALRANKDLRAHGLRVLSFVEKSVARIADCARLEELALELGRSXY-RYN-APPRYYQYVGTEFISAVCPMLHDKW-TAEVEEAWKGLFAYICTVMERGYQEEERRHSDGRSLIDGLQGNKGLI-- Frog_GbY -----------------------------------------------------------------------------------------------------------------------------------MADL-------TGADIENINEVWSKIYAN-PEESGRTVVIS-LFLTYPQTKIYFKNL---KNIS----TLQEMQDNAGIRAHGKRVMGALNHVIENLKDWDAVCSALSHLAKRHQDVHK-VEVNNFELLFLVIISVFKEALGSGF-TPEQSKSWEKLFSITYKYLESCYANTDS--------------------- Frog_HbA1 ------------------------------------------------------------------------------------------------------------------------------------MHL-------TADDKKHIKAIWPSVAAH-GDKYGGEALHR-MFMCAPKTKTYFPDF-------------DFSEHSKHILAHGKKVSDALNEACNHLDN---IAGCLSKLSDLHAYDLR-VDPGNFPLLAHQILVVVAIHFPKQF-DPATHKALDKFLVSVSNVLTSKYR------------------------- Frog_HbB M-----------------------------------------------------------------------------------------------------------------------------------VNL-------TAKERQLITGTWSKIC---AKTLGKQALGS-MLYTYPWTQRYFSSF---GNLS----SIEAIFHNAAVATHGEKVLTSIGEAIKHMDD---IKGYYAQLSKYHSETLH-VDPYNFKRFCSCTIISMAQTLQEDF-TPELQAAFEKLFAAIADALGKGYH------------------------- Frog_NgB ME---------------------------------------------------------------------------------------------------------------------------------KDQL-------SGPQKELIRESWQTVSQD-QLHHGTVLFSSDIFQLKSGLYWSSEVPRECLIRV----VHQDCLSSAEFTEHIRKVMTVIDAAVSSLDCLSSLDEYLTSLGRKHR-AVG-VKLESFNTVGESLLFALESCLGDAF-TSDTREAWSLLYANVVQSMSRGWHRDSQEQREGI--------------- Hagfish_Hb1 MPI---------------------------------------------------------------------------------------------------------------TDQG------------PLPTL-------SEGDKKAIRESWPQIYQN-FEQTGLVVLLE-FLQKNPGAQQSFPKF---SAT------KCNLEQDNEVKWQASRIINAVNHTIGLMDKEAAMKQYLKELSAKHSSEFQ-VDPKLFKELSAIFVSTI-----------RGKAAYEKLFSIICTLLRSSYDE------------------------ Hagfish_Hb2 M-----------------------------------------------------------------------------------------------------------------SAH-------------GIART-------TEGERAAVRASWAVLMKD-YEHAGVQILDK-FFKANPAAKPFFTKM---KDLH----TLEDLASSADARWHVERIIQAVNFAVINIEDREKLSNKFVKLSQDHIEEFHVTDPQYFMILSQTILDEVEKRNGGL--SGEGKSGWHKVMTIICKMLKSKY-------------------------- Hagfish_Hb3 MPI---------------------------------------------------------------------------------------------------------------TDHG------------QPPTL-------SEGDKKAIRESWPQIYKN-FEQNSLAVLLE-FLKKFPKAQDSFPKF---SAK------KSHLEQDPAVKLQAEVIINAVNHTIGLMDKEAAMKKYLKDLSTKHSTEFQ-VNPDMFKELSAVFVSTM-----------GGKAAYEKLFSIIATLLRSTYDA------------------------ Hagfish_Hb4 MPI---------------------------------------------------------------------------------------------------------------TDQR------------PLPTL-------SEGEKKAIKESWPQIYQN-FEQTSLDVLIE-FLQKFPEAQDSFPKF---SAK------KCHLEQDNEVKWQASRIINAVNAVVGHLDNEVAMKQYLKELSVKHSSEFQ-VDPKMFKELSAIFVSTI-----------RGKAAYEKLFSIICTLLRSSYDE------------------------ Houndshark_HbA ------------------------------------------------------------------------------------------------------------------------------------MAF-------TACEKQTIGKIAQVLAKS-PEAYGAECLAR-LFVTHPGSKSYFEYK-------------DYSAAGAKVQVHGGKVIRAVVKAAEHVDD---LHSHLETLALTHGKKLL-VDPQNFPMLSECIIVTLATHLTEF--SPDTHCAVDKLLSAICQELSSRYR------------------------- Houndshark_HbB M-----------------------------------------------------------------------------------------------------------------------------------VHW-------TQEERDEISKTFQGTD---MKTVVTQALDR-MFKVYPWTNRYFQKR-----------------TDFRSSIHAGIVVGALQDAVKHMDD---VKTLFKDLSKKHADDLH-VDPGSFHLLTDCIIVELAYLRKDCF-TPHIQGIWDKFFEVVIDAISKQYH------------------------- Houndshark_Mb -----------------------------------------------------------------------------------------------------------------------------------------------MVDWEKVNSVWSAVESD-LTAIGQNILLR-LFEQYPESQNHFPKF---KNKS-----LGELKDTADIKAQADTVLSALGNIVKKKGS---HSQPVKALAATHITTHK-IPPHYFTKITTIAVDVLSEMYPSEM-NAQVQAAFSGAFKIICSDIEKEYKAANFQG------------------- Human_Cygb MEKVPG--------------------------------------------------------------------------------------------------------EMEIERRE------------RSEEL-------SEAERKAVQAMWARLYAN-CEDVGVAILVR-FFVNFPSAKQYFSQF---KHME----DPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHK-VEPVYFKILSGVILEVVAEEFASDF-PPETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATTPPATLPSSGP-- Human_HbA ------------------------------------------------------------------------------------------------------------------------------------MVL-------SPADKTNVKAAWGKVGAH-AGEYGAEALER-MFLSFPTTKTYFPHF-------------DLSHGSAQVKGHGKKVADALTNAVAHVDD---MPNALSALSDLHAHKLR-VDPVNFKLLSHCLLVTLAAHLPAEF-TPAVHASLDKFLASVSTVLTSKYR------------------------- Human_HbB M-----------------------------------------------------------------------------------------------------------------------------------VHL-------TPEEKSAVTALWGKVN---VDEVGGEALGR-LLVVYPWTQRFFESF---GDLS----TPDAVMGNPKVKAHGKKVLGAFSDGLAHLDN---LKGTFATLSELHCDKLH-VDPENFRLLGNVLVCVLAHHFGKEF-TPPVQAAYQKVVAGVANALAHKYH------------------------- Human_Mb ------------------------------------------------------------------------------------------------------------------------------------MGL-------SDGEWQLVLNVWGKVEAD-IPGHGQEVLIR-LFKGHPETLEKFDKF---KHLK----SEDEMKASEDLKKHGATVLTALGGILKKKGH---HEAEIKPLAQSHATKHK-IPVKYLEFISECIIQVLQSKHPGDF-GADAQGAMNKALELFRKDMASNYKELGFQG------------------- Human_NgB ---------------------------------------------------------------------------------------------------------------------------------------------MERPEPELIRQSWRAVSRS-PLEHGTVLFAR-LFALEPDLLPLFQYN--CRQFS----SPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHR-AVG-VKLSSFSTVGESLLYMLEKCLGPAF-TPATRAAWSQLYGAVVQAMSRGWDGE----------------------- Medaka_Cygb_1 MERKQ----------------------------------------------------------------------------------------------------------GEVDHLE------------RSRPL-------TDKERVMIQDSWAKVYQN-CDDAGVAILVR-LFVNFPSSKQYFSQF---KHIE----DAEELEKSSQLRKHARRVMNAINTLVESLDNSDKVSSVLNAVGKAHAIRHK-VDPVYFKILSGVILEVLGEAYPQVM-TAEVASAWTNLLAILCCSIKAVYEELGWPHLSNSTS------------- Medaka_Cygb_2 MSCRESPPPPSPPP-----------------------------------------------------------------------------------------QMLGVQRGECEDRPE------------RAEPL-------SDAEMEIIQHTWGHVYKN-CEDVGVSVLIR-FFVNFPSAKQYFSQF---QDMQ----DPEEMEKSSQLRQHARRVMNAIN-VVENLQDPEKVSSVLALVGKAHAVKHK-VEPIYFKILSGVMLSVLSEDFPEFF-TAEVQLVWTKLMAAVYWHVTGAYTEVGWLQVSSSAV------------- Medaka_GbX MGCAIS--------------------------------------------------------------------------------------------------------GLAAKTDLAERS----REDAAVEHP-------NEEQIQMIKDSWKVIRDD-IAKVGIIMFVR-LFETHPECKDVFFLF---RDVE----DLERLRTNRELRAHGLRVMSFIEKSVARLDQPERLEALAVELGKSHY-HYN-APPKYYNYVGAEFICAVQPILKEQW-TTELEKAWQTLFQFVTALMKQGYQEESARQRQLATSPKDRLDKRNTAL- Medaka_HbA -----------------------------------------------------------------------------------------------------------------------------------KMSL-------SAKDKAAVKAFWAKVSGQ-ADAIGSDALSR-MLVVYPQTKTYFAHW---KDL---------SPGSAPVKKHGKTVMGGIADAVGKIDD---ISSGLLNLSELHAFTLR-VDPTNFKILSHNILVVMAIMFPQDF-TPEVHVALDKFLAAVSLALSEKYR------------------------- Medaka_HbB M-----------------------------------------------------------------------------------------------------------------------------------VEW-------TEQERSIITNIFGNLD---YEDVGSKALSR-CLIVYPWTQRYFASF---GNLY----NAEAIKTNPNIAAHGTKVLHGLDRAVKNMDN---IKATYAELSVLHSEKLH-VDPDNFKLLADCLTIVIAAKLGSAF-SPEIQATFQKFLAVVVSALGRQYH------------------------- Medaka_Mb -----------------------------------------------------------------------------------------------------------------------------------------------MADYDMVLKHWGPVEAD-YNTHGNLVLTR-LFHEYPETQKLFPKF---AGIA-----KGDMAGNAALSAHGATVLKKLGELLKARGN---HGAILKPLANSHATKHK-IPINNFRLITEVIGKVMAEKAGL---DAAGQQALRSVMAGIIAEIEADYKELGFAG------------------- Medaka_NgB M-----------------------------------------------------------------------------------------------------------------------------------EKL-------SGKDKELIRGSWESLGKN-KVPHGVIMFSR-LFELDPALLSLFNYN---TNCG----STQDCLSSPEFLDHVTKVMLVIDAAVNHLDDLHSLEDFLLNLGRKHQ-AVG-VSTQSFAVVGESLLYMLQCSLGQAY-TAALSQAWLNMYSIVVAAMSRGWAKNGEDKAD----------------- Platypus_GbY -----------------------------------------------------------------------------------------------------------------------------------MVQV-------TDVEKANIQSIWSKMMEN-LEKNGIDIFTR-LFREYPETKKYFKNI---PL-------EGNLQEDPLLRSHGRRVMVALNRIIQNLDNWKQVCKILNPLAEKHKIIHS-VDVENFQFMLKCVGDVCQDYLGPCY-TPEIAESFQKLQSSLYDQVVITYLHSGSD-------------------- Platypus_HbA ------------------------------------------------------------------------------------------------------------------------------------MGL-------TDGEKKEVAALWANVSGH-EEEFGAEALDR-LFLSFPPTKTYFPHF-------------ELSQGSAQVKAHGKKVADALTTAVAHLDD---LDSTLSALSDLHAHKLR-VDPINFKLLAHCILVVVARHLPAEF-TPSAHAALDKFLSKVATVLTSKYR------------------------- Platypus_HbB M-----------------------------------------------------------------------------------------------------------------------------------VHL-------SGGEKSAVTNLWGKVN---INELGGEALGR-LLVVYPWTQRFFEAF---GDLS----SAGAVMGNPKVKAHGAKVLTSFGDALKNLDD---LKGTFAKLSELHCDKLH-VDPENFNRLGNVLIVVLARHFSKDF-SPEVQAAWQKLVSGVAHALGHKYH------------------------- Platypus_HbW M-----------------------------------------------------------------------------------------------------------------------------------VNW-------TSEEKHAIVSIWGKVD---IEETGANALSR-LLVVYPWTQRYFSAF---GNLS----SPTAIVGNPRVRAHGKKVLTSFGEAVKDLDH---VKSNFAKLSQLHSEKLH-VDPENFRLLGDNLIIVLAATLGKDF-TPEAQAAWQKLVGVVASALSSQYH------------------------- Platypus_Mb ------------------------------------------------------------------------------------------------------------------------------------MGL-------SDGEWQLVLKVWGKVEGD-LPGHGQEVLIR-LFKTHPETLEKFDKF---KGLK----TEDEMKASADLKKHGGTVLTALGNILKKKGQ---HEAELKPLAQSHATKHK-ISIKFLEYISEAIIHVLQSKHSADF-GADAQAAMGKALELFRNDMAAKYKEFGFQG------------------- Platypus_NgB ME---------------------------------------------------------------------------------------------------------------------------------NGRL-------SGPEQELIRESWRSVNSN-PLEHGMILFTR-LFDLEPDLLPLFQYN--CRQFS----SPRDCLASPEFLDHIRKVMLVIDAAVIHLDDLSSLEEYLTNLGRKHK-AIG-VKLSSFSTVGESLLFMLEKCLGPAF-SPATREAWTRLYTAMVHAMSRGWGGE----------------------- Port_Jackson_shark_Mb -----------------------------------------------------------------------------------------------------------------------------------------------MTEWEHVNKVWAVVEPD-IPAVGLAILLR-LFKEHKETKDLFPKF---KEIP-----VQQLGNNEDLRKHGVTVLRALGNILKQKGK---HSTNVKELADTHINKHK-IPPKNFVLITNIAVKVLTEMYPSDM-TGPMQESFSKVFTVICSDLETLYKEANFQG------------------- Sea_lamprey_Hb1a MPI---------------------------------------------------------------------------------------------------------------VDSG------------SVPAL-------TAAEKATIRTAWAPVYAK-YQSTGVDILIK-FFTSNPAAQAFFPKF---QGLT----SADQLKKSMDVRWHAERIINAVNDAVVAMDDTEKMSLKLRELSGKHAKSFQ-VDPQYFKVLAAVIVDTVL----------PGDAGLEKLMSMICILLRSSY-------------------------- Sea_lamprey_Hb1b MPI---------------------------------------------------------------------------------------------------------------VDSG------------SVSPL-------SDAEKNKIRAAWDLVYKD-YEKTGVDILVK-FFTGTPAAQAFFPKF---KGLT----TADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFY-VDRQYFKVLAGIIADTTA----------PGDAGFEKLMSMICILLSSAY-------------------------- Sea_lamprey_Hb2 MPI---------------------------------------------------------------------------------------------------------------VDTG------------SVAPL-------SAAEKTKIRSAWAPVYSN-YETSGVDILVK-FFTSTPAAQEFFPKF---KGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQ-VDPQYFKVLAAVIADTVA----------AGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb3 MPI---------------------------------------------------------------------------------------------------------------VDSG------------SVAPL-------SAAEKTKIRSAWAPVYSN-YETTGVDILVK-FFTSTPAAQEFFPKF---KGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLGDLSGKHAKSFQ-VDPQYFKVLAAVIADTVA----------AGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb5 MPI---------------------------------------------------------------------------------------------------------------VDTG------------SVAPL-------SAAEKTKIRSAWAPVYST-YETSGVDILVK-FFTSTPAAQEFFPKF---KGLT----TADQLKKSADVRWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQ-VDPQYFKVLAAVIADTVA----------AGDAGFEKLMSMICILLRSAY-------------------------- Sea_lamprey_Hb_PMII MPI---------------------------------------------------------------------------------------------------------------VDTG------------SVAPL-------SAAEKTKIRSAWAPVYSN-YETSGVDILVK-FFTSTPAAQEFFPKF---KGLT----TADQLKKSADVRWHAERIINAVNDAVVSMDDTEKMSMKLRDLSGKHAKSFQ-VDPQYFKVLAAVIADTVA----------AGDAGFEKLMSMICILLRSAY-------------------------- Sea_squirt_Glb1 ------------------------------------------------------------------------------------------------------------------------------------MPF-------TDEELKLLRDSWDEVKKLGMKEVGLHIFTG-LLNAAPSLRTLFYTI---DLPDEEELTIDVMRENKKVVAHATRIANAISKFIKFLDQPDELEKLLTSLGESHA-RRQ-VDPESFEYVAPVILSVIGGHLKLPS-NSPTLQAWVKAYGVLRNGIVSAMEA------------------------ Sea_squirt_Glb2 ------------------------------------------------------------------------------------------------------------------------------------MGL-------TTEEIGLLRSSWNEMKTIGMKELGLLIFHR-LFSDVPRIRKMFYNL---ELPDDETLTMEAMRSNQKMSRHATRIATSISTYLKLADQPEELKTFLNGLGELHA-GHN-VEPEDFEYLAPVMLAVIGGQLNLNS-NSSILQAWVKAYGVLRNGIVRGMYAYQG--------------------- Sea_squirt_Glb3 ------------------------------------------------------------------------------------------------------------------------------------MSL-------TSEQVVLLRSSWQTIGKLGMSNVGLAVLHR-LFNDVPETLPFFHSV---LSPTQ-QTEIEVLKSNAKVVRHASRVGLSIDKIINLLDNGEELVKYLLFLGQVHV-KRS-IPRKYFSAMGPVLLSVISAVLEKDL-DAPVMQAWATAYGVIEQGIIDGM-------------------------- Sea_squirt_Glb4 MKIICGLILFSTFAIIFVSGLNCWTCNVLGGNNVCRRSGGLRTCFNNQVCYNEVRRRGNTINIRKGCKNSGVCENHIMQSMSTPNPNNQCVNGPNYFCSCCCGNSVCNSNWLTCVTAGSVAPTVSTTVPPADEGL-------KRSDIINIQDSWNTLKGFGYETVGMLVLHR-LFNDAPQTRYLFSQL---SLSSNESFTLEQMRNNSRVVYHANRVARAVGRLVDLIELPTNFTDHLVWLGQRHA-YHG-VAPVNFDYMGPVLLETIKVNLELPS-DSPTLSAWAKAYGVIKNGIKDAIIATYAEG------------------- Stingray_HbA ------------------------------------------------------------------------------------------------------------------------------------MVL-------SSQNKKAIEELGNLIKAN-AEAWGADALAR-LFELHPQTKTYFSKF---SGF---------EACNEQVKKHGKRVMNALADATHHLDN---LHLHLEDLARKHGENLL-VDPHNFHLFADCIVVTLAVNLQAF--TPVTHCAVDKFLELVAYELSSCYR------------------------- Stingray_HbB M-----------------------------------------------------------------------------------------------------------------------------------VKL-------SEDQEHYIKGVWKDVD---HKQITAKALER-VFVVYPWTTRLFSKL---QGLF--------SANDIGVQQHADKVQRALGEAIDDLKK---VEINFQNLSGKHQ-EIG-VDTQNFKLLGQTFMVELALHYKKTF-RPKEHAAAYKFFRLVAEALSSNYH------------------------- Tetraodon_Cygb_1 MERMQR--------------------------------------------------------------------------------------------------------DGEVDHVE------------QPGPL-------TEKEKVMIQDSWAKVFQS-CDDAGVAILVR-FFVNFPSSKQFFKDF---KHME----EPEEMQQSVQLRKHAHRVMTALNTLVESLDNADRVASVLKSVGRAHALRHN-VDPKYFKILSGVILEVLGEAFTEII-TAEVASAWTKLLANMCCGIAAVYKEAGWTELSSSVE------------- Tetraodon_Cygb_2 MSHREPPPPQLA---------------------------------------------------------------------------------------------VQRRDVDGQDGPE------------RAEPL-------SDTEREMIRDAWGHVYKN-CEDVGVSILIR-FFVNFPSAKQYFSQF---QDME----EPEEMERSSQLRHHACRVMNALNTVVENLHDPEKVSSVLAVVGRAHAVKHK-VEPMYFKILSGVILEVLCEDFPEFF-TADVQLVWSKLMATVYWHVTGAYTDVGWLQVSSSAV------------- Tetraodon_GbX M-GCAISSLGAKAEF---------------------------------------------------------------------------------------GDRSAEEEDAAAAA--------------AVVYP-------REDQIQMIKDSWKVIRDD-IAKVGIIMFVR-LFETHPECKDVFFLF---RDVE----DLERLRSSRELRAHGLRVMSFIEKSVARLDQQDRLEALAVELGKSHY-HYN-APPKYYSYVGAEFICAVQPILKERF-TSELEEAWKTLFQYVTGLMRKGHQEEGSRQRHLALPPKDGPEKRTSAL- Tetraodon_HbA M-----------------------------------------------------------------------------------------------------------------------------------TSL-------STKDKETVRAFWAKVASN-REEIGASALCR-LLSVYPQTKTYFSHW---KDQ---------SPNSASAKKHGITIMNAVGDAVSKIDD---LKTGLFNLSELHAFTLR-VDPANFKLLAQCMMVVIAIMYPADF-TPEVHVAMDKFLASLALALSEKYR------------------------- Tetraodon_HbB M-----------------------------------------------------------------------------------------------------------------------------------VVW-------TDQERAIIDNIFSNLD---YEDVGSKALIR-CLIVYPWTQRYFSSF---GNLY----NAEAIRNNPNVAKHGVTVLHGLDRALKNMDN---IKEEYKK----HSEKLH-VDPDNFKLLSDCLTVVIAGKLGSKF-TPEYQAALQKFLAVVVSALGRQYH------------------------- Tetraodon_Mb -----------------------------------------------------------------------------------------------------------------------------------------------MGDFDMVLKFWGPVEAD-YSAHGGMVLTR-LFTENPETQQLFPKF---VGIA-----QSELAGNAAVSAHGATVLKKLGELLKAKGN---HAAILQPLANSHATKHK-IPIKNFKLIAEVIGKVMAEKAGL---DTAGQQALRNIMATIIADIDATYKELGFS-------------------- Tetraodon_NgB M-----------------------------------------------------------------------------------------------------------------------------------EKL-------SSKDKELIRGSWDSLGKN-KVPHGVILFSR-LFELDPELLNLFHYT---TNCG----STQDCLSSPEFLEHVTKVMLVIDAAVSHLDDLHSLEDFLLNLGRKHQ-AVG-VKPQSFAMVGESLLYMLQCSLGQAY-TASLRQAWLNMYSVVVASMSRGWAKNGEDKAD----------------- Zebrafish_Cygb_1 MEGDG-----------------------------------------------------------------------------------------------------------GVQLTQ------------SPDSL-------TEEDVCVIQDTWKPVYAE-RDNAGVAVLVR-FFTNFPSAKQYFEHF---RELQ----DPAEMQQNAQLKKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHK-VDPVYFKILAGVILEVLVEAFPQCFSPAEVQSSWSKLMGILYWQMNRVYAEVGWENSKK---------------- Zebrafish_Cygb_2 MEKERE--------------------------------------------------------------------------------------------------------DEETEGRE------------RPEPL-------TDVERGIIKDTWARVYAS-CEDVGVTILIR-FFVNFPSAKQYFSQF---QDME----DPEEMEKSSQLRKHARRVMNAINTVVENLHDPEKVSSVLVLVGKAHAFKYK-VEPVYFKILSGVILEILAEEFGECF-TPEVQTSWSKLMAALYWHITGAYTEVGWVKLSSSAV------------- Zebrafish_GbX MGCAIS--------------------------------------------------------------------------------------------------------GSGLTAGAPEIR---PGEEETPAGL-------TTNHIRLIKESWRLIQED-IAKVGIIMFVR-LFETHPECKDVFFLF---RDVE----DLERLRTSRELRAHGLRVMSFIEKSVARLDQLERLETLALELGKSHY-RYN-APPKYYGYVGAEFICAVRPILKDRW-TPELEEAWKTLFQYVTSIMREGFLEEERNKRSNTQTSSRERPDKRSTAI Zebrafish_HbA ------------------------------------------------------------------------------------------------------------------------------------MSL-------SDTDKAVVKAIWAKISPK-ADEIGAEALAR-MLTVYPQTKTYFSHW---ADL---------SPGSGPVKKHGKTIMGAVGEAVSKIDD---LVGGLAALSELHAFKLR-VDPANFKILSHNVIVVIAMLFPADF-TPEVHVSVDKFFNNLALALSEKYR------------------------- Zebrafish_HbB M-----------------------------------------------------------------------------------------------------------------------------------VEW-------TDAERTAILGLWGKLN---IDEIGPQALSR-CLIVYPWTQRYFATF---GNLS----SPAAIMGNPKVAAHGRTVMGGLERAIKNMDN---VKNTYAALSVMHSEKLH-VDPDNFRLLADCITVCAAMKFGQAGFNADVQEAWQKFLAVVVSALCRQYH------------------------- Zebrafish_Mb -----------------------------------------------------------------------------------------------------------------------------------------------MADHDLVLKCWGAVEAD-YAANGGEVLNR-LFKEYPDTLKLFPKF---SGIS-----QGDLAGSPAVAAHGATVLKKLGELLKAKGD---HAALLKPLANTHANIHK-VALNNFRLITEVLVKVMAEKAGL---DAAGQGALRRVMDAVIGDIDGYYKEIGFAG------------------- Zebrafish_NgB M-----------------------------------------------------------------------------------------------------------------------------------EKL-------SEKDKGLIRDSWESLGKN-KVPHGIVLFTR-LFELDPALLTLFSYS---TNCG----DAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKHQ-AVG-VNTQSFALVGESLLYMLQSSLGPAY-TTSLRQAWLTMYSIVVSAMTRGWAKNGEHKSN----------------- ; end;