Mechanisms Involved in the Selection of HIV-1 Reverse Transcriptase Thumb Subdomain Polymorphisms Associated with Nucleoside Analogue Therapy Failure -- Betancor et al. 54 (11): 4799 Data Supplement - Supplemental material -- Antimicrobial Agents and Chemotherapy

Mechanisms Involved in the Selection of HIV-1 Reverse Transcriptase Thumb Subdomain Polymorphisms Associated with Nucleoside Analogue Therapy Failure
Antimicrob. Agents Chemother. Betancor et al. 54: 4799

Supplemental material

Files in this Data Supplement:

Supplemental file 1 - Figure S1, effects of the AZT concentration on the replication kinetics of recombinant HIV-1 clones bearing mutant or WT RTs. Figure S2, kinetics of formation of the -10 RNase H cleavage product generated by WT and mutant RTs during ATP-mediated AZTMP excision. Figure S3, RNase H activity of WT and mutant RTs under limiting concentrations of template-primer. Supplemental table, ability of the next complementary dNTP to inhibit ATP-dependent rescue of primers terminated with d4T in RNA-DNA duplexes, by mutant RTs.
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