Novel Small-Molecule Inhibitor of Apurinic/Apyrimidinic Endonuclease 1 Blocks Proliferation and Reduces Viability of Glioblastoma Cells

Data Supplement

Files in this Data Supplement:

• Data Supplement - Supplementary Table 1: List of compounds with IC50 values less than 50 M
• Data Supplement - Supplementary Table 2: IC50 values of the known inhibitor compounds of Ape1's DNA repair activity as calculated in our assay.
• Data Supplement - Supplementary Figure 1: Workflow summary used to identify the top 4 compounds.
• Data Supplement - Supplementary Figure 2: Structures of the compounds listed in Table 1.
• Data Supplement - Supplementary Figure 3a: Effect of AR02 and AR06 on the activity of purified Ape1 and endonuclease IV proteins in the gel-based AP endonuclease assay.
• Data Supplement - Supplementary Figure 3b: Effect of AR02 and AR06 on the activity of purified Ape1 and endonuclease IV proteins in the gel-based AP endonuclease assay.
• Data Supplement - Supplementary Figure 4a: Ability of AR02 and AR06 to inhibit Ape1's activity in cell extracts made from SF767 glioblastoma cells.
• Data Supplement - Supplementary Figure 4b: Ability of AR02 and AR06 to inhibit Ape1's activity in cell extracts made from SF767 glioblastoma cells.
• Data Supplement - Supplementary Figure 5: Killing curve of AR03 against SF767 glioblastoma cells using the MTT assay.